JP6962663B2 - 眼科用組成物及びその製造方法 - Google Patents
眼科用組成物及びその製造方法 Download PDFInfo
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- JP6962663B2 JP6962663B2 JP2018555057A JP2018555057A JP6962663B2 JP 6962663 B2 JP6962663 B2 JP 6962663B2 JP 2018555057 A JP2018555057 A JP 2018555057A JP 2018555057 A JP2018555057 A JP 2018555057A JP 6962663 B2 JP6962663 B2 JP 6962663B2
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- Prior art keywords
- oil
- polyoxyethylene
- tear
- preferable
- castor oil
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- 238000004519 manufacturing process Methods 0.000 title claims description 13
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- 239000004359 castor oil Substances 0.000 claims description 45
- 235000019438 castor oil Nutrition 0.000 claims description 43
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 43
- 239000002736 nonionic surfactant Substances 0.000 claims description 17
- 239000002202 Polyethylene glycol Substances 0.000 claims description 15
- 229920001223 polyethylene glycol Polymers 0.000 claims description 15
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 8
- 150000003505 terpenes Chemical class 0.000 claims description 8
- 238000013329 compounding Methods 0.000 claims description 7
- 238000002834 transmittance Methods 0.000 claims description 6
- 238000004945 emulsification Methods 0.000 claims description 5
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- 235000014113 dietary fatty acids Nutrition 0.000 claims description 4
- 239000000194 fatty acid Substances 0.000 claims description 4
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- 239000003795 chemical substances by application Substances 0.000 description 8
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- 235000019386 wax ester Nutrition 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011576 zinc lactate Substances 0.000 description 1
- 235000000193 zinc lactate Nutrition 0.000 description 1
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- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
Classifications
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- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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- A—HUMAN NECESSITIES
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- A61K31/01—Hydrocarbons
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
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- Public Health (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| JP2021167153A JP7388418B2 (ja) | 2016-12-08 | 2021-10-12 | 眼科用組成物及びその製造方法 |
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| KR102665630B1 (ko) * | 2017-12-07 | 2024-05-14 | 라이온 가부시키가이샤 | 수성 안과용 조성물 및 에멀션 입자의 미립화 방법 |
| JP7172438B2 (ja) * | 2018-10-24 | 2022-11-16 | ライオン株式会社 | 水性眼科用組成物及び保存効力向上方法 |
| KR20210107607A (ko) * | 2018-12-26 | 2021-09-01 | 라이온 가부시키가이샤 | 안과용 조성물 |
| JP7467911B2 (ja) * | 2019-12-25 | 2024-04-16 | ライオン株式会社 | 眼科用組成物及び外観安定化方法 |
| CA3190636A1 (en) * | 2020-07-31 | 2022-02-03 | Altaire Pharmaceuticals, Inc. | Ophthalmic compositions for removing meibum or inhibiting meibum buildup |
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| JP2827295B2 (ja) * | 1989-07-04 | 1998-11-25 | 大正製薬株式会社 | ビタミンａ類含有点眼剤 |
| JP2003095897A (ja) * | 2001-09-27 | 2003-04-03 | Lion Corp | 毛髪褪色予防剤組成物 |
| JP5748385B2 (ja) | 2006-01-13 | 2015-07-15 | 大正製薬株式会社 | Ｏ／ｗ型エマルション水性点眼剤 |
| JP5176132B2 (ja) * | 2006-09-14 | 2013-04-03 | 大正製薬株式会社 | 眼科用剤 |
| JP2008222638A (ja) * | 2007-03-13 | 2008-09-25 | Teika Seiyaku Kk | 油成分含有眼用組成物 |
| JP5563745B2 (ja) * | 2007-04-04 | 2014-07-30 | 大正製薬株式会社 | 点眼剤 |
| JP5722299B2 (ja) * | 2012-12-07 | 2015-05-20 | バイオアバイラビリティ，インク． | 栄養学的に使用するための高濃度自己マイクロエマルジョン化コエンザイムｑ１０調製物 |
| EP2978409B1 (en) * | 2013-03-27 | 2018-01-10 | Comprehensive Drug Enterprises Ltd | Ophthalmic composition, method for preparing the same, and use of the same |
| US11103464B2 (en) * | 2013-11-29 | 2021-08-31 | Rohto Pharmaceutical Co., Ltd. | Aqueous composition for ophthalmological use or otolaryngological use |
| WO2015152155A1 (ja) * | 2014-03-31 | 2015-10-08 | ロート製薬株式会社 | 眼科用又は耳鼻科用水性組成物 |
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| JP6688569B2 (ja) * | 2014-07-03 | 2020-04-28 | ロート製薬株式会社 | 局所粘膜用水性組成物 |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2018105681A1 (ja) | 2018-06-14 |
| JPWO2018105681A1 (ja) | 2019-12-12 |
| CN109996538B (zh) | 2023-03-07 |
| CN109996538A (zh) | 2019-07-09 |
| KR102497952B1 (ko) | 2023-02-09 |
| TWI776831B (zh) | 2022-09-11 |
| JP7388418B2 (ja) | 2023-11-29 |
| JP2022001595A (ja) | 2022-01-06 |
| TW201825077A (zh) | 2018-07-16 |
| KR20190093551A (ko) | 2019-08-09 |
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