JP2023002484A5 - - Google Patents
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- Publication number
- JP2023002484A5 JP2023002484A5 JP2022099223A JP2022099223A JP2023002484A5 JP 2023002484 A5 JP2023002484 A5 JP 2023002484A5 JP 2022099223 A JP2022099223 A JP 2022099223A JP 2022099223 A JP2022099223 A JP 2022099223A JP 2023002484 A5 JP2023002484 A5 JP 2023002484A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- olfactory receptor
- residue
- acid sequence
- consensus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000012547 Olfactory receptors Human genes 0.000 claims 132
- 108050002069 Olfactory receptors Proteins 0.000 claims 132
- 125000003275 alpha amino acid group Chemical group 0.000 claims 67
- 125000000539 amino acid group Chemical group 0.000 claims 60
- 229920001184 polypeptide Polymers 0.000 claims 32
- 108090000765 processed proteins & peptides Proteins 0.000 claims 32
- 102000004196 processed proteins & peptides Human genes 0.000 claims 32
- 238000000034 method Methods 0.000 claims 25
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 12
- 239000003446 ligand Substances 0.000 claims 8
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 8
- 241000894007 species Species 0.000 claims 8
- 239000000126 substance Substances 0.000 claims 6
- 238000005259 measurement Methods 0.000 claims 4
- 101000586111 Homo sapiens Olfactory receptor 5I1 Proteins 0.000 claims 2
- 101001138328 Homo sapiens Olfactory receptor 7E24 Proteins 0.000 claims 2
- 101000982216 Homo sapiens Olfactory receptor 9K2 Proteins 0.000 claims 2
- 102100030084 Olfactory receptor 5I1 Human genes 0.000 claims 2
- 102100020763 Olfactory receptor 7E24 Human genes 0.000 claims 2
- 102100026647 Olfactory receptor 9K2 Human genes 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims 1
- 238000012286 ELISA Assay Methods 0.000 claims 1
- 102000006747 Transforming Growth Factor alpha Human genes 0.000 claims 1
- 101800004564 Transforming growth factor alpha Proteins 0.000 claims 1
- 241000269368 Xenopus laevis Species 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910001424 calcium ion Inorganic materials 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 210000000287 oocyte Anatomy 0.000 claims 1
- 238000003571 reporter gene assay Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023203814A JP2024015143A (ja) | 2021-06-22 | 2023-12-01 | 嗅覚受容体の発現方法及び応答測定方法 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021103675 | 2021-06-22 | ||
| JP2021103675 | 2021-06-22 | ||
| JP2022021606 | 2022-02-15 | ||
| JP2022021606 | 2022-02-15 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023203814A Division JP2024015143A (ja) | 2021-06-22 | 2023-12-01 | 嗅覚受容体の発現方法及び応答測定方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023002484A JP2023002484A (ja) | 2023-01-10 |
| JP2023002484A5 true JP2023002484A5 (https=) | 2023-03-06 |
| JP7397917B2 JP7397917B2 (ja) | 2023-12-13 |
Family
ID=84545724
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022099223A Active JP7397917B2 (ja) | 2021-06-22 | 2022-06-20 | 嗅覚受容体の発現方法及び応答測定方法 |
| JP2023203814A Pending JP2024015143A (ja) | 2021-06-22 | 2023-12-01 | 嗅覚受容体の発現方法及び応答測定方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023203814A Pending JP2024015143A (ja) | 2021-06-22 | 2023-12-01 | 嗅覚受容体の発現方法及び応答測定方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20240279302A1 (https=) |
| EP (1) | EP4361272A4 (https=) |
| JP (2) | JP7397917B2 (https=) |
| WO (1) | WO2022270481A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023084473A (ja) * | 2021-12-07 | 2023-06-19 | 花王株式会社 | フェノール化合物を原因とするにおいの抑制剤の評価及び／又は選択方法 |
| JP2023084478A (ja) * | 2021-12-07 | 2023-06-19 | 花王株式会社 | アルデヒドを原因とするにおいの抑制剤の評価及び／又は選択方法 |
| US20250353895A1 (en) * | 2022-06-16 | 2025-11-20 | Kao Corporation | Method for analyzing g-protein conjugated receptor |
| WO2025257381A1 (en) | 2024-06-14 | 2025-12-18 | Givaudan Sa | Modified olfactory receptors |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050084868A1 (en) * | 2003-10-16 | 2005-04-21 | Wolfgang Aehle | Generation of stabilized proteins by combinatorial consensus mutagenesis |
| JP6114439B2 (ja) | 2015-05-29 | 2017-04-12 | 花王株式会社 | 匂い抑制物質の選択方法 |
| WO2016194788A1 (ja) | 2015-05-29 | 2016-12-08 | 花王株式会社 | 匂い抑制物質の選択方法 |
| JP6122181B2 (ja) | 2015-06-17 | 2017-04-26 | 花王株式会社 | スルフィド化合物の臭いの抑制剤の評価又は選択方法 |
| JP6849399B2 (ja) | 2016-11-09 | 2021-03-24 | 花王株式会社 | 龍涎香様の匂いを呈する香料素材の探索方法 |
| EP3336544B1 (en) | 2016-12-14 | 2019-11-27 | Takasago International Corporation | Method for identifying malodour counteractants |
| WO2018162638A1 (en) | 2017-03-09 | 2018-09-13 | Firmenich Sa | Method of identifying malodor modulating compounds |
| US12163950B2 (en) | 2018-06-26 | 2024-12-10 | Duke University | Synthetic odorant receptors |
| JP7197298B2 (ja) | 2018-07-17 | 2022-12-27 | 花王株式会社 | メチルメルカプタン臭抑制剤の評価及び／又は選択方法 |
| US20250353895A1 (en) * | 2022-06-16 | 2025-11-20 | Kao Corporation | Method for analyzing g-protein conjugated receptor |
-
2022
- 2022-06-20 WO PCT/JP2022/024613 patent/WO2022270481A1/ja not_active Ceased
- 2022-06-20 EP EP22828398.2A patent/EP4361272A4/en active Pending
- 2022-06-20 US US18/571,388 patent/US20240279302A1/en active Pending
- 2022-06-20 JP JP2022099223A patent/JP7397917B2/ja active Active
-
2023
- 2023-12-01 JP JP2023203814A patent/JP2024015143A/ja active Pending
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