JP7082827B2 - 化粧料 - Google Patents
化粧料 Download PDFInfo
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- JP7082827B2 JP7082827B2 JP2020151578A JP2020151578A JP7082827B2 JP 7082827 B2 JP7082827 B2 JP 7082827B2 JP 2020151578 A JP2020151578 A JP 2020151578A JP 2020151578 A JP2020151578 A JP 2020151578A JP 7082827 B2 JP7082827 B2 JP 7082827B2
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- lactobacillus plantarum
- action
- culture supernatant
- cells
- skin
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006505496A (ja) | 2002-03-01 | 2006-02-16 | エル・ヴェ・エム・アッシュ ルシェルシュ | フィトスフィンゴシンのスリミング剤としての化粧的使用、及び、フィトスフィンゴシンを含む化粧組成物 |
| JP2009124943A (ja) | 2007-11-19 | 2009-06-11 | Maruzen Pharmaceut Co Ltd | 新規乳酸菌、乳酸菌組成物及び植物エキス、並びに、植物エキス及び低分子ポリフェノールの製造方法。 |
| WO2009104405A1 (ja) | 2008-02-19 | 2009-08-27 | 雪印種苗株式会社 | 植物成長調整剤組成物 |
| WO2012014971A1 (ja) | 2010-07-30 | 2012-02-02 | 株式会社明治 | メタボリックシンドローム改善効果を有する乳酸菌 |
| CN102389411A (zh) | 2011-09-29 | 2012-03-28 | 北京农学院 | 没食子酸在制备磷酸二酯酶抑制剂抗炎药物中的应用 |
| JP2013035795A (ja) | 2011-08-09 | 2013-02-21 | Maruzen Pharmaceut Co Ltd | 新規フェニルエタノイド配糖体及び皮膚化粧料 |
| JP2014080398A (ja) | 2012-10-18 | 2014-05-08 | Yukijirushi Shubyo Kk | 植物成長調整剤 |
| JP2015096476A (ja) | 2013-11-15 | 2015-05-21 | 株式会社東洋新薬 | コラーゲン産生促進用組成物、コラーゲン吸収促進用組成物、抗肥満用組成物 |
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| JPH03198770A (ja) * | 1989-12-27 | 1991-08-29 | Kanebo Ltd | 新規乳酸菌 |
| JP3055882B2 (ja) * | 1996-12-27 | 2000-06-26 | 株式会社コーセー | 皮膚化粧料 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006505496A (ja) | 2002-03-01 | 2006-02-16 | エル・ヴェ・エム・アッシュ ルシェルシュ | フィトスフィンゴシンのスリミング剤としての化粧的使用、及び、フィトスフィンゴシンを含む化粧組成物 |
| JP2009124943A (ja) | 2007-11-19 | 2009-06-11 | Maruzen Pharmaceut Co Ltd | 新規乳酸菌、乳酸菌組成物及び植物エキス、並びに、植物エキス及び低分子ポリフェノールの製造方法。 |
| WO2009104405A1 (ja) | 2008-02-19 | 2009-08-27 | 雪印種苗株式会社 | 植物成長調整剤組成物 |
| WO2012014971A1 (ja) | 2010-07-30 | 2012-02-02 | 株式会社明治 | メタボリックシンドローム改善効果を有する乳酸菌 |
| JP2013035795A (ja) | 2011-08-09 | 2013-02-21 | Maruzen Pharmaceut Co Ltd | 新規フェニルエタノイド配糖体及び皮膚化粧料 |
| CN102389411A (zh) | 2011-09-29 | 2012-03-28 | 北京农学院 | 没食子酸在制备磷酸二酯酶抑制剂抗炎药物中的应用 |
| JP2014080398A (ja) | 2012-10-18 | 2014-05-08 | Yukijirushi Shubyo Kk | 植物成長調整剤 |
| JP2015096476A (ja) | 2013-11-15 | 2015-05-21 | 株式会社東洋新薬 | コラーゲン産生促進用組成物、コラーゲン吸収促進用組成物、抗肥満用組成物 |
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