JP7128204B2 - Ｃ５－アニリノキナゾリン化合物及び癌の処置におけるそれらの使用 - Google Patents

Ｃ５－アニリノキナゾリン化合物及び癌の処置におけるそれらの使用 Download PDF

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JP7128204B2
JP7128204B2 JP2019557764A JP2019557764A JP7128204B2 JP 7128204 B2 JP7128204 B2 JP 7128204B2 JP 2019557764 A JP2019557764 A JP 2019557764A JP 2019557764 A JP2019557764 A JP 2019557764A JP 7128204 B2 JP7128204 B2 JP 7128204B2
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amino
phenyl
compound
acetamide
triazol
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Japanese (ja)
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JP2020517677A (ja
JP2020517677A5 (https=
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テューダー・グレク
ジェイソン・グラント・ケトル
マーティン・ジョン・パッカー
スチュアート・エリック・ピアソン
ジェイムズ・マイケル・スミス
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AstraZeneca AB
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2019557764A 2017-04-27 2018-04-26 Ｃ５－アニリノキナゾリン化合物及び癌の処置におけるそれらの使用 Active JP7128204B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762490859P 2017-04-27 2017-04-27
US62/490,859 2017-04-27
PCT/EP2018/060798 WO2018197642A1 (en) 2017-04-27 2018-04-26 C5-anilinoquinazoline compounds and their use in treating cancer

Publications (3)

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JP2020517677A JP2020517677A (ja) 2020-06-18
JP2020517677A5 JP2020517677A5 (https=) 2021-04-22
JP7128204B2 true JP7128204B2 (ja) 2022-08-30

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JP2019557764A Active JP7128204B2 (ja) 2017-04-27 2018-04-26 Ｃ５－アニリノキナゾリン化合物及び癌の処置におけるそれらの使用

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US (2) US10273227B2 (https=)
EP (1) EP3615522B1 (https=)
JP (1) JP7128204B2 (https=)
KR (1) KR102603153B1 (https=)
CN (1) CN110573505B (https=)
AR (1) AR111494A1 (https=)
AU (1) AU2018259078B2 (https=)
CA (1) CA3059283A1 (https=)
ES (1) ES2888298T3 (https=)
MX (1) MX389244B (https=)
RU (1) RU2769694C2 (https=)
TW (1) TWI774758B (https=)
WO (1) WO2018197642A1 (https=)

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JP7128204B2 (ja) * 2017-04-27 2022-08-30 アストラゼネカ・アクチエボラーグ Ｃ５－アニリノキナゾリン化合物及び癌の処置におけるそれらの使用
EP3867280A4 (en) * 2018-10-18 2022-11-09 Sinomab Bioscience Limited METHODS OF TREATMENT OF RHEUMATOID ARTHRITIS
AR117788A1 (es) * 2019-01-14 2021-08-25 Pi Industries Ltd Compuestos de fenilamidina 3-sustituida, preparación y uso
MX2022013797A (es) 2020-05-08 2022-11-30 Genmab As Anticuerpos biespecificos contra cd3 y cd20.
WO2022040341A1 (en) * 2020-08-20 2022-02-24 The Board Of Trustees Of The Leland Stanford Junior University Abscopal therapy for cancer
CN116782933A (zh) 2020-09-10 2023-09-19 健玛保 用于治疗弥漫性大b细胞淋巴瘤的联合疗法中的针对cd3和cd20的双特异性抗体
KR20230066040A (ko) 2020-09-10 2023-05-12 젠맵 에이/에스 만성 림프구성 백혈병을 치료하기 위한 cd3 및 cd20에 대한 이중특이적 항체
CA3189883A1 (en) 2020-09-10 2022-03-17 Brian Elliott Bispecific antibody against cd3 and cd20 in combination therapy for treating follicular lymphoma
CA3190376A1 (en) 2020-09-10 2022-03-17 Brian Elliott Bispecific antibody against cd3 and cd20 in combination therapy for treating follicular lymphoma
US20240034812A1 (en) 2020-09-10 2024-02-01 Genmab A/S Bispecific antibody against cd3 and cd20 in combination therapy for treating diffuse large b-cell lymphoma
TW202345831A (zh) * 2021-12-09 2023-12-01 美商迪賽孚爾製藥有限公司 Ｋｉｔ激酶抑制劑及其使用方法
US20250275978A1 (en) * 2024-03-04 2025-09-04 Cardiff Oncology, Inc. Use of onvansertib as monotherapy and in combination with cetuximab in treating ras wild-type colorectal cancer

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JP2006527748A (ja) 2003-06-17 2006-12-07 アストラゼネカ アクチボラグ Ａｕｒｏｒａキナーゼ阻害剤としてのキナゾリン誘導体
WO2012089137A1 (zh) 2010-12-30 2012-07-05 上海医药工业研究院 一种芳基脲类化合物、其中间体及其应用

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DK1382604T3 (da) 2001-04-27 2006-04-18 Kirin Brewery Quinolinderivater med en azolylgruppe og quinazolinderivater
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BRPI0516093A (pt) 2004-10-12 2008-08-19 Astrazeneca Ab derivado de quinazolina, processo para a preparação do mesmo, composição farmacêutica, uso de um derivado de quinazolina, e, método para tratamento de distúrbios proliferativos celulares em um animal de sanque quente
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JP2006527748A (ja) 2003-06-17 2006-12-07 アストラゼネカ アクチボラグ Ａｕｒｏｒａキナーゼ阻害剤としてのキナゾリン誘導体
WO2012089137A1 (zh) 2010-12-30 2012-07-05 上海医药工业研究院 一种芳基脲类化合物、其中间体及其应用

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Also Published As

Publication number Publication date
CA3059283A1 (en) 2018-11-01
US20180312490A1 (en) 2018-11-01
MX389244B (es) 2025-03-20
CN110573505B (zh) 2023-04-11
BR112019022229A2 (pt) 2020-05-12
RU2019136279A (ru) 2021-05-27
RU2019136279A3 (https=) 2021-05-31
AR111494A1 (es) 2019-07-17
ES2888298T3 (es) 2022-01-03
AU2018259078A1 (en) 2019-10-17
JP2020517677A (ja) 2020-06-18
RU2769694C2 (ru) 2022-04-05
EP3615522A1 (en) 2020-03-04
TWI774758B (zh) 2022-08-21
EP3615522B1 (en) 2021-08-04
MX2019012847A (es) 2022-01-07
TW201904960A (zh) 2019-02-01
AU2018259078B2 (en) 2021-10-07
US20190263787A1 (en) 2019-08-29
US10273227B2 (en) 2019-04-30
WO2018197642A1 (en) 2018-11-01
US10829479B2 (en) 2020-11-10
KR20190141203A (ko) 2019-12-23
CN110573505A (zh) 2019-12-13
KR102603153B1 (ko) 2023-11-15

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