KR102722182B1 - 디아자인돌 화합물 - Google Patents

디아자인돌 화합물 Download PDF

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Publication number
KR102722182B1
KR102722182B1 KR1020207020851A KR20207020851A KR102722182B1 KR 102722182 B1 KR102722182 B1 KR 102722182B1 KR 1020207020851 A KR1020207020851 A KR 1020207020851A KR 20207020851 A KR20207020851 A KR 20207020851A KR 102722182 B1 KR102722182 B1 KR 102722182B1
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pyrrolo
pyrimidin
piperidin
isopropyl
dimethoxyphenyl
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Korean (ko)
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KR20200100760A (ko
Inventor
알라릭 제이. 딕맨
담펄 에스. 도드
크리스토퍼 피. 무사리
브라이언 케이. 화이틀리
스리칸타 라트나 쿠마르
아누파마 칸디 라마찬드라 레디
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브리스톨-마이어스 스큅 컴퍼니
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Publication of KR20200100760A publication Critical patent/KR20200100760A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020207020851A 2017-12-20 2018-12-18 디아자인돌 화합물 Active KR102722182B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762607941P 2017-12-20 2017-12-20
US62/607,941 2017-12-20
PCT/US2018/066108 WO2019126083A1 (en) 2017-12-20 2018-12-18 Diazaindole compounds

Publications (2)

Publication Number Publication Date
KR20200100760A KR20200100760A (ko) 2020-08-26
KR102722182B1 true KR102722182B1 (ko) 2024-10-24

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KR1020207020851A Active KR102722182B1 (ko) 2017-12-20 2018-12-18 디아자인돌 화합물

Country Status (14)

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US (1) US11299501B2 (enExample)
EP (1) EP3728264B1 (enExample)
JP (1) JP7382938B2 (enExample)
KR (1) KR102722182B1 (enExample)
CN (1) CN111511744B (enExample)
AU (1) AU2018390544A1 (enExample)
BR (1) BR112020012002A2 (enExample)
CA (1) CA3085937A1 (enExample)
EA (1) EA202091530A1 (enExample)
ES (1) ES2904773T3 (enExample)
IL (1) IL275505A (enExample)
MX (1) MX2020006014A (enExample)
SG (1) SG11202005733QA (enExample)
WO (1) WO2019126083A1 (enExample)

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Also Published As

Publication number Publication date
CA3085937A1 (en) 2019-06-27
CN111511744B (zh) 2023-09-22
ES2904773T3 (es) 2022-04-06
EA202091530A1 (ru) 2020-09-14
JP2021506941A (ja) 2021-02-22
SG11202005733QA (en) 2020-07-29
WO2019126083A1 (en) 2019-06-27
US20200308195A1 (en) 2020-10-01
US11299501B2 (en) 2022-04-12
KR20200100760A (ko) 2020-08-26
IL275505A (en) 2020-08-31
BR112020012002A2 (pt) 2020-11-17
AU2018390544A1 (en) 2020-08-06
CN111511744A (zh) 2020-08-07
JP7382938B2 (ja) 2023-11-17
EP3728264B1 (en) 2021-12-01
EP3728264A1 (en) 2020-10-28
MX2020006014A (es) 2020-08-17

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