JP7375755B2 - 陽電子放出核種で標識された脂肪酸誘導体 - Google Patents

陽電子放出核種で標識された脂肪酸誘導体 Download PDF

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JP7375755B2
JP7375755B2 JP2020531374A JP2020531374A JP7375755B2 JP 7375755 B2 JP7375755 B2 JP 7375755B2 JP 2020531374 A JP2020531374 A JP 2020531374A JP 2020531374 A JP2020531374 A JP 2020531374A JP 7375755 B2 JP7375755 B2 JP 7375755B2
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fatty acid
salt
acid derivative
compound
labeled fatty
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JPWO2020017620A5 (https=
JPWO2020017620A1 (ja
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佳裕 村上
洋司 伏木
優史 藤田
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Astellas Pharma Inc
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Astellas Pharma Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/54—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/16—Measuring radiation intensity
    • G01T1/161—Applications in the field of nuclear medicine, e.g. in vivo counting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nuclear Medicine (AREA)
JP2020531374A 2018-07-20 2019-07-19 陽電子放出核種で標識された脂肪酸誘導体 Active JP7375755B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018136483 2018-07-20
JP2018136483 2018-07-20
PCT/JP2019/028380 WO2020017620A1 (ja) 2018-07-20 2019-07-19 陽電子放出核種で標識された脂肪酸誘導体

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JPWO2020017620A1 JPWO2020017620A1 (ja) 2021-08-02
JPWO2020017620A5 JPWO2020017620A5 (https=) 2022-06-20
JP7375755B2 true JP7375755B2 (ja) 2023-11-08

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JP2020531374A Active JP7375755B2 (ja) 2018-07-20 2019-07-19 陽電子放出核種で標識された脂肪酸誘導体

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US (1) US12029797B2 (https=)
EP (1) EP3825302B1 (https=)
JP (1) JP7375755B2 (https=)
KR (1) KR102718221B1 (https=)
CN (1) CN112638868B (https=)
AU (1) AU2019304781B2 (https=)
CA (1) CA3106903A1 (https=)
ES (1) ES3009015T3 (https=)
WO (1) WO2020017620A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES3009015T3 (en) 2018-07-20 2025-03-25 Astellas Pharma Inc Fatty acid derivative labeled with positron-emitting radionuclide
US20230065079A1 (en) * 2020-01-17 2023-03-02 Astellas Pharma Inc. Fatty acid derivative labeled with positron-emitting radionuclide

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063216A1 (en) 1999-04-19 2000-10-26 Duke University F-18-labeled thia fatty acids and methods of making and using the same

Family Cites Families (9)

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DE2828623C2 (de) 1978-06-29 1983-11-17 Kernforschungsanlage Jülich GmbH, 5170 Jülich Mit radioaktivem Flour markierte C↓1↓↓6↓-bis C↓1↓↓8↓- Fettsäuren, ein Verfahren zu ihrer Herstellung sowie deren Verwendung
CA2522737C (en) * 2003-04-17 2017-06-06 The General Hospital Corporation Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid
CN1217924C (zh) 2003-10-17 2005-09-07 江苏省原子医学研究所 一种氟标记脂肪酸心肌代谢显像剂14(r,s)－氟[18f]－6－硫十七烷酸的纯化方法
CA2760334A1 (en) 2009-05-04 2010-11-11 Washington University Pet radiotracers for imaging fatty acid metabolism and storage
WO2014179341A1 (en) 2013-04-29 2014-11-06 Matinas Biopharma, Inc. Treatment with omega-3 fatty acid compositions
WO2015023631A2 (en) 2013-08-12 2015-02-19 Carolyn Anderson Fatty acid analogs and their use
CN105523977B (zh) 2016-02-04 2017-05-24 河南中医学院 [11c]‑巯甲基脂肪酸的制备方法与应用
ES3009015T3 (en) 2018-07-20 2025-03-25 Astellas Pharma Inc Fatty acid derivative labeled with positron-emitting radionuclide
US20230065079A1 (en) 2020-01-17 2023-03-02 Astellas Pharma Inc. Fatty acid derivative labeled with positron-emitting radionuclide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063216A1 (en) 1999-04-19 2000-10-26 Duke University F-18-labeled thia fatty acids and methods of making and using the same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CAI,Z. et al.，Synthesis and preliminary evaluation of an 18F-labeled oleic acid analog for PET imaging of fatty ac，Nuclear Medicine and Biology，2016年，Vol.43, No.1，p.108-115
DEGRADO,T.R. et al.，Synthesis and preliminary evaluation of 18-18F-fluoro-4-thia-oleate as a PET probe of fatty acid oxi，Journal of Nuclear Medicine，2010年，Vol.51, No.8，p.1310-1317
PANDEY,M.K. et al.，Structure Dependence of Long-Chain [18F]Fluorothia Fatty Acids as Myocardial Fatty Acid Oxidation Pr，Journal of Medicinal Chemistry，2012年，Vol.55, No.23，p.10674-10684

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AU2019304781B2 (en) 2023-12-21
US20210338845A1 (en) 2021-11-04
CN112638868B (zh) 2023-06-20
KR102718221B1 (ko) 2024-10-15
US12029797B2 (en) 2024-07-09
ES3009015T3 (en) 2025-03-25
EP3825302A1 (en) 2021-05-26
CN112638868A (zh) 2021-04-09
WO2020017620A1 (ja) 2020-01-23
EP3825302B1 (en) 2025-01-08
AU2019304781A1 (en) 2021-02-11
KR20210032392A (ko) 2021-03-24
CA3106903A1 (en) 2020-01-23
EP3825302A4 (en) 2022-05-04
JPWO2020017620A1 (ja) 2021-08-02

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