JP7014449B2 - 神経障害を処置するための間葉系細胞由来エキソソーム - Google Patents

神経障害を処置するための間葉系細胞由来エキソソーム Download PDF

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JP7014449B2
JP7014449B2 JP2019508178A JP2019508178A JP7014449B2 JP 7014449 B2 JP7014449 B2 JP 7014449B2 JP 2019508178 A JP2019508178 A JP 2019508178A JP 2019508178 A JP2019508178 A JP 2019508178A JP 7014449 B2 JP7014449 B2 JP 7014449B2
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JP2019524824A (ja
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オフェン，ダニエル
ペレツ，ニシム
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ラモット アット テル アビブ ユニバーシティ， リミテッド
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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JP2019508178A 2016-08-14 2017-08-14 神経障害を処置するための間葉系細胞由来エキソソーム Active JP7014449B2 (ja)

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US201662374852P 2016-08-14 2016-08-14
US62/374,852 2016-08-14
PCT/IL2017/050899 WO2018033911A1 (en) 2016-08-14 2017-08-14 Mesenchymal cell-derived exosomes to treat neurological disorders

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US11930808B2 (en) * 2018-09-20 2024-03-19 Universidad De Valladolid Method for obtaining an enriched population of functional mesenchymal stem cells, cells obtained thereof and compositions and comprising the same
AU2020303456B2 (en) 2019-06-26 2026-01-08 Technion Research And Development Foundation Limited Production of extracellular vesicles from stem cells
JP6830286B1 (ja) 2020-06-26 2021-02-17 デクソンファーマシューティカルズ株式会社 精巣機能改善剤および精巣機能改善方法
US20230210910A1 (en) 2020-07-17 2023-07-06 Dexon Pharmaceuticals Inc. Method for preventing infection of a healthy person or a healthy animal with a virus that uses ace2 as a receptor, binding inhibitor and medical device
CN116171158A (zh) 2020-09-08 2023-05-26 Dexon制药株式会社 细胞因子风暴抑制剂、细胞因子风暴抑制剂的使用方法和筛选方法
JP6974892B1 (ja) 2021-05-27 2021-12-01 デクソンファーマシューティカルズ株式会社 癌悪液質の改善剤および癌悪液質の改善方法
JP7492757B2 (ja) 2022-03-22 2024-05-30 Ｄｅｘｏｎファーマシューティカルズ株式会社 遺伝子の発現制御剤、アルツハイマー病の予防薬または治療薬および認知症の改善方法
WO2023223312A1 (en) 2022-05-15 2023-11-23 Nurexone Biologic Ltd. Anti-pten rna interference oligonucleotides and uses thereof
CN115006427A (zh) * 2022-05-31 2022-09-06 尧舜泽生物医药(南京)有限公司 骨髓间充质干细胞外泌体在治疗帕金森病中的应用
EP4541358A1 (en) 2022-06-20 2025-04-23 Dexon Pharmaceuticals Inc. Hmgb1 expression suppressor, prophylactic or therapeutic drug for acute lung injury, acute respiratory distress syndrome or sepsis, and method for ameliorating such disease
CN119403562A (zh) 2022-06-20 2025-02-07 Dexon制药株式会社 Ptx3表达调控剂；类风湿性关节炎、自身免疫疾病所伴随的血管炎或皮肤硬化的预防药或治疗药，或它们的改善方法
CN118878610B (zh) * 2024-03-19 2025-09-02 北京达尔文细胞生物科技有限公司 一种蛋白聚合物及其生产工艺
CN120078807B (zh) * 2025-02-08 2026-03-31 广东省人民医院 改善卵巢功能的MSC-sEVs药物及其制备方法和应用

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JP2019524824A (ja) 2019-09-05
EP3496730B1 (en) 2022-05-25
CN109843305B (zh) 2023-03-10
US11129852B2 (en) 2021-09-28
US20210361717A1 (en) 2021-11-25
EP3496730A1 (en) 2019-06-19
CN109843305A (zh) 2019-06-04
IL264825A (enExample) 2019-04-30
WO2018033911A1 (en) 2018-02-22
ES2925527T3 (es) 2022-10-18
AU2017311684A2 (en) 2019-03-28
IL264825B (en) 2022-08-01
CA3033951A1 (en) 2018-02-22
US20190209621A1 (en) 2019-07-11
AU2017311684A1 (en) 2019-03-07
PL3496730T3 (pl) 2022-09-26
EP3496730A4 (en) 2020-05-06
SG11201901272WA (en) 2019-03-28
AU2017311684B2 (en) 2023-05-04

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