JP6834178B2 - ゲル状組成物 - Google Patents
ゲル状組成物 Download PDFInfo
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- JP6834178B2 JP6834178B2 JP2016108880A JP2016108880A JP6834178B2 JP 6834178 B2 JP6834178 B2 JP 6834178B2 JP 2016108880 A JP2016108880 A JP 2016108880A JP 2016108880 A JP2016108880 A JP 2016108880A JP 6834178 B2 JP6834178 B2 JP 6834178B2
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- 239000000203 mixture Substances 0.000 title claims description 86
- 150000001413 amino acids Chemical class 0.000 claims description 28
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- 230000002378 acidificating effect Effects 0.000 claims description 20
- 125000000217 alkyl group Chemical group 0.000 claims description 19
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 18
- 125000004432 carbon atom Chemical group C* 0.000 claims description 18
- WCYBYZBPWZTMDW-UHFFFAOYSA-N dibutylazanide Chemical compound CCCC[N-]CCCC WCYBYZBPWZTMDW-UHFFFAOYSA-N 0.000 claims description 17
- 238000004090 dissolution Methods 0.000 claims description 14
- 229940071085 lauroyl glutamate Drugs 0.000 claims description 14
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 claims description 12
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims description 10
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 10
- 150000005846 sugar alcohols Polymers 0.000 claims description 10
- RDMFQRSUPLBCIQ-SFHVURJKSA-N (4s)-5-(dibutylamino)-4-[ethyl(hexanoyl)amino]-5-oxopentanoic acid Chemical compound CCCCCC(=O)N(CC)[C@@H](CCC(O)=O)C(=O)N(CCCC)CCCC RDMFQRSUPLBCIQ-SFHVURJKSA-N 0.000 claims description 9
- 229940043375 1,5-pentanediol Drugs 0.000 claims description 8
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- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 8
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- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 7
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 7
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- 125000002252 acyl group Chemical group 0.000 claims description 7
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- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 7
- CAYHVMBQBLYQMT-UHFFFAOYSA-N 2-decyltetradecan-1-ol Chemical compound CCCCCCCCCCCCC(CO)CCCCCCCCCC CAYHVMBQBLYQMT-UHFFFAOYSA-N 0.000 claims description 6
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- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims description 6
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- 229940049906 glutamate Drugs 0.000 description 17
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- 239000004094 surface-active agent Substances 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
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- PBGGNZZGJIKBMJ-UHFFFAOYSA-N di(propan-2-yl)azanide Chemical compound CC(C)[N-]C(C)C PBGGNZZGJIKBMJ-UHFFFAOYSA-N 0.000 description 7
- 150000004665 fatty acids Chemical class 0.000 description 7
- NJBCRXCAPCODGX-UHFFFAOYSA-N 2-methyl-n-(2-methylpropyl)propan-1-amine Chemical compound CC(C)CNCC(C)C NJBCRXCAPCODGX-UHFFFAOYSA-N 0.000 description 6
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 6
- 125000002947 alkylene group Chemical group 0.000 description 6
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 6
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- 238000004519 manufacturing process Methods 0.000 description 6
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- OBYVIBDTOCAXSN-UHFFFAOYSA-N n-butan-2-ylbutan-2-amine Chemical compound CCC(C)NC(C)CC OBYVIBDTOCAXSN-UHFFFAOYSA-N 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 5
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- 239000003349 gelling agent Substances 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
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- AVBJHQDHVYGQLS-UHFFFAOYSA-N 2-(dodecanoylamino)pentanedioic acid Chemical compound CCCCCCCCCCCC(=O)NC(C(O)=O)CCC(O)=O AVBJHQDHVYGQLS-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 4
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 229940070808 lauroyl aspartate Drugs 0.000 description 4
- 229940070800 myristoyl glutamate Drugs 0.000 description 4
- 229940070802 palmitoyl glutamate Drugs 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000000475 sunscreen effect Effects 0.000 description 4
- 239000000516 sunscreening agent Substances 0.000 description 4
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 239000004471 Glycine Substances 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000002738 chelating agent Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 229960002989 glutamic acid Drugs 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
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- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 239000000344 soap Substances 0.000 description 3
- 239000011787 zinc oxide Substances 0.000 description 3
- WAALGYWQBMAYGC-JTQLQIEISA-N (3S)-3-amino-4-[bis(2-methylpropyl)amino]-4-oxobutanoic acid Chemical compound C(C(C)C)N(C([C@@H](N)CC(=O)O)=O)CC(C)C WAALGYWQBMAYGC-JTQLQIEISA-N 0.000 description 2
- YWRQRRZOYCDDPH-RTBKNWGFSA-N (3S)-3-amino-4-[di(butan-2-yl)amino]-4-oxobutanoic acid Chemical compound C(C)(CC)N(C([C@@H](N)CC(=O)O)=O)C(C)CC YWRQRRZOYCDDPH-RTBKNWGFSA-N 0.000 description 2
- ZKMSTUGBDYJSLT-JTQLQIEISA-N (3s)-3-amino-4-(dibutylamino)-4-oxobutanoic acid Chemical compound CCCCN(CCCC)C(=O)[C@@H](N)CC(O)=O ZKMSTUGBDYJSLT-JTQLQIEISA-N 0.000 description 2
- 125000006219 1-ethylpentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- XXAXVMUWHZHZMJ-UHFFFAOYSA-N Chymopapain Chemical compound OC1=CC(S(O)(=O)=O)=CC(S(O)(=O)=O)=C1O XXAXVMUWHZHZMJ-UHFFFAOYSA-N 0.000 description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 description 2
- 238000010306 acid treatment Methods 0.000 description 2
- 125000004442 acylamino group Chemical group 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
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- WJJMNDUMQPNECX-UHFFFAOYSA-N dipicolinic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=N1 WJJMNDUMQPNECX-UHFFFAOYSA-N 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
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- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
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Landscapes
- Cosmetics (AREA)
Description
[1](A)式(I):
(B)多価アルコール及び
(C)極性油
を含むゲル状組成物。
[2]式(I)で表わされるN−アシル酸性アミノ酸ジアルキルアミドが、N−2−エチルヘキサノイルグルタミン酸ジブチルアミド及びN−ラウロイルグルタミン酸ジブチルアミドからなる群から選択される少なくとも1種である[1]に記載のゲル状組成物。
[3](B)が、ペンチレングリコール、イソペンチルジオール、プロピレングリコール、ヘキサンジオール及びジプロピレングリコールからなる群から選択される少なくとも1種である[1]又は[2]に記載のゲル状組成物。
[4](C)が、イソステアリルアルコール、オクチルドデカノール、オレイルアルコール、イソステアリン酸、ステアリン酸、デシルテトラデカノール、セチルアルコール及びパルミチン酸からなる群から選択される少なくとも1種である[1]〜[3]のいずれかに記載のゲル状組成物。
[5]さらに(D)アシル酸性アミノ酸を含む[1]〜[4]のいずれかに記載のゲル状組成物。
[6]化粧品、香粧品又は医薬部外品組成物である[1]〜[5]のいずれかに記載のゲル状組成物。
本発明のゲル状組成物を化粧品や香粧品の製造に使用する際には、従来のような非常に高い温度処理を施す必要がなく、容易に製造することができ、化粧品等の製造工程を大幅に簡素化できる。
本発明におけるN−アシル酸性アミノ酸ジアルキルアミド(A)は、式(I)で表される。
例えば、N−2−エチルヘキサノイルグルタミン酸ジブチルアミド(A1)及びN−ラウロイルグルタミン酸ジブチルアミド(A2)を使用する場合の重量比(A1):(A2)は、特に限定されないが、通常1:20〜20:1であり、1:9〜9:1が好ましく、1:4〜4:1がより好ましい。
本発明における(B)多価アルコールは、水酸基が2個以上のものであれば特に限定されず、例えば、エチレングリコール、ジプロピレングリコール、ブチレングリコール、モノカプリル酸グリセリル、カプリリルグリコール、グリセリン、ジグリセリン、プロピレングリコール、1,3−プロパンジオール、ペンチレングリコール、1,5−ペンタンジオール、1,6−ペンタンジオール、1,6−ヘキサンジオール、1,2−ヘキサンジオール、ヘキシレングリコール、1,3−ブチレングリコール、ネオペンチルグリコール、イソプレングリコール、低重合ポリエチレングリコール、エチルヘキシルグリセリンが挙げられ、ペンチレングリコール、イソペンチルジオール、プロピレングリコール、ヘキサンジオール、ジプロピレングリコールが好ましく、ペンチレングリコール、イソペンチルジオール、プロピレングリコールがより好ましい。
本発明における(C)極性油は、有機概念図で20以上の無機性値を有する油であり、例えば、イソステアリルアルコール、オクチルドデカノール、オレイルアルコール、デシルテトラデカノール、セチルアルコール、イソステアリン酸、ステアリン酸、パルミチン酸が挙げられ、イソステアリルアルコール、オクチルドデカノール、オレイルアルコール、ステアリン酸が好ましく、イソステアリルアルコール、ステアリン酸がより好ましい。
本発明におけるアシル酸性アミノ酸としては、N−ココイル−L−グルタミン酸、N−ラウロイル−L−グルタミン酸、N−ミリストイル−L−グルタミン酸、N−ステアロイル−L−グルタミン酸などが挙げられ、N−ココイル−L−グルタミン酸、N−ラウロイル−L−グルタミン酸などが好ましい。
表1に記載の割合(重量%)の(A)〜(C)の混合物10gをガラス瓶に入れ、加熱混合し完全に溶解させた。そのまま室温まで放冷し、ゲル状組成物を得た。この組成物を再度加熱し、完全に溶解した温度を温度計によって測定した。N−ラウロイル−L−グルタミン酸ジブチルアミドは、味の素株式会社製のアミノ酸系ゲル化剤「GP−1」を使用した(以下同様)。結果を表1に示す。
表2に記載の割合(重量%)の(A)〜(C)の混合物10gをガラス瓶に入れ、加熱混合し完全に溶解させた。そのまま室温まで放冷し、ゲル状組成物を得た。この組成物を再度加熱し、完全に溶解した温度を温度計によって測定した。N−2−エチルヘキサノイルグルタミン酸ジブチルアミドは、味の素株式会社製のアミノ酸系ゲル化剤「EB−21」を使用した(以下同様)。結果を表2に示す。
表3に記載の割合(重量%)の(A)〜(D)の混合物10gをガラス瓶に入れ、加熱混合し溶解させた。そのまま室温まで放冷し、ゲル状組成物を得た。この組成物を再度加熱し、完全に溶解した温度を温度計によって測定した。結果を表3に示す。
Claims (9)
- (A)式(I):
(式中、R 1 及びR 2 はそれぞれ独立に炭素原子数1〜7の直鎖又は分枝鎖のアルキル基を示し、R 3 は炭素原子数3〜15の直鎖又は分枝鎖のアルキル基を示し、nは1又は2を示す)で表わされるN−アシル酸性アミノ酸ジアルキルアミドの少なくとも1種、
(B)ペンチレングリコール、イソペンチルジオール、プロピレングリコール、ヘキサンジオール及びジプロピレングリコールからなる群から選択される少なくとも1種の多価アルコール、
(C)イソステアリルアルコール、オクチルドデカノール、オレイルアルコール、イソステアリン酸、ステアリン酸、デシルテトラデカノール、セチルアルコール及びパルミチン酸からなる群から選択される少なくとも1種の極性油ならびに
(D)アシル酸性アミノ酸
を含むゲル状組成物であって、
組成物中の(A)の含有量が、10重量%以上40重量%以下、
組成物中の(B)の含有量が、(A)1重量部に対して0.5〜6重量部及び
組成物中の(C)の含有量が、(A)1重量部に対して0.2〜6重量部
である、ゲル状組成物。 - 組成物中の(D)の含有量が0.01重量%以上10重量%以下である、請求項1に記載のゲル状組成物。
- (A)式(I):
(式中、R1及びR2はそれぞれ独立に炭素原子数1〜7の直鎖又は分枝鎖のアルキル基を示し、R3は炭素原子数3〜15の直鎖又は分枝鎖のアルキル基を示し、nは1又は2を示す)で表わされるN−アシル酸性アミノ酸ジアルキルアミドの少なくとも1種、
(B)ペンチレングリコール、イソペンチルジオール及びヘキサンジオールからなる群から選択される少なくとも1種の多価アルコールならびに
(C)イソステアリルアルコール、オクチルドデカノール、オレイルアルコール、イソステアリン酸、ステアリン酸、デシルテトラデカノール、セチルアルコール及びパルミチン酸からなる群から選択される少なくとも1種の極性油
を含むゲル状組成物であって、
組成物中の(A)の含有量が、10重量%以上40重量%以下、
組成物中の(B)の含有量が、(A)1重量部に対して0.5〜6重量部、
組成物中の(C)の含有量が、(A)1重量部に対して0.2〜6重量部及び
ゲル状組成物の溶解温度が、56℃〜78℃
である、ゲル状組成物。 - 式(I)で表わされるN−アシル酸性アミノ酸ジアルキルアミドが、N−2−エチルヘキサノイルグルタミン酸ジブチルアミド及びN−ラウロイルグルタミン酸ジブチルアミドからなる群から選択される少なくとも1種である請求項1〜3のいずれか一項に記載のゲル状組成物。
- 組成物中の(A)の含有量が、20重量%以上40重量%以下である請求項1〜4のいずれか一項に記載のゲル状組成物。
- (A)が、N−2−エチルヘキサノイルグルタミン酸ジブチルアミド(A1)及びN−ラウロイルグルタミン酸ジブチルアミド(A2)であって、重量比(A1):(A2)が1:20〜20:1である請求項1〜5のいずれか一項に記載のゲル状組成物。
- (A)式(I):
(式中、R 1 及びR 2 はそれぞれ独立に炭素原子数1〜7の直鎖又は分枝鎖のアルキル基を示し、R 3 は炭素原子数3〜15の直鎖又は分枝鎖のアルキル基を示し、nは1又は2を示す)で表わされるN−アシル酸性アミノ酸ジアルキルアミドの少なくとも1種を78℃以下で溶解させる方法であって、
(A)を、(B)ペンチレングリコール、イソペンチルジオール、プロピレングリコール、ヘキサンジオール及びジプロピレングリコールからなる群から選択される少なくとも1種の多価アルコール、(C)イソステアリルアルコール、オクチルドデカノール、オレイルアルコール、イソステアリン酸、ステアリン酸、デシルテトラデカノール、セチルアルコール及びパルミチン酸からなる群から選択される少なくとも1種の極性油ならびに(D)アシル酸性アミノ酸
を含む組成物中に溶解させる工程
を含む方法。 - (A)式(I):
(式中、R1及びR2はそれぞれ独立に炭素原子数1〜7の直鎖又は分枝鎖のアルキル基を示し、R3は炭素原子数3〜15の直鎖又は分枝鎖のアルキル基を示し、nは1又は2を示す)で表わされるN−アシル酸性アミノ酸ジアルキルアミドの少なくとも1種を56℃〜78℃以下で溶解させる方法であって、
(A)を、(B)ペンチレングリコール、イソペンチルジオール及びヘキサンジオールからなる群から選択される少なくとも1種の多価アルコールならびに(C)イソステアリルアルコール、オクチルドデカノール、オレイルアルコール、イソステアリン酸、ステアリン酸、デシルテトラデカノール、セチルアルコール及びパルミチン酸からなる群から選択される少なくとも1種の極性油を含む組成物中に溶解させる工程
を含む方法。 - (A)を10重量%以上40重量%以下の濃度で溶解させることを特徴とする、請求項7又は8に記載の方法。
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