JP7352807B2 - アリール炭化水素受容体アンタゴニスト及びその使用 - Google Patents

アリール炭化水素受容体アンタゴニスト及びその使用 Download PDF

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JP7352807B2
JP7352807B2 JP2019555784A JP2019555784A JP7352807B2 JP 7352807 B2 JP7352807 B2 JP 7352807B2 JP 2019555784 A JP2019555784 A JP 2019555784A JP 2019555784 A JP2019555784 A JP 2019555784A JP 7352807 B2 JP7352807 B2 JP 7352807B2
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hematopoietic stem
optionally substituted
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グレン ロメロ アーサー
エイ ゴンカルブス ケビン
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Dianthus Therapeutics Inc
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Magenta Therapeutics Inc
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    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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JP2019555784A 2017-04-12 2018-04-12 アリール炭化水素受容体アンタゴニスト及びその使用 Active JP7352807B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762484692P 2017-04-12 2017-04-12
US62/484,692 2017-04-12
US201862613382P 2018-01-03 2018-01-03
US62/613,382 2018-01-03
US201862625896P 2018-02-02 2018-02-02
US62/625,896 2018-02-02
PCT/US2018/027265 WO2018191476A1 (en) 2017-04-12 2018-04-12 Aryl hydrocarbon receptor antagonists and uses thereof

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JP2020516639A JP2020516639A (ja) 2020-06-11
JP2020516639A5 JP2020516639A5 (https=) 2021-05-27
JP7352807B2 true JP7352807B2 (ja) 2023-09-29

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US (4) US10457683B2 (https=)
EP (1) EP3609890B1 (https=)
JP (1) JP7352807B2 (https=)
KR (1) KR20190138837A (https=)
CN (1) CN110785419B (https=)
AU (1) AU2018253115B2 (https=)
BR (1) BR112019021282A2 (https=)
CA (1) CA3057159A1 (https=)
CO (1) CO2019012473A2 (https=)
IL (2) IL293956A (https=)
MX (1) MX392743B (https=)
SG (1) SG11201908624SA (https=)
TW (1) TW201841916A (https=)
WO (1) WO2018191476A1 (https=)
ZA (1) ZA201906209B (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201841916A (zh) 2017-04-12 2018-12-01 美商麥珍塔治療學股份有限公司 芳香烴受體拮抗劑及其用途
MX2019012431A (es) 2017-04-21 2020-08-03 Ikena Oncology Inc Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos.
BR112020003116A2 (pt) 2017-08-17 2020-08-04 Ikena Oncology, Inc. inibidores de ahr e usos dos mesmos
US20190314407A1 (en) * 2017-10-31 2019-10-17 Magenta Therapeutics Inc. Compositions and methods for the expansion of hematopoietic stem and progenitor cells
US20200338132A1 (en) * 2018-01-03 2020-10-29 Magenta Therapeutics Inc. Compositions and methods for the expansion of hematopoietic stem and progenitor cells and treatment of inherited metabolic disorders
WO2019156989A1 (en) * 2018-02-06 2019-08-15 Ideaya Biosciences, Inc. COMPOUNDS AND METHODS FOR THE MODULATION OF AhR
CN113301897A (zh) * 2018-10-17 2021-08-24 美真达治疗公司 用芳烃受体拮抗剂治疗癌症的方法
US12419865B2 (en) 2018-12-06 2025-09-23 Arisan Therapeutics Inc. Compounds for the treatment of arenavirus infection
WO2021028382A1 (en) * 2019-08-12 2021-02-18 Bayer Aktiengesellschaft [1,2,4]triazolo[1,5-c]quinazolin-5-amines
EP4051298A1 (en) 2019-11-01 2022-09-07 Magenta Therapeutics, Inc. Dosing regimens for the mobilization of hematopoietic stem and progentor cells
AU2020394424A1 (en) 2019-11-26 2022-06-16 Ikena Oncology, Inc. Polymorphic carbazole derivatives and uses thereof
CN114369097B (zh) * 2020-10-15 2023-07-14 山东轩竹医药科技有限公司 杂芳环类AhR抑制剂
CA3201841A1 (en) 2020-12-23 2022-06-30 Scott Bryan HOYT Multi-cyclic irak and flt3 inhibiting compounds and uses thereof
WO2022197776A1 (en) 2021-03-16 2022-09-22 Magenta Therapeutics, Inc. Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients
WO2023250431A2 (en) * 2022-06-22 2023-12-28 Children's Hospital Medical Center Multi-cyclic irak and flt3 inhibiting compounds and uses thereof

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006507254A (ja) 2002-09-19 2006-03-02 シェーリング コーポレイション サイクリン依存性キナーゼインヒビターとしてのイミダゾピリジン
JP2009515882A (ja) 2005-11-10 2009-04-16 シェーリング コーポレイション プロテインキナーゼを阻害するための方法
WO2011013729A1 (ja) 2009-07-30 2011-02-03 オンコセラピー・サイエンス株式会社 Ttk阻害作用を有する縮合イミダゾール誘導体
JP2012507554A (ja) 2008-10-30 2012-03-29 アイアールエム・リミテッド・ライアビリティ・カンパニー 造血幹細胞を増加させる化合物
JP2013545779A (ja) 2010-12-17 2013-12-26 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 過剰増殖性障害の治療におけるmps−1およびtkk阻害剤として使用するための6置換イミダゾピラジン
JP2013545778A (ja) 2010-12-17 2013-12-26 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 過剰増殖性障害の治療におけるmps−1およびtkk阻害剤として使用するための6置換イミダゾピラジン
JP2013545776A (ja) 2010-12-17 2013-12-26 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 過剰増殖性障害の治療におけるmps−1およびtkk阻害剤として使用するための6置換イミダゾピラジン
JP2014510118A (ja) 2011-04-06 2014-04-24 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 置換イミダゾピリジン類およびその中間体
WO2014080241A1 (en) 2012-11-21 2014-05-30 Piramal Enterprises Limited Imidazopyridine compounds and uses thereof

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US5233044A (en) 1989-06-08 1993-08-03 Millipore Corporation Active esters for solid phase peptide synthesis
US5512421A (en) 1991-02-19 1996-04-30 The Regents Of The University Of California Generation, concentration and efficient transfer of VSV-G pseudotyped retroviral vectors
DK0752248T3 (da) 1992-11-13 2000-11-13 Idec Pharma Corp Terapeutisk anvendelse af kimæriske og radioaktivt mærkede antistoffer mod humant B-lymfocytbegrænset differentieringsantig
US6447766B1 (en) 1993-06-08 2002-09-10 Smithkline Beecham Corporation Method of mobilizing hematopoietic stem cells
ES2210255T3 (es) 1993-06-08 2004-07-01 Smithkline Beecham Corporation Metodos para mejorar la actividad biologica de quimiocinas.
US5547892A (en) 1995-04-27 1996-08-20 Taiwan Semiconductor Manufacturing Company Process for forming stacked contacts and metal contacts on static random access memory having thin film transistors
US5801030A (en) 1995-09-01 1998-09-01 Genvec, Inc. Methods and vectors for site-specific recombination
KR100463630B1 (ko) 1997-02-11 2005-05-25 말린크로트, 인코포레이티드 고상 펩티드 합성용 반응기 및 방법_
ES2156581T5 (es) 1998-03-30 2015-01-21 Northwest Biotherapeutics, Inc. Aplicaciones terapéuticas y diagnósticas basadas en el papel del gen CXCR-4 en la tumorigénesis
AP1654A (en) 1999-03-24 2006-09-01 Anormed Inc Chemokine receptor binding heterocyclic compounds.
DE10120829A1 (de) 2000-04-27 2001-12-20 Max Delbrueck Centrum Sleeping Beauty, ein Transposonvektor mit breitem Wirtsbereich für die genetische Transformation bei Wirbeltieren
EP1286684B1 (en) 2000-05-09 2004-04-28 The University Of British Columbia use of cxcr4 antagonists for treating autoimmune diseases and cancer
MXPA02012067A (es) 2000-06-05 2004-08-19 Univ Columbia Identificacion y uso de celulas endoteliales precursoras derivadas de medula osea par mejorar la funcion del miocardio despues de dano isquemico.
JP5170934B2 (ja) 2001-08-16 2013-03-27 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 改良dnaリポフェクションならびに/または徐放性プロドラッグおよび薬物療法のための試薬の合成と使用
US20030199464A1 (en) 2002-04-23 2003-10-23 Silviu Itescu Regeneration of endogenous myocardial tissue by induction of neovascularization
US7683036B2 (en) 2003-07-31 2010-03-23 Regulus Therapeutics Inc. Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
US7622108B2 (en) 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
JP2008509928A (ja) 2004-08-13 2008-04-03 アノーメド インコーポレイテッド 前駆/幹細胞を動員するためのケモカインの組み合わせ
US20070033666A1 (en) 2005-06-24 2007-02-08 Harris Reuben S Using cytosine deaminases to diminish retroelement transfer from pigs to humans
ES2582091T3 (es) 2005-10-18 2016-09-09 Precision Biosciences Meganucleasas diseñadas racionalmente con especificidad de secuencia y afinidad de unión a ADN alteradas
CN101421393B (zh) 2006-02-14 2013-08-14 塞勒兰特治疗公司 提高造血干细胞植入的方法和组合物
WO2007145227A1 (ja) 2006-06-14 2007-12-21 Chugai Seiyaku Kabushiki Kaisha 造血幹細胞増加促進剤
US8372797B2 (en) 2006-06-22 2013-02-12 Creative Medical Health, Inc. Treatment of erectile dysfunction by stem cell therapy
EP1995316A1 (de) 2007-05-25 2008-11-26 Qiagen GmbH Verfahren zur schonenden Zellaufreinigung, Zellgewinnung und Transfektion von Zellen
EP2009095A1 (en) 2007-06-28 2008-12-31 Innovalor AG Method of generating glucose-responsive cells
EP2215223B1 (en) 2007-10-31 2013-05-01 Precision Biosciences, Inc. Rationally-designed single-chain meganucleases with non-palindromic recognition sequences
WO2010085699A2 (en) 2009-01-23 2010-07-29 The Johns Hopkins University Mammalian piggybac transposon and methods of use
EP2270025A1 (en) 2009-06-29 2011-01-05 Centre National pour la Recherche Scientifique (CNRS) Solid phase peptide synthesis of peptide alcohols
EP2533629B1 (en) 2010-02-11 2018-11-28 Recombinetics, Inc. Methods and materials for producing transgenic artiodactyls
CN103459031A (zh) * 2010-12-16 2013-12-18 能源技术公司 催化剂、催化剂的制备方法、脱氧的方法以及用于燃料制造的系统
MX363013B (es) 2011-02-25 2019-03-04 Recombinetics Inc Animales genéticamente modificados y métodos para su obtención.
US8673905B2 (en) * 2011-03-17 2014-03-18 Hoffmann-La Roche Inc. Imidazo pyrazines
EP2788476B1 (en) * 2011-12-08 2019-05-22 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
US9388212B2 (en) 2013-02-21 2016-07-12 Chemical & Biopharmaceutical Laboratories Of Patras S.A. Solid phase peptide synthesis via side chain attachment
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
US9169287B2 (en) 2013-03-15 2015-10-27 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
WO2015048570A2 (en) 2013-09-26 2015-04-02 Sanford-Burnham Medical Research Institute Ebi2 modulators
US10117899B2 (en) 2013-10-17 2018-11-06 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
HK1256681A1 (zh) 2015-04-06 2019-10-04 President And Fellows Of Harvard College 用於非清髓性预处理的组合物和方法
HK1254892A1 (zh) * 2016-01-14 2019-08-02 韩德株式会社 拮抗a3腺苷受体的化合物、其制备方法、及其医学用途
EP4049665B1 (en) 2016-03-15 2025-03-12 The Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion
TW201841916A (zh) 2017-04-12 2018-12-01 美商麥珍塔治療學股份有限公司 芳香烴受體拮抗劑及其用途
MX2019012431A (es) * 2017-04-21 2020-08-03 Ikena Oncology Inc Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos.
EP3703715A1 (en) 2017-10-31 2020-09-09 Magenta Therapeutics, Inc. Compositions and methods for hematopoietic stem and progenitor cell transplant therapy
US20190314407A1 (en) 2017-10-31 2019-10-17 Magenta Therapeutics Inc. Compositions and methods for the expansion of hematopoietic stem and progenitor cells

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006507254A (ja) 2002-09-19 2006-03-02 シェーリング コーポレイション サイクリン依存性キナーゼインヒビターとしてのイミダゾピリジン
JP2009515882A (ja) 2005-11-10 2009-04-16 シェーリング コーポレイション プロテインキナーゼを阻害するための方法
JP2012507554A (ja) 2008-10-30 2012-03-29 アイアールエム・リミテッド・ライアビリティ・カンパニー 造血幹細胞を増加させる化合物
WO2011013729A1 (ja) 2009-07-30 2011-02-03 オンコセラピー・サイエンス株式会社 Ttk阻害作用を有する縮合イミダゾール誘導体
JP2013545779A (ja) 2010-12-17 2013-12-26 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 過剰増殖性障害の治療におけるmps−1およびtkk阻害剤として使用するための6置換イミダゾピラジン
JP2013545778A (ja) 2010-12-17 2013-12-26 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 過剰増殖性障害の治療におけるmps−1およびtkk阻害剤として使用するための6置換イミダゾピラジン
JP2013545776A (ja) 2010-12-17 2013-12-26 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 過剰増殖性障害の治療におけるmps−1およびtkk阻害剤として使用するための6置換イミダゾピラジン
JP2014510118A (ja) 2011-04-06 2014-04-24 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 置換イミダゾピリジン類およびその中間体
WO2014080241A1 (en) 2012-11-21 2014-05-30 Piramal Enterprises Limited Imidazopyridine compounds and uses thereof

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