CN110785419B - 芳烃受体拮抗剂及其用途 - Google Patents
芳烃受体拮抗剂及其用途 Download PDFInfo
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- CN110785419B CN110785419B CN201880040109.4A CN201880040109A CN110785419B CN 110785419 B CN110785419 B CN 110785419B CN 201880040109 A CN201880040109 A CN 201880040109A CN 110785419 B CN110785419 B CN 110785419B
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762484692P | 2017-04-12 | 2017-04-12 | |
| US62/484,692 | 2017-04-12 | ||
| US201862613382P | 2018-01-03 | 2018-01-03 | |
| US62/613,382 | 2018-01-03 | ||
| US201862625896P | 2018-02-02 | 2018-02-02 | |
| US62/625,896 | 2018-02-02 | ||
| PCT/US2018/027265 WO2018191476A1 (en) | 2017-04-12 | 2018-04-12 | Aryl hydrocarbon receptor antagonists and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110785419A CN110785419A (zh) | 2020-02-11 |
| CN110785419B true CN110785419B (zh) | 2024-03-01 |
Family
ID=62090081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880040109.4A Active CN110785419B (zh) | 2017-04-12 | 2018-04-12 | 芳烃受体拮抗剂及其用途 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US10457683B2 (https=) |
| EP (1) | EP3609890B1 (https=) |
| JP (1) | JP7352807B2 (https=) |
| KR (1) | KR20190138837A (https=) |
| CN (1) | CN110785419B (https=) |
| AU (1) | AU2018253115B2 (https=) |
| BR (1) | BR112019021282A2 (https=) |
| CA (1) | CA3057159A1 (https=) |
| CO (1) | CO2019012473A2 (https=) |
| IL (2) | IL293956A (https=) |
| MX (1) | MX392743B (https=) |
| SG (1) | SG11201908624SA (https=) |
| TW (1) | TW201841916A (https=) |
| WO (1) | WO2018191476A1 (https=) |
| ZA (1) | ZA201906209B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201841916A (zh) | 2017-04-12 | 2018-12-01 | 美商麥珍塔治療學股份有限公司 | 芳香烴受體拮抗劑及其用途 |
| MX2019012431A (es) | 2017-04-21 | 2020-08-03 | Ikena Oncology Inc | Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos. |
| BR112020003116A2 (pt) | 2017-08-17 | 2020-08-04 | Ikena Oncology, Inc. | inibidores de ahr e usos dos mesmos |
| US20190314407A1 (en) * | 2017-10-31 | 2019-10-17 | Magenta Therapeutics Inc. | Compositions and methods for the expansion of hematopoietic stem and progenitor cells |
| US20200338132A1 (en) * | 2018-01-03 | 2020-10-29 | Magenta Therapeutics Inc. | Compositions and methods for the expansion of hematopoietic stem and progenitor cells and treatment of inherited metabolic disorders |
| WO2019156989A1 (en) * | 2018-02-06 | 2019-08-15 | Ideaya Biosciences, Inc. | COMPOUNDS AND METHODS FOR THE MODULATION OF AhR |
| CN113301897A (zh) * | 2018-10-17 | 2021-08-24 | 美真达治疗公司 | 用芳烃受体拮抗剂治疗癌症的方法 |
| US12419865B2 (en) | 2018-12-06 | 2025-09-23 | Arisan Therapeutics Inc. | Compounds for the treatment of arenavirus infection |
| WO2021028382A1 (en) * | 2019-08-12 | 2021-02-18 | Bayer Aktiengesellschaft | [1,2,4]triazolo[1,5-c]quinazolin-5-amines |
| EP4051298A1 (en) | 2019-11-01 | 2022-09-07 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progentor cells |
| AU2020394424A1 (en) | 2019-11-26 | 2022-06-16 | Ikena Oncology, Inc. | Polymorphic carbazole derivatives and uses thereof |
| CN114369097B (zh) * | 2020-10-15 | 2023-07-14 | 山东轩竹医药科技有限公司 | 杂芳环类AhR抑制剂 |
| CA3201841A1 (en) | 2020-12-23 | 2022-06-30 | Scott Bryan HOYT | Multi-cyclic irak and flt3 inhibiting compounds and uses thereof |
| WO2022197776A1 (en) | 2021-03-16 | 2022-09-22 | Magenta Therapeutics, Inc. | Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients |
| WO2023250431A2 (en) * | 2022-06-22 | 2023-12-28 | Children's Hospital Medical Center | Multi-cyclic irak and flt3 inhibiting compounds and uses thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010059401A2 (en) * | 2008-10-30 | 2010-05-27 | Irm Llc | Compounds that expand hematopoietic stem cells |
| WO2012083236A2 (en) * | 2010-12-16 | 2012-06-21 | Energia Technologies, Inc. | Catalysts, methods of preparation of catalyst, methods of deoxygenation, and systems for fuel production |
| WO2013086436A1 (en) * | 2011-12-08 | 2013-06-13 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| CN103443100A (zh) * | 2010-12-17 | 2013-12-11 | 拜耳知识产权有限责任公司 | 在过度增殖性病症的治疗中用作mps-1和tkk抑制剂的取代的6-咪唑并吡嗪 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US5233044A (en) | 1989-06-08 | 1993-08-03 | Millipore Corporation | Active esters for solid phase peptide synthesis |
| US5512421A (en) | 1991-02-19 | 1996-04-30 | The Regents Of The University Of California | Generation, concentration and efficient transfer of VSV-G pseudotyped retroviral vectors |
| DK0752248T3 (da) | 1992-11-13 | 2000-11-13 | Idec Pharma Corp | Terapeutisk anvendelse af kimæriske og radioaktivt mærkede antistoffer mod humant B-lymfocytbegrænset differentieringsantig |
| US6447766B1 (en) | 1993-06-08 | 2002-09-10 | Smithkline Beecham Corporation | Method of mobilizing hematopoietic stem cells |
| ES2210255T3 (es) | 1993-06-08 | 2004-07-01 | Smithkline Beecham Corporation | Metodos para mejorar la actividad biologica de quimiocinas. |
| US5547892A (en) | 1995-04-27 | 1996-08-20 | Taiwan Semiconductor Manufacturing Company | Process for forming stacked contacts and metal contacts on static random access memory having thin film transistors |
| US5801030A (en) | 1995-09-01 | 1998-09-01 | Genvec, Inc. | Methods and vectors for site-specific recombination |
| KR100463630B1 (ko) | 1997-02-11 | 2005-05-25 | 말린크로트, 인코포레이티드 | 고상 펩티드 합성용 반응기 및 방법_ |
| ES2156581T5 (es) | 1998-03-30 | 2015-01-21 | Northwest Biotherapeutics, Inc. | Aplicaciones terapéuticas y diagnósticas basadas en el papel del gen CXCR-4 en la tumorigénesis |
| AP1654A (en) | 1999-03-24 | 2006-09-01 | Anormed Inc | Chemokine receptor binding heterocyclic compounds. |
| DE10120829A1 (de) | 2000-04-27 | 2001-12-20 | Max Delbrueck Centrum | Sleeping Beauty, ein Transposonvektor mit breitem Wirtsbereich für die genetische Transformation bei Wirbeltieren |
| EP1286684B1 (en) | 2000-05-09 | 2004-04-28 | The University Of British Columbia | use of cxcr4 antagonists for treating autoimmune diseases and cancer |
| MXPA02012067A (es) | 2000-06-05 | 2004-08-19 | Univ Columbia | Identificacion y uso de celulas endoteliales precursoras derivadas de medula osea par mejorar la funcion del miocardio despues de dano isquemico. |
| JP5170934B2 (ja) | 2001-08-16 | 2013-03-27 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 改良dnaリポフェクションならびに/または徐放性プロドラッグおよび薬物療法のための試薬の合成と使用 |
| US20030199464A1 (en) | 2002-04-23 | 2003-10-23 | Silviu Itescu | Regeneration of endogenous myocardial tissue by induction of neovascularization |
| MY133311A (en) | 2002-09-19 | 2007-11-30 | Schering Corp | Novel imidazopyridines as cyclin dependent kinase inhibitors |
| US7683036B2 (en) | 2003-07-31 | 2010-03-23 | Regulus Therapeutics Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding RNAs |
| US7622108B2 (en) | 2004-04-23 | 2009-11-24 | Bioe, Inc. | Multi-lineage progenitor cells |
| JP2008509928A (ja) | 2004-08-13 | 2008-04-03 | アノーメド インコーポレイテッド | 前駆/幹細胞を動員するためのケモカインの組み合わせ |
| US20070033666A1 (en) | 2005-06-24 | 2007-02-08 | Harris Reuben S | Using cytosine deaminases to diminish retroelement transfer from pigs to humans |
| ES2582091T3 (es) | 2005-10-18 | 2016-09-09 | Precision Biosciences | Meganucleasas diseñadas racionalmente con especificidad de secuencia y afinidad de unión a ADN alteradas |
| TW200803863A (en) | 2005-11-10 | 2008-01-16 | Schering Corp | Method for inhibiting protein kinases |
| CN101421393B (zh) | 2006-02-14 | 2013-08-14 | 塞勒兰特治疗公司 | 提高造血干细胞植入的方法和组合物 |
| WO2007145227A1 (ja) | 2006-06-14 | 2007-12-21 | Chugai Seiyaku Kabushiki Kaisha | 造血幹細胞増加促進剤 |
| US8372797B2 (en) | 2006-06-22 | 2013-02-12 | Creative Medical Health, Inc. | Treatment of erectile dysfunction by stem cell therapy |
| EP1995316A1 (de) | 2007-05-25 | 2008-11-26 | Qiagen GmbH | Verfahren zur schonenden Zellaufreinigung, Zellgewinnung und Transfektion von Zellen |
| EP2009095A1 (en) | 2007-06-28 | 2008-12-31 | Innovalor AG | Method of generating glucose-responsive cells |
| EP2215223B1 (en) | 2007-10-31 | 2013-05-01 | Precision Biosciences, Inc. | Rationally-designed single-chain meganucleases with non-palindromic recognition sequences |
| WO2010085699A2 (en) | 2009-01-23 | 2010-07-29 | The Johns Hopkins University | Mammalian piggybac transposon and methods of use |
| EP2270025A1 (en) | 2009-06-29 | 2011-01-05 | Centre National pour la Recherche Scientifique (CNRS) | Solid phase peptide synthesis of peptide alcohols |
| TW201107329A (en) | 2009-07-30 | 2011-03-01 | Oncotherapy Science Inc | Fused imidazole derivative having ttk inhibitory action |
| EP2533629B1 (en) | 2010-02-11 | 2018-11-28 | Recombinetics, Inc. | Methods and materials for producing transgenic artiodactyls |
| JP2013545776A (ja) | 2010-12-17 | 2013-12-26 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 過剰増殖性障害の治療におけるmps−1およびtkk阻害剤として使用するための6置換イミダゾピラジン |
| CA2821819A1 (en) * | 2010-12-17 | 2012-06-21 | Marcus Koppitz | 6-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| MX363013B (es) | 2011-02-25 | 2019-03-04 | Recombinetics Inc | Animales genéticamente modificados y métodos para su obtención. |
| US8673905B2 (en) * | 2011-03-17 | 2014-03-18 | Hoffmann-La Roche Inc. | Imidazo pyrazines |
| WO2012136531A1 (en) | 2011-04-06 | 2012-10-11 | Bayer Pharma Aktiengesellschaft | Substituted imidazopyridines and intermediates thereof |
| US9388212B2 (en) | 2013-02-21 | 2016-07-12 | Chemical & Biopharmaceutical Laboratories Of Patras S.A. | Solid phase peptide synthesis via side chain attachment |
| WO2014080241A1 (en) | 2012-11-21 | 2014-05-30 | Piramal Enterprises Limited | Imidazopyridine compounds and uses thereof |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| US9169287B2 (en) | 2013-03-15 | 2015-10-27 | Massachusetts Institute Of Technology | Solid phase peptide synthesis processes and associated systems |
| WO2015048570A2 (en) | 2013-09-26 | 2015-04-02 | Sanford-Burnham Medical Research Institute | Ebi2 modulators |
| US10117899B2 (en) | 2013-10-17 | 2018-11-06 | Sangamo Therapeutics, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells |
| HK1256681A1 (zh) | 2015-04-06 | 2019-10-04 | President And Fellows Of Harvard College | 用於非清髓性预处理的组合物和方法 |
| HK1254892A1 (zh) * | 2016-01-14 | 2019-08-02 | 韩德株式会社 | 拮抗a3腺苷受体的化合物、其制备方法、及其医学用途 |
| EP4049665B1 (en) | 2016-03-15 | 2025-03-12 | The Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion |
| TW201841916A (zh) | 2017-04-12 | 2018-12-01 | 美商麥珍塔治療學股份有限公司 | 芳香烴受體拮抗劑及其用途 |
| MX2019012431A (es) * | 2017-04-21 | 2020-08-03 | Ikena Oncology Inc | Inhibidores del receptor de hidrocarburos de arilo (ahr) de indol y usos de los mismos. |
| EP3703715A1 (en) | 2017-10-31 | 2020-09-09 | Magenta Therapeutics, Inc. | Compositions and methods for hematopoietic stem and progenitor cell transplant therapy |
| US20190314407A1 (en) | 2017-10-31 | 2019-10-17 | Magenta Therapeutics Inc. | Compositions and methods for the expansion of hematopoietic stem and progenitor cells |
-
2018
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010059401A2 (en) * | 2008-10-30 | 2010-05-27 | Irm Llc | Compounds that expand hematopoietic stem cells |
| WO2012083236A2 (en) * | 2010-12-16 | 2012-06-21 | Energia Technologies, Inc. | Catalysts, methods of preparation of catalyst, methods of deoxygenation, and systems for fuel production |
| CN103443100A (zh) * | 2010-12-17 | 2013-12-11 | 拜耳知识产权有限责任公司 | 在过度增殖性病症的治疗中用作mps-1和tkk抑制剂的取代的6-咪唑并吡嗪 |
| WO2013086436A1 (en) * | 2011-12-08 | 2013-06-13 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
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| AU2018253115A1 (en) | 2019-10-03 |
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