IL264825B - Mesenchymal cell-derived exosomes to treat neurological disorders - Google Patents

Mesenchymal cell-derived exosomes to treat neurological disorders

Info

Publication number
IL264825B
IL264825B IL264825A IL26482519A IL264825B IL 264825 B IL264825 B IL 264825B IL 264825 A IL264825 A IL 264825A IL 26482519 A IL26482519 A IL 26482519A IL 264825 B IL264825 B IL 264825B
Authority
IL
Israel
Prior art keywords
msc
exosomes
btbr
mesenchymal stem
saline
Prior art date
Application number
IL264825A
Other languages
English (en)
Hebrew (he)
Other versions
IL264825A (enExample
Inventor
Daniel Offen
Perets Nisim
Original Assignee
Univ Ramot
Daniel Offen
Perets Nisim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ramot, Daniel Offen, Perets Nisim filed Critical Univ Ramot
Publication of IL264825A publication Critical patent/IL264825A/en
Publication of IL264825B publication Critical patent/IL264825B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL264825A 2016-08-14 2017-08-14 Mesenchymal cell-derived exosomes to treat neurological disorders IL264825B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662374852P 2016-08-14 2016-08-14
PCT/IL2017/050899 WO2018033911A1 (en) 2016-08-14 2017-08-14 Mesenchymal cell-derived exosomes to treat neurological disorders

Publications (2)

Publication Number Publication Date
IL264825A IL264825A (enExample) 2019-04-30
IL264825B true IL264825B (en) 2022-08-01

Family

ID=61196484

Family Applications (1)

Application Number Title Priority Date Filing Date
IL264825A IL264825B (en) 2016-08-14 2017-08-14 Mesenchymal cell-derived exosomes to treat neurological disorders

Country Status (10)

Country Link
US (2) US11129852B2 (enExample)
EP (1) EP3496730B1 (enExample)
JP (1) JP7014449B2 (enExample)
CN (1) CN109843305B (enExample)
AU (1) AU2017311684B2 (enExample)
ES (1) ES2925527T3 (enExample)
IL (1) IL264825B (enExample)
PL (1) PL3496730T3 (enExample)
SG (1) SG11201901272WA (enExample)
WO (1) WO2018033911A1 (enExample)

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US11930808B2 (en) * 2018-09-20 2024-03-19 Universidad De Valladolid Method for obtaining an enriched population of functional mesenchymal stem cells, cells obtained thereof and compositions and comprising the same
AU2020303456B2 (en) 2019-06-26 2026-01-08 Technion Research And Development Foundation Limited Production of extracellular vesicles from stem cells
JP6830286B1 (ja) 2020-06-26 2021-02-17 デクソンファーマシューティカルズ株式会社 精巣機能改善剤および精巣機能改善方法
US20230210910A1 (en) 2020-07-17 2023-07-06 Dexon Pharmaceuticals Inc. Method for preventing infection of a healthy person or a healthy animal with a virus that uses ace2 as a receptor, binding inhibitor and medical device
CN116171158A (zh) 2020-09-08 2023-05-26 Dexon制药株式会社 细胞因子风暴抑制剂、细胞因子风暴抑制剂的使用方法和筛选方法
JP6974892B1 (ja) 2021-05-27 2021-12-01 デクソンファーマシューティカルズ株式会社 癌悪液質の改善剤および癌悪液質の改善方法
JP7492757B2 (ja) 2022-03-22 2024-05-30 Dexonファーマシューティカルズ株式会社 遺伝子の発現制御剤、アルツハイマー病の予防薬または治療薬および認知症の改善方法
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CN115006427A (zh) * 2022-05-31 2022-09-06 尧舜泽生物医药(南京)有限公司 骨髓间充质干细胞外泌体在治疗帕金森病中的应用
EP4541358A1 (en) 2022-06-20 2025-04-23 Dexon Pharmaceuticals Inc. Hmgb1 expression suppressor, prophylactic or therapeutic drug for acute lung injury, acute respiratory distress syndrome or sepsis, and method for ameliorating such disease
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Also Published As

Publication number Publication date
JP2019524824A (ja) 2019-09-05
EP3496730B1 (en) 2022-05-25
CN109843305B (zh) 2023-03-10
US11129852B2 (en) 2021-09-28
US20210361717A1 (en) 2021-11-25
EP3496730A1 (en) 2019-06-19
CN109843305A (zh) 2019-06-04
IL264825A (enExample) 2019-04-30
WO2018033911A1 (en) 2018-02-22
ES2925527T3 (es) 2022-10-18
AU2017311684A2 (en) 2019-03-28
CA3033951A1 (en) 2018-02-22
US20190209621A1 (en) 2019-07-11
JP7014449B2 (ja) 2022-02-01
AU2017311684A1 (en) 2019-03-07
PL3496730T3 (pl) 2022-09-26
EP3496730A4 (en) 2020-05-06
SG11201901272WA (en) 2019-03-28
AU2017311684B2 (en) 2023-05-04

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