AU2016331658B2 - Antimicrobial polymyxin derivative compounds - Google Patents

Antimicrobial polymyxin derivative compounds Download PDF

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Publication number
AU2016331658B2
AU2016331658B2 AU2016331658A AU2016331658A AU2016331658B2 AU 2016331658 B2 AU2016331658 B2 AU 2016331658B2 AU 2016331658 A AU2016331658 A AU 2016331658A AU 2016331658 A AU2016331658 A AU 2016331658A AU 2016331658 B2 AU2016331658 B2 AU 2016331658B2
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AU
Australia
Prior art keywords
carboxyl
dap
trifluoromethyl
compound
purity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2016331658A
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English (en)
Other versions
AU2016331658A1 (en
Inventor
Jian Li
Roger L. NATION
Kade D. Roberts
Philip E. Thompson
Tony Velkov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monash University
Original Assignee
Monash University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2015903961A external-priority patent/AU2015903961A0/en
Application filed by Monash University filed Critical Monash University
Publication of AU2016331658A1 publication Critical patent/AU2016331658A1/en
Application granted granted Critical
Publication of AU2016331658B2 publication Critical patent/AU2016331658B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2016331658A 2015-09-29 2016-09-29 Antimicrobial polymyxin derivative compounds Active AU2016331658B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2015903961A AU2015903961A0 (en) 2015-09-29 Antimicrobial compounds
AU2015903961 2015-09-29
PCT/AU2016/050915 WO2017054047A1 (en) 2015-09-29 2016-09-29 Antimicrobial polymyxin derivative compounds

Publications (2)

Publication Number Publication Date
AU2016331658A1 AU2016331658A1 (en) 2018-04-19
AU2016331658B2 true AU2016331658B2 (en) 2021-04-01

Family

ID=58422486

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016331658A Active AU2016331658B2 (en) 2015-09-29 2016-09-29 Antimicrobial polymyxin derivative compounds

Country Status (7)

Country Link
US (1) US11225505B2 (cg-RX-API-DMAC7.html)
EP (1) EP3356387B1 (cg-RX-API-DMAC7.html)
JP (2) JP7367950B2 (cg-RX-API-DMAC7.html)
CN (1) CN108350034B (cg-RX-API-DMAC7.html)
AU (1) AU2016331658B2 (cg-RX-API-DMAC7.html)
CA (1) CA3000032A1 (cg-RX-API-DMAC7.html)
WO (1) WO2017054047A1 (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4477272A3 (en) 2014-04-01 2025-03-12 Monash University Polymyxin derivatives as antimicrobial compounds
CN107108699A (zh) 2014-11-26 2017-08-29 新药物许可控股有限公司 化合物
EP3356387B1 (en) * 2015-09-29 2024-06-26 Monash University Antimicrobial polymyxin derivative compounds
KR102170659B1 (ko) * 2015-11-25 2020-10-27 오사카 유니버시티 레지스트패턴 형성방법 및 레지스트재료
CN111527100A (zh) 2017-11-02 2020-08-11 昆士兰大学 肽类抗生素
BR112020026663A2 (pt) * 2018-06-25 2021-03-23 Spero Therapeutics, Inc. Compostos
CN109402008B (zh) * 2018-11-15 2021-09-14 中国农业科学院饲料研究所 一株具有吲哚降解能力的不动杆菌tat1-6a及其应用
JP7045520B2 (ja) 2020-01-02 2022-03-31 上海上薬第一生化薬業有限公司 ポリミキシンｂ成分又はその塩、その製造方法及び使用
CN111072757B (zh) * 2020-01-02 2021-10-15 上海上药第一生化药业有限公司 多黏菌素b组分或其盐及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006083317A2 (en) * 2004-07-01 2006-08-10 Biosource Pharm, Inc. Peptide antibiotics and methods for making same
WO2012051663A1 (en) * 2010-10-21 2012-04-26 Monash University Antimicrobial compounds
WO2012168820A1 (en) * 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents
WO2015135976A1 (en) * 2014-03-11 2015-09-17 New Pharma Licence Holdings Limited Polymyxin derivatives and their use in combination therapy together with different antibiotics

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006045156A1 (en) 2004-10-29 2006-05-04 Monash University Therapy for multi-drug resistant microorganisms
KR100750658B1 (ko) 2005-12-09 2007-08-20 한국생명공학연구원 폴리믹신 생합성 효소 및 이를 코딩하는 유전자 군
US8329645B2 (en) 2008-02-08 2012-12-11 Northern Antibiotics Ltd. Polymyxin derivatives and uses thereof
US8343912B2 (en) * 2008-12-23 2013-01-01 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2010130007A1 (en) 2009-05-14 2010-11-18 Monash University Antimicrobial compounds
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
BR112014012016A2 (pt) 2011-11-18 2017-05-16 Cantab Anti-Infectives Ltd compostos
WO2014108469A1 (en) * 2013-01-11 2014-07-17 Xellia Pharmaceuticals Aps Polymyxins, compositions, methods of making and methods of use
PL2999711T3 (pl) * 2013-05-22 2022-09-26 Spero Therapeutics, Inc. Pochodne polimyksyny i ich zastosowanie w terapii skojarzonej razem z różnymi antybiotykami
EP4477272A3 (en) 2014-04-01 2025-03-12 Monash University Polymyxin derivatives as antimicrobial compounds
EP3356387B1 (en) * 2015-09-29 2024-06-26 Monash University Antimicrobial polymyxin derivative compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006083317A2 (en) * 2004-07-01 2006-08-10 Biosource Pharm, Inc. Peptide antibiotics and methods for making same
WO2012051663A1 (en) * 2010-10-21 2012-04-26 Monash University Antimicrobial compounds
WO2012168820A1 (en) * 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents
WO2015135976A1 (en) * 2014-03-11 2015-09-17 New Pharma Licence Holdings Limited Polymyxin derivatives and their use in combination therapy together with different antibiotics

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MAGEE, T.V. et al. "Discovery of Dap‑3 Polymyxin Analogues for the Treatment of Multidrug-Resistant Gram-Negative Nosocomial Infections" Journal of Medicinal Chemistry (2013) Vol.56 No.12, pages 5079 to 5093 *

Also Published As

Publication number Publication date
JP7367950B2 (ja) 2023-10-24
EP3356387A4 (en) 2019-03-13
US11225505B2 (en) 2022-01-18
CN108350034B (zh) 2022-03-11
EP3356387A1 (en) 2018-08-08
EP3356387B1 (en) 2024-06-26
CA3000032A1 (en) 2017-04-06
WO2017054047A1 (en) 2017-04-06
AU2016331658A1 (en) 2018-04-19
NZ741027A (en) 2024-05-31
JP2022009368A (ja) 2022-01-14
US20180282374A1 (en) 2018-10-04
JP2018531241A (ja) 2018-10-25
CN108350034A (zh) 2018-07-31

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