JP6971239B2 - グルタミナーゼ阻害剤とイムノオンコロジー薬剤との併用療法 - Google Patents
グルタミナーゼ阻害剤とイムノオンコロジー薬剤との併用療法 Download PDFInfo
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- JP6971239B2 JP6971239B2 JP2018536710A JP2018536710A JP6971239B2 JP 6971239 B2 JP6971239 B2 JP 6971239B2 JP 2018536710 A JP2018536710 A JP 2018536710A JP 2018536710 A JP2018536710 A JP 2018536710A JP 6971239 B2 JP6971239 B2 JP 6971239B2
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
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- Communicable Diseases (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
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- Microbiology (AREA)
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- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562237287P | 2015-10-05 | 2015-10-05 | |
| US62/237,287 | 2015-10-05 | ||
| US201662323179P | 2016-04-15 | 2016-04-15 | |
| US62/323,179 | 2016-04-15 | ||
| PCT/US2016/055316 WO2017062354A1 (en) | 2015-10-05 | 2016-10-04 | Combination therapy with glutaminase inhibitors and immuno-oncology agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529780A JP2018529780A (ja) | 2018-10-11 |
| JP2018529780A5 JP2018529780A5 (https=) | 2019-11-07 |
| JP6971239B2 true JP6971239B2 (ja) | 2021-11-24 |
Family
ID=58447081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018536710A Expired - Fee Related JP6971239B2 (ja) | 2015-10-05 | 2016-10-04 | グルタミナーゼ阻害剤とイムノオンコロジー薬剤との併用療法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10258619B2 (https=) |
| EP (1) | EP3359150A4 (https=) |
| JP (1) | JP6971239B2 (https=) |
| KR (1) | KR20180059544A (https=) |
| CN (1) | CN108601767A (https=) |
| AU (1) | AU2016335991A1 (https=) |
| CA (1) | CA3000996A1 (https=) |
| IL (1) | IL258500A (https=) |
| SG (1) | SG11201802830QA (https=) |
| WO (1) | WO2017062354A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015010955A2 (pt) | 2012-11-16 | 2017-07-11 | Calithera Biosciences Inc | inibidores de glutaminase heterocíclica |
| WO2015109391A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
| MX2017001620A (es) | 2014-08-07 | 2017-05-10 | Calithera Biosciences Inc | Formas cristalinas de inhibidores de glutaminasa. |
| EP3359150A4 (en) | 2015-10-05 | 2019-11-06 | Calithera Biosciences, Inc. | COMBINATION THERAPY WITH GLUTAMINASE INHIBITORS AND IMMUNO-ONCOLOGICAL AGENTS |
| JP2020534289A (ja) * | 2017-09-14 | 2020-11-26 | ランケナー インスティテュート フォー メディカル リサーチ | がんの治療のための方法および組成物 |
| US20210177841A1 (en) * | 2017-11-03 | 2021-06-17 | Calithera Biosciences, Inc. | Conjoint therapy with glutaminase inhibitors |
| WO2020014611A1 (en) * | 2018-07-12 | 2020-01-16 | Cedars-Sinai Medical Center | Compositions and methods targeting glutamine and its metabolism for diagnosing and treating cancer and therapy-associated side effects |
| WO2021038097A1 (en) * | 2019-08-30 | 2021-03-04 | Vestlandets Innovasjonsselskap As | Method for the treatment of chronic fatigue syndrome using an inhibitory or cytotoxic agent against plasma cells |
| CN111643669A (zh) * | 2020-06-30 | 2020-09-11 | 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) | 谷氨酰胺酶抑制剂在制备治疗银屑病的药物中的应用 |
| US11839659B2 (en) | 2020-07-02 | 2023-12-12 | Northwestern University | Proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of indoleamine 2,3-dioxygenase (IDO) protein |
| US20250281609A1 (en) * | 2021-10-19 | 2025-09-11 | Organoidsciences Ltd. | Composition for treating or preventing cancer |
| TW202406539A (zh) * | 2022-04-21 | 2024-02-16 | 大陸商北京加科思新藥研發有限公司 | 藥物組合及其用途 |
| CN116284398A (zh) * | 2023-01-30 | 2023-06-23 | 中山大学附属第五医院 | 一种表达pd-l1抗体的细胞囊泡及其制备方法和应用 |
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2016
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- 2016-10-04 KR KR1020187012679A patent/KR20180059544A/ko not_active Ceased
- 2016-10-04 JP JP2018536710A patent/JP6971239B2/ja not_active Expired - Fee Related
- 2016-10-04 AU AU2016335991A patent/AU2016335991A1/en not_active Abandoned
- 2016-10-04 CA CA3000996A patent/CA3000996A1/en not_active Abandoned
- 2016-10-04 SG SG11201802830QA patent/SG11201802830QA/en unknown
- 2016-10-04 WO PCT/US2016/055316 patent/WO2017062354A1/en not_active Ceased
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| AU2016335991A1 (en) | 2018-05-10 |
| EP3359150A4 (en) | 2019-11-06 |
| JP2018529780A (ja) | 2018-10-11 |
| US20210361649A1 (en) | 2021-11-25 |
| KR20180059544A (ko) | 2018-06-04 |
| IL258500A (en) | 2018-05-31 |
| WO2017062354A1 (en) | 2017-04-13 |
| US10258619B2 (en) | 2019-04-16 |
| US10940148B2 (en) | 2021-03-09 |
| US20190231776A1 (en) | 2019-08-01 |
| CN108601767A (zh) | 2018-09-28 |
| EP3359150A1 (en) | 2018-08-15 |
| SG11201802830QA (en) | 2018-05-30 |
| CA3000996A1 (en) | 2017-04-13 |
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