JP7206222B2 - Ｐｄ－１のアンタゴニストとして作用する免疫調節剤 - Google Patents

Ｐｄ－１のアンタゴニストとして作用する免疫調節剤 Download PDF

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Publication number
JP7206222B2
JP7206222B2 JP2019570808A JP2019570808A JP7206222B2 JP 7206222 B2 JP7206222 B2 JP 7206222B2 JP 2019570808 A JP2019570808 A JP 2019570808A JP 2019570808 A JP2019570808 A JP 2019570808A JP 7206222 B2 JP7206222 B2 JP 7206222B2
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alkyl
cancer
coupling procedure
resin
hydrogen
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JP2020525429A (ja
JP2020525429A5 (enExample
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ケビン・ダブリュー・ギルマン
ジェイソン・グッドリッチ
リ－チアン・スン
エリック・マル
デイビッド・アール・ラングレー
ポール・マイケル・スコラ
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2019570808A 2017-06-23 2018-06-21 Ｐｄ－１のアンタゴニストとして作用する免疫調節剤 Active JP7206222B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762523903P 2017-06-23 2017-06-23
US62/523,903 2017-06-23
PCT/US2018/038768 WO2018237153A1 (en) 2017-06-23 2018-06-21 Immunomodulators acting as antagonists of pd-1

Publications (3)

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JP2020525429A JP2020525429A (ja) 2020-08-27
JP2020525429A5 JP2020525429A5 (enExample) 2021-07-29
JP7206222B2 true JP7206222B2 (ja) 2023-01-17

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JP2019570808A Active JP7206222B2 (ja) 2017-06-23 2018-06-21 Ｐｄ－１のアンタゴニストとして作用する免疫調節剤

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US (1) US11066445B2 (enExample)
EP (1) EP3642220A1 (enExample)
JP (1) JP7206222B2 (enExample)
KR (1) KR102735038B1 (enExample)
CN (1) CN110997698B (enExample)
WO (1) WO2018237153A1 (enExample)

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EP4031873A1 (en) 2019-09-22 2022-07-27 Bristol-Myers Squibb Company Quantitative spatial profiling for lag-3 antagonist therapy
KR20220093349A (ko) 2019-11-08 2022-07-05 브리스톨-마이어스 스큅 컴퍼니 흑색종에 대한 lag-3 길항제 요법
ES2967135T3 (es) 2020-01-06 2024-04-26 Bristol Myers Squibb Co Inmunomoduladores
EP4126902B1 (en) 2020-03-30 2023-12-06 Bristol-Myers Squibb Company Immunomodulators
CN111961117B (zh) * 2020-08-19 2022-03-11 中山大学 一种环肽化合物及其应用
BR112023003427A2 (pt) 2020-08-28 2023-03-21 Bristol Myers Squibb Co Terapia com antagonista de lag-3 para carcinoma hepatocelular
MX2023002326A (es) 2020-08-31 2023-03-21 Bristol Myers Squibb Co Firma de localizacion celular e inmunoterapia.
KR20230093282A (ko) 2020-10-23 2023-06-27 브리스톨-마이어스 스큅 컴퍼니 폐암에 대한 lag-3 길항제 요법
WO2022120179A1 (en) 2020-12-03 2022-06-09 Bristol-Myers Squibb Company Multi-tumor gene signatures and uses thereof
JP2024512074A (ja) * 2021-03-24 2024-03-18 ブリストル－マイヤーズ スクイブ カンパニー 免疫調節剤
WO2022212400A1 (en) 2021-03-29 2022-10-06 Juno Therapeutics, Inc. Methods for dosing and treatment with a combination of a checkpoint inhibitor therapy and a car t cell therapy
KR20230169230A (ko) * 2021-04-12 2023-12-15 브리스톨-마이어스 스큅 컴퍼니 시클릭 펩티드 면역조정제
EP4419540A1 (en) * 2021-10-20 2024-08-28 Bristol-Myers Squibb Company Immunomodulators
MX2024005053A (es) 2021-10-29 2024-05-10 Bristol Myers Squibb Co Terapia con antagonista del gen de activacion de linfocitos 3 (lag-3) para cancer hematologico.
CA3249004A1 (en) 2022-01-26 2023-08-03 Bristol-Myers Squibb Company Polytherapy for Hepatocellular Carcinoma
IL315992A (en) 2022-04-08 2024-11-01 Bristol Myers Squibb Co Identification, classification and quantification of tertiary lymphoid structures using machine learning
AU2023409221A1 (en) 2022-12-21 2025-06-12 Bristol-Myers Squibb Company Combination therapy for lung cancer
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Also Published As

Publication number Publication date
US20200172578A1 (en) 2020-06-04
KR102735038B1 (ko) 2024-11-28
US11066445B2 (en) 2021-07-20
JP2020525429A (ja) 2020-08-27
KR20200020858A (ko) 2020-02-26
WO2018237153A1 (en) 2018-12-27
CN110997698B (zh) 2023-12-26
CN110997698A (zh) 2020-04-10
EP3642220A1 (en) 2020-04-29

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