PL3496730T3 - Egzosomy pochodzące z komórek mezenchymalnych do leczenia zaburzeń neurologicznych - Google Patents
Egzosomy pochodzące z komórek mezenchymalnych do leczenia zaburzeń neurologicznychInfo
- Publication number
- PL3496730T3 PL3496730T3 PL17841210.2T PL17841210T PL3496730T3 PL 3496730 T3 PL3496730 T3 PL 3496730T3 PL 17841210 T PL17841210 T PL 17841210T PL 3496730 T3 PL3496730 T3 PL 3496730T3
- Authority
- PL
- Poland
- Prior art keywords
- neurological disorders
- mesenchymal cell
- derived exosomes
- treat neurological
- treat
- Prior art date
Links
- 208000012902 Nervous system disease Diseases 0.000 title 1
- 208000025966 Neurological disease Diseases 0.000 title 1
- 210000004027 cell Anatomy 0.000 title 1
- 210000001808 exosome Anatomy 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662374852P | 2016-08-14 | 2016-08-14 | |
| PCT/IL2017/050899 WO2018033911A1 (en) | 2016-08-14 | 2017-08-14 | Mesenchymal cell-derived exosomes to treat neurological disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3496730T3 true PL3496730T3 (pl) | 2022-09-26 |
Family
ID=61196484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17841210.2T PL3496730T3 (pl) | 2016-08-14 | 2017-08-14 | Egzosomy pochodzące z komórek mezenchymalnych do leczenia zaburzeń neurologicznych |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11129852B2 (enExample) |
| EP (1) | EP3496730B1 (enExample) |
| JP (1) | JP7014449B2 (enExample) |
| CN (1) | CN109843305B (enExample) |
| AU (1) | AU2017311684B2 (enExample) |
| ES (1) | ES2925527T3 (enExample) |
| IL (1) | IL264825B (enExample) |
| PL (1) | PL3496730T3 (enExample) |
| SG (1) | SG11201901272WA (enExample) |
| WO (1) | WO2018033911A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3773506A4 (en) * | 2018-03-29 | 2021-12-22 | Technion Research & Development Foundation Limited | VESICLES INCLUDING A PTEN INHIBITOR AND THEIR USES |
| KR102506822B1 (ko) * | 2018-09-20 | 2023-03-06 | 시토스핀, 에스.엘. | 기능적 중간엽 줄기 세포의 농축된 집단을 수득하는 방법, 이의 수득된 세포 및 이를 포함하는 조성물 |
| EP3990625A4 (en) | 2019-06-26 | 2023-07-19 | Technion Research & Development Foundation Limited | PRODUCTION OF EXTRACELLULAR VESICLES FROM STEM CELLS |
| JP6830286B1 (ja) | 2020-06-26 | 2021-02-17 | デクソンファーマシューティカルズ株式会社 | 精巣機能改善剤および精巣機能改善方法 |
| CN115768871A (zh) | 2020-07-17 | 2023-03-07 | Dexon制药株式会社 | 组合物、结合抑制剂、医疗器械和covid-19的预防方法 |
| WO2022054565A1 (ja) | 2020-09-08 | 2022-03-17 | デクソンファーマシューティカルズ株式会社 | サイトカインストーム抑制剤、サイトカインストーム抑制剤の使用方法およびスクリーニング方法 |
| JP6974892B1 (ja) | 2021-05-27 | 2021-12-01 | デクソンファーマシューティカルズ株式会社 | 癌悪液質の改善剤および癌悪液質の改善方法 |
| JP7492757B2 (ja) | 2022-03-22 | 2024-05-30 | Ｄｅｘｏｎファーマシューティカルズ株式会社 | 遺伝子の発現制御剤、アルツハイマー病の予防薬または治療薬および認知症の改善方法 |
| IL316553A (en) | 2022-05-15 | 2024-12-01 | Nurexone Biologic Ltd | RNA interference oligonucleotides against PTEN and their use |
| CN115006427A (zh) * | 2022-05-31 | 2022-09-06 | 尧舜泽生物医药(南京)有限公司 | 骨髓间充质干细胞外泌体在治疗帕金森病中的应用 |
| CN119365204A (zh) | 2022-06-20 | 2025-01-24 | Dexon制药株式会社 | Hmgb1的表达调控剂；急性肺损伤、急性呼吸窘迫综合征或败血症的预防药或治疗药，或它们的改善方法 |
| WO2023248845A1 (ja) | 2022-06-20 | 2023-12-28 | Ｄｅｘｏｎファーマシューティカルズ株式会社 | Ｐｔｘ３の発現制御剤；関節リウマチ、自己免疫疾患に伴う血管炎または皮膚硬化の予防薬または治療薬、あるいはそれらの改善方法 |
| CN120078807A (zh) * | 2025-02-08 | 2025-06-03 | 广东省人民医院 | 改善卵巢功能的MSC-sEVs药物及其制备方法和应用 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| CN101184499B (zh) * | 2005-02-23 | 2012-03-28 | 阿尔扎公司 | 活性剂向中枢神经系统的鼻内施用 |
| WO2008036374A2 (en) * | 2006-09-21 | 2008-03-27 | Medistem Laboratories, Inc. | Allogeneic stem cell transplants in non-conditioned recipients |
| WO2009087361A1 (en) | 2008-01-04 | 2009-07-16 | Lydac Neuroscience Limited | Microvesicles |
| CN102014934B (zh) | 2008-02-22 | 2014-08-20 | 新加坡科技研究局 | 间充质干细胞颗粒 |
| KR20100054711A (ko) | 2008-11-14 | 2010-05-25 | 메디포스트(주) | 간엽 줄기세포 또는 이의 배양액을 포함하는 신경질환의 예방 또는 치료용 조성물 |
| JP5667180B2 (ja) * | 2009-07-01 | 2015-02-12 | イオン メディックス インコーポレイテッド | 哺乳類の有核細胞に由来するマイクロベシクル及びその用途 |
| WO2011118795A1 (ja) | 2010-03-26 | 2011-09-29 | 国立大学法人名古屋大学 | 損傷部治療用組成物 |
| JP5608927B2 (ja) | 2010-04-13 | 2014-10-22 | 国立大学法人名古屋大学 | 歯髄幹細胞を用いた神経疾患治療用組成物 |
| GB201011589D0 (en) | 2010-07-09 | 2010-08-25 | Reneuron Ltd | Therapeutic cells |
| WO2012020307A2 (en) * | 2010-08-13 | 2012-02-16 | The University Court Of The University Of Glasgow | Therapeutic uses of microvesicles and related micrornas |
| GB2502704B (en) * | 2010-11-15 | 2019-12-04 | Accelerated Biosciences Corp | Generation of neural stem cells from human trophoblast stem cells |
| EP2709636A2 (en) | 2011-05-19 | 2014-03-26 | Ariel-University Research and Development Company Ltd. | Use of mesenchymal stem cells for the improvement of affective and cognitive function |
| EP3401393B1 (en) * | 2012-02-22 | 2020-02-19 | Exostem Biotec Ltd | Micrornas for the generation of astrocytes |
| JP6450673B2 (ja) * | 2012-04-03 | 2019-01-09 | リニューロン・リミテッドＲｅＮｅｕｒｏｎ Ｌｉｍｉｔｅｄ | 幹細胞微粒子 |
| WO2013186735A2 (en) | 2012-06-14 | 2013-12-19 | Bar-Ilan Research And Development Company Ltd. | Photothermal detection |
| SG11201601939VA (en) * | 2013-09-16 | 2016-04-28 | Agency Science Tech & Res | Method |
| WO2016149358A1 (en) * | 2015-03-16 | 2016-09-22 | Duncan Ross | Method of treatment comprising membrane-enclosed vesicle |
-
2017
- 2017-08-14 SG SG11201901272WA patent/SG11201901272WA/en unknown
- 2017-08-14 ES ES17841210T patent/ES2925527T3/es active Active
- 2017-08-14 US US16/325,445 patent/US11129852B2/en active Active
- 2017-08-14 CN CN201780063347.2A patent/CN109843305B/zh active Active
- 2017-08-14 PL PL17841210.2T patent/PL3496730T3/pl unknown
- 2017-08-14 IL IL264825A patent/IL264825B/en unknown
- 2017-08-14 JP JP2019508178A patent/JP7014449B2/ja active Active
- 2017-08-14 WO PCT/IL2017/050899 patent/WO2018033911A1/en not_active Ceased
- 2017-08-14 AU AU2017311684A patent/AU2017311684B2/en active Active
- 2017-08-14 EP EP17841210.2A patent/EP3496730B1/en active Active
-
2021
- 2021-08-04 US US17/394,008 patent/US20210361717A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201901272WA (en) | 2019-03-28 |
| JP2019524824A (ja) | 2019-09-05 |
| US20190209621A1 (en) | 2019-07-11 |
| JP7014449B2 (ja) | 2022-02-01 |
| US20210361717A1 (en) | 2021-11-25 |
| CN109843305A (zh) | 2019-06-04 |
| EP3496730A4 (en) | 2020-05-06 |
| IL264825A (enExample) | 2019-04-30 |
| AU2017311684B2 (en) | 2023-05-04 |
| CA3033951A1 (en) | 2018-02-22 |
| AU2017311684A2 (en) | 2019-03-28 |
| US11129852B2 (en) | 2021-09-28 |
| WO2018033911A1 (en) | 2018-02-22 |
| EP3496730B1 (en) | 2022-05-25 |
| AU2017311684A1 (en) | 2019-03-07 |
| IL264825B (en) | 2022-08-01 |
| CN109843305B (zh) | 2023-03-10 |
| EP3496730A1 (en) | 2019-06-19 |
| ES2925527T3 (es) | 2022-10-18 |
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