JP6894489B2 - ベラプロスト−３１４ｄ・一水和物結晶及びその製造方法 - Google Patents

ベラプロスト−３１４ｄ・一水和物結晶及びその製造方法 Download PDF

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Publication number
JP6894489B2
JP6894489B2 JP2019212064A JP2019212064A JP6894489B2 JP 6894489 B2 JP6894489 B2 JP 6894489B2 JP 2019212064 A JP2019212064 A JP 2019212064A JP 2019212064 A JP2019212064 A JP 2019212064A JP 6894489 B2 JP6894489 B2 JP 6894489B2
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beraprost
monohydrate
type
solvent
xrpd
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Japanese (ja)
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JP2020083892A5 (enExample
JP2020083892A (ja
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ウェイ，シ−イ
ジェン，ジアン−バン
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Chirogate International Inc
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Chirogate International Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
JP2019212064A 2018-11-26 2019-11-25 ベラプロスト−３１４ｄ・一水和物結晶及びその製造方法 Active JP6894489B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16/199,471 2018-11-26
US16/199,471 US10577341B1 (en) 2018-11-26 2018-11-26 Beraprost-314d monohydrate crystals and methods for preparation thereof

Publications (3)

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JP2020083892A JP2020083892A (ja) 2020-06-04
JP2020083892A5 JP2020083892A5 (enExample) 2021-03-25
JP6894489B2 true JP6894489B2 (ja) 2021-06-30

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JP2019212064A Active JP6894489B2 (ja) 2018-11-26 2019-11-25 ベラプロスト−３１４ｄ・一水和物結晶及びその製造方法

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Country Link
US (1) US10577341B1 (enExample)
EP (1) EP3656767A1 (enExample)
JP (1) JP6894489B2 (enExample)
KR (1) KR102317032B1 (enExample)
CN (1) CN111217782A (enExample)
TW (1) TWI724651B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11447440B2 (en) * 2020-10-29 2022-09-20 Chirogate International Inc. Treprostinil monohydrate crystals and methods for preparation thereof
CN115611838A (zh) * 2021-07-15 2023-01-17 四川国为制药有限公司 一种前列环素衍生物的晶型

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59134787A (ja) * 1983-01-19 1984-08-02 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体の製造法
JP4503942B2 (ja) * 2003-06-11 2010-07-14 大正製薬株式会社 止痒剤
KR101978530B1 (ko) * 2011-06-16 2019-05-14 렁 바이오테크놀로지 피비씨 베라프로스트의 제조 방법
AU2014235346A1 (en) * 2013-03-15 2015-10-08 Gemmus Pharma Inc. Beraprost isomer as agent for the treatment of viral infection
CN103242274B (zh) * 2013-05-22 2014-11-05 孙威 一种贝前列素钠化合物及其制备方法
CA2949528A1 (en) * 2014-05-20 2015-11-26 Lung Biotechnology Pbc Methods for producing beraprost and its derivatives
CA2995364C (en) * 2015-08-12 2019-12-17 United Therapeutics Corporation Process for making beraprost
HU231080B1 (hu) * 2016-04-05 2020-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás optikailag aktív Beraprost előállítására
KR101777632B1 (ko) * 2016-04-11 2017-09-12 연성정밀화학(주) 베라프로스트 나트륨 결정형 및 이의 제조방법

Also Published As

Publication number Publication date
TWI724651B (zh) 2021-04-11
KR20200063070A (ko) 2020-06-04
JP2020083892A (ja) 2020-06-04
KR102317032B1 (ko) 2021-10-26
US10577341B1 (en) 2020-03-03
TW202021960A (zh) 2020-06-16
CN111217782A (zh) 2020-06-02
EP3656767A1 (en) 2020-05-27

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