CN112638868B - 由正电子放射性核素标记的脂肪酸衍生物 - Google Patents

由正电子放射性核素标记的脂肪酸衍生物 Download PDF

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CN112638868B
CN112638868B CN201980048149.8A CN201980048149A CN112638868B CN 112638868 B CN112638868 B CN 112638868B CN 201980048149 A CN201980048149 A CN 201980048149A CN 112638868 B CN112638868 B CN 112638868B
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fatty acid
salt
acid derivative
compound
labeled fatty
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Chinese (zh)
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CN112638868A (zh
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村上佳裕
伏木洋司
藤田优史
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Astellas Pharma Inc
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Astellas Pharma Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/54—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/16—Measuring radiation intensity
    • G01T1/161—Applications in the field of nuclear medicine, e.g. in vivo counting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nuclear Medicine (AREA)
CN201980048149.8A 2018-07-20 2019-07-19 由正电子放射性核素标记的脂肪酸衍生物 Active CN112638868B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018-136483 2018-07-20
JP2018136483 2018-07-20
PCT/JP2019/028380 WO2020017620A1 (ja) 2018-07-20 2019-07-19 陽電子放出核種で標識された脂肪酸誘導体

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CN112638868A CN112638868A (zh) 2021-04-09
CN112638868B true CN112638868B (zh) 2023-06-20

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US (1) US12029797B2 (https=)
EP (1) EP3825302B1 (https=)
JP (1) JP7375755B2 (https=)
KR (1) KR102718221B1 (https=)
CN (1) CN112638868B (https=)
AU (1) AU2019304781B2 (https=)
CA (1) CA3106903A1 (https=)
ES (1) ES3009015T3 (https=)
WO (1) WO2020017620A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102718221B1 (ko) 2018-07-20 2024-10-15 아스텔라스세이야쿠 가부시키가이샤 양전자 방출 핵종으로 표지된 지방산 유도체
JP7652084B2 (ja) 2020-01-17 2025-03-27 アステラス製薬株式会社 陽電子放出核種で標識された脂肪酸誘導体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2828623C2 (de) * 1978-06-29 1983-11-17 Kernforschungsanlage Jülich GmbH, 5170 Jülich Mit radioaktivem Flour markierte C↓1↓↓6↓-bis C↓1↓↓8↓- Fettsäuren, ein Verfahren zu ihrer Herstellung sowie deren Verwendung
WO2000063216A1 (en) 1999-04-19 2000-10-26 Duke University F-18-labeled thia fatty acids and methods of making and using the same
WO2004093650A2 (en) 2003-04-17 2004-11-04 The General Hospital Corporation Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid
CN1217924C (zh) 2003-10-17 2005-09-07 江苏省原子医学研究所 一种氟标记脂肪酸心肌代谢显像剂14(r,s)－氟[18f]－6－硫十七烷酸的纯化方法
AU2010246010A1 (en) 2009-05-04 2011-11-17 Washington University PET radiotracers for imaging fatty acid metablolism and storage
WO2014179341A1 (en) * 2013-04-29 2014-11-06 Matinas Biopharma, Inc. Treatment with omega-3 fatty acid compositions
WO2015023631A2 (en) 2013-08-12 2015-02-19 Carolyn Anderson Fatty acid analogs and their use
CN105523977B (zh) 2016-02-04 2017-05-24 河南中医学院 [11c]‑巯甲基脂肪酸的制备方法与应用
KR102718221B1 (ko) 2018-07-20 2024-10-15 아스텔라스세이야쿠 가부시키가이샤 양전자 방출 핵종으로 표지된 지방산 유도체
JP7652084B2 (ja) 2020-01-17 2025-03-27 アステラス製薬株式会社 陽電子放出核種で標識された脂肪酸誘導体

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Publication number Publication date
CN112638868A (zh) 2021-04-09
WO2020017620A1 (ja) 2020-01-23
KR20210032392A (ko) 2021-03-24
US12029797B2 (en) 2024-07-09
EP3825302A4 (en) 2022-05-04
CA3106903A1 (en) 2020-01-23
JP7375755B2 (ja) 2023-11-08
US20210338845A1 (en) 2021-11-04
EP3825302A1 (en) 2021-05-26
EP3825302B1 (en) 2025-01-08
ES3009015T3 (en) 2025-03-25
KR102718221B1 (ko) 2024-10-15
AU2019304781A1 (en) 2021-02-11
JPWO2020017620A1 (ja) 2021-08-02
AU2019304781B2 (en) 2023-12-21

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