JP2018531241A5 - - Google Patents
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- Publication number
- JP2018531241A5 JP2018531241A5 JP2018516423A JP2018516423A JP2018531241A5 JP 2018531241 A5 JP2018531241 A5 JP 2018531241A5 JP 2018516423 A JP2018516423 A JP 2018516423A JP 2018516423 A JP2018516423 A JP 2018516423A JP 2018531241 A5 JP2018531241 A5 JP 2018531241A5
- Authority
- JP
- Japan
- Prior art keywords
- heteroaryl
- carboxyl
- aryl
- alkyl
- nhc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001072 heteroaryl group Chemical group 0.000 claims 72
- -1 5-chloronicotinoyl Chemical group 0.000 claims 38
- 125000003118 aryl group Chemical group 0.000 claims 28
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 125000000623 heterocyclic group Chemical group 0.000 claims 21
- 125000003342 alkenyl group Chemical group 0.000 claims 20
- 125000000304 alkynyl group Chemical group 0.000 claims 20
- 229940024606 amino acid Drugs 0.000 claims 10
- 235000001014 amino acid Nutrition 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 9
- QWCKQJZIFLGMSD-UHFFFAOYSA-N alpha-aminobutyric acid Chemical compound CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 claims 8
- NPDBDJFLKKQMCM-SCSAIBSYSA-N (2s)-2-amino-3,3-dimethylbutanoic acid Chemical compound CC(C)(C)[C@H](N)C(O)=O NPDBDJFLKKQMCM-SCSAIBSYSA-N 0.000 claims 6
- 208000027096 gram-negative bacterial infections Diseases 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- SNDPXSYFESPGGJ-BYPYZUCNSA-N L-2-aminopentanoic acid Chemical compound CCC[C@H](N)C(O)=O SNDPXSYFESPGGJ-BYPYZUCNSA-N 0.000 claims 4
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 4
- SNDPXSYFESPGGJ-UHFFFAOYSA-N L-norVal-OH Natural products CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 claims 4
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 claims 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 4
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 4
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 4
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 4
- 239000004473 Threonine Substances 0.000 claims 4
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 4
- 235000004279 alanine Nutrition 0.000 claims 4
- 125000005605 benzo group Chemical group 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 230000036457 multidrug resistance Effects 0.000 claims 4
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 4
- 239000004474 valine Substances 0.000 claims 4
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 3
- AGPKZVBTJJNPAG-UHNVWZDZSA-N L-allo-Isoleucine Chemical compound CC[C@@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-UHNVWZDZSA-N 0.000 claims 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 3
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 3
- 229960000310 isoleucine Drugs 0.000 claims 3
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 3
- MTCFGRXMJLQNBG-UWTATZPHSA-N D-Serine Chemical compound OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 claims 2
- 241000257303 Hymenoptera Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- TUCRZHGAIRVWTI-UHFFFAOYSA-N 2-bromothiophene Chemical compound BrC1=CC=CS1 TUCRZHGAIRVWTI-UHFFFAOYSA-N 0.000 claims 1
- IHCCAYCGZOLTEU-UHFFFAOYSA-N 3-furoic acid Chemical group OC(=O)C=1C=COC=1 IHCCAYCGZOLTEU-UHFFFAOYSA-N 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021172501A JP2022009368A (ja) | 2015-09-29 | 2021-10-21 | 抗菌性ポリミキシン誘導体化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2015903961A AU2015903961A0 (en) | 2015-09-29 | Antimicrobial compounds | |
| AU2015903961 | 2015-09-29 | ||
| PCT/AU2016/050915 WO2017054047A1 (en) | 2015-09-29 | 2016-09-29 | Antimicrobial polymyxin derivative compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021172501A Division JP2022009368A (ja) | 2015-09-29 | 2021-10-21 | 抗菌性ポリミキシン誘導体化合物 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2018531241A JP2018531241A (ja) | 2018-10-25 |
| JP2018531241A6 JP2018531241A6 (ja) | 2018-12-13 |
| JP2018531241A5 true JP2018531241A5 (cg-RX-API-DMAC7.html) | 2019-11-07 |
| JP7367950B2 JP7367950B2 (ja) | 2023-10-24 |
Family
ID=58422486
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516423A Active JP7367950B2 (ja) | 2015-09-29 | 2016-09-29 | 抗菌性ポリミキシン誘導体化合物 |
| JP2021172501A Pending JP2022009368A (ja) | 2015-09-29 | 2021-10-21 | 抗菌性ポリミキシン誘導体化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021172501A Pending JP2022009368A (ja) | 2015-09-29 | 2021-10-21 | 抗菌性ポリミキシン誘導体化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11225505B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3356387B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7367950B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN108350034B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016331658B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3000032A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017054047A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4477272A3 (en) | 2014-04-01 | 2025-03-12 | Monash University | Polymyxin derivatives as antimicrobial compounds |
| CN107108699A (zh) | 2014-11-26 | 2017-08-29 | 新药物许可控股有限公司 | 化合物 |
| EP3356387B1 (en) * | 2015-09-29 | 2024-06-26 | Monash University | Antimicrobial polymyxin derivative compounds |
| KR102170659B1 (ko) * | 2015-11-25 | 2020-10-27 | 오사카 유니버시티 | 레지스트패턴 형성방법 및 레지스트재료 |
| CN111527100A (zh) | 2017-11-02 | 2020-08-11 | 昆士兰大学 | 肽类抗生素 |
| BR112020026663A2 (pt) * | 2018-06-25 | 2021-03-23 | Spero Therapeutics, Inc. | Compostos |
| CN109402008B (zh) * | 2018-11-15 | 2021-09-14 | 中国农业科学院饲料研究所 | 一株具有吲哚降解能力的不动杆菌tat1-6a及其应用 |
| JP7045520B2 (ja) | 2020-01-02 | 2022-03-31 | 上海上薬第一生化薬業有限公司 | ポリミキシンｂ成分又はその塩、その製造方法及び使用 |
| CN111072757B (zh) * | 2020-01-02 | 2021-10-15 | 上海上药第一生化药业有限公司 | 多黏菌素b组分或其盐及其制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060004185A1 (en) | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
| WO2006045156A1 (en) | 2004-10-29 | 2006-05-04 | Monash University | Therapy for multi-drug resistant microorganisms |
| KR100750658B1 (ko) | 2005-12-09 | 2007-08-20 | 한국생명공학연구원 | 폴리믹신 생합성 효소 및 이를 코딩하는 유전자 군 |
| US8329645B2 (en) | 2008-02-08 | 2012-12-11 | Northern Antibiotics Ltd. | Polymyxin derivatives and uses thereof |
| US8343912B2 (en) * | 2008-12-23 | 2013-01-01 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| WO2010130007A1 (en) | 2009-05-14 | 2010-11-18 | Monash University | Antimicrobial compounds |
| US8415307B1 (en) | 2010-06-23 | 2013-04-09 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
| WO2012051663A1 (en) * | 2010-10-21 | 2012-04-26 | Monash University | Antimicrobial compounds |
| WO2012168820A1 (en) * | 2011-06-08 | 2012-12-13 | Pfizer Inc. | Polymyxin derivatives useful as antibacterial agents |
| BR112014012016A2 (pt) | 2011-11-18 | 2017-05-16 | Cantab Anti-Infectives Ltd | compostos |
| WO2014108469A1 (en) * | 2013-01-11 | 2014-07-17 | Xellia Pharmaceuticals Aps | Polymyxins, compositions, methods of making and methods of use |
| PL2999711T3 (pl) * | 2013-05-22 | 2022-09-26 | Spero Therapeutics, Inc. | Pochodne polimyksyny i ich zastosowanie w terapii skojarzonej razem z różnymi antybiotykami |
| DK3116897T3 (da) | 2014-03-11 | 2022-03-28 | Spero Therapeutics Inc | Polymyxinderivater og deres anvendelse i kombinationsterapi sammen med forskellige antibiotika |
| EP4477272A3 (en) | 2014-04-01 | 2025-03-12 | Monash University | Polymyxin derivatives as antimicrobial compounds |
| EP3356387B1 (en) * | 2015-09-29 | 2024-06-26 | Monash University | Antimicrobial polymyxin derivative compounds |
-
2016
- 2016-09-29 EP EP16849954.9A patent/EP3356387B1/en active Active
- 2016-09-29 AU AU2016331658A patent/AU2016331658B2/en active Active
- 2016-09-29 JP JP2018516423A patent/JP7367950B2/ja active Active
- 2016-09-29 CN CN201680065339.7A patent/CN108350034B/zh active Active
- 2016-09-29 WO PCT/AU2016/050915 patent/WO2017054047A1/en not_active Ceased
- 2016-09-29 CA CA3000032A patent/CA3000032A1/en active Pending
- 2016-09-29 US US15/763,954 patent/US11225505B2/en active Active
-
2021
- 2021-10-21 JP JP2021172501A patent/JP2022009368A/ja active Pending