CL2020003197A1 - Compuestos de bencenosulfonamida y su uso como agentes terapéuticos. - Google Patents
Compuestos de bencenosulfonamida y su uso como agentes terapéuticos.Info
- Publication number
- CL2020003197A1 CL2020003197A1 CL2020003197A CL2020003197A CL2020003197A1 CL 2020003197 A1 CL2020003197 A1 CL 2020003197A1 CL 2020003197 A CL2020003197 A CL 2020003197A CL 2020003197 A CL2020003197 A CL 2020003197A CL 2020003197 A1 CL2020003197 A1 CL 2020003197A1
- Authority
- CL
- Chile
- Prior art keywords
- therapeutic agents
- benzenesulfonamide compounds
- benzenesulfonamide
- compounds
- seizures
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/50—Nitrogen atoms bound to hetero atoms
- C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Esta invención está dirigida a compuestos de bencensulfonamida, como estereoisómeros,<br /> enantiómeros, tautómeros de los mismos o mezclas de los mismos; o sus sales, solvatos o<br /> profármacos farmacéuticamente aceptables, para el tratamiento de enfermedades o afecciones<br /> asociadas con canales de sodio dependientes de voltaje, tales como epilepsia y/o trastornos de<br /> ataques epilépticos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862684436P | 2018-06-13 | 2018-06-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2020003197A1 true CL2020003197A1 (es) | 2021-04-30 |
Family
ID=67138087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2020003197A CL2020003197A1 (es) | 2018-06-13 | 2020-12-09 | Compuestos de bencenosulfonamida y su uso como agentes terapéuticos. |
Country Status (23)
Country | Link |
---|---|
US (2) | US10745392B2 (es) |
EP (1) | EP3807281A1 (es) |
JP (2) | JP7371029B2 (es) |
KR (1) | KR20210019507A (es) |
CN (1) | CN112262142B (es) |
AU (1) | AU2019285184B2 (es) |
BR (1) | BR112020024729A2 (es) |
CA (1) | CA3103600A1 (es) |
CL (1) | CL2020003197A1 (es) |
CR (1) | CR20200613A (es) |
EA (1) | EA202092719A1 (es) |
EC (1) | ECSP20079861A (es) |
IL (1) | IL278949B1 (es) |
JO (1) | JOP20200304A1 (es) |
MA (1) | MA52888A (es) |
MX (1) | MX2020013317A (es) |
NI (1) | NI202000098A (es) |
PE (1) | PE20211389A1 (es) |
PH (1) | PH12020552111A1 (es) |
SA (1) | SA520420768B1 (es) |
SG (1) | SG11202011862PA (es) |
UA (1) | UA127024C2 (es) |
WO (1) | WO2019241533A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11201809702SA (en) * | 2016-05-20 | 2018-12-28 | Xenon Pharmaceuticals Inc | Benzenesulfonamide compounds and their use as therapeutic agents |
SG10201912372XA (en) | 2016-12-09 | 2020-02-27 | Xenon Pharmaceuticals Inc | Benzenesulfonamide compounds and their use as therapeutic agents |
PE20211389A1 (es) * | 2018-06-13 | 2021-07-27 | Xenon Pharmaceuticals Inc | Compuestos de bencenosulfonamida y su uso como agentes terapeuticos |
PE20211066A1 (es) | 2018-08-31 | 2021-06-09 | Xenon Pharmaceuticals Inc | Compuestos de sulfonamida sustituidos con heteroarilo y su uso como agentes terapeuticos |
Family Cites Families (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
US5877193A (en) | 1996-07-19 | 1999-03-02 | Hoffmann-La Roche Inc. | Use of N-(4-aryl-thiazol-2-yl)-sulfonamides |
CN1184957C (zh) | 1997-05-07 | 2005-01-19 | 盖伦(化学制品)有限公司 | 用于给药睾酮和睾酮前体的阴道内给药装置 |
WO2000042003A1 (en) | 1999-01-13 | 2000-07-20 | Warner-Lambert Company | Benzenesulfonamide derivatives and their use as mek inhibitors |
DE19907385A1 (de) | 1999-02-20 | 2000-08-24 | Boehringer Ingelheim Pharma | Neue substituierte 3-Phenoxy- und 3-Phenylalkyloxy-2-phenyl-propylamine |
CA2378381A1 (en) | 1999-07-16 | 2001-01-25 | Warner-Lambert Company | Method for treating chronic pain using mek inhibitors |
GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
FR2836917B1 (fr) | 2002-03-11 | 2006-02-24 | Lipha | Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant en tant que medicaments utilisables dans le traitement des pathologies caracterisees par une situation de stress oxydatif |
KR101116627B1 (ko) | 2002-06-27 | 2012-10-09 | 노보 노르디스크 에이/에스 | 치료제로서 아릴 카르보닐 유도체 |
JP2005162726A (ja) | 2003-01-24 | 2005-06-23 | Tanabe Seiyaku Co Ltd | ピラゾロピリミジン化合物およびその製法 |
WO2004092123A2 (en) | 2003-04-10 | 2004-10-28 | Microbia, Inc. | Inhibitors of fungal invasion |
WO2005000309A2 (en) | 2003-06-27 | 2005-01-06 | Ionix Pharmaceuticals Limited | Chemical compounds |
WO2005005421A1 (en) | 2003-07-08 | 2005-01-20 | Novartis Ag | Benzenesulfonylamino compounds and pharmaceutical compositions containing these compounds |
JP2007501804A (ja) | 2003-08-08 | 2007-02-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | 電位開口型のナトリウムチャネルのインヒビターとして有用な組成物 |
HU227684B1 (en) | 2003-08-29 | 2011-11-28 | Sanofi Aventis | Adamantane and azabicyclo-octane and nonane derivatives and their use as dpp-iv inhibitors |
JP2008524244A (ja) | 2004-12-17 | 2008-07-10 | タケダ サン ディエゴ インコーポレイテッド | 水酸化ステロイド脱水素酵素阻害剤 |
GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
JP2009510144A (ja) | 2005-10-06 | 2009-03-12 | サノフィ−アベンティス | 4−オキシ−n−[1,3,4]−チアジアゾール−2−イル−ベンゼンスルホンアミド類、それらの製造方法及びそれらの医薬品としての使用 |
CA2633653A1 (en) | 2005-12-21 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
CN101506165B (zh) | 2006-08-15 | 2012-07-04 | 霍夫曼-拉罗奇有限公司 | 苯基、吡啶和喹啉衍生物 |
RU2474582C2 (ru) | 2006-10-19 | 2013-02-10 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Гетероарильные соединения, их композиции и их применение в качестве ингибиторов протеинкиназы |
CA2693588C (en) | 2007-07-13 | 2015-11-17 | Icagen, Inc. | Sodium channel inhibitors |
JP5463285B2 (ja) | 2007-07-13 | 2014-04-09 | アイカジェン, インコーポレイテッド | ナトリウムチャネル阻害物質 |
WO2009013171A2 (en) | 2007-07-24 | 2009-01-29 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
WO2009099177A1 (ja) | 2008-02-06 | 2009-08-13 | Taisho Pharmaceutical Co., Ltd. | アミノイミダゾール誘導体 |
CA2727340A1 (en) | 2008-06-25 | 2009-12-30 | Daiichi Sankyo Company, Limited | Carboxylic acid compound |
US7846954B2 (en) | 2008-07-01 | 2010-12-07 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
US20110294853A1 (en) | 2008-09-12 | 2011-12-01 | Benjamin Pelcman | Bis Aromatic Compounds for Use in the Treatment of Inflammation |
DK2385938T3 (en) | 2009-01-12 | 2015-04-27 | Pfizer Ltd | Sulfonamidderivater |
ES2533065T3 (es) | 2010-07-09 | 2015-04-07 | Pfizer Limited | Bencenosulfonamidas útiles como inhibidores de los canales de sodio |
NZ606751A (en) | 2010-08-20 | 2015-04-24 | Hutchison Medipharma Ltd | Pyrrolopyrimidine compounds and uses thereof |
WO2013025883A1 (en) | 2011-08-17 | 2013-02-21 | Amgen Inc. | Heteroaryl sodium channel inhibitors |
AU2012328561A1 (en) | 2011-10-28 | 2014-04-17 | Merck Sharp & Dohme Corp. | Benzoxazolinone compounds with selective activity in voltage-gated sodium channels |
RU2014121984A (ru) | 2011-10-31 | 2015-12-10 | Ксенон Фармасьютикалз Инк. | Бензолсульфонамидные соединения и их применение в качестве терапевтических средств |
BR112014010368A2 (pt) | 2011-10-31 | 2017-04-25 | Xenon Pharmaceuticals Inc | biaril éter sulfonamidas e seu uso como agentes terapêuticos |
US8889741B2 (en) | 2012-02-09 | 2014-11-18 | Daiichi Sankyo Company, Limited | Cycloalkane derivatives |
WO2013122897A1 (en) | 2012-02-13 | 2013-08-22 | Amgen Inc. | Dihydrobenzoxazine and tetrahydroquinoxaline sodium channel inhibitors |
MX2014014234A (es) | 2012-05-22 | 2015-05-07 | Genentech Inc | Benzamidas n-sustituidas y su uso en el tratamiento del dolor. |
ES2828503T3 (es) | 2012-10-15 | 2021-05-26 | Dae Woong Pharma | Bloqueadores de los canales de sodio, método de preparación de los mismos y uso de los mismos |
US9624208B2 (en) | 2012-10-26 | 2017-04-18 | Merck Sharp & Dohme Corp. | Benzoxazolinone compounds with selective activity in voltage-gated sodium channels |
CN104869992A (zh) | 2012-10-26 | 2015-08-26 | 默沙东公司 | 具有电压门控性钠通道选择性活性的n-取代的吲唑磺酰胺化合物 |
TW201443025A (zh) | 2013-04-19 | 2014-11-16 | Pfizer Ltd | 化學化合物 |
TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
US9776995B2 (en) | 2013-06-12 | 2017-10-03 | Amgen Inc. | Bicyclic sulfonamide compounds as sodium channel inhibitors |
GB201310542D0 (en) | 2013-06-13 | 2013-07-31 | Antabio Sas | Compounds |
CN105705501B (zh) | 2013-09-09 | 2019-04-19 | 百时美施贵宝公司 | RORγ调节剂 |
MY181928A (en) | 2013-09-10 | 2021-01-14 | Chromocell Corp | Sodium channel modulators for the treatment of pain and diabetes |
CA2931732A1 (en) | 2013-11-27 | 2015-06-04 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
WO2015077905A1 (en) | 2013-11-29 | 2015-06-04 | Merck Sharp & Dohme Corp. | Bicycloamine-substituted-n-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels |
JP6337124B2 (ja) | 2013-12-23 | 2018-06-06 | パーデュー、ファーマ、リミテッド、パートナーシップ | インダゾール及びその使用 |
WO2016177340A1 (zh) | 2015-05-05 | 2016-11-10 | 上海海雁医药科技有限公司 | 双环取代的苯磺酰胺衍生物、其制法与医药上的用途 |
US10519147B2 (en) | 2015-12-18 | 2019-12-31 | Merck Sharp & Dohme Corp. | Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels |
WO2017165204A1 (en) | 2016-03-22 | 2017-09-28 | Merck Sharp & Dohme Corp. | N1-phenylpropane-1,2-diamine compounds with selective activity in voltage-gated sodium channels |
SG11201809702SA (en) | 2016-05-20 | 2018-12-28 | Xenon Pharmaceuticals Inc | Benzenesulfonamide compounds and their use as therapeutic agents |
US10836758B2 (en) | 2016-10-27 | 2020-11-17 | Bristol-Myers Squibb Company | Acyl sulfonamide NaV1.7 inhibitors |
WO2018093694A1 (en) | 2016-11-17 | 2018-05-24 | Merck Sharp & Dohme Corp. | Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels |
SG10201912372XA (en) * | 2016-12-09 | 2020-02-27 | Xenon Pharmaceuticals Inc | Benzenesulfonamide compounds and their use as therapeutic agents |
PE20211389A1 (es) | 2018-06-13 | 2021-07-27 | Xenon Pharmaceuticals Inc | Compuestos de bencenosulfonamida y su uso como agentes terapeuticos |
JP7383012B2 (ja) | 2018-08-31 | 2023-11-17 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ヘテロアリール置換スルホンアミド化合物、およびナトリウムチャネル阻害剤としてのその使用 |
PE20211066A1 (es) | 2018-08-31 | 2021-06-09 | Xenon Pharmaceuticals Inc | Compuestos de sulfonamida sustituidos con heteroarilo y su uso como agentes terapeuticos |
-
2019
- 2019-06-13 PE PE2020001990A patent/PE20211389A1/es unknown
- 2019-06-13 BR BR112020024729-4A patent/BR112020024729A2/pt unknown
- 2019-06-13 US US16/440,459 patent/US10745392B2/en active Active
- 2019-06-13 EA EA202092719A patent/EA202092719A1/ru unknown
- 2019-06-13 EP EP19735024.2A patent/EP3807281A1/en active Pending
- 2019-06-13 MX MX2020013317A patent/MX2020013317A/es unknown
- 2019-06-13 MA MA052888A patent/MA52888A/fr unknown
- 2019-06-13 AU AU2019285184A patent/AU2019285184B2/en active Active
- 2019-06-13 WO PCT/US2019/037011 patent/WO2019241533A1/en unknown
- 2019-06-13 UA UAA202008102A patent/UA127024C2/uk unknown
- 2019-06-13 SG SG11202011862PA patent/SG11202011862PA/en unknown
- 2019-06-13 CA CA3103600A patent/CA3103600A1/en active Pending
- 2019-06-13 IL IL278949A patent/IL278949B1/en unknown
- 2019-06-13 CN CN201980039029.1A patent/CN112262142B/zh active Active
- 2019-06-13 KR KR1020217000602A patent/KR20210019507A/ko unknown
- 2019-06-13 JP JP2020568796A patent/JP7371029B2/ja active Active
- 2019-06-13 CR CR20200613A patent/CR20200613A/es unknown
- 2019-12-13 JO JOP/2020/0304A patent/JOP20200304A1/ar unknown
-
2020
- 2020-07-13 US US16/927,178 patent/US11325902B2/en active Active
- 2020-12-09 CL CL2020003197A patent/CL2020003197A1/es unknown
- 2020-12-09 PH PH12020552111A patent/PH12020552111A1/en unknown
- 2020-12-10 SA SA520420768A patent/SA520420768B1/ar unknown
- 2020-12-10 EC ECSENADI202079861A patent/ECSP20079861A/es unknown
- 2020-12-10 NI NI202000098A patent/NI202000098A/es unknown
-
2023
- 2023-08-08 JP JP2023129150A patent/JP2023138672A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
PE20211389A1 (es) | 2021-07-27 |
EA202092719A1 (ru) | 2021-03-16 |
JP7371029B2 (ja) | 2023-10-30 |
JP2021528387A (ja) | 2021-10-21 |
US10745392B2 (en) | 2020-08-18 |
ECSP20079861A (es) | 2021-03-31 |
WO2019241533A1 (en) | 2019-12-19 |
CN112262142A (zh) | 2021-01-22 |
PH12020552111A1 (en) | 2021-08-02 |
US11325902B2 (en) | 2022-05-10 |
MX2020013317A (es) | 2021-04-13 |
MA52888A (fr) | 2021-04-21 |
IL278949B1 (en) | 2024-04-01 |
IL278949A (en) | 2021-01-31 |
US20200361927A1 (en) | 2020-11-19 |
KR20210019507A (ko) | 2021-02-22 |
SG11202011862PA (en) | 2020-12-30 |
JP2023138672A (ja) | 2023-10-02 |
EP3807281A1 (en) | 2021-04-21 |
CR20200613A (es) | 2021-06-10 |
AU2019285184B2 (en) | 2023-11-16 |
CA3103600A1 (en) | 2019-12-19 |
CN112262142B (zh) | 2023-11-14 |
JOP20200304A1 (ar) | 2020-11-25 |
NI202000098A (es) | 2021-05-28 |
AU2019285184A1 (en) | 2021-01-28 |
UA127024C2 (uk) | 2023-03-15 |
BR112020024729A2 (pt) | 2021-03-23 |
SA520420768B1 (ar) | 2022-08-30 |
US20190382398A1 (en) | 2019-12-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NI202100013A (es) | Compuestos de sulfonamida sustituidos con heteroarilo y su uso como agentes terapéuticos. | |
CO2019005552A2 (es) | Compuestos de bencenosulfonamida y su uso como agentes terapéuticos | |
CL2020003197A1 (es) | Compuestos de bencenosulfonamida y su uso como agentes terapéuticos. | |
CO2018012485A2 (es) | Compuestos de bencenosulfonamida y sus usos como agentes terapéuticos | |
MX2020004405A (es) | Compuestos biciclicos en puente como moduladores del receptor farnesoide x. | |
CO2017012545A2 (es) | Sulfonas tricíclicas como moduladores del receptor huérfano relacionado con retinoide gamma (rorγ) | |
UY36630A (es) | Moduladores tricíclicos de la señalización por tnf | |
ECSP20061378A (es) | COMPUESTOS DIÓLICOS DE AMINOPIRAZINA COMO INHIBIDORES DE PI3K-gamma | |
CO2021010611A2 (es) | Compuestos bicíclicos sustituidos como moduladores del receptor farnesoide x | |
ECSP19072975A (es) | Derivados pirazol[1,5-a]pirimidina sustituidos con alicíclicos farmacológicamente activos | |
EA201991128A1 (ru) | ТРИЦИКЛИЧЕСКИЕ СУЛЬФОНЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ RORγ | |
DOP2020000234A (es) | Compuestos de bencenosulfonamida y su uso como agentes terapéuticos | |
CO2021007442A2 (es) | Compuesto de 1,3,4-oxadiazolona y fármaco | |
CL2021002144A1 (es) | Compuesto heterociclo pentacíclico. |