JP7152393B2 - 医薬化合物 - Google Patents

医薬化合物 Download PDF

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Publication number
JP7152393B2
JP7152393B2 JP2019520588A JP2019520588A JP7152393B2 JP 7152393 B2 JP7152393 B2 JP 7152393B2 JP 2019520588 A JP2019520588 A JP 2019520588A JP 2019520588 A JP2019520588 A JP 2019520588A JP 7152393 B2 JP7152393 B2 JP 7152393B2
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Prior art keywords
dimethylisoxazol
benzo
pyrrolidin
imidazol
methylsulfonyl
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JP2019520588A
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Japanese (ja)
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JP2019537571A (ja
JP2019537571A5 (enExample
Inventor
アンソニー ペッグ、ネイル
トーマス オニオンズ、スチュアート
マイケル エイドリアン タッディ、デイヴィッド
シャノン、ジョナサン
パオレッタ、シルヴィア
ジェームス ブラウン、リチャード
スミス、ドン
ハーボトル、ガレス
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セルセントリック・リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2019520588A 2016-10-18 2017-10-18 医薬化合物 Active JP7152393B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1617630.7A GB201617630D0 (en) 2016-10-18 2016-10-18 Pharmaceutical compounds
GB1617630.7 2016-10-18
PCT/GB2017/053152 WO2018073586A1 (en) 2016-10-18 2017-10-18 Pharmaceutical compounds

Publications (3)

Publication Number Publication Date
JP2019537571A JP2019537571A (ja) 2019-12-26
JP2019537571A5 JP2019537571A5 (enExample) 2020-11-26
JP7152393B2 true JP7152393B2 (ja) 2022-10-12

Family

ID=57680668

Family Applications (1)

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JP2019520588A Active JP7152393B2 (ja) 2016-10-18 2017-10-18 医薬化合物

Country Status (24)

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US (2) US10696666B2 (enExample)
EP (1) EP3529248B1 (enExample)
JP (1) JP7152393B2 (enExample)
KR (1) KR102578786B1 (enExample)
CN (1) CN110049983B (enExample)
AU (1) AU2017346453B2 (enExample)
CA (1) CA3039641A1 (enExample)
CY (1) CY1123666T1 (enExample)
DK (1) DK3529248T3 (enExample)
EA (1) EA201990643A1 (enExample)
ES (1) ES2828504T3 (enExample)
GB (1) GB201617630D0 (enExample)
HR (1) HRP20201444T1 (enExample)
HU (1) HUE052443T2 (enExample)
IL (1) IL266017B (enExample)
LT (1) LT3529248T (enExample)
MX (1) MX384438B (enExample)
PT (1) PT3529248T (enExample)
RS (1) RS61007B1 (enExample)
SG (1) SG11201903155XA (enExample)
SI (1) SI3529248T1 (enExample)
SM (1) SMT202000593T1 (enExample)
WO (1) WO2018073586A1 (enExample)
ZA (1) ZA201902334B (enExample)

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GB201806320D0 (en) * 2018-04-18 2018-05-30 Cellcentric Ltd Process
KR102805503B1 (ko) 2018-06-29 2025-05-09 포르마 세라퓨틱스 인크. Creb 결합 단백질(cbp)의 저해
WO2020190791A1 (en) 2019-03-15 2020-09-24 Forma Therapeutics, Inc. Inhibiting cyclic amp-responsive element-binding protein (creb)
CN119684285A (zh) * 2019-03-15 2025-03-25 福马治疗股份有限公司 抑制环amp-应答元件结合蛋白(creb)
CN112574178B (zh) * 2019-09-27 2025-12-16 海创药业股份有限公司 一种氘代苯并咪唑类化合物及其作为ep300/cbp抑制剂的用途
CN112574189B (zh) * 2019-09-27 2024-05-31 海创药业股份有限公司 一种ep300/cbp抑制剂
CN112574191B (zh) * 2019-09-29 2024-01-23 南京圣和药业股份有限公司 异噁唑杂环类化合物及其应用
CN115701996B (zh) 2020-06-25 2024-12-24 托雷莫治疗股份公司 用于治疗EGFR突变型NSCLC的CBP/p300溴结构域抑制剂和EGFR抑制剂的组合
CA3184076A1 (en) 2020-06-25 2021-12-30 Stefanie Fluckiger-Mangual Combination of a cbp/p300 bromodomain inhibitor and a kras inhibitor for the treatment of cancer
US11801243B2 (en) 2020-09-23 2023-10-31 Forma Therapeutics, Inc. Bromodomain inhibitors for androgen receptor-driven cancers
US11795168B2 (en) 2020-09-23 2023-10-24 Forma Therapeutics, Inc. Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP)
TW202227429A (zh) * 2020-11-06 2022-07-16 大陸商貝達藥業股份有限公司 Ｐ３００抑制劑、包含其的藥物組合物、其應用及製備其的方法
JPWO2022138944A1 (enExample) * 2020-12-25 2022-06-30
CN116670129A (zh) * 2020-12-31 2023-08-29 南京明德新药研发有限公司 苯并咪唑类化合物及其应用
CN114989158A (zh) * 2021-03-02 2022-09-02 复旦大学 组蛋白乙酰转移酶p300溴结构域抑制剂及其药用组合物及其应用
WO2022184664A1 (en) 2021-03-02 2022-09-09 Boehringer Ingelheim International Gmbh Anticancer combination therapy
EP4257130A1 (de) * 2022-04-08 2023-10-11 Justus-Liebig-Universität Gießen Inobrodib zur behandlung von pulmonaler arterieller hypertonie

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CA3039641A1 (en) 2018-04-26
US11377443B2 (en) 2022-07-05
HUE052443T2 (hu) 2021-04-28
EA201990643A1 (ru) 2019-11-29
WO2018073586A1 (en) 2018-04-26
MX384438B (es) 2025-03-14
AU2017346453B2 (en) 2022-02-17
HRP20201444T1 (hr) 2020-12-11
MX2019004113A (es) 2019-09-09
ZA201902334B (en) 2022-10-26
JP2019537571A (ja) 2019-12-26
BR112019007834A2 (pt) 2019-07-16
SMT202000593T1 (it) 2020-11-10
GB201617630D0 (en) 2016-11-30
AU2017346453A1 (en) 2019-05-02
IL266017A (en) 2019-06-30
US10696666B2 (en) 2020-06-30
ES2828504T3 (es) 2021-05-26
PT3529248T (pt) 2020-09-03
RS61007B1 (sr) 2020-11-30
EP3529248A1 (en) 2019-08-28
CY1123666T1 (el) 2022-03-24
DK3529248T3 (da) 2020-09-14
CN110049983A (zh) 2019-07-23
US20190375740A1 (en) 2019-12-12
US20200407349A1 (en) 2020-12-31
SI3529248T1 (sl) 2020-11-30
SG11201903155XA (en) 2019-05-30
LT3529248T (lt) 2020-10-26
NZ752354A (en) 2025-02-28
KR102578786B1 (ko) 2023-09-15
KR20190075095A (ko) 2019-06-28
EP3529248B1 (en) 2020-08-19
CN110049983B (zh) 2022-06-14
IL266017B (en) 2021-08-31

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