JP7170030B2 - キナーゼを調節する化合物の製剤 - Google Patents

キナーゼを調節する化合物の製剤 Download PDF

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JP7170030B2
JP7170030B2 JP2020502185A JP2020502185A JP7170030B2 JP 7170030 B2 JP7170030 B2 JP 7170030B2 JP 2020502185 A JP2020502185 A JP 2020502185A JP 2020502185 A JP2020502185 A JP 2020502185A JP 7170030 B2 JP7170030 B2 JP 7170030B2
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compound
disease
composition
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cancer
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JP2020528884A5 (enExample
JP2020528884A (ja
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プラブハ・エヌ・イブラヒム
ハミド・レザエイ
ゲイリー・コナード・バイザー
倫有 加茂
浩 山小瀬
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Plexxikon Inc
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    • A—HUMAN NECESSITIES
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
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  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020502185A 2017-07-25 2018-07-24 キナーゼを調節する化合物の製剤 Active JP7170030B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762536574P 2017-07-25 2017-07-25
US62/536,574 2017-07-25
PCT/US2018/043433 WO2019023198A1 (en) 2017-07-25 2018-07-24 FORMULATION OF A COMPOUND MODULATING KINASES

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JP2020528884A JP2020528884A (ja) 2020-10-01
JP2020528884A5 JP2020528884A5 (enExample) 2021-09-02
JP7170030B2 true JP7170030B2 (ja) 2022-11-11

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US (3) US10435404B2 (enExample)
EP (1) EP3658189A1 (enExample)
JP (1) JP7170030B2 (enExample)
KR (1) KR102615829B1 (enExample)
CN (1) CN110944670B (enExample)
AU (1) AU2018307910B2 (enExample)
BR (1) BR112019028235B1 (enExample)
CA (1) CA3070505C (enExample)
TW (1) TWI805599B (enExample)
WO (1) WO2019023198A1 (enExample)

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WO2019023198A1 (en) * 2017-07-25 2019-01-31 Plexxikon Inc. FORMULATION OF A COMPOUND MODULATING KINASES
US10717735B2 (en) 2017-10-13 2020-07-21 Plexxikon Inc. Solid forms of a compound for modulating kinases
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US11149011B2 (en) 2018-03-20 2021-10-19 Plexxikon Inc. Compounds and methods for IDO and TDO modulation, and indications therefor
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TW202206422A (zh) 2020-04-23 2022-02-16 美商普雷辛肯公司 用於ｃｄ７３調節之化合物及方法及其適應症
CA3192047A1 (en) 2020-08-21 2022-02-24 Plexxikon Inc. Combinational drug anticancer therapies
CN117567449A (zh) 2020-10-13 2024-02-20 勃林格殷格翰国际有限公司 再加工方法
CN115925700B (zh) * 2022-11-21 2025-02-18 罗欣药业(上海)有限公司 一种酪氨酸激酶抑制剂的晶型及其制备方法
KR20250123931A (ko) 2022-12-30 2025-08-18 아비켄나 바이오사이언시스, 인크. 아자인돌 rock 억제제

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