KR102796989B1 - 방향족 니트릴 화합물의 제조 방법 - Google Patents

방향족 니트릴 화합물의 제조 방법 Download PDF

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KR102796989B1
KR102796989B1 KR1020207033680A KR20207033680A KR102796989B1 KR 102796989 B1 KR102796989 B1 KR 102796989B1 KR 1020207033680 A KR1020207033680 A KR 1020207033680A KR 20207033680 A KR20207033680 A KR 20207033680A KR 102796989 B1 KR102796989 B1 KR 102796989B1
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carboxylic acid
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KR20210005663A (ko
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마사키 나가하마
히데키 오오미야
다이키 오카도
히로츠구 다니이케
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유비이 가부시키가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/20—Preparation of carboxylic acid nitriles by dehydration of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/34—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfuric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/06—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/305—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with sulfur or sulfur-containing compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C07C57/40—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic containing condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/194—Radicals derived from thio- or thiono carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/33—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring with cyano groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020207033680A 2018-04-26 2019-04-26 방향족 니트릴 화합물의 제조 방법 Active KR102796989B1 (ko)

Priority Applications (1)

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KR1020247025451A KR20240121346A (ko) 2018-04-26 2019-04-26 방향족 니트릴 화합물의 제조 방법

Applications Claiming Priority (5)

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US201862663014P 2018-04-26 2018-04-26
US62/663,014 2018-04-26
US201862780445P 2018-12-17 2018-12-17
US62/780,445 2018-12-17
PCT/JP2019/018065 WO2019208807A1 (ja) 2018-04-26 2019-04-26 芳香族ニトリル化合物の製造方法

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KR1020247025451A Division KR20240121346A (ko) 2018-04-26 2019-04-26 방향족 니트릴 화합물의 제조 방법

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KR20210005663A KR20210005663A (ko) 2021-01-14
KR102796989B1 true KR102796989B1 (ko) 2025-04-18

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KR1020247025451A Pending KR20240121346A (ko) 2018-04-26 2019-04-26 방향족 니트릴 화합물의 제조 방법

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US (2) US12054448B2 (https=)
EP (2) EP3786152B1 (https=)
JP (1) JP7399850B2 (https=)
KR (2) KR102796989B1 (https=)
CN (3) CN118439973A (https=)
CA (1) CA3098437C (https=)
ES (1) ES3015171T3 (https=)
PL (1) PL3786152T3 (https=)
WO (1) WO2019208807A1 (https=)

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WO2018159028A1 (ja) * 2017-03-01 2018-09-07 株式会社エーピーアイ コーポレーション Ｎ－ベンジル－２－ブロモ－３－メトキシプロピオン酸アミド及びその中間体の製造方法
WO2021085468A1 (ja) * 2019-10-29 2021-05-06 株式会社エーピーアイ コーポレーション 高純度２－ナフチルアセトニトリル及びその製造方法
CN115784929B (zh) * 2022-12-21 2023-10-13 浦拉司科技（上海）有限责任公司 一种巴豆腈的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014001939A1 (en) * 2012-06-30 2014-01-03 Alembic Pharmaceuticals Limited Process for preparation of agomelatine and crystalline form i thereof

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JPS61268650A (ja) * 1985-05-21 1986-11-28 Otsuka Pharmaceut Factory Inc ナフトキノン誘導体
JP2001039904A (ja) 1999-07-29 2001-02-13 Sumikin Chemical Co Ltd ブロモアルキルナフタレンの製造方法
SE0201938D0 (sv) 2002-06-20 2002-06-20 Astrazeneca Ab New process
NZ592836A (en) 2005-07-27 2013-01-25 Dov Pharmaceutical Inc Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
JP2010268650A (ja) * 2009-05-18 2010-11-25 Daikin Ind Ltd アキシャルギャップ型回転電機
KR20160101012A (ko) 2013-12-09 2016-08-24 뉴로반스, 인크. 신규 조성물
WO2021085468A1 (ja) 2019-10-29 2021-05-06 株式会社エーピーアイ コーポレーション 高純度２－ナフチルアセトニトリル及びその製造方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014001939A1 (en) * 2012-06-30 2014-01-03 Alembic Pharmaceuticals Limited Process for preparation of agomelatine and crystalline form i thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A. Hulkenberg et al., Tetrahedron Lett. 1982, 23, 1501-1508 (1982.01.01.) 1부*
C. C. Price et al., J. Org. Chem. 1949, 14, 111-117(1949.01.01.) 1부.*
M. S. Newman, J. Org. Chem. 1944, 9, 518-528(1944.11.01.) 1부.*

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Publication number Publication date
WO2019208807A1 (ja) 2019-10-31
EP3786152A4 (en) 2021-06-16
JP7399850B2 (ja) 2023-12-18
EP3786152B1 (en) 2024-12-25
US12054448B2 (en) 2024-08-06
EP4520753A3 (en) 2025-05-28
JPWO2019208807A1 (ja) 2021-04-30
CN120441453A (zh) 2025-08-08
ES3015171T3 (en) 2025-04-29
KR20240121346A (ko) 2024-08-08
PL3786152T3 (pl) 2025-04-28
CA3098437C (en) 2025-04-01
EP3786152A1 (en) 2021-03-03
CA3098437A1 (en) 2019-10-31
KR20210005663A (ko) 2021-01-14
US20240351978A1 (en) 2024-10-24
CN118439973A (zh) 2024-08-06
EP4520753A2 (en) 2025-03-12
CN112041298A (zh) 2020-12-04
US20210078940A1 (en) 2021-03-18

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