JP7228586B2 - キナーゼ阻害剤としてのアミノイミダゾピリダジン - Google Patents

キナーゼ阻害剤としてのアミノイミダゾピリダジン Download PDF

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Publication number
JP7228586B2
JP7228586B2 JP2020524156A JP2020524156A JP7228586B2 JP 7228586 B2 JP7228586 B2 JP 7228586B2 JP 2020524156 A JP2020524156 A JP 2020524156A JP 2020524156 A JP2020524156 A JP 2020524156A JP 7228586 B2 JP7228586 B2 JP 7228586B2
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Prior art keywords
pyridazin
methyl
acetamidoimidazo
carboxamide
phenyl
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JP2020524156A
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English (en)
Japanese (ja)
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JP2021501179A (ja
JP2021501179A5 (enExample
Inventor
マイケル・イー・マーツマン
キャロリン・ダイアン・ジアーバ
ジェイソン・エム・ガーノン
エイミー・シー・ハート
グアンリン・ルオ
ジョン・イー・マコー
ウィリアム・ジェイ・ピッツ
ジャンリアン・シ
スティーブン・エイチ・スパーゲル
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of JP2021501179A publication Critical patent/JP2021501179A/ja
Publication of JP2021501179A5 publication Critical patent/JP2021501179A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2020524156A 2017-10-30 2018-10-29 キナーゼ阻害剤としてのアミノイミダゾピリダジン Active JP7228586B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762578607P 2017-10-30 2017-10-30
US62/578,607 2017-10-30
US201862626853P 2018-02-06 2018-02-06
US62/626,853 2018-02-06
PCT/US2018/057968 WO2019089442A1 (en) 2017-10-30 2018-10-29 Aminoimidazopyridines as kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2021501179A JP2021501179A (ja) 2021-01-14
JP2021501179A5 JP2021501179A5 (enExample) 2021-12-09
JP7228586B2 true JP7228586B2 (ja) 2023-02-24

Family

ID=64332173

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020524156A Active JP7228586B2 (ja) 2017-10-30 2018-10-29 キナーゼ阻害剤としてのアミノイミダゾピリダジン

Country Status (23)

Country Link
US (1) US11440913B2 (enExample)
EP (1) EP3704118B1 (enExample)
JP (1) JP7228586B2 (enExample)
KR (1) KR102662197B1 (enExample)
CN (1) CN111566103B (enExample)
AU (1) AU2018361249B2 (enExample)
BR (1) BR112020007557A2 (enExample)
CA (1) CA3080402A1 (enExample)
CY (1) CY1124984T1 (enExample)
DK (1) DK3704118T3 (enExample)
ES (1) ES2905948T3 (enExample)
HR (1) HRP20220297T1 (enExample)
HU (1) HUE058292T2 (enExample)
IL (1) IL274207B2 (enExample)
LT (1) LT3704118T (enExample)
MX (1) MX2020003706A (enExample)
PL (1) PL3704118T3 (enExample)
PT (1) PT3704118T (enExample)
RS (1) RS62974B1 (enExample)
SG (1) SG11202003824PA (enExample)
SI (1) SI3704118T1 (enExample)
SM (1) SMT202200087T1 (enExample)
WO (1) WO2019089442A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2902676T3 (es) 2017-02-13 2022-03-29 Bristol Myers Squibb Co Aminotriazolopiridinas como inhibidores de cinasa
CA3088548A1 (en) 2018-01-26 2019-08-01 Bristol-Myers Squibb Company Aminopyrrolotriazines as kinase inhibitors
BR112021004310A2 (pt) 2018-09-13 2021-05-25 Bristol-Myers Squibb Company indazolcarboxamidas como inibidores de cinase
BR112021004385A2 (pt) 2018-09-13 2021-07-20 Bristol-Myers Squibb Company 1h-indazol carboxamidas como inibidores de proteína quinase de interação com o receptor 1 (ripk1)
GB201905721D0 (en) 2019-04-24 2019-06-05 Univ Dundee Compounds
US12275721B2 (en) 2019-10-03 2025-04-15 Bristol-Myers Squibb Company Indazole carboxamides as kinase inhibitors
WO2021168521A1 (en) * 2020-02-27 2021-09-02 Anaxis Pharma Pty Ltd Inhibitors of necroptosis
CN114262322A (zh) * 2020-09-16 2022-04-01 中国科学院上海有机化学研究所 一类细胞程序性坏死抑制剂及其制备方法和用途
WO2022081522A1 (en) 2020-10-13 2022-04-21 The Johns Hopkins University SUBSTITUTED 4-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES AND USE THEREOF
AR123793A1 (es) * 2020-10-19 2023-01-11 Bristol Myers Squibb Co Compuestos de triazolopiridinilo como inhibidores de quinasas
CN120530112A (zh) * 2022-12-30 2025-08-22 广州市联瑞制药有限公司 双环类化合物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009530233A (ja) 2006-02-14 2009-08-27 ノバルティス アーゲー Ｐｉ−３キナーゼインヒビターおよびそれらの使用方法
JP2011507854A (ja) 2007-12-19 2011-03-10 アムジエン・インコーポレーテツド Ｐｉ３キナーゼの阻害薬
JP2020507582A (ja) 2017-02-13 2020-03-12 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ キナーゼ阻害剤としてのアミノトリアゾロピリジン

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CA2750517A1 (en) * 2009-02-04 2010-08-12 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
BR112014030147B1 (pt) 2012-06-22 2019-10-15 Sumitomo Chemical Company, Limited Compostos heterocíclicos fundidos, composição e método para controlar pestes
EP2897949B1 (en) 2012-09-18 2018-01-10 Bristol-Myers Squibb Company Iap antagonists
ES2749467T3 (es) 2012-11-20 2020-03-20 Biogen Ma Inc Agentes moduladores de S1p y/o ATX
EP2970266B1 (en) 2013-03-15 2018-01-31 Epizyme, Inc. 1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof
CN105246891A (zh) 2013-06-10 2016-01-13 拜耳制药股份公司 用于治疗癌症的新化合物
WO2016027253A1 (en) 2014-08-21 2016-02-25 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as rip1 kinase inhibitors as medicaments
WO2017192930A1 (en) 2016-05-05 2017-11-09 Lysosomal Therapeutics Inc. SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
WO2018017435A1 (en) 2016-07-22 2018-01-25 Accro Bioscience Inc. Heteroaryl compounds as inhibitors of necrosis, composition and application thereof
CA3088548A1 (en) 2018-01-26 2019-08-01 Bristol-Myers Squibb Company Aminopyrrolotriazines as kinase inhibitors
BR112021004385A2 (pt) 2018-09-13 2021-07-20 Bristol-Myers Squibb Company 1h-indazol carboxamidas como inibidores de proteína quinase de interação com o receptor 1 (ripk1)
BR112021004310A2 (pt) 2018-09-13 2021-05-25 Bristol-Myers Squibb Company indazolcarboxamidas como inibidores de cinase
EP3877371A4 (en) * 2018-11-07 2022-07-27 Dana-Farber Cancer Institute, Inc. IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES USED AS JANUS KINASE 2 INHIBITORS AND ASSOCIATED USES

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2009530233A (ja) 2006-02-14 2009-08-27 ノバルティス アーゲー Ｐｉ−３キナーゼインヒビターおよびそれらの使用方法
JP2011507854A (ja) 2007-12-19 2011-03-10 アムジエン・インコーポレーテツド Ｐｉ３キナーゼの阻害薬
JP2020507582A (ja) 2017-02-13 2020-03-12 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ キナーゼ阻害剤としてのアミノトリアゾロピリジン

Non-Patent Citations (2)

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Title
HARRIS, Philip A. et al.，ACS Med.Chem.Lett.，2013年，4，1238-1243
HARRIS, Philip A. et al.，J.Med.Chem.，2017年，60，1247-1261

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Publication number Publication date
IL274207B2 (en) 2023-04-01
JP2021501179A (ja) 2021-01-14
SMT202200087T1 (it) 2022-03-21
BR112020007557A2 (pt) 2020-09-24
PL3704118T3 (pl) 2022-04-04
HRP20220297T1 (hr) 2022-05-13
US20200277296A1 (en) 2020-09-03
AU2018361249A1 (en) 2020-06-11
RS62974B1 (sr) 2022-03-31
KR102662197B1 (ko) 2024-04-29
CN111566103B (zh) 2023-06-23
MX2020003706A (es) 2020-07-22
EP3704118A1 (en) 2020-09-09
SI3704118T1 (sl) 2022-04-29
LT3704118T (lt) 2022-02-25
CN111566103A (zh) 2020-08-21
AU2018361249B2 (en) 2022-08-25
WO2019089442A8 (en) 2019-06-27
HUE058292T2 (hu) 2022-07-28
KR20200078591A (ko) 2020-07-01
EP3704118B1 (en) 2022-01-12
CY1124984T1 (el) 2023-01-05
SG11202003824PA (en) 2020-05-28
IL274207B (en) 2022-12-01
IL274207A (en) 2020-06-30
DK3704118T3 (da) 2022-03-14
ES2905948T3 (es) 2022-04-12
WO2019089442A1 (en) 2019-05-09
CA3080402A1 (en) 2019-05-09
PT3704118T (pt) 2022-02-14
US11440913B2 (en) 2022-09-13

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