JP6946575B2 - 眼の状態の治療のためのピロカルピン塩酸塩の使用 - Google Patents

眼の状態の治療のためのピロカルピン塩酸塩の使用 Download PDF

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Publication number
JP6946575B2
JP6946575B2 JP2020559558A JP2020559558A JP6946575B2 JP 6946575 B2 JP6946575 B2 JP 6946575B2 JP 2020559558 A JP2020559558 A JP 2020559558A JP 2020559558 A JP2020559558 A JP 2020559558A JP 6946575 B2 JP6946575 B2 JP 6946575B2
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weight
pharmaceutical composition
eye
pilocarpine
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JP2021522256A (ja
Inventor
マイケル アール ロビンソン
マイケル アール ロビンソン
モハメド ディバス
モハメド ディバス
ジャヤ ギヤナニ
ジャヤ ギヤナニ
アヌラーダー ゴア
アヌラーダー ゴア
ソンウク リー
ソンウク リー
ハイシア リウ
ハイシア リウ
アイリーン モーガン
アイリーン モーガン
ジハオ チョウ
ジハオ チョウ
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Allergan Inc
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Allergan Inc
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Publication of JP2021522256A publication Critical patent/JP2021522256A/ja
Priority to JP2021150116A priority Critical patent/JP7470667B2/ja
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Priority to JP2024062082A priority patent/JP2024096131A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2020559558A 2018-04-24 2019-04-24 眼の状態の治療のためのピロカルピン塩酸塩の使用 Active JP6946575B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021150116A JP7470667B2 (ja) 2018-04-24 2021-09-15 眼の状態の治療のためのピロカルピン塩酸塩の使用
JP2024062082A JP2024096131A (ja) 2018-04-24 2024-04-08 眼の状態の治療のためのピロカルピン塩酸塩の使用

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862662144P 2018-04-24 2018-04-24
US62/662,144 2018-04-24
US201862780117P 2018-12-14 2018-12-14
US62/780,117 2018-12-14
US201962790957P 2019-01-10 2019-01-10
US62/790,957 2019-01-10
PCT/US2019/028917 WO2019209955A2 (en) 2018-04-24 2019-04-24 Presbyopia treatments

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021150116A Division JP7470667B2 (ja) 2018-04-24 2021-09-15 眼の状態の治療のためのピロカルピン塩酸塩の使用

Publications (2)

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JP2021522256A JP2021522256A (ja) 2021-08-30
JP6946575B2 true JP6946575B2 (ja) 2021-10-06

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ID=66821312

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Application Number Title Priority Date Filing Date
JP2020559558A Active JP6946575B2 (ja) 2018-04-24 2019-04-24 眼の状態の治療のためのピロカルピン塩酸塩の使用
JP2021150116A Active JP7470667B2 (ja) 2018-04-24 2021-09-15 眼の状態の治療のためのピロカルピン塩酸塩の使用
JP2024062082A Pending JP2024096131A (ja) 2018-04-24 2024-04-08 眼の状態の治療のためのピロカルピン塩酸塩の使用

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JP2021150116A Active JP7470667B2 (ja) 2018-04-24 2021-09-15 眼の状態の治療のためのピロカルピン塩酸塩の使用
JP2024062082A Pending JP2024096131A (ja) 2018-04-24 2024-04-08 眼の状態の治療のためのピロカルピン塩酸塩の使用

Country Status (25)

Country Link
US (4) US10610518B2 (https=)
EP (2) EP4066830A1 (https=)
JP (3) JP6946575B2 (https=)
KR (2) KR20210005134A (https=)
CN (1) CN112272558A (https=)
AU (3) AU2019261598B9 (https=)
BR (1) BR112020021845A2 (https=)
CA (2) CA3162141A1 (https=)
CL (1) CL2020002734A1 (https=)
CO (1) CO2020014563A2 (https=)
CY (1) CY1125325T1 (https=)
DK (1) DK3681500T3 (https=)
ES (1) ES2920803T5 (https=)
HR (1) HRP20220762T1 (https=)
HU (1) HUE058931T2 (https=)
IL (1) IL278178A (https=)
LT (1) LT3681500T (https=)
MX (1) MX2020011301A (https=)
PH (1) PH12020551766A1 (https=)
PL (1) PL3681500T3 (https=)
PT (1) PT3681500T (https=)
RS (1) RS63360B1 (https=)
SG (1) SG11202010472XA (https=)
SI (1) SI3681500T1 (https=)
WO (1) WO2019209955A2 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019018749A1 (en) 2017-07-20 2019-01-24 Alan Laboratories, Inc. COMPOSITION AND METHODS FOR THE TREATMENT OF MYOPIA
US20210251970A1 (en) 2018-10-10 2021-08-19 Presbyopia Therapies Inc Compositions and methods for storage stable ophthalmic drugs
EP3866790A4 (en) 2018-10-15 2022-08-03 Ocuphire Pharma, Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF GLAUCOMA AND RELATED DISEASES
CA3116589A1 (en) 2018-10-26 2020-04-30 Ocuphire Pharma, Inc. Methods and compositions for treatment of presbyopia, mydriasis, and other ocular disorders
JP7766680B2 (ja) * 2020-09-11 2025-11-10 イントラタス－ネバダ インコーポレイテッド 老視、遠視、乱視、低減した立体視、および低下したコントラスト感度を治療するための組成物および方法
AU2022212108A1 (en) * 2021-01-28 2023-08-17 Glaukos Corporation Formulations
WO2022232205A1 (en) * 2021-04-28 2022-11-03 Lenz Therapeutics, Inc. A method of reducing brow ache
CN115368310B (zh) 2021-05-18 2025-06-27 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法
US12180206B2 (en) 2021-11-17 2024-12-31 Lenz Therapeutics Operations, Inc. Aceclidine derivatives, compositions thereof and methods of use thereof
WO2023125544A1 (zh) 2021-12-28 2023-07-06 沈阳兴齐眼药股份有限公司 组合物及其在制备用于治疗老花眼的药物中的用途
US20230270671A1 (en) * 2022-01-14 2023-08-31 Somerset Therapeutics, Llc Pharmaceutically stable pilocarpine formulations with substantially reduced buffer content and related methods
US11969410B2 (en) 2022-02-09 2024-04-30 Somerset Therapeutics, Llc Low pH pilocarpine and brimonidine compound formulations and related methods
AU2023257375A1 (en) 2022-04-21 2024-11-07 Glaukos Corporation Ophthalmic topical cream compositions
EP4525826A1 (en) 2022-05-18 2025-03-26 Glaukos Corporation Novel applications of zwitterions in ophthalmic topical cream compositions and preparations
CN117243888A (zh) * 2023-09-22 2023-12-19 南京海纳制药有限公司 一种含有盐酸毛果芸香碱滴眼水性药物组合物及其制备方法
US12414942B1 (en) 2024-03-15 2025-09-16 Lenz Therapeutics Operations, Inc. Compositions, methods, and systems for treating presbyopia

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US4851521A (en) 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
CA2003198C (en) 1988-11-29 1995-03-21 Anthony J. Dziabo, Jr. Aqueous ophthalmic solutions and method for preserving same
US5122522A (en) 1989-06-21 1992-06-16 The Trustees Of The University Of Pennsylvania Treatment and control of ocular development
US5055467A (en) 1989-11-13 1991-10-08 Allergan, Inc. Pharmaceutical epinephrine-pilocarpine compounds
US5496471A (en) 1990-01-08 1996-03-05 Ciba-Geigy Corporation Apparatus for removing components from solutions
US5776916A (en) 1990-07-10 1998-07-07 Gramer; Eugen Medicament for reducing the intraocular pressure
JP2536806B2 (ja) 1991-03-27 1996-09-25 アルコン ラボラトリーズ インコーポレイテッド ゲル化多糖類と微粉砕された薬剤担体とを組み合わせた局部眼科用組成物
US5459133A (en) 1992-06-05 1995-10-17 Telor Ophthalmic Pharmaceuticals, Inc. Methods and products for treating presbyopia
AU4653993A (en) 1992-07-02 1994-01-31 Telor Ophthalmic Pharmaceuticals, Inc. Methods and products for treating presbyopia
SE512871C2 (sv) 1992-08-20 2000-05-29 Santen Oy Oftalmologisk beredning innehållande pilokarpin och ytterligare medel för behandling av okular hypertension
WO1994010976A1 (en) * 1992-11-16 1994-05-26 Ciba Vision Ag, Hettlingen Polyvinyl alcohol/borate ophthalmic drug delivery system
US5422116A (en) 1994-02-18 1995-06-06 Ciba-Geigy Corporation Liquid ophthalmic sustained release delivery system
SE9401109D0 (sv) 1994-03-31 1994-03-31 Leiras Oy Opthalmic composition II
US5574518A (en) 1995-01-10 1996-11-12 Les Laboratoires Opti-Centre Inc. System incorporation two different sphero-non-spherical contact lenses for correcting presbytia
US5612027A (en) 1995-04-18 1997-03-18 Galin; Miles A. Controlled release of miotic and mydriatic drugs in the anterior chamber
US6291466B1 (en) * 1998-07-30 2001-09-18 Allergan Sales, Inc. Cholinergic agents in the treatment of presbyopia
US6164282A (en) 1999-01-27 2000-12-26 Allergan Sales, Inc. Methods for restoring and/or enhancing accommodation in pseudo phakia
CH693625A5 (it) 1999-02-18 2003-11-28 Inpharma Sa Composizioni farmaceutiche contenenti composti ad attività promotrice di assorbimento di principi attivi.
IT1306135B1 (it) * 1999-04-26 2001-05-30 Farmigea Spa Composizioni oftalmiche per il trattamento delle turbe visivecaratterizzate da ridotta sensibilita' al contrasto.
EP1214065A4 (en) 1999-09-16 2009-01-07 Ocularis Pharma Inc METHOD USING THE ALPHA AGONIST TO OPTIMIZE THE SIZE OF THE PUPIL
US6420407B1 (en) 1999-09-16 2002-07-16 Gerald Horn Ophthalmic formulation which modulates dilation
TWI227143B (en) 1999-12-15 2005-02-01 Guo-Jiun Sung In situ gel formation for ophthalmic delivery by combining Pluronic/Carbopol medic composition and its preparing method
US6218428B1 (en) 2000-04-28 2001-04-17 Emil Chynn Ophthalmic composition
PE20020146A1 (es) 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
US6572849B2 (en) 2000-09-20 2003-06-03 Lee Shahinian, Jr. Self-preserved antibacterial nasal, inhalable, and topical ophthalmic preparations and medications
US6273092B1 (en) 2000-09-22 2001-08-14 Gerard M. Nolan Methods for treating various eye disorders
ITMI20010708A1 (it) 2001-04-03 2002-10-03 Alessandro Randazzo Trattamento farmacologico degli aloni notturni e delle immagini fantasma con parasimpaticomimetici diluiti aceclidina/pilocarpina dopo inter
US20030139737A1 (en) 2002-01-24 2003-07-24 J.T. Lin Method and apparatus for treatment of presbyopia by lens relaxation and anterior shift
PT1534313E (pt) 2002-07-30 2013-01-25 Omeros Corp Soluções e método de irrigação oftalmológica
US20050261641A1 (en) 2002-09-26 2005-11-24 Warchol Mark P Method for ophthalmic administration of medicament
US20070211212A1 (en) 2002-09-26 2007-09-13 Percy Bennwik Eye state sensor
US20050205101A1 (en) * 2002-10-17 2005-09-22 Lin J T Combined pharmocological and surgical method and system for the treatment of eye disorders
US20040078009A1 (en) 2002-10-17 2004-04-22 Lin J. T. Method and apparatus for the treatment of presbyopia and other eye disorders combining pharmocological and surgical means
NZ540885A (en) 2002-12-20 2009-02-28 Chakshu Res Inc Ophthalmic formulation for the prevention and treatment of ocular conditions
US20060177430A1 (en) 2002-12-20 2006-08-10 Chakshu Research Inc Treatment of ocular disorders with ophthalmic formulations containing methylsulfonylmethane as a transport enhancer
ES2532399T3 (es) 2003-03-05 2015-03-26 Halozyme, Inc. Glicoproteína hialuronidasa soluble (sHASEGP), proceso para prepararla, usos y composiciones farmacéuticas que la comprenden
US20050119262A1 (en) 2003-08-21 2005-06-02 Pharmacia Corporation Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
PL1754491T3 (pl) 2004-05-21 2010-08-31 Senju Pharma Co Preparat do oczu do wchłaniania przezskórnego zawierający agonistę receptora muskarynowego
US20050279369A1 (en) 2004-06-21 2005-12-22 Lin J T Method and apparatus for the treatment of presbyopia and glaucoma by ciliary body ablation
EP1827330A1 (en) 2004-10-22 2007-09-05 Acufocus System and method for aligning an optic with an axis of an eye
ES2365161T3 (es) 2005-09-02 2011-09-23 Theravida, Inc. Terapia para el tratamiento de la vejiga hiperactiva.
US8158152B2 (en) 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
PT2038252T (pt) 2006-07-12 2016-12-16 Univ Tennessee Res Found Acilanilidos substituidos e métodos de utilização dos mesmos
ES2329161T3 (es) 2006-12-18 2009-11-23 Jorge Luis Benozzi Composiciones oftalmicas de estimulantes parasimpaticos y antiinflamatorios para su uso en el tratamiento de la presbicia.
NZ584275A (en) 2007-10-08 2012-06-29 Fovea Pharmaceuticals Aqueous cyclosporine ophthalmic formulations
AU2015202175A1 (en) 2007-12-15 2015-05-14 Anant Sharma Optical correction
GB0724558D0 (en) 2007-12-15 2008-01-30 Sharma Anant Optical correction
WO2010125416A1 (en) 2009-04-27 2010-11-04 Raouf Rekik Drug delivery to the anterior and posterior segments of the eye
WO2010135731A1 (en) 2009-05-22 2010-11-25 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
US8299079B2 (en) 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
TW201109325A (en) 2009-07-30 2011-03-16 Wakamoto Pharma Co Ltd Aqueous composition for eye drops
AR081049A1 (es) 2010-08-17 2012-06-06 Gonzalez Santos Alejandro Raul Medicamento oftalmico para el tratamiento de la hipermetropia
UA114705C2 (uk) * 2011-01-26 2017-07-25 Аллерган, Інк. Андрогенна композиція для лікування офтальмологічного захворювання
MX357635B (es) 2011-09-20 2018-07-17 Allergan Inc Composiciones y metodos para el tratamiento de presbicia, hipermetropia leve, y astigmatismo irregular.
US20150010634A1 (en) 2011-10-12 2015-01-08 Ascendis Pharma Ophthamology Division A/S Prevention and treatment of ocular conditions
KR20140103168A (ko) 2011-12-16 2014-08-25 알러간, 인코포레이티드 폴리비닐 카프라락탐-폴리비닐 아세테이트-폴리에틸렌 글리콜 그라프트 코폴리머를 포함하는 안과 조성물
EP2630952A1 (en) 2012-02-23 2013-08-28 Novagali Pharma S.A. Self-preserved oil dispersions comprising boric acid
US10507245B2 (en) 2012-07-19 2019-12-17 Luis Felipe Vejarano Restrepo Ophthalmic formulation and method for ameliorating presbyopia
DK2950648T3 (da) 2013-02-01 2019-12-02 Ocuphire Pharma Inc Vandige oftalmiske opløsninger af phentolamin og medicinske anvendelser deraf
AU2014212275B2 (en) 2013-02-01 2018-09-06 Ocuphire Pharma, Inc. Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance
US9314427B2 (en) 2013-08-28 2016-04-19 Presbyopia Therapies Llc Compositions and methods for the improvement of distance vision and the treatment of refractive errors of the eye
US9968594B2 (en) 2013-08-28 2018-05-15 Presbyopia Therapies Llc Compositions and methods for the treatment of presbyopia
US9089562B2 (en) 2013-08-28 2015-07-28 Presbyopia Therapies Llc Compositions and methods for the treatment of presbyopia
US8859623B1 (en) 2013-11-14 2014-10-14 Paragon BioTeck, Inc. Methods and compositions of stable phenylephrine formulations
ES2538551B1 (es) * 2013-12-20 2016-01-13 Eurocanarias Oftalmológica, Sl Composición Oftálmica para la corrección de la presbicia
GEP20186917B (en) * 2014-01-10 2018-11-12 Pharmaceutical Co Ltd Santen Pharmaceutical preparation including pyridylamino acetic acid compound
CN106456584A (zh) 2014-02-11 2017-02-22 阿拉西斯医药公司 用于矫正老视的药理学眼科用组合物和其施用
HK1248570A1 (zh) 2015-05-29 2018-10-19 西德奈克西斯公司 D2o稳定化的药物制剂
US20190000808A1 (en) 2015-07-13 2019-01-03 Allergan, Inc. Composition and methods for the treatment of blephopharoptosis
CH711969A2 (it) 2015-12-29 2017-06-30 Pinelli Roberto Composizione per il trattamento della presbiopia.
US10231968B2 (en) 2016-08-01 2019-03-19 David R. Hardten Medicinal solution to be continuously or pulse-delivered to the eye for treating ophthalmological conditions/maladies
AU2017311636B2 (en) 2016-08-19 2023-08-10 Orasis Pharmaceuticals Ltd. Ophthalmic pharmaceutical compositions and uses relating thereto
CN110114119B (zh) 2016-10-12 2022-05-31 Ps治疗有限公司 人工泪液、隐形眼镜和药物载体组合物及其使用方法

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RS63360B1 (sr) 2022-07-29
AU2019261598B2 (en) 2020-05-14
WO2019209955A2 (en) 2019-10-31
CY1125325T1 (el) 2025-03-28
JP7470667B2 (ja) 2024-04-18
US10610518B2 (en) 2020-04-07
JP2021522256A (ja) 2021-08-30
PL3681500T3 (pl) 2022-08-01
SG11202010472XA (en) 2020-11-27
MX2020011301A (es) 2021-01-29
ES2920803T5 (en) 2025-11-11
JP2024096131A (ja) 2024-07-12
US20190321337A1 (en) 2019-10-24
PH12020551766A1 (en) 2021-07-12
EP4066830A1 (en) 2022-10-05
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