JP6873917B2 - ヌクレアーゼ介在性遺伝子発現調節 - Google Patents

ヌクレアーゼ介在性遺伝子発現調節 Download PDF

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JP6873917B2
JP6873917B2 JP2017559044A JP2017559044A JP6873917B2 JP 6873917 B2 JP6873917 B2 JP 6873917B2 JP 2017559044 A JP2017559044 A JP 2017559044A JP 2017559044 A JP2017559044 A JP 2017559044A JP 6873917 B2 JP6873917 B2 JP 6873917B2
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JP2018516556A (ja
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アンドレアス レイク，
アンドレアス レイク，
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Sangamo Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C12N9/222—Clustered regularly interspaced short palindromic repeats [CRISPR]-associated [CAS] enzymes
    • C12N9/224—Class 1 CAS enzyme complex, e.g. multi-enzyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

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  • Gastroenterology & Hepatology (AREA)
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  • Biophysics (AREA)
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  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Developmental Biology & Embryology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2017559044A 2015-05-12 2016-05-12 ヌクレアーゼ介在性遺伝子発現調節 Active JP6873917B2 (ja)

Priority Applications (1)

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JP2021071881A JP7365374B2 (ja) 2015-05-12 2021-04-21 ヌクレアーゼ介在性遺伝子発現調節

Applications Claiming Priority (5)

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US201562160396P 2015-05-12 2015-05-12
US62/160,396 2015-05-12
US201662303595P 2016-03-04 2016-03-04
US62/303,595 2016-03-04
PCT/US2016/032049 WO2016183298A2 (en) 2015-05-12 2016-05-12 Nuclease-mediated regulation of gene expression

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JP2018516556A JP2018516556A (ja) 2018-06-28
JP2018516556A5 JP2018516556A5 (https=) 2019-06-13
JP6873917B2 true JP6873917B2 (ja) 2021-05-19

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US (2) US10808020B2 (https=)
EP (1) EP3294866A4 (https=)
JP (2) JP6873917B2 (https=)
KR (1) KR20170141217A (https=)
AU (2) AU2016261927B2 (https=)
BR (1) BR112017024115A2 (https=)
CA (1) CA2984013A1 (https=)
CL (1) CL2017002843A1 (https=)
CO (1) CO2017012026A2 (https=)
HK (1) HK1251011A1 (https=)
IL (3) IL284707B2 (https=)
MX (2) MX382223B (https=)
PH (1) PH12017502026A1 (https=)
SA (1) SA517390307B1 (https=)
SG (1) SG10202112057QA (https=)
WO (1) WO2016183298A2 (https=)
ZA (1) ZA201707016B (https=)

Cited By (1)

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JP2021106611A (ja) * 2015-05-12 2021-07-29 サンガモ セラピューティクス， インコーポレイテッド ヌクレアーゼ介在性遺伝子発現調節

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JP7365374B2 (ja) 2015-05-12 2023-10-19 サンガモ セラピューティクス， インコーポレイテッド ヌクレアーゼ介在性遺伝子発現調節

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