AU2017311684B2 - Mesenchymal cell-derived exosomes to treat neurological disorders - Google Patents

Mesenchymal cell-derived exosomes to treat neurological disorders Download PDF

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Publication number
AU2017311684B2
AU2017311684B2 AU2017311684A AU2017311684A AU2017311684B2 AU 2017311684 B2 AU2017311684 B2 AU 2017311684B2 AU 2017311684 A AU2017311684 A AU 2017311684A AU 2017311684 A AU2017311684 A AU 2017311684A AU 2017311684 B2 AU2017311684 B2 AU 2017311684B2
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msc
mesenchymal stem
btbr
exosomes
saline
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AU2017311684A2 (en
AU2017311684A1 (en
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Daniel Offen
Nisim PERETS
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Ramot at Tel Aviv University Ltd
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Ramot at Tel Aviv University Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2017311684A 2016-08-14 2017-08-14 Mesenchymal cell-derived exosomes to treat neurological disorders Active AU2017311684B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662374852P 2016-08-14 2016-08-14
US62/374,852 2016-08-14
PCT/IL2017/050899 WO2018033911A1 (en) 2016-08-14 2017-08-14 Mesenchymal cell-derived exosomes to treat neurological disorders

Publications (3)

Publication Number Publication Date
AU2017311684A1 AU2017311684A1 (en) 2019-03-07
AU2017311684A2 AU2017311684A2 (en) 2019-03-28
AU2017311684B2 true AU2017311684B2 (en) 2023-05-04

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AU2017311684A Active AU2017311684B2 (en) 2016-08-14 2017-08-14 Mesenchymal cell-derived exosomes to treat neurological disorders

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US (2) US11129852B2 (enExample)
EP (1) EP3496730B1 (enExample)
JP (1) JP7014449B2 (enExample)
CN (1) CN109843305B (enExample)
AU (1) AU2017311684B2 (enExample)
ES (1) ES2925527T3 (enExample)
IL (1) IL264825B (enExample)
PL (1) PL3496730T3 (enExample)
SG (1) SG11201901272WA (enExample)
WO (1) WO2018033911A1 (enExample)

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JP6830286B1 (ja) 2020-06-26 2021-02-17 デクソンファーマシューティカルズ株式会社 精巣機能改善剤および精巣機能改善方法
US20230210910A1 (en) 2020-07-17 2023-07-06 Dexon Pharmaceuticals Inc. Method for preventing infection of a healthy person or a healthy animal with a virus that uses ace2 as a receptor, binding inhibitor and medical device
CN116171158A (zh) 2020-09-08 2023-05-26 Dexon制药株式会社 细胞因子风暴抑制剂、细胞因子风暴抑制剂的使用方法和筛选方法
JP6974892B1 (ja) 2021-05-27 2021-12-01 デクソンファーマシューティカルズ株式会社 癌悪液質の改善剤および癌悪液質の改善方法
JP7492757B2 (ja) 2022-03-22 2024-05-30 Ｄｅｘｏｎファーマシューティカルズ株式会社 遺伝子の発現制御剤、アルツハイマー病の予防薬または治療薬および認知症の改善方法
WO2023223312A1 (en) 2022-05-15 2023-11-23 Nurexone Biologic Ltd. Anti-pten rna interference oligonucleotides and uses thereof
CN115006427A (zh) * 2022-05-31 2022-09-06 尧舜泽生物医药(南京)有限公司 骨髓间充质干细胞外泌体在治疗帕金森病中的应用
EP4541358A1 (en) 2022-06-20 2025-04-23 Dexon Pharmaceuticals Inc. Hmgb1 expression suppressor, prophylactic or therapeutic drug for acute lung injury, acute respiratory distress syndrome or sepsis, and method for ameliorating such disease
CN119403562A (zh) 2022-06-20 2025-02-07 Dexon制药株式会社 Ptx3表达调控剂；类风湿性关节炎、自身免疫疾病所伴随的血管炎或皮肤硬化的预防药或治疗药，或它们的改善方法
CN118878610B (zh) * 2024-03-19 2025-09-02 北京达尔文细胞生物科技有限公司 一种蛋白聚合物及其生产工艺
CN120078807B (zh) * 2025-02-08 2026-03-31 广东省人民医院 改善卵巢功能的MSC-sEVs药物及其制备方法和应用

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Also Published As

Publication number Publication date
JP2019524824A (ja) 2019-09-05
EP3496730B1 (en) 2022-05-25
CN109843305B (zh) 2023-03-10
US11129852B2 (en) 2021-09-28
US20210361717A1 (en) 2021-11-25
EP3496730A1 (en) 2019-06-19
CN109843305A (zh) 2019-06-04
IL264825A (enExample) 2019-04-30
WO2018033911A1 (en) 2018-02-22
ES2925527T3 (es) 2022-10-18
AU2017311684A2 (en) 2019-03-28
IL264825B (en) 2022-08-01
CA3033951A1 (en) 2018-02-22
US20190209621A1 (en) 2019-07-11
JP7014449B2 (ja) 2022-02-01
AU2017311684A1 (en) 2019-03-07
PL3496730T3 (pl) 2022-09-26
EP3496730A4 (en) 2020-05-06
SG11201901272WA (en) 2019-03-28

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