JP6845013B2 - 遺伝子改変動物を作製するための組成物および方法 - Google Patents

遺伝子改変動物を作製するための組成物および方法 Download PDF

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Publication number
JP6845013B2
JP6845013B2 JP2016552650A JP2016552650A JP6845013B2 JP 6845013 B2 JP6845013 B2 JP 6845013B2 JP 2016552650 A JP2016552650 A JP 2016552650A JP 2016552650 A JP2016552650 A JP 2016552650A JP 6845013 B2 JP6845013 B2 JP 6845013B2
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rodent
gene
male
disrupted
fertility gene
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Japanese (ja)
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JP2016539660A5 (cg-RX-API-DMAC7.html
JP2016539660A (ja
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フランク・ケントジェン
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Ozgene Holdings Pty Ltd
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Ozgene Holdings Pty Ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8775—Murine embryos
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2016552650A 2013-11-07 2014-11-07 遺伝子改変動物を作製するための組成物および方法 Active JP6845013B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AU2013904307 2013-11-07
AU2013904307A AU2013904307A0 (en) 2013-11-07 Compositions and methods for producing genetically modified animals
AU2014902162A AU2014902162A0 (en) 2014-06-06 Compostion and methods for producing genetically modified animals
AU2014902162 2014-06-06
PCT/AU2014/050339 WO2015066768A1 (en) 2013-11-07 2014-11-07 Compositions and methods for producing genetically modified animals

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020142700A Division JP2020202857A (ja) 2013-11-07 2020-08-26 遺伝子改変動物を作製するための組成物および方法

Publications (3)

Publication Number Publication Date
JP2016539660A JP2016539660A (ja) 2016-12-22
JP2016539660A5 JP2016539660A5 (cg-RX-API-DMAC7.html) 2017-11-30
JP6845013B2 true JP6845013B2 (ja) 2021-03-17

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JP2016552650A Active JP6845013B2 (ja) 2013-11-07 2014-11-07 遺伝子改変動物を作製するための組成物および方法
JP2020142700A Withdrawn JP2020202857A (ja) 2013-11-07 2020-08-26 遺伝子改変動物を作製するための組成物および方法

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US (2) US20160360736A1 (cg-RX-API-DMAC7.html)
EP (2) EP3066204B1 (cg-RX-API-DMAC7.html)
JP (2) JP6845013B2 (cg-RX-API-DMAC7.html)
KR (3) KR102444117B1 (cg-RX-API-DMAC7.html)
CN (1) CN105899667A (cg-RX-API-DMAC7.html)
AU (2) AU2014346342C1 (cg-RX-API-DMAC7.html)
CA (1) CA2928744C (cg-RX-API-DMAC7.html)
DK (1) DK3066204T3 (cg-RX-API-DMAC7.html)
ES (1) ES2886146T3 (cg-RX-API-DMAC7.html)
HU (1) HUE055766T2 (cg-RX-API-DMAC7.html)
IL (2) IL245306A0 (cg-RX-API-DMAC7.html)
NZ (2) NZ758970A (cg-RX-API-DMAC7.html)
PT (1) PT3066204T (cg-RX-API-DMAC7.html)
SG (2) SG11201603352SA (cg-RX-API-DMAC7.html)
WO (1) WO2015066768A1 (cg-RX-API-DMAC7.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3066204T (pt) 2013-11-07 2021-09-06 Ozgene Holdings Pty Ltd Composições e métodos para produção de animais geneticamente modificados
CN111566202A (zh) * 2018-01-12 2020-08-21 加利福利亚大学董事会 稳定的多能牛胚胎干细胞的高效衍生
GB201816633D0 (en) * 2018-10-12 2018-11-28 Univ Edinburgh Genetically modified avians and method for the reconstitution thereof
CN113136439B (zh) * 2021-05-28 2022-04-08 兰州大学 一种检测绵羊lipe基因单核苷酸多态性的方法及其应用
CN114592011B (zh) * 2022-05-10 2022-08-05 广东药康生物科技有限公司 一种ptdss2条件性基因敲除小鼠模型的构建方法

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JPH0334320U (cg-RX-API-DMAC7.html) * 1989-08-11 1991-04-04
JP3034320U (ja) * 1996-08-02 1997-02-18 幸夫 冨澤 蛇腹式カード
JP2001008577A (ja) * 1999-06-30 2001-01-16 Mitsubishi Chemicals Corp 生殖毒性化学物質のモニタリングに使用されるトランスジェニックマウス
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
EP1297163B1 (en) 2000-06-23 2011-04-27 E.I. Du Pont De Nemours And Company Recombinant constructs and their use in reducing gene expression
SI1409244T1 (sl) 2001-07-19 2008-04-30 Lankhorst Pure Composites Bv Poliolefinski film, trak ali nit
EP1484399A4 (en) 2002-02-14 2006-04-05 Japan Science & Tech Agency MOUSE-SPERMATOGENESIS, HUMAN MESES ASSOCIATED WITH MALE STERILITY, AND THIS DIAGNOSTIC SYSTEM USED
WO2003071869A1 (fr) * 2002-02-27 2003-09-04 Yasumitsu Nagao Procede de construction d'animal chimere a lignee germinale
AU2003213813A1 (en) * 2002-03-22 2003-10-13 St. Jude Children's Research Hospital Improved method for generating genetically modified animals
PL1802193T3 (pl) 2004-10-19 2014-09-30 Regeneron Pharma Sposób wytwarzania myszy homozygotycznej pod względem modyfikacji genetycznej
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JP4949434B2 (ja) * 2009-05-19 2012-06-06 株式会社マーク・コーポレーション ラベルシート
JP5935692B2 (ja) * 2010-08-31 2016-06-15 国立大学法人 熊本大学 マウス系統を樹立する方法
KR20130030355A (ko) * 2011-09-17 2013-03-27 유종현 배변패드
WO2012092284A1 (en) * 2010-12-27 2012-07-05 The Jackson Laboratory Compositions and methods relating to non-human animals modified to promote production of selected gametes
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KR20140106134A (ko) * 2013-02-26 2014-09-03 윤수경 배변패드 제조장치 및 이를 이용한 배변패드 제조방법
PT3066204T (pt) 2013-11-07 2021-09-06 Ozgene Holdings Pty Ltd Composições e métodos para produção de animais geneticamente modificados
KR20180005002A (ko) * 2016-07-05 2018-01-15 김윤수 애완견 배변패드
WO2019199003A1 (ko) * 2018-04-08 2019-10-17 김종수 애완동물 배설물 자동처리장치
CN209403260U (zh) * 2018-11-14 2019-09-20 绍兴兴科元管业有限公司 一种宠物尿垫组件

Also Published As

Publication number Publication date
AU2014346342B2 (en) 2020-02-20
KR20220142474A (ko) 2022-10-21
IL245306A0 (en) 2016-06-30
AU2014346342C1 (en) 2020-08-13
US20160360736A1 (en) 2016-12-15
US20220201992A1 (en) 2022-06-30
AU2014346342A1 (en) 2016-05-19
US11937586B2 (en) 2024-03-26
IL307495B1 (en) 2025-07-01
CA2928744A1 (en) 2015-05-14
AU2020202321B2 (en) 2021-12-16
ES2886146T3 (es) 2021-12-16
NZ758970A (en) 2022-10-28
KR102444117B1 (ko) 2022-09-16
IL307495B2 (en) 2025-11-01
IL307495A (en) 2023-12-01
CA2928744C (en) 2022-12-06
EP3066204A1 (en) 2016-09-14
WO2015066768A1 (en) 2015-05-14
HUE055766T2 (hu) 2021-12-28
PT3066204T (pt) 2021-09-06
EP3066204A4 (en) 2017-06-21
EP3066204B1 (en) 2021-06-02
SG11201603352SA (en) 2016-05-30
KR20240049835A (ko) 2024-04-17
CN105899667A (zh) 2016-08-24
EP4043575A1 (en) 2022-08-17
AU2020202321A1 (en) 2020-04-23
NZ719493A (en) 2020-02-28
KR20160084431A (ko) 2016-07-13
JP2016539660A (ja) 2016-12-22
JP2020202857A (ja) 2020-12-24
DK3066204T3 (da) 2021-08-30
SG10202112147UA (en) 2021-12-30

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