CN110997698B - 充当pd-1拮抗剂的免疫调节剂 - Google Patents

充当pd-1拮抗剂的免疫调节剂 Download PDF

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CN110997698B
CN110997698B CN201880052406.0A CN201880052406A CN110997698B CN 110997698 B CN110997698 B CN 110997698B CN 201880052406 A CN201880052406 A CN 201880052406A CN 110997698 B CN110997698 B CN 110997698B
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alkyl
cancer
group
coupling procedure
tumor
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CN110997698A (zh
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K·W·吉尔曼
J·古德里奇
孙力强
E·穆尔
D·R·兰勒
P·M·斯科拉
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201880052406.0A 2017-06-23 2018-06-21 充当pd-1拮抗剂的免疫调节剂 Active CN110997698B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762523903P 2017-06-23 2017-06-23
US62/523,903 2017-06-23
PCT/US2018/038768 WO2018237153A1 (en) 2017-06-23 2018-06-21 Immunomodulators acting as antagonists of pd-1

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CN110997698A CN110997698A (zh) 2020-04-10
CN110997698B true CN110997698B (zh) 2023-12-26

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US (1) US11066445B2 (enExample)
EP (1) EP3642220A1 (enExample)
JP (1) JP7206222B2 (enExample)
KR (1) KR102735038B1 (enExample)
CN (1) CN110997698B (enExample)
WO (1) WO2018237153A1 (enExample)

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CN111961117B (zh) * 2020-08-19 2022-03-11 中山大学 一种环肽化合物及其应用
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JP2024514245A (ja) 2021-03-29 2024-03-29 ジュノー セラピューティクス インコーポレイテッド チェックポイント阻害剤療法とｃａｒ ｔ細胞療法との組合せを用いた投薬および処置のための方法
EP4323380A2 (en) * 2021-04-12 2024-02-21 Bristol-Myers Squibb Company Cyclic peptide immunomodulators
KR20240089796A (ko) * 2021-10-20 2024-06-20 브리스톨-마이어스 스큅 컴퍼니 면역조정제
CN118176214A (zh) 2021-10-29 2024-06-11 百时美施贵宝公司 血液癌症的lag-3拮抗剂疗法
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JP2020525429A (ja) 2020-08-27
US20200172578A1 (en) 2020-06-04
JP7206222B2 (ja) 2023-01-17
WO2018237153A1 (en) 2018-12-27
KR20200020858A (ko) 2020-02-26
CN110997698A (zh) 2020-04-10
EP3642220A1 (en) 2020-04-29
KR102735038B1 (ko) 2024-11-28
US11066445B2 (en) 2021-07-20

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