JP7388750B2 - Method for producing water-soluble nanocolloidal silica for ingestion by animals and plants, and water-soluble nanocolloidal silica for ingestion by animals and plants - Google Patents

Description

The present invention relates to a method for producing water-soluble nanocolloidal silica, and a water-soluble nanocolloidal silica.

Silicon Si is the second most abundant element on earth after oxygen O. Silicon exists only in a state bonded to other elements or molecules such as oxygen, and exists, for example, in a state such as quartz (crystal) in which silicon dioxide SiO ₂ is crystallized. Silicic acids such as silicon dioxide are sometimes commonly referred to as "silica." Silica is contained in large amounts in the bones, joints, blood vessels, skin, hair, teeth, nails, etc. that make up the human body, and plays a role in suppressing aging by connecting tissues and maintaining flexibility and elasticity. ing. Silica also plays a role in preventing cholesterol from depositing in blood vessels and in binding collagen and hyaluronic acid, which are essential moisturizing ingredients for beauty. In this way, silica is considered to be an essential trace ingredient for maintaining health, so a lack of silica in the human body can cause hypothermia and a decline in immunity, and a severe lack of silica can make it difficult to maintain life. It can also be difficult.

For the reasons mentioned above, it is recommended to consume foods rich in silica. Examples of foods containing a large amount of silica include oats, millet, barley, wheat, potatoes, red turnips, corn, rice bran, and green seaweed. For this reason, it can be said that it is possible to ingest silica through regular meals (particularly Japanese food), but due to recent changes in dietary habits (for example, a shift away from Japanese food), opportunities to consume grains containing high amounts of silica are decreasing. be. Furthermore, even if the above-mentioned foods are ingested, the absorption rate of silica through digestion is poor, so the human body always tends to be deficient in silica.

For this reason, it is preferable that silica be efficiently absorbed into the body in the form of supplements or silicon-containing health foods. In particular, if it is in the form of a drink, silica can be ingested efficiently regardless of the time of day or place of ingestion. However, since quartz is an insoluble mineral, there is a problem in that even if silica is mixed into a fine powder into a beverage, it will precipitate. For this reason, research and development of beverages containing silica is underway (for example, Patent Documents 1 and 2), and various silica waters are known (for example, Non-Patent Document 1).

JP 2017-29046 Publication JP2012-44980A

Silicon Research Group Co., Ltd. Water-soluble silicon extracted from crystal (http://www.umo-keiso.com/)

However, the silica used in conventional silica water is colloidal silica synthesized from caustic soda-derived water glass (sodium silicate Na ₂ SiO ₃ ) and has the structure of metasilicate H ₂ SiO ₃ . Silica water made from water glass derived from caustic soda contains a large amount of Na (sodium ions), as shown in the elemental analysis results (FIG. 4) described later. When silica water contains a large amount of Na (sodium ions), it not only reduces its performance as a health drink, but also may have an adverse effect on the human body of the person who ingests the silica water. For this reason, there has been a desire to develop silica water that is safe and highly effective as a health drink.

The present invention has been made in view of these circumstances, and an object of the present invention is to provide silica water that is safe and highly effective as a health drink.

The present invention that achieves the above object is characterized by including a silicate ion generation step in which a reactant material having a surface made of at least silicon is subjected to an alkaline reaction to generate silicate ions while generating fine hydrogen bubbles. This is a method for producing water-soluble nanocolloidal silica.

According to this invention, since water glass derived from caustic soda (sodium silicate Na ₂ SiO ₃ ) is not used as a raw material, the content of Na (sodium ions) in the produced water-soluble nanocolloidal silica is suppressed and a large amount No residue remains. Therefore, it is possible to prevent the performance as a health drink from deteriorating, and also to prevent an adverse effect on the human body of the person who ingests the drink. As a result, water-soluble nanocolloidal silica, which is silica water that is safe and highly effective as a health drink, can be provided.

In the manufacturing method according to the present invention, before the silicate ion generation step, silicon dioxide and carbon are heated to react at least the surface of the silicon dioxide with carbon, and the generated carbon dioxide gas is removed. It is preferable that the method further includes a step of producing a reactant material by reducing the silicon element to the reactant material.

In the present invention, it is further preferable that the silicon dioxide has a porous structure.

The present invention also provides a water-soluble nanocolloidal silica produced by the above production method, which is characterized by having a negative zeta potential.

The water-soluble nanocolloidal silica according to the present invention preferably has a zeta potential of -10 mV to -90 mV.

The water-soluble nanocolloidal silica according to the present invention also preferably has a particle size in the range of 5 nm to 300 nm.

According to the method for producing water-soluble nanocolloidal silica of the present invention, it is possible to provide silica water that is safe and highly effective as a health drink.

FIG. 3 is a diagram showing the results of particle size distribution measurement of water-soluble nanocolloidal silica according to the present invention. 1 is a graph showing the results of elemental analysis of water-soluble nanocolloidal silica according to the present invention. 2 is a graph showing the results of analysis of elements contained in ultra-fine quartz crystals. It is a graph showing the results of elemental analysis of silica water using conventional water glass derived from caustic soda as a raw material.

The method for producing water-soluble nanocolloidal silica according to the present invention will be explained with reference to the drawings. Note that the present invention is not limited to the embodiments described below.

<Production method of water-soluble nanocolloidal silica>
The method for producing water-soluble nanocolloidal silica according to the present invention includes a silicate ion generation step in which a reactant material having a surface made of at least silicon is reacted with an alkali to generate silicate ions while generating fine hydrogen bubbles. including.

The silica water (water-soluble nanocolloidal silica) produced by this production method does not use caustic soda-derived water glass (sodium silicate Na ₂ SiO ₃ ), which has traditionally been used as a raw material for silica water, so it will be described later. As shown in the measurement results (FIG. 2), the content of Na (sodium ions) is at a level around the detection limit value, and even if it is contained, it is extremely low. Therefore, Na (sodium ions) is not contained in large amounts in silica water (water-soluble nanocolloidal silica), which prevents deterioration of its performance as a health drink. can prevent adverse effects on the human body of those who ingest it. As a result, it is possible to provide silica water (water-soluble nanocolloidal silica) that is safe and highly effective as a health drink.

The water-soluble nanocolloidal silica produced by the production method of the present invention preferably has an orthosilicate Si(OH) ₄ structure. Such water-soluble nanocolloidal silica also has a predetermined zeta potential, particle size, total scattering strength, etc., and becomes silica water with excellent antioxidant properties and permeability.

In the present invention, the total scattering intensity is calculated based on the assumption that the shape of the measured particles is a perfect sphere, and using all the amounts of scattered light obtained during the measurement, from the scattering intensity basis to the volume basis and then to the number basis. Say something.
Furthermore, the zeta potential in the present invention refers to the potential difference between a sliding surface in an electric double layer formed around fine particles in a solution and a portion sufficiently distant from the interface. When the zeta potential approaches zero, the mutual repulsion of the particles weakens and they eventually aggregate.

Hereinafter, each component of the method for producing water-soluble nanocolloidal silica according to the present invention will be explained in detail.

[Silicate ion generation process]
The silicate ion generation step constituting the manufacturing method of the present invention is a step in which a reactant material having a surface made of at least silicon is reacted with an alkali to generate silicate ions while generating fine hydrogen bubbles. There is no particular restriction on the reactant material used here, and various known materials can be used. For example, single-crystal silicon produced by the Czochralski method or the like may be used, or quartz powder such as diatomaceous earth, silica, or crystal, or one whose bulk surface has been reduced by the method described later may also be used. . Here, elemental silicon refers to a substance mainly consisting of elemental silicon, for example, a substance in which 90% by mass or more consists of elemental silicon. In the present invention, high-purity silicon for Si chip manufacturing is not necessarily required, but various known substances can be used as simple silicon. There are no particular restrictions on its crystal structure, and single crystal, polycrystalline, or amorphous silicon can be used.

As the alkali used in the silicate ion generation step, it is preferable to use an aqueous alkali solution that does not contain sodium ions in order to minimize the sodium content in the water-soluble nanocolloidal silica produced. There is no particular restriction on the concentration of the alkaline aqueous solution, but for example, from the viewpoint of promoting the alkaline reaction in the silicate ion generation step, it is preferable to use a strong alkaline aqueous solution with a pH of 13 or more at the start of the silicate ion generation step. preferable. In the silicate ion generation process, it is observed that the pH tends to decrease over time, and the production status of water-soluble nanocolloidal silica can be understood from this pH value. Further, there is no particular restriction on the temperature during the reaction, but it is preferably carried out at a temperature of about 0 to 90°C, particularly about 5 to 50°C. Such a reaction with an alkali can produce silicate ions, particularly orthosilicate ions SiO ₄ ^4- with a tetrahedral structure. Note that although the reaction for producing silicate ions from simple silicon proceeds even under neutral conditions, from the viewpoint of reaction rate, it is practical to carry out under alkaline conditions.

In addition, in the silicate ion generation step, fine bubbles of hydrogen H ₂ continue to be generated from the surface of the silicon element due to the alkaline reaction. For this reason, silicate ions are generated in an aqueous solution by reacting with hydrogen nanobubbles (microbubbles) on the surface of a single silicon in the presence of dissolved oxygen, and the generated silicate ions mainly have a tetrahedral structure. It is believed that stable water-soluble nanocolloidal silica with a particle size of about 5 to 300 nm, particularly about 10 to 250 nm, can be produced by forming orthosilicic acid: Si(OH) ₄ . The detailed mechanism of the reaction in this process is not clear, and the present invention is not limited by any particular theory, but it is believed that microbubbles of hydrogen react with dissolved oxygen, etc., producing chemical species like diatomaceous earth. There is a possibility. Note that nanobubbles (fine bubbles) refer to bubbles having a number average diameter of less than 1 μm (micrometer). The period for performing the silicate ion generation step is not particularly limited, and orthosilicate Si(OH) ₄ is produced as the main silicate compound, and the particle size is about 5 to 300 nm, preferably about 10 to 250 nm. Any period of time is sufficient as long as it is possible to produce the water-soluble nanocolloidal silica of the present invention. The silicate ion generation step may be carried out for about 6 months, for example.

[Preprocessing]
Prior to the silicate ion generation step in the present invention, the material to be reacted may be subjected to pretreatment, for example, physical treatment such as pulverization or washing, or chemical treatment such as surface treatment to make it hydrophilic or reprecipitation. In the silicate ion generation step of the present invention, a reacted material with a surface consisting of at least simple silicon is used, so when using silicon dioxide such as silica powder as a starting material, at least the surface layer is reduced to simple silicon. There is a need to.

[Reacted material production process]
For the above reasons, in the method for producing water-soluble nanocolloidal silica of the present invention, silicon dioxide and carbon are heated before the silicate ion generation step to cause at least the surface of the silicon dioxide to react with the carbon. It is also possible to perform a reactant material production step in which the generated carbon dioxide gas is removed and reduced to the silicon element to produce the reactant material. In addition, when using a high-purity silicon raw material, the above-mentioned silicate ion generation step may be directly started without going through this reaction material preparation step.

The reaction material production process is a process using a so-called carbon reduction method, and there are no particular restrictions on the raw materials or reaction conditions used therein. The raw material silicon dioxide preferably has a porous structure, but is not limited thereto, and silicon dioxide such as various commercially available silica powders and crystals, and carbon such as charcoal and carbon black can be used. For example, crystal (silicon dioxide SiO ₂ ) and carbon material (for example, charcoal such as charcoal or coal, material whose main component is carbon C such as carbon black) are heated together at 600 to 2400°C, preferably 800 to 2000°C. A reduction refining method is used in which single crystal silicon (Si) with a purity of 99.9% is produced by heating the silicon dioxide to a temperature of 0.degree. C. and separating and removing oxygen in the silicon dioxide as carbon dioxide gas _CO2 . Note that the temperature at which silicon dioxide SiO ₂ and carbon C are heated is not limited to the above, and may be any temperature that can separate and remove oxygen from silicon dioxide SiO ₂ as carbon dioxide gas CO ₂ to generate silicon. Bye.

<Water-soluble nanocolloidal silica>
The water-soluble nanocolloidal silica of the present invention produced in this way has almost no residual sodium ions, etc., and has high efficacy as a safe health drink. The present invention also includes water-soluble nanocolloidal silica produced by the production method described above. The water-soluble nanocolloidal silica of the present invention exhibits a negative zeta potential, and its value is preferably in the range of -10 mV to -90 mV, more preferably -30 mV to -80 mV, particularly preferably -40 mV to -70 mV. The water-soluble nanocolloidal silica of the present invention has the above-mentioned negative zeta potential, so nanocolloidal silica particles repel each other, so that it can maintain a stable state for a period of one year or more without causing precipitation. can. The particle size of the colloid is about 5 to 300 nm as described above, but preferably in the range of 10 to 250 nm. The water-soluble nanocolloidal silica of the present invention also exhibits characteristic physical properties such as total scattering intensity and dissolved concentration, and the silicate ion concentration in silica water is higher than that of conventional silica water, for example, 5000 mg/L or more. It is also possible to do so.

The water-soluble nanocolloidal silica of the present invention also has a pH of about 10 to 12 after production, in most cases about 10 to 11, particularly about slightly less than 11. Although it does not adversely affect the gastrointestinal tract when drunk in its alkaline state, it is also possible to lower the pH to below 9, for example around 8, and ingest it if desired. As shown in the Examples described below, depending on blood lipids, the reduction effect may be greater if the blood lipids are neutralized to a pH of about 8 and ingested. The acid used for neutralization is not particularly limited, and various acids such as acetic acid, hydrochloric acid, and citric acid can be used, but acetic acid is particularly preferred. You can also use general-purpose edible vinegar.

Hereinafter, how the production of water-soluble nanocolloidal silica according to the present invention is normally proceeded will be explained using typical examples as examples, but the present invention is not limited to the following examples.

(1) Test example 1
In the most general embodiment of the production of water-soluble nanocolloidal silica according to the present invention, a simple silicon production step (step S1) is first performed. By the reduction refining method as described above, silicon dioxide powder (particle size: about 50 to 300 μm) is heated together with carbon to, for example, 500 to 2,500°C, preferably 500 to 2,400°C, and oxygen is removed as carbon dioxide gas. to produce simple silicon. Next, a silicate ion generation step (step S2) is performed in which the generated silicon element is subjected to an alkali reaction to generate fine hydrogen bubbles. Step S2 is started in an alkaline aqueous solution with a pH of about 13, and if left for a long time, for example, 6 months, the pH will eventually drop to about 10, and the transparent liquid will turn into a whitened colloidal solution. Here, since the zeta potential of the colloidal solution is a negative value, no precipitate such as scum is generated.

The results of analyzing the particle size, zeta potential, total scattering intensity, and dissolved concentration of the water-soluble nanocolloidal silica of the present invention produced according to the above examples are shown below.

[Particle size]
(Measurement 1)
The particle size d of the water-soluble nanocolloidal silica of the present invention was measured by a dynamic light scattering method (JIS Z8828:2013). In addition, in measurement 1, the measurement was performed using Zetasizer Nano ZS manufactured by Malvern Co., Ltd. and a disposable cell for particle size measurement as a measurement and analysis device. Regarding the measurement environment, the temperature was 25.0° C., the actual measurement time was 60 seconds, the count rate was 262.7 kcps (count per second), and the measurement position was 4.65 mm.

(Result 1)
FIG. 1 is a diagram showing the results of particle size distribution measurement of water-soluble nanocolloidal silica of the present invention, and is a graph of scattering intensity for each particle size. As shown in FIG. 1, the particle size distribution formed a single peak. As described above, the water-soluble nanocolloidal silica of the present invention can have a particle size d in a suitable range of about 10 to 250 nm, and can have a clean particle size distribution with a single peak. In addition, since the particle size of conventional products is usually around 800 nm, the particle size of the water-soluble nanocolloidal silica of the present invention (250 nm or less) is about one-fourth or less of the particle size of conventional products, which is significantly smaller. I understand that.

[Zeta potential]
(Measurement 2)
The zeta potential of the water-soluble nanocolloidal silica of the present invention was measured by electrophoresis. Measurements were performed multiple times.
In addition, in measurement 2, the measurement was performed using Malvern's Zetasizer Nano ZS (electrophoresis method) and a capillary cell (disposable zeta potential measurement cell) as a measurement and analysis device.
Regarding the measurement environment, the sample was thoroughly shaken and mixed in the container, then collected in a cell, and zeta potential measurement was performed with n=2. The refractive index, viscosity, and dielectric constant of the solvent were set to the measured values for water.

(Result 2)
As shown in Table 1, the zeta potential was -52 mV in the first measurement, and -47 mV in the second measurement. As described above, the zeta potential of the water-soluble nanocolloidal silica of the present invention can be suitably set to a negative value, for example, −10 mV to −90 mV, particularly −45 to 55 mV.

[Contained elemental analysis]
FIG. 2 is a chart showing the results of elemental analysis of silica powder obtained by drying the water-soluble nanocolloidal silica of the present invention using EDX (energy dispersive X-ray spectroscopy).
In the water-soluble nanocolloidal silica of the present invention, as shown in Figure 2, the content ratio of O (oxygen) is 58.70%, the content ratio of Si (silicon) is 39.61%, and other A trace amount of Na (sodium ion) at an impurity level is included in the trace amount of contained elements. In this way, the water-soluble nanocolloidal silica of the present invention does not contain a large amount of Na (sodium ions), so it prevents the performance as a health drink from deteriorating and makes it easier to consume the water-soluble nanocolloidal silica of the present invention. This can prevent harmful effects on the human body of those who have done so. As a result, it is possible to provide silica water (water-soluble nanocolloidal silica) that is safe and highly effective as a health drink.

Here, as a substance having a composition very similar to the water-soluble nanocolloidal silica of the present invention, there is quartz crystal made into fine particles by crushing (hereinafter referred to as "ultrafine quartz crystal"). FIG. 3 is a chart showing the results of elemental analysis of ultra-fine quartz using EDX (energy dispersive X-ray spectroscopy).

As shown in Figure 3, the ultra-fine quartz crystal contains 56.26% O (oxygen) and 41.05% Si (silicon), as well as trace amounts of other elements. It contains trace amounts of Na (sodium ions) at the level of impurities. Therefore, similarly to the water-soluble nanocolloidal silica of the present invention, a large amount of Na (sodium ions) is not contained.

However, since the ultra-fine quartz crystal is simply a quartz crystal made into fine particles by crushing, the structure remains quartz SiO ₂ . As mentioned above, quartz is an insoluble mineral, and even if it is mixed into a drink in the form of a fine powder, it will precipitate. For this reason, ultrafine crystals are not suitable for beverages.

Figure 4 shows that silica powder, which is made by drying colloidal silica synthesized from caustic soda-derived water glass (sodium silicate Na ₂ SiO ₃ ) used in conventional silica water, is processed using EDX (Energy Dispersive X-ray). 3 is a chart showing the results of analysis of contained elements using line spectroscopy.

As shown in FIG. 4, the conventional colloidal silica contains Na at a high concentration of 10%. Therefore, not only is the performance of silica water as a health drink low, but there is also a risk that it may have an adverse effect on the human body of those who ingest the silica water.

As described above, the water-soluble nanocolloidal silica of the present invention has special characteristics different from conventional silica water and ultrafine crystals. The water-soluble nanocolloidal silica of the present invention also exhibits the Tyndall phenomenon because it exists in the state of a colloidal solution, unlike the ultrafine crystals described above. In other words, when light passes through the water-soluble nanocolloidal silica of the present invention, the light is scattered and the path of the light appears to shine uniformly.

(2) Test example 2
[Examples 1 to 4, comparative examples]
Below, the results of testing the effects of the water-soluble nanocolloidal silica of the present invention produced as described above using rats will be explained. The test was commissioned to an overseas university, and the water-soluble nanocolloidal silica of the present invention (hereinafter sometimes abbreviated as "silica water") was tested at a room temperature of 24°C and a relative humidity of 40 to 50%. Silicon concentration was 5660 mg/L. , pH 10.93). For verification and comparison, a neutralized product of the water-soluble nanocolloidal silica (water-soluble nanocolloidal silica of the present invention neutralized with white vinegar, hereinafter referred to as "neutralized product", pH 8.05), distilled Separate tests were also conducted using water and simvastatin (general-purpose dyslipidemia treatment, 5% CMC-Na preparation).
Fifty-six male rats weighing 160±10 g were randomly divided into the following 7 groups, and drugs of the following types and amounts were intragastrically administered to each group along with 20 g of feed every day. Note that the amount of the drug below is the mass (mg) of the pure drug component (silicon component, etc.) per 1 kg of rat.
・1 set (reference example): general feed + distilled water ・2 sets (control example): high-fat feed + distilled water ・3 sets (comparative example): high-fat feed + simvastatin 1.54 mg/kg
・4 groups (Example 1): High fat feed + silica water 10.94mg/kg
・5 groups (Example 2): High fat feed + silica water 5.47mg/kg
・6 groups (Example 3): High fat feed + silica water 2.83mg/kg
・7 groups (Example 4): High-fat feed + neutralized product 10.94 mg/kg
After administering each of the above drugs for 15 days, and giving only water without food for another 15 days, serum was collected and analyzed using a fully automatic biochemical analyzer to determine TC (total cholesterol), TG (neutral fat), LDL-C. (bad cholesterol), HDL-C (good cholesterol), AST, and ALT values were measured. Table 2 shows the average value of the measurement results for each group of 8 animals.

As shown in Table 2, in Examples 1 to 4 in which rats were administered silica water, the total cholesterol value, TG, LDL-C, AST, and ALT were significantly lower than in the control example in which rats were administered distilled water. It was found that the water-soluble nanocolloidal silica of the present invention has a blood fat reducing effect. In particular, regarding TG and ALT, all of Examples 1 to 4 showed superior effects compared to comparative examples in which rats were administered a general-purpose dyslipidemia drug, and the ALT values were lower than those given the general diet. It was also lower than the reference example. On the other hand, the HDL-C (good cholesterol) values of Examples 1 to 4 were equal to or higher than those of the control examples and comparative examples. Furthermore, among Examples 1 to 4, Example 4, which used a neutralized product with a pH of about 8, had the highest effect of reducing total cholesterol and LDL-C values, as well as improving the HDL-C value. Ta.

[Example 5]
To test the acute toxicity of the water-soluble nanocolloidal silica of the present invention, silica water was orally administered to equal numbers of male and female mice weighing 20±1.5 g. The test was conducted at an overseas university at a temperature of 20-23°C and a relative humidity of 70%.
0.77 ml of the above silica water was administered to each of the 20 mice four times during 24 hours (silicon dose per mouse: 17.4 mg). Not a single animal died, and a value for the half-lethal dose ID50 could not be obtained.
Next, the dose to mice was increased, but no deaths occurred even at the maximum dose of 870 mg/kg (363 times the human clinical dose).

The above examples showed that the water-soluble nanocolloidal silica according to the present invention is safe and highly effective as a health drink.

<Applications of water-soluble nanocolloidal silica>
Various applications suitable for using water-soluble nanocolloidal silica are then described below.

For example, in the above-described embodiments, the use of the water-soluble nanocolloidal silica of the present invention as a beverage is described, but the use of the water-soluble nanocolloidal silica of the present invention is not limited to use as a beverage. The water-soluble nanocolloidal silica of the present invention has excellent abilities in terms of sterilizing power, cleaning power, penetrating power, anti-inflammatory power, cell activation power, antioxidant power, decomposition power, etc., so it can be used in various ways that take advantage of these abilities. It can be used for various purposes.

In other words, the water-soluble nanocolloidal silica of the present invention has a sterilizing power that instantly sterilizes Legionella bacteria and coliform bacteria, a detergent power that washes away environmental pollutants that have adhered to the surface of food or penetrated into the inside, and has a cleaning power of 2.5 billion minutes. It has a penetrating power that can be subdivided into units of 1 m (meter). It also has an anti-inflammatory power that extinguishes inflammation by strengthening immunity, and a cell activation power that activates cells by directly inputting energy into the cell nucleus. In addition, it has decomposition power that dissolves dirt and substances in blood vessels and repairs blood vessels, and anti-inflammatory properties that stop the progression of putrefaction in the intestines, making bad bacteria bacteriostatic, activating good bacteria, and strengthening immunity. It has oxidizing power.

As described above, the water-soluble nanocolloidal silica of the present invention not only brings about good effects on human health, but also brings about the following effects. That is, since the water-soluble nanocolloidal silica of the present invention has the effect of eliminating waste products, it can eliminate constipation, swelling (water intoxication), and water accumulation in joints. It also has the effect of eliminating toxins from the mind, such as stress, depression, and insomnia. It also has the effect of improving stiff shoulders, headaches, lower back pain, dizziness, numbness, etc.

Furthermore, since the water-soluble nanocolloidal silica of the present invention has the effect of delaying oxidation, by using it for washing vegetables and fruits, the freshness of the vegetables and fruits can be maintained better than when washing with tap water. Due to the excellent penetration power of the water-soluble nanocolloidal silica of the present invention, it is also possible to remove agricultural chemicals that have penetrated into the inside of vegetables. Specifically, for example, when cherry tomatoes grown using pesticides are soaked in a mixture of the water-soluble nanocolloidal silica of the present invention and water, the pesticides ooze out from the cherry tomatoes, and the cherry tomatoes are soaked. The water turns yellow.

Furthermore, when the water-soluble nano-colloidal silica of the present invention is attached to perishables such as seafood, bacteria etc. become difficult to adhere to the parts to which the water-soluble nano-colloidal silica is attached, so the freshness of perishables such as seafood is improved. It can be maintained for a long time.

Furthermore, the water-soluble nanocolloidal silica of the present invention may be used for cooking rice, hot pot dishes, simmered dishes, and other dishes. For example, when the water-soluble nanocolloidal silica of the present invention is used for cooking rice, the excellent penetrating power of the water-soluble nanocolloidal silica removes oxidized substances from inside the rice, resulting in delicious rice. Furthermore, by adding the water-soluble nanocolloidal silica of the present invention to coffee, it has the effect of removing bitterness and making the taste mellow. Furthermore, when the water-soluble nanocolloidal silica of the present invention is used when brewing green tea, there is also the effect that the color of the green tea appears darker than when brewing with tap water. In this way, the water-soluble nanocolloidal silica of the present invention has the effect of bringing out the flavor of the ingredients and making them more delicious when added to dishes. Furthermore, since the water-soluble nanocolloidal silica of the present invention decomposes oil, it not only improves the taste but also has the effect of making dishes healthier.

The water-soluble nano-colloidal silica of the present invention has benefits beyond human diet. For example, by adding a few drops of water-soluble nanocolloidal silica to the drinking water or food of pets such as dogs and cats, or spraying diluted water-soluble nanocolloidal silica on the pet's body, you can improve the coat's coat and improve body odor. It has the effect of suppressing

Moreover, it is effective not only for humans and animals such as pets, but also for plants. For example, by using the water-soluble nanocolloidal silica of the present invention when watering houseplants, it is possible to maintain the freshness of the houseplants and extend their lifespan. Moreover, in the case of fresh flowers, the flowering period can be extended.

Furthermore, the water-soluble nanocolloidal silica of the present invention has an excellent ability to decompose alcohol, and is therefore effective against hangovers. Furthermore, the water-soluble nanocolloidal silica of the present invention has the effect of removing active oxygen, and therefore has a cosmetic effect. For example, by performing skin care with a spray, the beauty ingredient of water-soluble nanocolloidal silica can be effectively penetrated into the skin. Furthermore, stains, wrinkles, acne, and pimples can be effectively removed by applying the undiluted solution of water-soluble nanocolloidal silica directly to the skin.

In addition, when the water-soluble nanocolloidal silica of the present invention is used for tooth brushing, it can remove tea stains and tar adhering to the teeth due to its silicon adsorption effect, and also eliminate periodontal disease, gingivitis, and hypersensitivity. You can also do it.

Furthermore, the water-soluble nanocolloidal silica of the present invention can also be used in the agricultural field, fishery field, medical field, etc. Water-soluble nano-colloidal silica can be used as fertilizer in the agricultural field, and water-soluble nano-colloidal silica can be used as feed in the fishing field.

In the medical field, by having patients ingest the water-soluble nanocolloidal silica of the present invention, it has the effect of improving atopy, hay fever, asthma, cerebral infarction, myocardial infarction, renal failure (uremia), etc. Furthermore, water-soluble nanocolloidal silica can also be used to treat cancers such as prostate cancer, uterine cancer, and colon cancer. Specifically, for example, water-soluble nanocolloidal silica can be used in near-infrared ray-based cancer immunotherapy (developed by Hisataka Kobayashi, Principal Researcher at the National Cancer Institute). In this treatment, phthalocyanine, a dye that causes a chemical reaction when exposed to near-infrared rays, is attached to antibodies that specifically bind to cancer cells, and then injected intravenously into the patient's body. Originally, phthalocyanine cannot be introduced into a patient's body because it is not water-soluble, but by adding the water-soluble nanocolloidal silica of the present invention to phthalocyanine, it becomes water-soluble. Antibodies that enter the body bind to cancer cells, and when this bond is irradiated with near-infrared light, a chemical reaction occurs and destroys the cancer cells. Furthermore, the water-soluble nanocolloidal silica of the present invention can be used alone for cancer treatment. Specifically, the water-soluble nanocolloidal silica of the present invention activates mitochondria within cancer cells, and enzymes (cytochrome C) are produced within the mitochondria. The enzyme (cytochrome C) activates the function of proteolytic enzymes (caspases) that cause apoptosis (suicide) within cancer cells. As a result, apoptotic degeneration occurs in the DNA (deoxyribonucleic acid) of cancer cells, and the cancer cells begin to disappear. Since the water-soluble nanocolloidal silica of the present invention has a small particle size, it can also be used in artificial dialysis and the like.

As described above, the water-soluble nanocolloidal silica of the present invention has the advantage of not leaving a large amount of sodium ions and not precipitating for a long period of time. The present invention has made it possible to provide silica water that is safe and highly effective as a healthy drink.

Claims (5)

A silicate ion generation step in which silicon alone formed on at least the surface of the reacted material is reacted with an aqueous solution of an alkali other than an alkali containing sodium ions to generate silicate ions while generating fine hydrogen bubbles. A method for producing water-soluble nanocolloidal silica for ingestion by animals and plants, comprising:
The water-soluble nanocolloidal silica has a negative zeta potential, and
When elemental analysis of the silica powder obtained by drying the water-soluble nanocolloidal silica was performed using EDX (energy dispersive X-ray spectroscopy), it was found that the silica powder did not contain sodium or A method for producing water-soluble nanocolloidal silica for ingestion by animals and plants, characterized in that even if it contains sodium, the amount is at a detection limit level. Before the silicate ion generation step, silicon dioxide and carbon are heated to cause at least the surface of the silicon dioxide to react with the carbon, and the generated carbon dioxide gas is removed and the silicon dioxide is reduced to the simple substance. The method for producing water-soluble nanocolloidal silica for ingestion by animals and plants according to claim 1, further comprising a step of producing a reactant material. The method for producing water-soluble nanocolloidal silica for ingestion by animals and plants according to claim 2, wherein the silicon dioxide has a porous structure. The method for producing water-soluble nanocolloidal silica for ingestion by animals and plants according to any one of claims 1 to 3, wherein the zeta potential is -10 mV to -90 mV. The method for producing water -soluble nanocolloidal silica for ingestion by animals and plants according to any one of claims 1 to 4, wherein the particle size of the water-soluble nanocolloidal silica is in the range of 5 nm to 300 nm.

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