JP6901479B2 - Cxcr2の阻害剤 - Google Patents
Cxcr2の阻害剤 Download PDFInfo
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- JP6901479B2 JP6901479B2 JP2018526187A JP2018526187A JP6901479B2 JP 6901479 B2 JP6901479 B2 JP 6901479B2 JP 2018526187 A JP2018526187 A JP 2018526187A JP 2018526187 A JP2018526187 A JP 2018526187A JP 6901479 B2 JP6901479 B2 JP 6901479B2
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Description
連邦政府の支援による研究及び開発によりなされた発明の権利に関する声明
コンパクトディスクにより提出された「配列リスト」、表、又はコンピュータプログラムのリストなどの参照
又はその任意の塩、溶媒和物、水和物、N−オキシド、互変異性体、若しくは回転異性体が提供される。
本発明は、式Iの化合物が、CXCR2受容体の強力かつ選択的なアンタゴニストとして作用するという発見に由来する。これらの化合物はインビボの抗炎症活性を有し、優れた薬物動態特性を有する。従って本明細書で提供される化合物は、CXCR2媒介疾患の治療のための医薬組成物として、方法として、及び競合的CXCR2アンタゴニストの同定のためのアッセイにおける対照として有用である。
「アルキル」という用語は、それ自体又は他の置換基の一部として、特に別の指定がなければ、指定された炭素原子数(すなわち、C1-8は1〜8個の炭素を意味する)を有する直鎖又は分枝鎖炭化水素基を意味する。アルキル基の例には、メチル、エチル、n−プロピル、イソプロピル、n−ブチル、t−ブチル、イソブチル、sec−ブチル、n−ペンチル、n−ヘキシル、n−ヘプチル、n−オクチルなどが含まれる。「アルケニル」という用語は、1つ以上の二重結合を有する不飽和アルキル基を指す。同様に「アルキニル」という用語は、1つ以上の三重結合を有する不飽和アルキル基を指す。このような不飽和アルキル基の例には、ビニル、2−プロペニル、クロチル、2−イソペンテニル、2−(ブタジエニル)、2,4−ペンタジエニル、3−(1,4−ペンタジエニル)、エチニル、1−及び3−プロピニル、3−ブチニル、及びより高次の同族体及び異性体が含まれる。「シクロアルキル」という用語はまた、示された数の環原子を有し(例えば、C3-6シクロアルキル)、完全に飽和しているか、又は環の頂点間に1個以下の二重結合を有する炭化水素環を指す。「シクロアルキル」はまた、例えばビシクロ[2.2.1]ヘプタン、ビシクロ[2.2.2]オクタンなどの二環式及び多環式炭化水素環も指す。用語「シクロアルケニル」は、環頂点間に少なくとも1つの二重結合を有するシクロアルキル基を指す。シクロアルケニルの例は、シクロペンテニル及びシクロヘキセニルである。「スピロシクロアルキル」という用語は、単一の環頂点が、分子の2つの他の非水素部分に結合しているシクロアルキル基を指す。スピロシクロアルキル置換基は、アルキレン鎖(典型的にはアルキレン鎖の末端)の2つの炭素原子が、分子の残りの部分の同じ炭素原子に結合しているものである。「ヘテロシクロアルキル」という用語は、N、O、及びSから選択される1〜5個のヘテロ原子シクロアルキル環を指し、ここで窒素及び硫黄原子は場合により酸化され、窒素原子は場合により四級化される。ヘテロシクロアルキルは、単環式、二環式、又は多環式環系であってもよい。ヘテロシクロアルキル基の非限定的な例には、ピロリジン、イミダゾリジン、ピラゾリジン、ブチロラクタム、バレロラクタム、イミダゾリジノン、ヒダントイン、ジオキソラン、フタルイミド、ピペリジン、1,4−ジオキサン、モルホリン、チオモルホリン、チオモルホリン−S−オキシド、チオモルホリン−S、S−オキシド、ピペラジン、ピラン、ピリドン、3−ピロリン、チオピラン、ピロン、テトラヒドロフラン、テトラヒドロチオフェン、キヌクリジンなどが挙げられる。ヘテロシクロアルキル基は、環炭素又はヘテロ原子を介して、分子の残りに結合することができる。
又は、その任意の塩、溶媒和物、水和物、N−オキシド、互変異性体、又は回転異性体が提供される。
又はその任意の塩、溶媒和物、水和物、N−オキシド、若しくは回転異性体が提供される。
又はその任意の塩、溶媒和物、水和物、N−オキシド、若しくは回転異性体が提供される。
本発明の特定の化合物は、本明細書の実施例の項に記載されている方法に従って調製することができる。さらに、本発明の化合物の調製に有用な特定の中間体化合物の合成も記載される。
上記で提供される化合物に加えて、ヒト及び動物におけるCXCR2活性を調節するための組成物は、典型的には、薬学的担体又は希釈剤を含有する。
本開示の化合物を含む医薬組成物が提供される。いくつかの実施態様において、医薬組成物は、1つ以上の追加の治療薬をさらに含む。いくつかの実施態様において、1種以上の追加の治療薬は、細胞傷害性化学療法、抗癌又は抗腫瘍ワクチン、抗免疫サイトカイン療法、免疫サイトカイン療法、キメラ抗原受容体(CAR)T細胞受容体、遺伝子導入療法、及びチェックポイント阻害剤からなる群から選択される。いくつかの実施態様において、1種以上の追加の治療薬は、CTLA−4(CD152)、PD−1(CD279)、PDL−1(CD274)、TIM−3、LAG−3(CD223)、VISTA、KIR、NKG2A、BTLA、PD−1H、TIGIT、CD96,4−1BB(CD137)、4−1BBL(CD137L)、GARP、CSF−1R、A2AR、CD73、CD47、トリプトファン2,3ジオキシゲナーゼ(IDO)、又はインドールアミン2,3−ジオキシゲナーゼ(IDO)の活性を阻止する薬剤、及びOX40、GITR、4−1BB、ICOS、STING、又はCD40のアゴニストからなる群から選択される。
特定の理論に拘束されることを望まないが、本明細書で提供される化合物及び組成物は、CXCR2受容体を阻害することによって治療効果を提供すると考えられる。従って、本明細書で提供される化合物及び組成物は、CXCR2受容体の阻害が治療効果を提供する哺乳動物の疾患又は障害の治療又は予防に使用することができる。
より具体的には本発明はまた、癌を治療する方法を提供する。癌を治療するための好適な方法は、癌を治療するのに十分な時間、癌患者に治療上有効な量の1種以上の前記化合物(又はその塩)を投与することを含む。
さらに、本明細書で提供される化合物及び組成物は、炎症の治療に有用であり、本化合物を用いる癌又は炎症の治療の前、後、又は同時に、治療を必要とし得る治療有用性を有する他の化合物及び組成物と組み合わせることができる。従って、併用法及び組成物はまた、目的の症状又は疾患、例えば炎症性又は自己免疫障害、症状、及び疾患(炎症性腸疾患、関節リウマチ、変形性関節症、乾癬性関節炎、多関節性関節炎、多発性硬化症、アレルギー性疾患、乾癬、アトピー性皮膚炎、及び喘息、ならびに上記の病状を含む)などを予防及び治療するための本発明の成分でもある。
さらに、本明細書で提供される化合物及び組成物は、CXCR2に関連する疾患及び障害の診断に有用である。特に本明細書で提供される化合物は、標識された形態(例えば放射性標識)で調製することができ、例えば癌の診断のために使用することができる。CXCR2に結合する本明細書で提供される標識化合物(例えばアンタゴニスト又はアゴニスト)を使用して、哺乳動物被験体におけるCXCR2のレベルを決定することができる。いくつかの実施態様において、CXCR2モジュレーター又はアンタゴニストは、癌を有する被験体に投与される。場合によっては標識化合物は、進行中の癌、例えば癌腫、神経膠腫、中皮腫、黒色腫、リンパ腫、白血病、腺癌、乳癌、卵巣癌、子宮頸癌、神経膠芽腫、白血病、リンパ腫、前立腺癌、バーキットリンパ腫、頭頸部癌、大腸癌、結腸直腸癌、非小細胞肺癌、小細胞肺癌、食道癌、胃癌、膵臓癌、肝胆道癌、胆嚢癌、小腸癌、直腸癌、腎臓癌、膀胱癌、前立腺癌、陰茎癌、尿道癌、精巣癌、子宮頸癌、膣癌、子宮癌、卵巣癌、甲状腺癌、副甲状腺癌、副腎癌、膵内分泌癌、カルチノイド癌、骨癌、皮膚癌、網膜芽細胞腫、ホジキンリンパ腫、非ホジキンリンパ腫(さらなる癌については、CANCER:PRINCIPLES AND PRACTICE (DeVita, V.T. et al. eds 1997)を参照のこと)、ならびに脳及びニューロンの機能不全、例えばアルツハイマー病及び多発性硬化症;腎機能障害;関節リウマチ;心臓同種移植片拒絶反応;アテローム性動脈硬化症(及び上昇したコレステロールレベル);喘息;糸球体腎炎;接触性皮膚炎;炎症性腸疾患;大腸炎;乾癬;再灌流傷害;ならびに本明細書に記載の他の障害及び疾患を、検出するために投与される。いくつかの実施態様において、被験体は、カポジ肉腫、多中心性キャッスルマン病、又はAIDS関連原発性滲出性リンパ腫を有しない。
(a)そのような画像化を必要とする被験体に、放射性標識形態又は検出可能な形態の式Iの化合物を投与する工程;そして
(b)前記化合物を検出して、前記化合物が前記被検体中のどこに濃縮されているかを測定する工程、を含む。
(a)CXCR2のレベル上昇が疑われる試料に、放射性標識形態又は検出可能な形態の式Iの化合物を接触させる工程;
(b)前記試料中に存在するCXCR2に結合した化合物のレベルを測定して、前記試料中に存在するCXCR2のレベルを決定する工程;そして
(c)工程(b)で測定されたレベルを対照試料と比較して、CXCR2のレベル上昇が前記試料中に存在するかどうかを決定する工程、を含む。
CXCR2の阻害剤は、単独で、又は1つ以上の他の薬物と一緒に供給することができる。可能性のある組み合わせパートナーは、例えば、追加の抗血管新生因子、及び/又は化学療法剤(例えば細胞傷害剤)、又は放射線、癌ワクチン、免疫調節剤、チェックポイント阻害剤、抗血管剤、シグナル伝達阻害剤、抗増殖剤、又はアポトーシス誘導剤である。
ロチド、フィマサルタン、アゼリラゴン、ピリドキサミン、コルチコトロピン、INT−767、エパルレスタット、トピロスタット、SER−150−DN、ピルフェニドン、VEGFR−1 mAb、AKB−9778、PF−489791、SHP−627、CS−3150、イミダプリル、ペリンドプリル、カプトプリル、エナラプリル、リシノプリル、ゾフェノプリル、リシノプリル、キナプリル、ベナゼプリル、トランドラプリル、シラザプリル、フォシノプリル、ラミプリル、バルドキソロンメチル、イルベサルタン+プロパゲマニウム、GKT−831、MT−3995、TAK−648、TAK−272、GS−4997、DW−1029M、ASP−8232、VPI−2690B、DM−199、レイン、PHN−033、GLY−230、及びサプロプテリン、スロデキシド、リリルマブ、IPH−4102、IPH−2101、IMP−321、BMS−986016、MGD−013、LAG−525、ヅルバルマブ、モナリズマブ、MCLA−134、MBG−453、CA−170、AUPM−170、AUPM−327、レスミノスタット、イピリムマブ、BGB−A317、トレメリムマブ、REGN−2810、AZD−5069、マシチニブ、ビニメチニブ、トラメチニブ、ルキソリチニブ、ダブラフェニブ、リナクロチド、イピリムマブ、アパチニブ、ニンテダニブ、カボザンチニブ、パゾパニブ、ベリノスタット、パニツムマブ、グアデシタビン、ビスモードジブ、ベムラフェニブ、ダサチニブ、トレメリムマブ、ベバシズマブ、オキサリプラチン、アフリベルセプト、バンデタニブ、エベロリムス、サリドマイド、ベリパリブ、エンコラフェニブ、ナパブカシン、アルペリジブ、アキチニブ、セジラニブ、ネチツムマブ、ラムシルマブ、イロフルベン、トリフルリジン+チピラシル、ドナフェニブ、パクリチニブ、ペキサスチモジン、デパシレプベク、チバンチニブ、GNR−011、タラポルフィン、ピクリデノソン、デシタビン、ガニトマブ、パノビノスタット、リンタトリモド、ポルマコキシブ、レボフォリネート、ファミチニブ、ボツムマブ、チボザニブ、エンチノスタット、プリチデプシン、レフィトリモド、OSE−2101、ビテスペン、TroVax、ブロモクリプチン、ミドスタウイン、フォスブレブリン、フルキンチニブ、ガネテスピブ、ブリバニブ、アンロチニブ、L19−TNF−アルファ、ラコツモマブ、ノバフェロン、ラルチトレキセド、エンザスタウリン、GM−CT−01、アルシツモマブ、又はそれらの任意の組み合わせが挙げられる。
用語「キット」及び「医薬キット」は、1つ以上の適切な容器に、1つ以上の医薬組成物、及びそれらの使用説明書を含む市販のキット又はパッケージを指す。1つの実施態様において、式(I)の化合物又はその医薬的に許容し得る塩、及び投与のための説明書を含むキットが提供される。1つの実施態様において、式(I)の化合物又はその医薬的に許容し得る塩を、1つ以上の(例えば、1、2、3、1又は2、又は1〜3の)追加の治療薬及び投与のための説明書と一緒に含むキットが提供される。
本実施態様はまた、本発明の化合物又はその医薬的に許容し得る塩の調製に有用なプロセス及び中間体に関する。
スキーム1
rt、室温;HPLC、高圧液体クロマトグラフィー;TFA、トリフルオロ酢酸;LC−MSD、液体クロマトグラフ/質量選択的検出器;LC−MS、液体クロマトグラフ/質量分析計;Pd2(dba)3、トリス(ジベンジリデンアセトン)ジパラジウム;THF、テトラヒドロフラン;DMF、ジメチルホルムアミド又はN,N−ジメチルホルムアミド;DCM、ジクロロメタン;DMSO、ジメチルスルホキシド;TLC、薄層クロマトグラフィー;KHMDS、カリウムヘキサメチルジシラザン;ES、電子噴霧;sat、飽和。
実施例1
実施例2
実施例3
実施例4
実施例5
実施例6
実施例7
実施例8
実施例9
実施例10
CXCR2活性のリガンド結合アッセイ
生物学的実施例2
CXCR2活性の遊走/走化性アッセイ
Claims (32)
- 式(I)を有する化合物:
R1及びR2は、それぞれH、ハロゲン、CN、C1-4アルキル、C1-4アルコキシ、及びC1-4ハロアルキルからなる群から独立して選択されるメンバーであり;
R3aは、メチル、エチル、プロピル、イソプロピル、トリフルオロメチル、CH2CF3、及びCF2CF3からなる群から選択されるメンバーであり;
R3bは、H及びDからなる群から選択されるメンバーであり;
R4は、H、C1-8アルキル、−Y、及びC1-4アルキレン−Yからなる群から選択されるメンバーであり;ここでYは、アリール又はヘテロアリールであり、各R4は、ハロゲン、−CN、−CO2Ra、−CONRaRb、−C(O)Ra、−OC(O)NRaRb、−NRaC(O)Rb、−NRaC(O)2Rc、−NRaC(O)NRaRb、−NRaRb、−ORa、−S(O)2NRaRb、−NRaS(O)2Rb、及び−Rcからなる群から選択される1〜4個の置換基で場合により置換され、ここで各Ra及びRbは、水素、C1-4アルキル、C1-4ヒドロキシアルキル、及びC1-4ハロアルキルから独立して選択され;Rcは、C1-4アルキル、C1-4ヒドロキシアルキル、及びC1-4ハロアルキルから選択され;
R5a及びR5bは、それぞれ、H、ハロゲン、C1-4アルキル、C1-4アルコキシ、及びCNからなる群から独立して選択されるメンバーであり;
R6a及びR6bは、それぞれ、H、C1-4アルキル、C1-4ヒドロキシアルキル、及びC1-4ハロアルキルからなる群から独立して選択されるメンバーであり;又は場合によりR6a及びR6bは一緒になってオキソ(=O)を形成し;
XはCH又はNである]、
又はその任意の塩、溶媒和物、水和物、N−オキシド、互変異性体、若しくは回転異性体。 - R3aがエチル又はイソプロピルである、請求項1に記載の化合物、又はその医薬的に許容し得る塩。
- R3bがHである、請求項1又は2に記載の化合物、又はその医薬的に許容し得る塩。
- R3bがDである、請求項1又は2に記載の化合物、又はその医薬的に許容し得る塩。
- R1がメチルである、請求項1〜4のいずれか1項に記載の化合物、又はその医薬的に許容し得る塩。
- XがCHである、請求項1〜5のいずれか1項に記載の化合物、又はその医薬的に許容し得る塩。
- XがNである、請求項1〜5のいずれか1項に記載の化合物、又はその医薬的に許容し得る塩。
- R5a及びR5bのそれぞれが、H、Cl、及びFからなる群から独立して選択される、請求項1〜7のいずれか1項に記載の化合物、又はその医薬的に許容し得る塩。
- R6a及びR6bのそれぞれが、H及びC1-4アルキルからなる群から独立して選択される、請求項1〜8のいずれか1項に記載の化合物、又はその医薬的に許容し得る塩。
- R4が、−ハロゲン、−CN、−CO2Ra、−CONRaRb、−C(O)Ra、−OC(O)NRaRb、−NRaC(O)Rb、−NRaC(O)2Rc、−NRaC(O)NRaRb、−NRaRb、−ORa、−S(O)2NRaRb、及び−NRaS(O)2Rbで場合により置換されたC1-8アルキルである、請求項1〜9のいずれか1項に記載の化合物、又はその医薬的に許容し得る塩。
- 式(Ia)を有する請求項1に記載の化合物:
R1は、Cl及びCH3からなる群から選択され;
R3bは、H及びDからなる群から選択され;
R4は、H及びC1-8アルキルからなる群から選択されるメンバーであり、ここでC1-8アルキルは、−CONRaRb、−OC(O)NRaRb、−NRaC(O)Rb、−NRaC(O)2Rc、−NRaRb、及び−ORaで場合により置換され、ここで各Ra及びRbは、水素、C1-4アルキル、C1-4ヒドロキシアルキル、及びC1-4ハロアルキルから独立して選択され、Rcは、C1-4アルキル、C1-4ヒドロキシアルキル、及びC1-4ハロアルキルから選択され;
R5a及びR5bは、それぞれ、H、F、Cl、及びCH3からなる群から独立して選択されるメンバーであり;
R6a及びR6bは、それぞれ、H、C1-4アルキル、C1-4ヒドロキシアルキル、及びC1-4ハロアルキルからなる群から独立して選択されるメンバーであり;又は場合によりR6a及びR6bは一緒になってオキソ(=O)を形成する]、
又はその任意の塩、溶媒和物、水和物、N−オキシド、若しくは回転異性体。 - R3bがHであり;R4がH又はCH3であり;R5aがH、F、又はClであり;R5bがH、F、Clであり;R6a及びR6bが、H及びCH3からなる群から独立して選択されるか、又は一緒になってオキソ(=O)を形成する、請求項11に記載の化合物、又はその医薬的に許容し得る塩。
- R3bがDであり;R4がH又はCH3であり;R5aがH、F、又はClであり;R5bがH、F、Clであり;R6a及びR6bが、H及びCH3からなる群から独立して選択されるか、又は一緒になってオキソ(=O)を形成する、請求項11に記載の化合物、又はその医薬的に許容し得る塩。
- 式(1b)を有する請求項1に記載の化合物:
R1は、Cl及びCH3からなる群から選択され;
R3bは、H及びDからなる群から選択され;
R4は、H及びC1-8アルキルからなる群から選択されるメンバーであり、ここでC1-8アルキルは、−CONRaRb、−OC(O)NRaRb、−NRaC(O)Rb、−NRaC(O)2Rc、−NRaRb、及び−ORaで場合により置換され、ここで各Ra及びRbは、水素、C1-4アルキル、C1-4ヒドロキシアルキル、及びC1-4ハロアルキルから独立して選択され、Rcは、C1-4アルキル、C1-4ヒドロキシアルキル、及びC1-4ハロアルキルから選択され;
R5a及びR5bは、それぞれ、H、F、Cl、及びCH3からなる群から独立して選択されるメンバーであり;
R6a及びR6bは、それぞれ、H、C1-4アルキル、C1-4ヒドロキシアルキル、及びC1-4ハロアルキルからなる群から独立して選択されるメンバーであり;又は場合によりR6a及びR6bは一緒になってオキソ(=O)を形成する]、
又はその任意の塩、溶媒和物、水和物、N−オキシド、若しくは回転異性体。 - R3bがHであり;R4がH又はCH3であり;R5aがH、F、又はClであり;R5bがH、F、Clであり;R6a及びR6bが、H及びCH3からなる群から独立して選択されるか、又は一緒になってオキソ(=O)を形成する、請求項14に記載の化合物、又はその医薬的に許容し得る塩。
- R3bがDであり;R4がH又はCH3であり;R5aがH、F、又はClであり;R5bがH、F、Clであり;R6a及びR6bが、H及びCH3からなる群から独立して選択されるか、又は一緒になってオキソ(=O)を形成する、請求項14に記載の化合物、又はその医薬的に許容し得る塩。
- 請求項1〜20のいずれか1項に記載の化合物を含む医薬組成物。
- 1種以上の追加の治療薬をさらに含む、請求項21に記載の医薬組成物。
- 前記1種以上の追加の治療薬が、細胞傷害性化学療法、抗癌若しくは抗腫瘍ワクチン、抗免疫サイトカイン療法、免疫サイトカイン療法、キメラ抗原受容体(CAR)T細胞受容体、遺伝子導入療法、及びチェックポイント阻害剤からなる群から選択される、請求項22に記載の医薬組成物。
- 前記1種以上の追加の治療薬が、CTLA−4(CD152)、PD−1(CD279)、PDL−1(CD274)、TIM−3、LAG−3(CD223)、VISTA、KIR、NKG2A、BTLA、PD−1H、TIGIT、CD96,4−1BB(CD137)、4−1BBL(CD137L)、GARP、CSF−1R、A2AR、CD73、CD47、トリプトファン2,3−ジオキシゲナーゼ(TDO)、又はインドールアミン2,3ジオキシゲナーゼ(IDO)の活性をブロックする薬剤、及びOX40、GITR、4−1BB、ICOS、STING、又はCD40のアゴニストからなる群から選択される、請求項22に記載の医薬組成物。
- 治療を必要とする被験体のCXCR2媒介疾患若しくは症状を治療する医薬組成物であって、請求項1〜20のいずれか1項に記載の化合物又はその医薬的に許容し得る塩の有効量を含む、上記医薬組成物。
- CXCR2媒介疾患は急性又は慢性の炎症性障害である、請求項25に記載の医薬組成物。
- 前記CXCR2媒介性の急性又は慢性の炎症性障害が、乾癬、関節リウマチ、放射線誘発線維性肺疾患、自己免疫性水疱性皮膚症(AIBD)、慢性閉塞性肺疾患、及びオゾン誘発性気道炎症からなる群から選択される、請求項26に記載の医薬組成物。
- 前記CXCR2媒介疾患が、横紋筋肉腫、ルイス肺癌(LLC)、非小細胞肺癌、食道扁平上皮癌、食道腺癌、腎細胞癌(RCC)、結腸直腸癌(CRC)、急性骨髄性白血病(AML)、乳癌、胃癌、前立腺小細胞神経内分泌癌(SCNC)、肝臓癌、神経膠芽腫、肝臓癌、口腔扁平上皮癌、頭頸部扁平上皮癌、膵臓癌、甲状腺乳頭癌、肝内胆管細胞癌、肝細胞癌、骨癌、及び鼻咽頭癌からなる群から選択される癌である、請求項25に記載の医薬組成物。
- 前記化合物又はその医薬的に許容し得る塩が、癌を治療するために、単独で使用されるか、又は1種以上の他の抗癌療法と組合せて使用される、請求項28に記載の医薬組成物。
- 前記化合物又はその医薬的に許容し得る塩が、癌を治療するために、細胞障害性化学療法、抗癌ワクチン、抗腫瘍ワクチン、抗免疫サイトカイン、免疫サイトカイン療法、及びキメラ抗原受容体(CAR)T細胞受容体、遺伝子導入療法の1種以上と組合せて使用される、請求項29に記載の医薬組成物。
- 前記化合物又はその医薬的に許容し得る塩が、癌を治療するために、1種以上のチェックポイント阻害剤と組合せて使用される、請求項29に記載の医薬組成物。
- 前記1種以上の他の抗癌療法が、CTLA−4(CD152)、PD−1(CD279)、PDL−1(CD274)、TIM−3、LAG−3(CD223)、VISTA、KIR、NKG2A、BTLA、PD−1H、TIGIT、CD96,4−1BB(CD137)、4−1BBL(CD137L)、GARP、CSF−1R、A2AR、CD73、CD47、トリプトファン2,3−ジオキシゲナーゼ(TDO)、又はインドールアミン2,3ジオキシゲナーゼ(IDO)の活性をブロックする薬剤、及びOX40、GITR、4−1BB、ICOS、STING、又はCD40のアゴニストからなる群から選択される、請求項29に記載の医薬組成物。
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI734715B (zh) | 2015-11-19 | 2021-08-01 | 美商卡默森屈有限公司 | 趨化因子受體調節劑 |
TWI724056B (zh) | 2015-11-19 | 2021-04-11 | 美商卡默森屈有限公司 | Cxcr2抑制劑 |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
WO2018106945A1 (en) | 2016-12-07 | 2018-06-14 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
WO2018112264A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
WO2018148224A1 (en) | 2017-02-07 | 2018-08-16 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Phospholipid ether (ple) car t cell tumor targeting (ctct) agents |
JP7178355B2 (ja) | 2017-02-28 | 2022-11-25 | エンドサイト・インコーポレイテッド | Car t細胞療法のための組成物および方法 |
US11344578B2 (en) | 2017-04-19 | 2022-05-31 | Board Of Regents, The University Of Texas System | Immune cells expressing engineered antigen receptors |
US11130740B2 (en) | 2017-04-25 | 2021-09-28 | Arbutus Biopharma Corporation | Substituted 2,3-dihydro-1H-indene analogs and methods using same |
RU2020106383A (ru) | 2017-08-14 | 2021-09-16 | Аллерган, Инк. | 3,4-двузамещенные 3-циклобутен-1,2-дионы и их применение |
EP3737366A4 (en) * | 2018-01-08 | 2022-07-27 | ChemoCentryx, Inc. | METHOD OF TREATMENT OF GENERALIZED PUSTULOUS PSORIASIS WITH AN ANTAGONIST OF CCR6 OR CXCR2 |
CN112055595A (zh) | 2018-01-22 | 2020-12-08 | 恩多塞特公司 | Car t细胞的使用方法 |
IL280831B2 (en) * | 2018-08-29 | 2024-05-01 | Chemocentryx Inc | Combination therapy with C-C antagonists such as cytokine receptor 4 (CCR4) and one or more immune checkpoint inhibitors |
EP3852879A1 (en) | 2018-09-21 | 2021-07-28 | Pfizer Inc. | N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamides useful as ccr6 inhibitors |
WO2020106757A1 (en) | 2018-11-19 | 2020-05-28 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
JP2022527835A (ja) * | 2019-04-08 | 2022-06-06 | ピーアイ インダストリーズ リミテッド | 植物病原性真菌を制御または予防するための新規オキサジアゾール化合物 |
JP2022539830A (ja) | 2019-07-10 | 2022-09-13 | ケモセントリックス,インコーポレイティド | Pd-l1阻害剤としてのインダン |
CN112274511B (zh) * | 2019-07-22 | 2024-04-02 | 正大天晴药业集团股份有限公司 | 用于治疗移植物抗宿主病的喹啉衍生物 |
WO2021119482A1 (en) | 2019-12-13 | 2021-06-17 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
CN113018438B (zh) * | 2019-12-24 | 2022-06-17 | 四川大学 | Cxcr2抑制剂在制备治疗鼻咽癌的药物中的用途 |
WO2021143928A1 (zh) * | 2020-01-19 | 2021-07-22 | 正大天晴药业集团股份有限公司 | 用于治疗类风湿性关节炎的喹啉衍生物 |
CN113952453B (zh) * | 2021-10-11 | 2023-01-24 | 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) | Cxcr2抑制剂在制备治疗肿瘤的药物中的应用 |
CN113995839B (zh) * | 2021-10-11 | 2023-03-03 | 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) | Cxcr2抑制剂在改善肿瘤免疫微环境中的应用 |
WO2024144816A1 (en) * | 2022-12-30 | 2024-07-04 | Cantex Pharmaceuticals, Inc. | Treatment of immunologically cold solid tumors |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1268002A (en) | 1917-09-12 | 1918-05-28 | William M Goodwin | Measuring instrument. |
US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
US6166050A (en) | 1998-12-14 | 2000-12-26 | American Home Products Corporation | 3,4-diamino-3-cyclobutene-1,2-dione derivatives which inhibit leukocyte adhesion mediated by VLA-4 |
AR033803A1 (es) | 2000-03-01 | 2004-01-07 | Smithkline Beecham Corp | Compuestos de dianilino escuarano, composiciones farmaceuticas que los comprenden, y el uso de los mismos en la fabricacion de medicamentos para tratar enfermedades mediadas por quimioquinas |
MXPA02011868A (es) | 2000-05-30 | 2003-04-10 | Smithkline Beecham Corp | Antagonistas de receptor de interleucina 8. |
DE60230722D1 (de) | 2001-01-16 | 2009-02-26 | Smithkline Beecham Corp | Il-8-rezeptor-antagonisten |
JP2004521106A (ja) | 2001-01-16 | 2004-07-15 | スミスクライン・ビーチャム・コーポレイション | Il−8受容体アンタゴニスト |
CA2436351A1 (en) | 2001-02-02 | 2002-10-03 | Schering Corporation | 3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine receptor antagonists |
US20030204085A1 (en) | 2001-02-02 | 2003-10-30 | Taveras Arthur G. | 3, 4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor antagonists |
SI1381590T1 (sl) * | 2001-04-16 | 2007-10-31 | Schering Corp | 3,4-disubstituirani ciklobuten-1,2-dioni kot ligandi CXC-kemokinskega receptorja |
US20040106794A1 (en) * | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
US20040097547A1 (en) | 2001-04-16 | 2004-05-20 | Taveras Arthur G. | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
US7132445B2 (en) | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
NZ535314A (en) | 2002-03-18 | 2007-08-31 | Schering Corp | Combination treatments for chemokine-mediated diseases |
CA2522748C (en) | 2003-04-18 | 2011-06-28 | Schering Corporation | Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[1(r)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide |
JP2007519751A (ja) | 2004-01-30 | 2007-07-19 | シェーリング コーポレイション | Cxc−ケモカインレセプターリガンドの結晶多形 |
US7521457B2 (en) * | 2004-08-20 | 2009-04-21 | Boehringer Ingelheim International Gmbh | Pyrimidines as PLK inhibitors |
GB0419481D0 (en) | 2004-09-02 | 2004-10-06 | Cancer Rec Tech Ltd | Isoindolin-1-one derivatives |
DE102005035742A1 (de) | 2005-07-29 | 2007-02-01 | Merck Patent Gmbh | Quadratsäurederivate II |
WO2008005570A1 (en) * | 2006-07-07 | 2008-01-10 | Schering Corporation | 3,4-di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands |
WO2008055570A1 (de) | 2006-11-07 | 2008-05-15 | Thyssenkrupp Drauz Nothelfer Gmbh | Verfahren und anlage zum herstellen von verstärkten blechplatinen |
US20080221093A1 (en) | 2007-03-07 | 2008-09-11 | Christian Gege | Metalloprotease inhibitors containing a heterocyclic moiety |
FR2915147B1 (fr) | 2007-04-17 | 2010-01-15 | Peugeot Citroen Automobiles Sa | Siege pour vehicule automobile convertible en siege enfant dos a la route et vehicule automobile associe. |
CA2689581A1 (en) | 2007-06-06 | 2008-12-11 | Novartis Ag | Anti -inflammatory substituted cyclobutenedione compounds |
EP2178826B1 (en) | 2007-07-03 | 2017-05-17 | Merck Sharp & Dohme Corp. | Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds |
JP2010532357A (ja) | 2007-07-05 | 2010-10-07 | シェーリング コーポレイション | 1,2−置換3,4−ジオキソ−1−シクロブテン化合物における制御された結晶サイズのための方法 |
WO2009012375A2 (en) | 2007-07-19 | 2009-01-22 | Wyeth | Squarate kinase inhibitors |
EP2573080A1 (en) | 2007-09-27 | 2013-03-27 | The United States of America, as Represented by the Secretary, Department of Health and Human Services | Isoindoline compounds for the treatment of spinal muscular atrophy and other uses |
US20110009482A1 (en) | 2007-12-04 | 2011-01-13 | Schering Corporation | Methods of treating copd |
CA2728806A1 (en) | 2008-06-24 | 2009-12-30 | Topotarget A/S | Squaric acid derivatives as inhibitors of the nicotinamide phosphoribosyltransferase |
UA103198C2 (en) | 2008-08-04 | 2013-09-25 | Новартис Аг | Squaramide derivatives as cxcr2 antagonists |
JP2012505898A (ja) | 2008-10-16 | 2012-03-08 | シェーリング コーポレイション | ピロリジン、ピペリジンおよびピペラジン誘導体ならびにそれらの使用方法 |
WO2010063802A1 (en) | 2008-12-05 | 2010-06-10 | Novartis Ag | 3, 4-di-substituted cyclobutene- 1, 2 -diones as cxcr2 receptor antagonists |
WO2010091543A1 (en) * | 2009-02-10 | 2010-08-19 | Merck Sharp & Dohme Corp. | Novel hydrazino-cyclobut-3-ene-1, 2-dione derivatives as cxcr2 antagonists |
WO2010131147A1 (en) | 2009-05-12 | 2010-11-18 | Pfizer Limited | Cyclobutenedione derivatives |
FR2961695B1 (fr) | 2010-06-29 | 2012-07-06 | Galderma Res & Dev | Utilisation de composes dans le traitement ou la prevention de troubles cutanes |
US8648118B2 (en) | 2010-12-17 | 2014-02-11 | Boehringer Ingelheim International Gmbh | Bicyclic ring system substituted amide functionalised phenols as medicaments |
US8648070B2 (en) | 2010-12-17 | 2014-02-11 | Boehringer Ingelheim International Gmbh | Bicyclic ring system substituted sulfonamide functionalised phenols as medicaments |
BR112014004963A2 (pt) | 2011-09-02 | 2017-03-21 | Novartis Ag | sal de colina do composto anti-inflamatório ciclobutanodiona substituído |
FR2981936B1 (fr) | 2011-10-28 | 2013-12-20 | Galderma Res & Dev | Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines. |
FR2981934B1 (fr) * | 2011-10-28 | 2013-12-20 | Galderma Res & Dev | Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines. |
FR2981935B1 (fr) | 2011-10-28 | 2015-08-07 | Galderma Res & Dev | Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines. |
AU2013265266A1 (en) | 2012-05-23 | 2015-01-15 | Stemergie Biotechnology Sa | Inhibitors of the activity of complex (III) of the mitochondrial electron transport chain and use thereof |
WO2015170430A1 (ja) | 2014-05-08 | 2015-11-12 | 学校法人慶應義塾 | 大動脈解離後の炎症性障害抑制剤 |
EP3220951A1 (en) | 2014-11-17 | 2017-09-27 | MedImmune Limited | Therapeutic combinations and methods for treating neoplasia |
TWI724056B (zh) | 2015-11-19 | 2021-04-11 | 美商卡默森屈有限公司 | Cxcr2抑制劑 |
TWI734715B (zh) | 2015-11-19 | 2021-08-01 | 美商卡默森屈有限公司 | 趨化因子受體調節劑 |
EP3737366A4 (en) | 2018-01-08 | 2022-07-27 | ChemoCentryx, Inc. | METHOD OF TREATMENT OF GENERALIZED PUSTULOUS PSORIASIS WITH AN ANTAGONIST OF CCR6 OR CXCR2 |
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