JP7371029B2 - ベンゼンスルホンアミド化合物および治療剤としてのその使用 - Google Patents

ベンゼンスルホンアミド化合物および治療剤としてのその使用 Download PDF

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Publication number
JP7371029B2
JP7371029B2 JP2020568796A JP2020568796A JP7371029B2 JP 7371029 B2 JP7371029 B2 JP 7371029B2 JP 2020568796 A JP2020568796 A JP 2020568796A JP 2020568796 A JP2020568796 A JP 2020568796A JP 7371029 B2 JP7371029 B2 JP 7371029B2
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methyl
amino
azabicyclo
heptan
fluoro
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JP2021528387A (ja
JP2021528387A5 (enExample
Inventor
ティーロ フォッケン，
クリステン ニコル バーフォード，
ヴァーナー アレクサンダー ロフストランド，
マイケル スコット ウィルソン，
アラ ユレブナ ゼノバ，
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Xenon Pharmaceuticals Inc
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Xenon Pharmaceuticals Inc
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Priority to JP2023129150A priority Critical patent/JP2023138672A/ja
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Publication of JP7371029B2 publication Critical patent/JP7371029B2/ja
Priority to JP2025090964A priority patent/JP2025128218A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2020568796A 2018-06-13 2019-06-13 ベンゼンスルホンアミド化合物および治療剤としてのその使用 Active JP7371029B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023129150A JP2023138672A (ja) 2018-06-13 2023-08-08 ベンゼンスルホンアミド化合物および治療剤としてのその使用
JP2025090964A JP2025128218A (ja) 2018-06-13 2025-05-30 ベンゼンスルホンアミド化合物および治療剤としてのその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862684436P 2018-06-13 2018-06-13
US62/684,436 2018-06-13
PCT/US2019/037011 WO2019241533A1 (en) 2018-06-13 2019-06-13 Benzenesulfonamide compounds and their use as therapeutic agents

Related Child Applications (1)

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JP2023129150A Division JP2023138672A (ja) 2018-06-13 2023-08-08 ベンゼンスルホンアミド化合物および治療剤としてのその使用

Publications (3)

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JP2021528387A JP2021528387A (ja) 2021-10-21
JP2021528387A5 JP2021528387A5 (enExample) 2022-06-15
JP7371029B2 true JP7371029B2 (ja) 2023-10-30

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JP2020568796A Active JP7371029B2 (ja) 2018-06-13 2019-06-13 ベンゼンスルホンアミド化合物および治療剤としてのその使用
JP2023129150A Withdrawn JP2023138672A (ja) 2018-06-13 2023-08-08 ベンゼンスルホンアミド化合物および治療剤としてのその使用
JP2025090964A Pending JP2025128218A (ja) 2018-06-13 2025-05-30 ベンゼンスルホンアミド化合物および治療剤としてのその使用

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JP2023129150A Withdrawn JP2023138672A (ja) 2018-06-13 2023-08-08 ベンゼンスルホンアミド化合物および治療剤としてのその使用
JP2025090964A Pending JP2025128218A (ja) 2018-06-13 2025-05-30 ベンゼンスルホンアミド化合物および治療剤としてのその使用

Country Status (23)

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US (2) US10745392B2 (enExample)
EP (1) EP3807281A1 (enExample)
JP (3) JP7371029B2 (enExample)
KR (1) KR102833674B1 (enExample)
CN (1) CN112262142B (enExample)
AU (1) AU2019285184B2 (enExample)
BR (1) BR112020024729A2 (enExample)
CA (1) CA3103600A1 (enExample)
CL (1) CL2020003197A1 (enExample)
CR (1) CR20200613A (enExample)
EA (1) EA202092719A1 (enExample)
EC (1) ECSP20079861A (enExample)
IL (1) IL278949B2 (enExample)
JO (1) JOP20200304A1 (enExample)
MA (1) MA52888A (enExample)
MX (1) MX2020013317A (enExample)
NI (1) NI202000098A (enExample)
PE (1) PE20211389A1 (enExample)
PH (1) PH12020552111A1 (enExample)
SA (1) SA520420768B1 (enExample)
SG (1) SG11202011862PA (enExample)
UA (1) UA127024C2 (enExample)
WO (1) WO2019241533A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023138672A (ja) * 2018-06-13 2023-10-02 ゼノン・ファーマシューティカルズ・インコーポレイテッド ベンゼンスルホンアミド化合物および治療剤としてのその使用

Families Citing this family (5)

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HRP20250505T1 (hr) * 2016-05-20 2025-06-20 Xenon Pharmaceuticals Inc. Spojevi benzensulfonamida i njihova uporaba za terapijska sredstva
ES2967410T3 (es) 2016-12-09 2024-04-30 Xenon Pharmaceuticals Inc Compuestos de bencenosulfonamida y sus usos en forma de agentes terapéuticos
MX2021001380A (es) 2018-08-31 2021-05-27 Xenon Pharmaceuticals Inc Compuestos de sulfonamida sustituidos con heteroarilo y su uso como agentes terapeuticos.
EP4655291A2 (en) * 2023-01-26 2025-12-03 Merck Sharp & Dohme LLC N-substituted indazole sulfonamide compounds with selective activity in voltage-gated sodium channels background
CN117510431A (zh) * 2023-11-08 2024-02-06 浙江雅辰药物科技股份有限公司 一种异噻唑-3-酮及其衍生物、合成方法

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WO2019241533A1 (en) 2019-12-19
JP2021528387A (ja) 2021-10-21
CN112262142B (zh) 2023-11-14
JP2025128218A (ja) 2025-09-02
EP3807281A1 (en) 2021-04-21
JP2023138672A (ja) 2023-10-02
JOP20200304A1 (ar) 2020-11-25
PH12020552111A1 (en) 2021-08-02
KR102833674B1 (ko) 2025-07-14
BR112020024729A2 (pt) 2021-03-23
US20200361927A1 (en) 2020-11-19
AU2019285184A1 (en) 2021-01-28
US10745392B2 (en) 2020-08-18
MA52888A (fr) 2021-04-21
MX2020013317A (es) 2021-04-13
AU2019285184B2 (en) 2023-11-16
US11325902B2 (en) 2022-05-10
IL278949B1 (en) 2024-04-01
EA202092719A1 (ru) 2021-03-16
CA3103600A1 (en) 2019-12-19
CL2020003197A1 (es) 2021-04-30
NI202000098A (es) 2021-05-28
US20190382398A1 (en) 2019-12-19
PE20211389A1 (es) 2021-07-27
CN112262142A (zh) 2021-01-22
KR20210019507A (ko) 2021-02-22
CR20200613A (es) 2021-06-10
IL278949A (en) 2021-01-31
SA520420768B1 (ar) 2022-08-30
UA127024C2 (uk) 2023-03-15
SG11202011862PA (en) 2020-12-30
IL278949B2 (en) 2024-08-01
ECSP20079861A (es) 2021-03-31

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