KR100828506B1 - 마우스 정자 형성 유전자와 인간 남성 불임 관련 유전자,및 이들을 사용한 진단 시스템 - Google Patents
마우스 정자 형성 유전자와 인간 남성 불임 관련 유전자,및 이들을 사용한 진단 시스템 Download PDFInfo
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Abstract
Description
Claims (33)
- 각 유전자로부터 전사되는 mRNA로부터 합성되는 cDNA가 각각 서열번호 1-89의 염기서열을 갖는 전체 89유전자의 집합인 것을 특징으로 하는 마우스 정자 형성 유전자 군.
- 제 1항에 기재된 마우스 정자 형성 유전자 군에 속하는 각 유전자 유래의 전체 cDNA에 의하여 구성되는 것을 특징으로 하는 cDNA 라이브러리.
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- 제 1항에 기재된 마우스 정자 형성 유전자 군에 속하는 각 유전자 DNA를 PCR 증폭하기 위한 프라이머의 집합인 것을 특징으로 하는 프라이머 세트 군.
- 제 2항에 기재된 cDNA 라이브러리에 속하는 전체 cDNA를 구비하는 것을 특징으로 하는 마이크로 어레이.
- 서열번호 90-167의 각 아미노산 서열로 이루어지는 전체 78의 폴리펩티드의 집합인 것을 특징으로 하는 마우스 정자 형성 폴리펩티드 군.
- 제 6항에 기재된 마우스 정자 형성 폴리펩티드 군에 속하는 각 폴리펩티드에 대한 항체의 집합인 것을 특징으로 하는 항체군.
- 제 1항에 기재된 마우스 정자 형성 유전자 군을 사용하여 그 가운데 하나 이상의 유전자의 발현 변조 또는 변이를 검출함으로써, 피험 물질의 인간 정자 형성 유전자에 대한 독성 또는 변이원성을 시험하는 것을 특징으로 하는 방법.
- 제 1항에 기재된 마우스 정자 형성 유전자 군을 사용하여 그 가운데 하나 이상의 유전자의 발현 변조 또는 변이를 검출함으로써, 피험 개체의 생식능력을 진단하는 것을 특징으로 하는 방법.
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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JP2002036649 | 2002-02-14 | ||
JPJP-P-2002-00036649 | 2002-02-14 | ||
JPJP-P-2002-00381241 | 2002-12-27 | ||
JP2002381241 | 2002-12-27 | ||
PCT/JP2003/001572 WO2003068969A1 (en) | 2002-02-14 | 2003-02-14 | Mouse spermatogenesis genes, human male sterility-associated genes and diagnostic system using the same |
Related Child Applications (1)
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KR1020077011884A Division KR20070061926A (ko) | 2002-02-14 | 2003-02-14 | 마우스 정자 형성 유전자와 인간 남성 불임 관련 유전자,및 이들을 사용한 진단 시스템 |
Publications (2)
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KR20040096564A KR20040096564A (ko) | 2004-11-16 |
KR100828506B1 true KR100828506B1 (ko) | 2008-05-13 |
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KR1020077011884A KR20070061926A (ko) | 2002-02-14 | 2003-02-14 | 마우스 정자 형성 유전자와 인간 남성 불임 관련 유전자,및 이들을 사용한 진단 시스템 |
KR1020047012460A KR100828506B1 (ko) | 2002-02-14 | 2003-02-14 | 마우스 정자 형성 유전자와 인간 남성 불임 관련 유전자,및 이들을 사용한 진단 시스템 |
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KR1020077011884A KR20070061926A (ko) | 2002-02-14 | 2003-02-14 | 마우스 정자 형성 유전자와 인간 남성 불임 관련 유전자,및 이들을 사용한 진단 시스템 |
Country Status (7)
Country | Link |
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US (1) | US7842783B2 (ko) |
EP (1) | EP1484399A4 (ko) |
JP (3) | JP4146353B2 (ko) |
KR (2) | KR20070061926A (ko) |
CN (1) | CN1643148B (ko) |
CA (1) | CA2476561A1 (ko) |
WO (1) | WO2003068969A1 (ko) |
Families Citing this family (15)
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JP2008067649A (ja) * | 2006-09-14 | 2008-03-27 | Osaka Univ | 妊孕性診断キット、変異検出方法、ポリヌクレオチド、及びポリペプチド |
JP2008237114A (ja) * | 2007-03-27 | 2008-10-09 | Osaka Univ | 妊孕性診断キット、変異検出方法、ポリヌクレオチド、ポリペプチド、発現ベクター、及び発現キット |
WO2010106788A1 (ja) | 2009-03-17 | 2010-09-23 | 凸版印刷株式会社 | 妊孕性検査方法、妊孕性検査キット、ポリヌクレオチド、ポリペプチド、及び抗体 |
CN101775372B (zh) * | 2009-12-02 | 2012-01-11 | 桂耀庭 | 一种抗睾丸hT279蛋白的抗体或抗体片段及其应用 |
CN101775371B (zh) * | 2009-12-02 | 2012-03-14 | 唐爱发 | 一种抗睾丸hTSC29蛋白的抗体或抗体片段及其应用 |
CN102262159B (zh) * | 2010-05-27 | 2014-03-26 | 李建远 | 用于检测生育相关人睾丸和附睾表达305种精子定位蛋白的方法 |
US9177098B2 (en) | 2012-10-17 | 2015-11-03 | Celmatix Inc. | Systems and methods for determining the probability of a pregnancy at a selected point in time |
US10162800B2 (en) | 2012-10-17 | 2018-12-25 | Celmatix Inc. | Systems and methods for determining the probability of a pregnancy at a selected point in time |
US9836577B2 (en) | 2012-12-14 | 2017-12-05 | Celmatix, Inc. | Methods and devices for assessing risk of female infertility |
KR102444117B1 (ko) | 2013-11-07 | 2022-09-16 | 오즈진 홀딩스 프로프라이어터리 리미티드 | 유전자 변형 동물을 생산하기 위한 조성물 및 방법 |
CN103743910B (zh) * | 2013-12-27 | 2015-11-18 | 上海市计划生育科学研究所 | Ctbs蛋白作为精卵结合受体的靶点在筛选精卵结合抑制剂中的应用 |
JP2017510250A (ja) * | 2014-01-27 | 2017-04-13 | セルマティックス, インコーポレイテッド | 遺伝的領域が、不妊に関連するか評価するための方法 |
CA2954895A1 (en) | 2014-07-17 | 2016-01-21 | Celmatix Inc. | Methods and systems for assessing infertility and related pathologies |
US10030241B2 (en) | 2015-03-30 | 2018-07-24 | General Electric Company | Methods and kits for capturing sperm nucleic acids |
US9957548B2 (en) | 2015-03-30 | 2018-05-01 | General Electric Company | Methods of capturing sperm nucleic acids |
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US6090555A (en) * | 1997-12-11 | 2000-07-18 | Affymetrix, Inc. | Scanned image alignment systems and methods |
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- 2003-02-14 CN CN038061627A patent/CN1643148B/zh not_active Expired - Lifetime
- 2003-02-14 JP JP2003568082A patent/JP4146353B2/ja not_active Expired - Fee Related
- 2003-02-14 CA CA002476561A patent/CA2476561A1/en not_active Abandoned
- 2003-02-14 WO PCT/JP2003/001572 patent/WO2003068969A1/ja active Application Filing
- 2003-02-14 EP EP03705175A patent/EP1484399A4/en not_active Withdrawn
- 2003-02-14 KR KR1020047012460A patent/KR100828506B1/ko active IP Right Grant
- 2003-02-14 US US10/504,582 patent/US7842783B2/en not_active Expired - Fee Related
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Non-Patent Citations (1)
Title |
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Genomics, Vol. 57, pp. 94-101 (1999) |
Also Published As
Publication number | Publication date |
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KR20040096564A (ko) | 2004-11-16 |
US20050176943A1 (en) | 2005-08-11 |
CA2476561A1 (en) | 2003-08-21 |
JP2008173125A (ja) | 2008-07-31 |
JP4276691B2 (ja) | 2009-06-10 |
CN1643148A (zh) | 2005-07-20 |
JP4146353B2 (ja) | 2008-09-10 |
WO2003068969A1 (en) | 2003-08-21 |
EP1484399A1 (en) | 2004-12-08 |
JP2008154592A (ja) | 2008-07-10 |
JP4229973B2 (ja) | 2009-02-25 |
CN1643148B (zh) | 2011-04-20 |
KR20070061926A (ko) | 2007-06-14 |
EP1484399A4 (en) | 2006-04-05 |
JPWO2003068969A1 (ja) | 2005-06-02 |
US7842783B2 (en) | 2010-11-30 |
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