JP7397917B2 - 嗅覚受容体の発現方法及び応答測定方法 - Google Patents

嗅覚受容体の発現方法及び応答測定方法 Download PDF

Info

Publication number
JP7397917B2
JP7397917B2 JP2022099223A JP2022099223A JP7397917B2 JP 7397917 B2 JP7397917 B2 JP 7397917B2 JP 2022099223 A JP2022099223 A JP 2022099223A JP 2022099223 A JP2022099223 A JP 2022099223A JP 7397917 B2 JP7397917 B2 JP 7397917B2
Authority
JP
Japan
Prior art keywords
amino acid
olfactory receptor
consensus
acid sequence
olfactory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2022099223A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023002484A5 (https=
JP2023002484A (ja
Inventor
敬一 吉川
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kao Corp
Original Assignee
Kao Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kao Corp filed Critical Kao Corp
Publication of JP2023002484A publication Critical patent/JP2023002484A/ja
Publication of JP2023002484A5 publication Critical patent/JP2023002484A5/ja
Priority to JP2023203814A priority Critical patent/JP2024015143A/ja
Application granted granted Critical
Publication of JP7397917B2 publication Critical patent/JP7397917B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Food Science & Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2022099223A 2021-06-22 2022-06-20 嗅覚受容体の発現方法及び応答測定方法 Active JP7397917B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023203814A JP2024015143A (ja) 2021-06-22 2023-12-01 嗅覚受容体の発現方法及び応答測定方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2021103675 2021-06-22
JP2021103675 2021-06-22
JP2022021606 2022-02-15
JP2022021606 2022-02-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023203814A Division JP2024015143A (ja) 2021-06-22 2023-12-01 嗅覚受容体の発現方法及び応答測定方法

Publications (3)

Publication Number Publication Date
JP2023002484A JP2023002484A (ja) 2023-01-10
JP2023002484A5 JP2023002484A5 (https=) 2023-03-06
JP7397917B2 true JP7397917B2 (ja) 2023-12-13

Family

ID=84545724

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022099223A Active JP7397917B2 (ja) 2021-06-22 2022-06-20 嗅覚受容体の発現方法及び応答測定方法
JP2023203814A Pending JP2024015143A (ja) 2021-06-22 2023-12-01 嗅覚受容体の発現方法及び応答測定方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023203814A Pending JP2024015143A (ja) 2021-06-22 2023-12-01 嗅覚受容体の発現方法及び応答測定方法

Country Status (4)

Country Link
US (1) US20240279302A1 (https=)
EP (1) EP4361272A4 (https=)
JP (2) JP7397917B2 (https=)
WO (1) WO2022270481A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023084473A (ja) * 2021-12-07 2023-06-19 花王株式会社 フェノール化合物を原因とするにおいの抑制剤の評価及び／又は選択方法
JP2023084478A (ja) * 2021-12-07 2023-06-19 花王株式会社 アルデヒドを原因とするにおいの抑制剤の評価及び／又は選択方法
US20250353895A1 (en) * 2022-06-16 2025-11-20 Kao Corporation Method for analyzing g-protein conjugated receptor
WO2025257381A1 (en) 2024-06-14 2025-12-18 Givaudan Sa Modified olfactory receptors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020006108A2 (en) 2018-06-26 2020-01-02 Duke University Synthetic odorant receptors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050084868A1 (en) * 2003-10-16 2005-04-21 Wolfgang Aehle Generation of stabilized proteins by combinatorial consensus mutagenesis
JP6114439B2 (ja) 2015-05-29 2017-04-12 花王株式会社 匂い抑制物質の選択方法
WO2016194788A1 (ja) 2015-05-29 2016-12-08 花王株式会社 匂い抑制物質の選択方法
JP6122181B2 (ja) 2015-06-17 2017-04-26 花王株式会社 スルフィド化合物の臭いの抑制剤の評価又は選択方法
JP6849399B2 (ja) 2016-11-09 2021-03-24 花王株式会社 龍涎香様の匂いを呈する香料素材の探索方法
EP3336544B1 (en) 2016-12-14 2019-11-27 Takasago International Corporation Method for identifying malodour counteractants
WO2018162638A1 (en) 2017-03-09 2018-09-13 Firmenich Sa Method of identifying malodor modulating compounds
JP7197298B2 (ja) 2018-07-17 2022-12-27 花王株式会社 メチルメルカプタン臭抑制剤の評価及び／又は選択方法
US20250353895A1 (en) * 2022-06-16 2025-11-20 Kao Corporation Method for analyzing g-protein conjugated receptor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020006108A2 (en) 2018-06-26 2020-01-02 Duke University Synthetic odorant receptors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Journal of Structural Biology，2007年，Vol.159，pp.400-412
PNAS，2020年02月11日，Vol.117, No.6，pp.2957-2967， https://www.pnas.org/doi/abs/10.1073/pnas.1915520117参照

Also Published As

Publication number Publication date
US20240279302A1 (en) 2024-08-22
EP4361272A1 (en) 2024-05-01
JP2024015143A (ja) 2024-02-01
EP4361272A4 (en) 2025-11-19
WO2022270481A1 (ja) 2022-12-29
JP2023002484A (ja) 2023-01-10

Similar Documents

Publication Publication Date Title
JP7397917B2 (ja) 嗅覚受容体の発現方法及び応答測定方法
JP6588715B2 (ja) 尿臭抑制剤の探索方法
Dibattista et al. The functional relevance of olfactory marker protein in the vertebrate olfactory system: a never-ending story
JP2020510436A (ja) 悪臭調節化合物の同定方法
Pu et al. Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans
WO2016194788A1 (ja) 匂い抑制物質の選択方法
JP6122181B2 (ja) スルフィド化合物の臭いの抑制剤の評価又は選択方法
JP7383453B2 (ja) インドール臭抑制剤の選択方法
WO2016204211A1 (ja) スルフィド化合物の臭いの抑制剤の評価又は選択方法
JP6393505B2 (ja) 生乾き臭抑制剤の探索方法
Kim et al. Evidence for functional diversity between the voltage-gated proton channel Hv1 and its closest related protein HVRP1
Pan et al. PRRT2 frameshift mutation reduces its mRNA stability resulting loss of function in paroxysmal kinesigenic dyskinesia
CN117677700A (zh) 嗅觉受体的表达方法和应答测定方法
JP2025010185A (ja) Ｇタンパク質共役型受容体の解析方法
JP2023084478A (ja) アルデヒドを原因とするにおいの抑制剤の評価及び／又は選択方法
Al-Khattaf et al. The Plasmodium alveolin IMC1a is stabilised by its terminal cysteine motifs and facilitates sporozoite morphogenesis and infectivity in a dose-dependent manner
JP6422665B2 (ja) 腋臭抑制剤の探索方法
JP5206882B2 (ja) 塩味調節物質のスクリーニング方法
JP2019129773A (ja) ２−ノナノンの匂いを抑制する物質のスクリーニング方法
JP2023084474A (ja) アミンを原因とするにおいの抑制剤の評価及び／又は選択方法
JP2023084479A (ja) 複素環式芳香族化合物を原因とするにおいの抑制剤の評価及び／又は選択方法
JP2023084477A (ja) 硫黄化合物を原因とするにおいの抑制剤の評価及び／又は選択方法
JP2023084473A (ja) フェノール化合物を原因とするにおいの抑制剤の評価及び／又は選択方法
JP2023084475A (ja) カルボン酸を原因とするにおいの抑制剤の評価及び／又は選択方法
JP2023084476A (ja) カビ臭抑制剤の評価及び／又は選択方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230224

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20230224

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20230224

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230404

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230605

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230707

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230912

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230928

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20231114

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20231201

R151 Written notification of patent or utility model registration

Ref document number: 7397917

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R151