JP2018529780A5 - - Google Patents

Download PDF

Info

Publication number
JP2018529780A5
JP2018529780A5 JP2018536710A JP2018536710A JP2018529780A5 JP 2018529780 A5 JP2018529780 A5 JP 2018529780A5 JP 2018536710 A JP2018536710 A JP 2018536710A JP 2018536710 A JP2018536710 A JP 2018536710A JP 2018529780 A5 JP2018529780 A5 JP 2018529780A5
Authority
JP
Japan
Prior art keywords
cancer
independently
substituted
arylalkyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018536710A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018529780A (ja
JP6971239B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/055316 external-priority patent/WO2017062354A1/en
Publication of JP2018529780A publication Critical patent/JP2018529780A/ja
Publication of JP2018529780A5 publication Critical patent/JP2018529780A5/ja
Application granted granted Critical
Publication of JP6971239B2 publication Critical patent/JP6971239B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018536710A 2015-10-05 2016-10-04 グルタミナーゼ阻害剤とイムノオンコロジー薬剤との併用療法 Expired - Fee Related JP6971239B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562237287P 2015-10-05 2015-10-05
US62/237,287 2015-10-05
US201662323179P 2016-04-15 2016-04-15
US62/323,179 2016-04-15
PCT/US2016/055316 WO2017062354A1 (en) 2015-10-05 2016-10-04 Combination therapy with glutaminase inhibitors and immuno-oncology agents

Publications (3)

Publication Number Publication Date
JP2018529780A JP2018529780A (ja) 2018-10-11
JP2018529780A5 true JP2018529780A5 (https=) 2019-11-07
JP6971239B2 JP6971239B2 (ja) 2021-11-24

Family

ID=58447081

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018536710A Expired - Fee Related JP6971239B2 (ja) 2015-10-05 2016-10-04 グルタミナーゼ阻害剤とイムノオンコロジー薬剤との併用療法

Country Status (10)

Country Link
US (3) US10258619B2 (https=)
EP (1) EP3359150A4 (https=)
JP (1) JP6971239B2 (https=)
KR (1) KR20180059544A (https=)
CN (1) CN108601767A (https=)
AU (1) AU2016335991A1 (https=)
CA (1) CA3000996A1 (https=)
IL (1) IL258500A (https=)
SG (1) SG11201802830QA (https=)
WO (1) WO2017062354A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015010955A2 (pt) 2012-11-16 2017-07-11 Calithera Biosciences Inc inibidores de glutaminase heterocíclica
WO2015109391A1 (en) 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
MX2017001620A (es) 2014-08-07 2017-05-10 Calithera Biosciences Inc Formas cristalinas de inhibidores de glutaminasa.
EP3359150A4 (en) 2015-10-05 2019-11-06 Calithera Biosciences, Inc. COMBINATION THERAPY WITH GLUTAMINASE INHIBITORS AND IMMUNO-ONCOLOGICAL AGENTS
JP2020534289A (ja) * 2017-09-14 2020-11-26 ランケナー インスティテュート フォー メディカル リサーチ がんの治療のための方法および組成物
US20210177841A1 (en) * 2017-11-03 2021-06-17 Calithera Biosciences, Inc. Conjoint therapy with glutaminase inhibitors
WO2020014611A1 (en) * 2018-07-12 2020-01-16 Cedars-Sinai Medical Center Compositions and methods targeting glutamine and its metabolism for diagnosing and treating cancer and therapy-associated side effects
WO2021038097A1 (en) * 2019-08-30 2021-03-04 Vestlandets Innovasjonsselskap As Method for the treatment of chronic fatigue syndrome using an inhibitory or cytotoxic agent against plasma cells
CN111643669A (zh) * 2020-06-30 2020-09-11 广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院) 谷氨酰胺酶抑制剂在制备治疗银屑病的药物中的应用
US11839659B2 (en) 2020-07-02 2023-12-12 Northwestern University Proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of indoleamine 2,3-dioxygenase (IDO) protein
US20250281609A1 (en) * 2021-10-19 2025-09-11 Organoidsciences Ltd. Composition for treating or preventing cancer
TW202406539A (zh) * 2022-04-21 2024-02-16 大陸商北京加科思新藥研發有限公司 藥物組合及其用途
CN116284398A (zh) * 2023-01-30 2023-06-23 中山大学附属第五医院 一种表达pd-l1抗体的细胞囊泡及其制备方法和应用

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1019519A (en) 1911-07-11 1912-03-05 Oscar Martin Polin Apparatus for making backing for teeth.
US4172896A (en) 1978-06-05 1979-10-30 Dainippon Pharmaceutical Co., Ltd. Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
GB9217295D0 (en) 1992-08-14 1992-09-30 Wellcome Found Controlled released tablets
GB9315856D0 (en) 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
US5358970A (en) 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
US5541231A (en) 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
DE69839355T2 (de) 1997-07-29 2009-06-04 Alcon Laboratories, Inc., Fort Worth Ophthalmische Zusammensetzungen enthaltend Galaktomannanpolymere und Borat
AU2483599A (en) 1998-01-29 1999-08-16 Sepracor, Inc. Pharmaceutical uses of optically pure (-)-bupropion
US8889112B2 (en) 1999-09-16 2014-11-18 Ocularis Pharma, Llc Ophthalmic formulations including selective alpha 1 antagonists
US6451828B1 (en) 2000-08-10 2002-09-17 Elan Pharmaceuticals, Inc. Selective inhibition of glutaminase by bis-thiadiazoles
AU2002305926A1 (en) 2001-02-05 2002-10-08 Exegenics Inc. Cysteine protease inhibitors
US7714139B2 (en) * 2003-03-27 2010-05-11 Lankenau Institute For Medcial Research IDO inhibitors and methods of use
US6933289B2 (en) 2003-07-01 2005-08-23 Allergan, Inc. Inhibition of irritating side effects associated with use of a topical ophthalmic medication
EP1654002B2 (en) 2003-08-07 2014-01-29 Allergan, Inc. Compositions for delivery of therapeutics into the eyes
US20050059744A1 (en) 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
ES2367311T3 (es) 2004-04-15 2011-11-02 University Of Florida Research Foundation, Inc. Productos de degradación proteolítica de map-2 como biomarcadores de diagnóstico para las lesiones neurales.
TW200911798A (en) 2007-08-02 2009-03-16 Amgen Inc PI3 kinase modulators and methods of use
US10047066B2 (en) * 2007-11-30 2018-08-14 Newlink Genetics Corporation IDO inhibitors
KR101325374B1 (ko) 2008-02-19 2013-11-08 가부시키가이샤 오츠까 세이야꾸 고죠 신체 기능의 회복에 유용한 경구 또는 경장 조성물
LT2389352T (lt) * 2009-01-26 2019-06-10 The Trustees Of The University Of Pennsylvania Arginazės inhibitoriai ir naudojimo būdai
WO2011143160A2 (en) 2010-05-10 2011-11-17 The Johns Hopkins University Metabolic inhibitor against tumors having an idh mutation
US10064885B2 (en) 2010-07-09 2018-09-04 Massachusetts Institute Of Technology Metabolic gene, enzyme, and flux targets for cancer therapy
WO2012068512A1 (en) 2010-11-18 2012-05-24 Deuteria Pharmaceuticals Llc 3-deutero-pomalidomide
CA2824599C (en) * 2010-12-31 2020-03-10 Astrazeneca Uk Limited Arginase inhibitors and methods of use thereof
CA2742342A1 (en) 2011-02-12 2012-08-12 Baylor Research Institute Msh3 expression status determines the responsiveness of cancer cells to the chemotherapeutic treatment with parp inhibitors and platinum drugs
FI20115876A0 (fi) 2011-09-06 2011-09-06 Turun Yliopisto Yhdistelmähoito
CN103030597B (zh) 2011-09-30 2014-10-01 南昌滨西科技有限公司 肾脏型谷氨酰胺酶抑制剂及其制备方法和用途
WO2013059437A1 (en) * 2011-10-19 2013-04-25 Mars, Incorporated Inhibitors of arginase and their therapeutic applications
US8604016B2 (en) 2011-11-21 2013-12-10 Calithera Biosciences Inc. Heterocyclic inhibitors of glutaminase
HRP20192144T1 (hr) * 2011-11-21 2020-02-21 Calithera Biosciences Inc. Heterociklični inhibitori glutaminaze
EP2855698A4 (en) 2012-05-24 2016-03-30 Dana Farber Cancer Inst Inc OBTAINING TO THE GLUTAMINE-TO-PYRUVAT SIGNAL PATH FOR THE TREATMENT OF CANCER ASSOCIATED WITH THE KRAS ONKOGEN
EP2892537A1 (en) 2012-09-10 2015-07-15 Celgene Corporation Methods for the treatment of locally advanced breast cancer
EP2895623B1 (en) 2012-09-17 2018-08-22 Agios Pharmaceuticals, Inc. Use of e-cadherin and vimentin for selection of treatment responsive patients
BR112015010955A2 (pt) 2012-11-16 2017-07-11 Calithera Biosciences Inc inibidores de glutaminase heterocíclica
MX369691B (es) 2012-11-21 2019-11-19 Agios Pharmaceuticals Inc Inhibidores de glutaminasa y métodos de empleo.
WO2014079011A1 (en) 2012-11-22 2014-05-30 Agios Pharmaceuticals, Inc. Heterocyclic compounds for inhibiting glutaminase and their methods of use
CA2892817A1 (en) * 2012-12-03 2014-06-12 Calithera Biosciences Inc. Treatment of cancer with heterocyclic inhibitors of glutaminase
EP2970114B1 (en) * 2013-03-15 2019-05-15 Bristol-Myers Squibb Company Ido inhibitors
EA201690746A1 (ru) * 2013-10-25 2016-12-30 Фармасайкликс Элэлси Лечение с применением ингибиторов тирозинкиназы брутона и иммунотерапии
WO2015061432A1 (en) 2013-10-25 2015-04-30 Calithera Biosciences, Inc. Treatment of viral infections with inhibitors of glutaminase
GB201322725D0 (en) * 2013-12-20 2014-02-05 Immodulon Therapeutics Ltd Cancer therapy
WO2015125652A1 (ja) * 2014-02-21 2015-08-27 Idacセラノスティクス株式会社 固形がんの治療剤
US20150258082A1 (en) 2014-03-14 2015-09-17 Francesco Parlati Combination therapy with glutaminase inhibitors
US10221459B2 (en) 2014-05-13 2019-03-05 Case Western Reserve University Compositions and methods of treating cancer harboring PIKC3A mutations
SG11201610333VA (en) 2014-06-13 2017-01-27 Calithera Biosciences Inc Combination therapy with glutaminase inhibitors
WO2016004413A2 (en) 2014-07-03 2016-01-07 Board Of Regents, University Of Texas System Gls1 inhibitors for treating disease
WO2016004418A1 (en) 2014-07-03 2016-01-07 Board Of Regents, University Of Texas System Glutaminase inhibitor therapy
WO2016014890A1 (en) * 2014-07-24 2016-01-28 Calithera Biosciences, Inc. Treatment of multiple myeloma with heterocyclic inhibitors of glutaminase
MX2017001620A (es) 2014-08-07 2017-05-10 Calithera Biosciences Inc Formas cristalinas de inhibidores de glutaminasa.
WO2016054388A1 (en) 2014-10-03 2016-04-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Glutaminase inhibitors
WO2016077632A2 (en) 2014-11-13 2016-05-19 Buck Institute For Research On Aging Inhibition of proline catabolism for the treatment of cancer and other therapeutic applications
BR112017020780A2 (pt) 2015-03-30 2018-06-26 Calithera Biosciences Inc métodos de administração de inibidores de glutaminase
AU2016246521B2 (en) 2015-04-06 2020-07-09 Calithera Biosciences, Inc. Treatment of lung cancer with inhibitors of glutaminase
CN108135875B (zh) 2015-07-31 2021-12-31 约翰霍普金斯大学 用于治疗代谢重编程病症的方法和组合物
US20190054090A1 (en) 2015-10-01 2019-02-21 Gilead Sciences, Inc. Combination of a btk inhibitor and a checkpoint inhibitor for treating cancers
EP3359150A4 (en) 2015-10-05 2019-11-06 Calithera Biosciences, Inc. COMBINATION THERAPY WITH GLUTAMINASE INHIBITORS AND IMMUNO-ONCOLOGICAL AGENTS
LT3458053T (lt) 2016-05-20 2022-02-25 Biohaven Pharmaceutical Holding Company Ltd. Riluzolo, rilizolo provaistų arba riluzolo analogų panaudojimas kartu su imunoterapijomis vėžio formų gydymui
US10195197B2 (en) 2016-08-25 2019-02-05 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors
KR20190040302A (ko) 2016-08-25 2019-04-17 칼리테라 바이오사이언시즈, 인코포레이티드 글루타미나제 억제제와의 병용 요법
WO2018039442A1 (en) 2016-08-25 2018-03-01 Calithera Biosciences, Inc. Treatment of cancer with inhibitors of glutaminase
US20200038398A1 (en) 2017-03-10 2020-02-06 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors
US20210177841A1 (en) * 2017-11-03 2021-06-17 Calithera Biosciences, Inc. Conjoint therapy with glutaminase inhibitors

Similar Documents

Publication Publication Date Title
JP2018529780A5 (https=)
JP2017517548A5 (https=)
JP2016505526A5 (https=)
JP2016502544A5 (https=)
AU2017263478B2 (en) Combination therapies of HDAC inhibitors and PD-1 inhibitors
JP2020510032A5 (https=)
JP2014533699A5 (https=)
AU2017264857B2 (en) Combination therapies of HDAC inhibitors and PD-L1 inhibitors
JP2019518741A5 (https=)
JP2023512038A5 (https=)
JP2020128432A (ja) がんの処置のための併用治療
JP7491220B2 (ja) 免疫チェックポイント阻害薬およびfolfirinox療法との併用によるがん治療
JP2017523991A5 (https=)
JP6279065B2 (ja) 抗cd38抗体およびカーフィルゾミブを含む組成物
JP5911929B2 (ja) 特定の癌の治療のためのrdea119/bay869766を含む組み合わせ医薬
JP2014500295A5 (https=)
RU2017145026A (ru) Соединение, ингибирующее brk
WO2016210106A1 (en) Compositions and methods for inhibiting arginase activity
JP2016179996A5 (https=)
RU2017112048A (ru) Синергистические комбинации ауристана
JP2019526560A5 (https=)
JP2022537358A5 (https=)
JP2020527173A5 (https=)
JP2019524852A5 (https=)
KR20180099712A (ko) 항증식성 화합물, 및 이의 약제학적 조성물 및 용도