JP2019524824A5 - - Google Patents
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- Publication number
- JP2019524824A5 JP2019524824A5 JP2019508178A JP2019508178A JP2019524824A5 JP 2019524824 A5 JP2019524824 A5 JP 2019524824A5 JP 2019508178 A JP2019508178 A JP 2019508178A JP 2019508178 A JP2019508178 A JP 2019508178A JP 2019524824 A5 JP2019524824 A5 JP 2019524824A5
- Authority
- JP
- Japan
- Prior art keywords
- scz
- schizophrenia
- disease
- neurodevelopmental disorder
- negative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662374852P | 2016-08-14 | 2016-08-14 | |
| US62/374,852 | 2016-08-14 | ||
| PCT/IL2017/050899 WO2018033911A1 (en) | 2016-08-14 | 2017-08-14 | Mesenchymal cell-derived exosomes to treat neurological disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019524824A JP2019524824A (ja) | 2019-09-05 |
| JP2019524824A5 true JP2019524824A5 (enExample) | 2021-12-16 |
| JP7014449B2 JP7014449B2 (ja) | 2022-02-01 |
Family
ID=61196484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019508178A Active JP7014449B2 (ja) | 2016-08-14 | 2017-08-14 | 神経障害を処置するための間葉系細胞由来エキソソーム |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11129852B2 (enExample) |
| EP (1) | EP3496730B1 (enExample) |
| JP (1) | JP7014449B2 (enExample) |
| CN (1) | CN109843305B (enExample) |
| AU (1) | AU2017311684B2 (enExample) |
| ES (1) | ES2925527T3 (enExample) |
| IL (1) | IL264825B (enExample) |
| PL (1) | PL3496730T3 (enExample) |
| SG (1) | SG11201901272WA (enExample) |
| WO (1) | WO2018033911A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102995657B1 (ko) | 2018-03-29 | 2026-07-28 | 테크니온 리서치 엔드 디벨로프먼트 화운데이션 엘티디. | Pten 억제제를 포함하는 소포 및 이의 용도 |
| US11930808B2 (en) * | 2018-09-20 | 2024-03-19 | Universidad De Valladolid | Method for obtaining an enriched population of functional mesenchymal stem cells, cells obtained thereof and compositions and comprising the same |
| AU2020303456B2 (en) | 2019-06-26 | 2026-01-08 | Technion Research And Development Foundation Limited | Production of extracellular vesicles from stem cells |
| JP6830286B1 (ja) | 2020-06-26 | 2021-02-17 | デクソンファーマシューティカルズ株式会社 | 精巣機能改善剤および精巣機能改善方法 |
| US20230210910A1 (en) | 2020-07-17 | 2023-07-06 | Dexon Pharmaceuticals Inc. | Method for preventing infection of a healthy person or a healthy animal with a virus that uses ace2 as a receptor, binding inhibitor and medical device |
| CN116171158A (zh) | 2020-09-08 | 2023-05-26 | Dexon制药株式会社 | 细胞因子风暴抑制剂、细胞因子风暴抑制剂的使用方法和筛选方法 |
| JP6974892B1 (ja) | 2021-05-27 | 2021-12-01 | デクソンファーマシューティカルズ株式会社 | 癌悪液質の改善剤および癌悪液質の改善方法 |
| JP7492757B2 (ja) | 2022-03-22 | 2024-05-30 | Ｄｅｘｏｎファーマシューティカルズ株式会社 | 遺伝子の発現制御剤、アルツハイマー病の予防薬または治療薬および認知症の改善方法 |
| WO2023223312A1 (en) | 2022-05-15 | 2023-11-23 | Nurexone Biologic Ltd. | Anti-pten rna interference oligonucleotides and uses thereof |
| CN115006427A (zh) * | 2022-05-31 | 2022-09-06 | 尧舜泽生物医药(南京)有限公司 | 骨髓间充质干细胞外泌体在治疗帕金森病中的应用 |
| EP4541358A1 (en) | 2022-06-20 | 2025-04-23 | Dexon Pharmaceuticals Inc. | Hmgb1 expression suppressor, prophylactic or therapeutic drug for acute lung injury, acute respiratory distress syndrome or sepsis, and method for ameliorating such disease |
| CN119403562A (zh) | 2022-06-20 | 2025-02-07 | Dexon制药株式会社 | Ptx3表达调控剂；类风湿性关节炎、自身免疫疾病所伴随的血管炎或皮肤硬化的预防药或治疗药，或它们的改善方法 |
| CN118878610B (zh) * | 2024-03-19 | 2025-09-02 | 北京达尔文细胞生物科技有限公司 | 一种蛋白聚合物及其生产工艺 |
| CN120078807B (zh) * | 2025-02-08 | 2026-03-31 | 广东省人民医院 | 改善卵巢功能的MSC-sEVs药物及其制备方法和应用 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| MX2007010244A (es) * | 2005-02-23 | 2008-03-10 | Johnson & Johnson | Administracion intranasal de agentes activos al sistema nervioso central. |
| US20120269774A1 (en) * | 2006-09-21 | 2012-10-25 | Medistem Laboratories, Inc | Allogeneic stem cell transplants in non-conditioned recipients |
| NZ586497A (en) | 2008-01-04 | 2012-07-27 | Lydac Neuroscience Ltd | Microvesicles |
| PT2254586E (pt) | 2008-02-22 | 2015-05-18 | Agency Science Tech & Res | Partículas de células estaminais mesenquimais |
| KR20100054711A (ko) | 2008-11-14 | 2010-05-25 | 메디포스트(주) | 간엽 줄기세포 또는 이의 배양액을 포함하는 신경질환의 예방 또는 치료용 조성물 |
| JP5667180B2 (ja) * | 2009-07-01 | 2015-02-12 | イオン メディックス インコーポレイテッド | 哺乳類の有核細胞に由来するマイクロベシクル及びその用途 |
| US20130195991A1 (en) | 2010-03-26 | 2013-08-01 | National University Corporation Nagoya University | Composition for Treatment of Damaged Part |
| JP5608927B2 (ja) | 2010-04-13 | 2014-10-22 | 国立大学法人名古屋大学 | 歯髄幹細胞を用いた神経疾患治療用組成物 |
| GB201011589D0 (en) | 2010-07-09 | 2010-08-25 | Reneuron Ltd | Therapeutic cells |
| EP2603592A2 (en) * | 2010-08-13 | 2013-06-19 | The University Court of the University of Glasgow | Therapeutic uses of microvesicles and related micrornas |
| AU2011329002C1 (en) * | 2010-11-15 | 2017-05-25 | Accelerated Biosciences Corp. | Generation of neural stem cells from human trophoblast stem cells |
| WO2012156968A2 (en) | 2011-05-19 | 2012-11-22 | Ariel - University Research And Development Company, Ltd. | Use of mesenchymal stem cells for the improvement of affective and cognitive function |
| EP2844744A2 (en) * | 2012-02-22 | 2015-03-11 | Brainstem Biotec Ltd. | MicroRNAS FOR THE GENERATION OF ASTROCYTES |
| EP3470073A1 (en) | 2012-04-03 | 2019-04-17 | Reneuron Limited | Stem cell microparticles |
| WO2013186735A2 (en) | 2012-06-14 | 2013-12-19 | Bar-Ilan Research And Development Company Ltd. | Photothermal detection |
| US20160220613A1 (en) * | 2013-09-16 | 2016-08-04 | Agency For Science, Technology And Research | Method |
| WO2016149358A1 (en) | 2015-03-16 | 2016-09-22 | Duncan Ross | Method of treatment comprising membrane-enclosed vesicle |
-
2017
- 2017-08-14 JP JP2019508178A patent/JP7014449B2/ja active Active
- 2017-08-14 EP EP17841210.2A patent/EP3496730B1/en active Active
- 2017-08-14 SG SG11201901272WA patent/SG11201901272WA/en unknown
- 2017-08-14 IL IL264825A patent/IL264825B/en unknown
- 2017-08-14 PL PL17841210.2T patent/PL3496730T3/pl unknown
- 2017-08-14 AU AU2017311684A patent/AU2017311684B2/en active Active
- 2017-08-14 CN CN201780063347.2A patent/CN109843305B/zh active Active
- 2017-08-14 WO PCT/IL2017/050899 patent/WO2018033911A1/en not_active Ceased
- 2017-08-14 US US16/325,445 patent/US11129852B2/en active Active
- 2017-08-14 ES ES17841210T patent/ES2925527T3/es active Active
-
2021
- 2021-08-04 US US17/394,008 patent/US20210361717A1/en active Pending
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