JP7382938B2 - ジアザインドール化合物 - Google Patents

ジアザインドール化合物 Download PDF

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Publication number
JP7382938B2
JP7382938B2 JP2020534861A JP2020534861A JP7382938B2 JP 7382938 B2 JP7382938 B2 JP 7382938B2 JP 2020534861 A JP2020534861 A JP 2020534861A JP 2020534861 A JP2020534861 A JP 2020534861A JP 7382938 B2 JP7382938 B2 JP 7382938B2
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alkyl
pyrrolo
piperidinyl
pyridinyl
pyrrolidinyl
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Japanese (ja)
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JP2021506941A5 (enExample
JP2021506941A (ja
Inventor
アラリック・ジェイ・ディックマン
ダームパル・エス・ドッド
クリストファー・ピー・マッサリ
ブライアン・ケイ・ホワイトリー
スリーカンタ・ラトナ・クマール
アヌパマ・カンディ・ラマチャンドラ・レディ
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2020534861A 2017-12-20 2018-12-18 ジアザインドール化合物 Active JP7382938B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762607941P 2017-12-20 2017-12-20
US62/607,941 2017-12-20
PCT/US2018/066108 WO2019126083A1 (en) 2017-12-20 2018-12-18 Diazaindole compounds

Publications (3)

Publication Number Publication Date
JP2021506941A JP2021506941A (ja) 2021-02-22
JP2021506941A5 JP2021506941A5 (enExample) 2022-01-06
JP7382938B2 true JP7382938B2 (ja) 2023-11-17

Family

ID=65003573

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020534861A Active JP7382938B2 (ja) 2017-12-20 2018-12-18 ジアザインドール化合物

Country Status (14)

Country Link
US (1) US11299501B2 (enExample)
EP (1) EP3728264B1 (enExample)
JP (1) JP7382938B2 (enExample)
KR (1) KR102722182B1 (enExample)
CN (1) CN111511744B (enExample)
AU (1) AU2018390544A1 (enExample)
BR (1) BR112020012002A2 (enExample)
CA (1) CA3085937A1 (enExample)
EA (1) EA202091530A1 (enExample)
ES (1) ES2904773T3 (enExample)
IL (1) IL275505A (enExample)
MX (1) MX2020006014A (enExample)
SG (1) SG11202005733QA (enExample)
WO (1) WO2019126083A1 (enExample)

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JP7434186B2 (ja) 2018-06-12 2024-02-20 エフ． ホフマン－ラ ロシュ アーゲー 自己免疫疾患の処置のための新規のヘテロアリールヘテロシクリル化合物
CN112584903B (zh) 2018-07-23 2025-12-23 豪夫迈·罗氏有限公司 用于自身免疫性疾病治疗的哌嗪化合物
CN112638908A (zh) 2018-09-04 2021-04-09 豪夫迈·罗氏有限公司 用于治疗自身免疫性疾病的苯并噻唑类化合物
CN112654618A (zh) 2018-09-06 2021-04-13 豪夫迈·罗氏有限公司 用于治疗自身免疫性疾病的新型环脒化合物
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KR20230053644A (ko) 2020-08-19 2023-04-21 브리스톨-마이어스 스큅 컴퍼니 섬유증의 치료를 위한 tlr9 억제제로서의 이미다조[1,2-a]피리딘 및 [1,2,4]트리아졸로[1,5-a]피리딘 유도체
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Publication number Publication date
CA3085937A1 (en) 2019-06-27
CN111511744B (zh) 2023-09-22
ES2904773T3 (es) 2022-04-06
EA202091530A1 (ru) 2020-09-14
JP2021506941A (ja) 2021-02-22
SG11202005733QA (en) 2020-07-29
WO2019126083A1 (en) 2019-06-27
US20200308195A1 (en) 2020-10-01
US11299501B2 (en) 2022-04-12
KR20200100760A (ko) 2020-08-26
IL275505A (en) 2020-08-31
BR112020012002A2 (pt) 2020-11-17
AU2018390544A1 (en) 2020-08-06
CN111511744A (zh) 2020-08-07
KR102722182B1 (ko) 2024-10-24
EP3728264B1 (en) 2021-12-01
EP3728264A1 (en) 2020-10-28
MX2020006014A (es) 2020-08-17

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