JP7367950B2 - 抗菌性ポリミキシン誘導体化合物 - Google Patents
抗菌性ポリミキシン誘導体化合物 Download PDFInfo
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- JP7367950B2 JP7367950B2 JP2018516423A JP2018516423A JP7367950B2 JP 7367950 B2 JP7367950 B2 JP 7367950B2 JP 2018516423 A JP2018516423 A JP 2018516423A JP 2018516423 A JP2018516423 A JP 2018516423A JP 7367950 B2 JP7367950 B2 JP 7367950B2
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- carboxyl
- heteroaryl
- trifluoromethyl
- amino acid
- alkyl
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- 125000001424 substituent group Chemical group 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
- C07K7/62—Polymyxins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| AU2015903961A AU2015903961A0 (en) | 2015-09-29 | Antimicrobial compounds | |
| AU2015903961 | 2015-09-29 | ||
| PCT/AU2016/050915 WO2017054047A1 (en) | 2015-09-29 | 2016-09-29 | Antimicrobial polymyxin derivative compounds |
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| JP2018531241A JP2018531241A (ja) | 2018-10-25 |
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| CA (1) | CA3000032A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017054047A1 (cg-RX-API-DMAC7.html) |
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| EP3126376B1 (en) | 2014-04-01 | 2024-08-21 | Monash University | Polymyxin derivatives as antimicrobial compounds |
| CN107108699A (zh) | 2014-11-26 | 2017-08-29 | 新药物许可控股有限公司 | 化合物 |
| CN108350034B (zh) * | 2015-09-29 | 2022-03-11 | 莫纳什大学 | 抗微生物的多黏菌素衍生的化合物 |
| JP6552070B2 (ja) * | 2015-11-25 | 2019-07-31 | 国立大学法人大阪大学 | レジストパターン形成方法およびレジスト材料 |
| JP2021501783A (ja) | 2017-11-02 | 2021-01-21 | ザ ユニバーシティー オブ クイーンズランド | ペプチド抗生物質 |
| LT3810633T (lt) * | 2018-06-25 | 2024-01-10 | Spero Therapeutics, Inc. | Junginiai |
| CN109402008B (zh) * | 2018-11-15 | 2021-09-14 | 中国农业科学院饲料研究所 | 一株具有吲哚降解能力的不动杆菌tat1-6a及其应用 |
| JP7045520B2 (ja) | 2020-01-02 | 2022-03-31 | 上海上薬第一生化薬業有限公司 | ポリミキシンｂ成分又はその塩、その製造方法及び使用 |
| CN111072757B (zh) * | 2020-01-02 | 2021-10-15 | 上海上药第一生化药业有限公司 | 多黏菌素b组分或其盐及其制备方法和应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008505858A (ja) | 2004-07-01 | 2008-02-28 | バイオソース・ファーム・インコーポレイテッド | ペプチド抗生物質およびその製造方法 |
| US20090215677A1 (en) | 2008-02-08 | 2009-08-27 | Martti Sakari Vaara | Polymyxin derivatives and uses thereof |
| WO2012168820A1 (en) | 2011-06-08 | 2012-12-13 | Pfizer Inc. | Polymyxin derivatives useful as antibacterial agents |
| WO2015135976A1 (en) | 2014-03-11 | 2015-09-17 | New Pharma Licence Holdings Limited | Polymyxin derivatives and their use in combination therapy together with different antibiotics |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006045156A1 (en) | 2004-10-29 | 2006-05-04 | Monash University | Therapy for multi-drug resistant microorganisms |
| KR100750658B1 (ko) | 2005-12-09 | 2007-08-20 | 한국생명공학연구원 | 폴리믹신 생합성 효소 및 이를 코딩하는 유전자 군 |
| WO2010075416A1 (en) | 2008-12-23 | 2010-07-01 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| WO2010130007A1 (en) | 2009-05-14 | 2010-11-18 | Monash University | Antimicrobial compounds |
| US8415307B1 (en) | 2010-06-23 | 2013-04-09 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| WO2012051663A1 (en) * | 2010-10-21 | 2012-04-26 | Monash University | Antimicrobial compounds |
| CA2855916A1 (en) * | 2011-11-18 | 2013-05-23 | Novacta Biosystems Limited | Polymyxin derivatives |
| RU2015132569A (ru) * | 2013-01-11 | 2017-02-14 | Кселлия Фармасьютикалз Апс | Полимиксины, композиции с ними, способы получения и способы применения |
| PT2999711T (pt) | 2013-05-22 | 2022-07-29 | Spero Therapeutics Inc | Derivados de polimixina e a sua utilização em terapia de combinação em conjunto com antibióticos diferentes |
| EP3126376B1 (en) * | 2014-04-01 | 2024-08-21 | Monash University | Polymyxin derivatives as antimicrobial compounds |
| CN108350034B (zh) * | 2015-09-29 | 2022-03-11 | 莫纳什大学 | 抗微生物的多黏菌素衍生的化合物 |
-
2016
- 2016-09-29 CN CN201680065339.7A patent/CN108350034B/zh active Active
- 2016-09-29 CA CA3000032A patent/CA3000032A1/en active Pending
- 2016-09-29 JP JP2018516423A patent/JP7367950B2/ja active Active
- 2016-09-29 EP EP16849954.9A patent/EP3356387B1/en active Active
- 2016-09-29 AU AU2016331658A patent/AU2016331658B2/en active Active
- 2016-09-29 US US15/763,954 patent/US11225505B2/en active Active
- 2016-09-29 WO PCT/AU2016/050915 patent/WO2017054047A1/en not_active Ceased
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008505858A (ja) | 2004-07-01 | 2008-02-28 | バイオソース・ファーム・インコーポレイテッド | ペプチド抗生物質およびその製造方法 |
| US20090215677A1 (en) | 2008-02-08 | 2009-08-27 | Martti Sakari Vaara | Polymyxin derivatives and uses thereof |
| WO2012168820A1 (en) | 2011-06-08 | 2012-12-13 | Pfizer Inc. | Polymyxin derivatives useful as antibacterial agents |
| WO2015135976A1 (en) | 2014-03-11 | 2015-09-17 | New Pharma Licence Holdings Limited | Polymyxin derivatives and their use in combination therapy together with different antibiotics |
Non-Patent Citations (3)
| Title |
|---|
| ＡＣＳ Ｃｈｅｍｉｃａｌ Ｂｉｏｌｏｇｙ，２０１４年，Ｖｏｌ．９，ｐ．１１７２－１１７７ |
| Ｃｈｅｍ．Ｐｈａｒｍ．Ｂｕｌｌ．，２００９年，Ｖｏｌ．５７，Ｎｏ．３，ｐ．２４０－２４４ |
| Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ，２０１３年，Ｖｏｌ．５６，ｐ．５０７９－５０９３ |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3000032A1 (en) | 2017-04-06 |
| EP3356387B1 (en) | 2024-06-26 |
| AU2016331658B2 (en) | 2021-04-01 |
| CN108350034A (zh) | 2018-07-31 |
| JP2022009368A (ja) | 2022-01-14 |
| EP3356387A1 (en) | 2018-08-08 |
| US20180282374A1 (en) | 2018-10-04 |
| NZ741027A (en) | 2024-05-31 |
| WO2017054047A1 (en) | 2017-04-06 |
| US11225505B2 (en) | 2022-01-18 |
| AU2016331658A1 (en) | 2018-04-19 |
| JP2018531241A (ja) | 2018-10-25 |
| EP3356387A4 (en) | 2019-03-13 |
| CN108350034B (zh) | 2022-03-11 |
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