JP6974487B2 - ４員ヘテロ環式アミドを含むｊａｋ阻害剤 - Google Patents

４員ヘテロ環式アミドを含むｊａｋ阻害剤 Download PDF

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Publication number
JP6974487B2
JP6974487B2 JP2019548449A JP2019548449A JP6974487B2 JP 6974487 B2 JP6974487 B2 JP 6974487B2 JP 2019548449 A JP2019548449 A JP 2019548449A JP 2019548449 A JP2019548449 A JP 2019548449A JP 6974487 B2 JP6974487 B2 JP 6974487B2
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compound
lung
pharmaceutically acceptable
pneumonia
transplant rejection
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JP2020510015A5 (https=
JP2020510015A (ja
Inventor
ポール アール． ファザリー，
ゲイリー イー．エル． ブラント，
キャメロン スミス，
スティーブン ディー．イー． サリバン，
オーデン， ロリ ジーン バン
メラニー エー． クラインシェック，
グレン ディー． クレーター，
Original Assignee
セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
JP2019548449A 2017-03-09 2018-03-08 ４員ヘテロ環式アミドを含むｊａｋ阻害剤 Active JP6974487B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762469073P 2017-03-09 2017-03-09
US62/469,073 2017-03-09
PCT/US2018/021489 WO2018165392A1 (en) 2017-03-09 2018-03-08 Jak inhibitors containing a 4-membered heterocyclic amide

Publications (3)

Publication Number Publication Date
JP2020510015A JP2020510015A (ja) 2020-04-02
JP2020510015A5 JP2020510015A5 (https=) 2021-04-01
JP6974487B2 true JP6974487B2 (ja) 2021-12-01

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JP2019548449A Active JP6974487B2 (ja) 2017-03-09 2018-03-08 ４員ヘテロ環式アミドを含むｊａｋ阻害剤
JP2019548369A Active JP7134990B2 (ja) 2017-03-09 2018-03-08 縮合イミダゾ－ピペリジンｊａｋ阻害剤

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JP2019548369A Active JP7134990B2 (ja) 2017-03-09 2018-03-08 縮合イミダゾ－ピペリジンｊａｋ阻害剤

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US (10) US10208040B2 (https=)
EP (2) EP3592742B1 (https=)
JP (2) JP6974487B2 (https=)
KR (2) KR102526764B1 (https=)
CN (2) CN110382498B (https=)
AR (2) AR111242A1 (https=)
AU (2) AU2018231032B2 (https=)
BR (2) BR112019018649A2 (https=)
CA (1) CA2997772A1 (https=)
DK (1) DK3592742T3 (https=)
EA (2) EA037748B1 (https=)
ES (1) ES2882186T3 (https=)
IL (2) IL268679B (https=)
MX (2) MX388749B (https=)
PH (2) PH12019501941A1 (https=)
PT (1) PT3592742T (https=)
SG (2) SG11201907544VA (https=)
TW (2) TWI754019B (https=)
WO (2) WO2018165392A1 (https=)
ZA (2) ZA201905585B (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3371185T3 (da) * 2015-11-03 2020-11-30 Topivert Pharma Ltd 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus-kinase-inhibitorer
UA123633C2 (uk) 2015-11-03 2021-05-05 Тереванс Байофарма Ар Енд Ді Айпі, Елелсі Сполуки інгібітору jak-кінази для лікування респіраторного захворювання
WO2018165392A1 (en) * 2017-03-09 2018-09-13 Theravance Biopharma R&D Ip, Llc Jak inhibitors containing a 4-membered heterocyclic amide
AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
WO2018204233A1 (en) 2017-05-01 2018-11-08 Theravance Biopharma R&D Ip, Llc Methods of treatment using a jak inhibitor compound
JP2021535176A (ja) 2018-09-04 2021-12-16 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Ｊａｋ阻害剤およびその中間体を調製するためのプロセス
UA127328C2 (uk) * 2018-09-04 2023-07-19 Тереванс Байофарма Ар Енд Ді Айпі, Елелсі 5-7-членні гетероциклічні аміди як інгібітори jak
FI3837258T3 (fi) * 2018-09-04 2024-05-27 Theravance Biopharma R&D Ip Llc Dimetyyliaminoatsetidiiniamideja jak-estäjinä
KR20210084512A (ko) 2018-10-29 2021-07-07 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 억제제로서 2-아자비시클로 헥산 화합물
HUE067145T2 (hu) 2019-02-25 2024-10-28 Henan Medinno Pharmaceutical Tech Co Ltd JAK inhibitor vegyület és alkalmazása
WO2020181034A1 (en) 2019-03-05 2020-09-10 Incyte Corporation Jak1 pathway inhibitors for the treatment of chronic lung allograft dysfunction
US11697648B2 (en) * 2019-11-26 2023-07-11 Theravance Biopharma R&D Ip, Llc Fused pyrimidine pyridinone compounds as JAK inhibitors
JP7580136B2 (ja) * 2019-12-30 2024-11-11 路良 Ｊａｋ阻害剤化合物及びその使用
TW202144343A (zh) * 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶水合物
EP3944859A1 (en) 2020-07-30 2022-02-02 Assistance Publique Hôpitaux de Paris Method for treating immune toxicities induced by immune checkpoint inhibitors
WO2022178215A1 (en) * 2021-02-19 2022-08-25 Theravance Biopharma R&D Ip, Llc Amino amide tetrahydro imidazo pyridines as jak inhibitors
EP4359402B1 (en) * 2021-06-25 2026-03-11 Theravance Biopharma R&D IP, LLC Imidazolo indazole compounds as jak inhibitors
KR20230092805A (ko) * 2021-12-17 2023-06-26 주식회사 대웅제약 (2R, 3S)-2-(3-(4,5-디클로로-1H-벤조[d]이미다졸-1-일)프로필)피페리딘-3-올의 신규한 산부가염 및 결정형
CN117658852B (zh) * 2023-11-15 2026-03-24 西北工业大学 取代苯氧乙酰肼类化合物及其制备方法和作为stat3的抗炎抑制剂的应用
WO2025157904A1 (en) * 2024-01-24 2025-07-31 Kiox Pharmaceuticals Aps Inhalable formulations of ruxolitinib, methods of manufacture and uses thereof
CN118903009B (zh) * 2024-10-11 2025-01-21 江苏长泰药业股份有限公司 一种调节呼吸道微生态的丙酮酸钠气雾剂及其制备方法和应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI262914B (en) 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
EP1648455A4 (en) 2003-07-23 2009-03-04 Exelixis Inc MODULATORS OF ALK PROTEIN (ANAPLASTIC LYMPHOMA KINASE) AND METHODS OF USE
US20050090529A1 (en) 2003-07-31 2005-04-28 Pfizer Inc 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
US7884109B2 (en) 2005-04-05 2011-02-08 Wyeth Llc Purine and imidazopyridine derivatives for immunosuppression
US8648069B2 (en) 2007-06-08 2014-02-11 Abbvie Inc. 5-substituted indazoles as kinase inhibitors
JP2010111624A (ja) 2008-11-06 2010-05-20 Shionogi & Co Ltd Ｔｔｋ阻害作用を有するインダゾール誘導体
WO2010114971A1 (en) 2009-04-03 2010-10-07 Sepracor Inc. Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
LT3001903T (lt) 2009-12-21 2018-01-10 Samumed, Llc 1h-pirazolo[3,4-b]piridinai ir jų terapinis panaudojimas
EP2338888A1 (en) 2009-12-24 2011-06-29 Almirall, S.A. Imidazopyridine derivatives as JAK inhibitors
US8575336B2 (en) * 2011-07-27 2013-11-05 Pfizer Limited Indazoles
EP2771340B1 (en) 2011-10-25 2016-04-13 Sanofi 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
SI3077395T1 (en) 2013-12-05 2018-03-30 Pfizer Inc. Pyrrolo(2,3-d)pyrimidinyl, pyrrolo(2,3-b)pyrazinyl and pyrrolo(2,3-d)pyridinyl acrylamides
KR20170002623A (ko) 2014-05-14 2017-01-06 화이자 인코포레이티드 피라졸로피리딘 및 피라졸로피리미딘
WO2016026078A1 (en) 2014-08-19 2016-02-25 Changzhou Jiekai Pharmatech Co., Ltd. Heterocyclic compounds as erk inhibitors
KR101663277B1 (ko) 2015-03-30 2016-10-06 주식회사 녹십자 TNIK, IKKε 및 TBK1 억제제로서의 피라졸계 유도체 및 이를 포함하는 약학적 조성물
UA123633C2 (uk) * 2015-11-03 2021-05-05 Тереванс Байофарма Ар Енд Ді Айпі, Елелсі Сполуки інгібітору jak-кінази для лікування респіраторного захворювання
WO2017077283A1 (en) 2015-11-03 2017-05-11 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
DK3371185T3 (da) 2015-11-03 2020-11-30 Topivert Pharma Ltd 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus-kinase-inhibitorer
WO2018165392A1 (en) 2017-03-09 2018-09-13 Theravance Biopharma R&D Ip, Llc Jak inhibitors containing a 4-membered heterocyclic amide
KR20200003121A (ko) 2017-05-01 2020-01-08 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 저해제 화합물의 결정형
WO2018204233A1 (en) 2017-05-01 2018-11-08 Theravance Biopharma R&D Ip, Llc Methods of treatment using a jak inhibitor compound
AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
KR102032418B1 (ko) 2017-06-15 2019-10-16 한국화학연구원 접합 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 브루톤티로신 키나제 활성 관련 질환의 예방 또는 치료용 약학적 조성물
FI3837258T3 (fi) 2018-09-04 2024-05-27 Theravance Biopharma R&D Ip Llc Dimetyyliaminoatsetidiiniamideja jak-estäjinä
JP2021535176A (ja) 2018-09-04 2021-12-16 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Ｊａｋ阻害剤およびその中間体を調製するためのプロセス
UA127328C2 (uk) 2018-09-04 2023-07-19 Тереванс Байофарма Ар Енд Ді Айпі, Елелсі 5-7-членні гетероциклічні аміди як інгібітори jak

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MX388749B (es) 2025-03-11
US10550118B2 (en) 2020-02-04
PH12019501985A1 (en) 2020-10-05
CN110382498A (zh) 2019-10-25
US20180258087A1 (en) 2018-09-13
EP3592743A1 (en) 2020-01-15
US11254669B2 (en) 2022-02-22
EA201992128A1 (ru) 2020-01-29
IL268679A (en) 2019-10-31
BR112019018648A2 (pt) 2020-06-16
US10392386B2 (en) 2019-08-27
NZ756823A (en) 2021-04-30
US20200181141A1 (en) 2020-06-11
SG11201907544VA (en) 2019-09-27
AR111241A1 (es) 2019-06-19
US11453668B2 (en) 2022-09-27
AU2018231032B2 (en) 2021-08-19
TWI754019B (zh) 2022-02-01
BR112019018649A2 (pt) 2020-04-07
US20230063643A1 (en) 2023-03-02
KR102533646B1 (ko) 2023-05-17
US10208040B2 (en) 2019-02-19
US10954237B2 (en) 2021-03-23
TWI779016B (zh) 2022-10-01
AU2018231032A8 (en) 2019-10-17
CN110461839A (zh) 2019-11-15
EA037261B1 (ru) 2021-03-01
CA2997772A1 (en) 2018-09-09
MX2019010539A (es) 2019-10-21
AU2018231035B2 (en) 2021-09-09
US20190119275A1 (en) 2019-04-25
CN110382498B (zh) 2022-07-12
AR111242A1 (es) 2019-06-19
US20190127371A1 (en) 2019-05-02
US20220289737A1 (en) 2022-09-15
JP2020510015A (ja) 2020-04-02
ES2882186T3 (es) 2021-12-01
IL268679B (en) 2021-10-31
EA201992126A1 (ru) 2020-02-05
KR20190127796A (ko) 2019-11-13
KR20190127798A (ko) 2019-11-13
DK3592742T3 (da) 2021-08-09
MX388750B (es) 2025-03-20
WO2018165395A1 (en) 2018-09-13
JP7134990B2 (ja) 2022-09-12
US20210269436A1 (en) 2021-09-02
CN110461839B (zh) 2022-08-23
US11878977B2 (en) 2024-01-23
SG11201907840RA (en) 2019-09-27
KR102526764B1 (ko) 2023-04-27
IL268689A (en) 2019-10-31
US10519153B2 (en) 2019-12-31
PH12019501941A1 (en) 2020-07-06
US20190337945A1 (en) 2019-11-07
US20200216447A1 (en) 2020-07-09
US11667637B2 (en) 2023-06-06
IL268689B (en) 2022-10-01
AU2018231035A1 (en) 2019-09-05
TW201840560A (zh) 2018-11-16
EA037748B1 (ru) 2021-05-18
US10196393B2 (en) 2019-02-05
EP3592742B1 (en) 2021-05-19
JP2020510010A (ja) 2020-04-02
US20180258088A1 (en) 2018-09-13
AU2018231032A1 (en) 2019-09-05
ZA201905585B (en) 2020-05-27
IL268689B2 (en) 2023-02-01
MX2019010541A (es) 2019-10-21
WO2018165392A1 (en) 2018-09-13
ZA201905618B (en) 2021-05-26
TW201837037A (zh) 2018-10-16
EP3592742A1 (en) 2020-01-15
PT3592742T (pt) 2021-07-30

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