JP6826135B2 - トロンビン処理幹細胞に由来するエクソソームを含む皮膚傷治療用組成物 - Google Patents

トロンビン処理幹細胞に由来するエクソソームを含む皮膚傷治療用組成物 Download PDF

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JP6826135B2
JP6826135B2 JP2018568285A JP2018568285A JP6826135B2 JP 6826135 B2 JP6826135 B2 JP 6826135B2 JP 2018568285 A JP2018568285 A JP 2018568285A JP 2018568285 A JP2018568285 A JP 2018568285A JP 6826135 B2 JP6826135 B2 JP 6826135B2
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stem cells
thrombin
derived
exosome
exosomes
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JP2019520365A5 (cg-RX-API-DMAC10.html
JP2019520365A (ja
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ユン シル チャン、
ユン シル チャン、
ウォン ソン パク、
ウォン ソン パク、
ドン キュン ソン、
ドン キュン ソン、
ソ ユン アン、
ソ ユン アン、
Original Assignee
サムソン ライフ パブリック ウェルフェア ファウンデーション
サムソン ライフ パブリック ウェルフェア ファウンデーション
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Priority claimed from PCT/KR2017/006776 external-priority patent/WO2018004237A1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells

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  • Animal Behavior & Ethology (AREA)
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  • Public Health (AREA)
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  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
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  • Zoology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
JP2018568285A 2016-07-01 2017-06-27 トロンビン処理幹細胞に由来するエクソソームを含む皮膚傷治療用組成物 Active JP6826135B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR20160083703 2016-07-01
KR10-2016-0083703 2016-07-01
KR1020170080366A KR101860266B1 (ko) 2016-07-01 2017-06-26 트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 피부상처 치료용 조성물
KR10-2017-0080366 2017-06-26
PCT/KR2017/006776 WO2018004237A1 (ko) 2016-07-01 2017-06-27 트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 피부상처 치료용 조성물

Publications (3)

Publication Number Publication Date
JP2019520365A JP2019520365A (ja) 2019-07-18
JP2019520365A5 JP2019520365A5 (cg-RX-API-DMAC10.html) 2020-04-09
JP6826135B2 true JP6826135B2 (ja) 2021-02-03

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JP2018568285A Active JP6826135B2 (ja) 2016-07-01 2017-06-27 トロンビン処理幹細胞に由来するエクソソームを含む皮膚傷治療用組成物

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US (1) US12239695B2 (cg-RX-API-DMAC10.html)
EP (1) EP3479831B1 (cg-RX-API-DMAC10.html)
JP (1) JP6826135B2 (cg-RX-API-DMAC10.html)
KR (1) KR101860266B1 (cg-RX-API-DMAC10.html)
CN (1) CN109641013B (cg-RX-API-DMAC10.html)

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KR101973284B1 (ko) 2017-01-16 2019-04-29 사회복지법인 삼성생명공익재단 신생아 ｈｉｅ 치료용 조성물
KR102278102B1 (ko) 2018-07-27 2021-07-15 주식회사 엑소스템텍 엑소좀을 유효성분으로 포함하는 급성 간질환의 예방 또는 치료용 조성물
EP3831397A4 (en) 2018-07-27 2022-05-18 Exostemtech Co., Ltd. COMPOSITION WITH EXOSOME AS AN AGENTS FOR PREVENTION OR TREATMENT OF ACUTE LIVER FAILURE
KR102323056B1 (ko) * 2019-05-02 2021-11-09 에스씨엠생명과학 주식회사 hPL 함유 배지에서 배양된 중간엽 줄기세포의 배양액을 포함하는 화장료 조성물
KR102159394B1 (ko) * 2019-10-04 2020-09-24 (주)에스디생명공학 바다제비집에서 유래된 엑소좀을 유효성분으로 포함하는 피부 상태 개선용 조성물
US12491212B2 (en) 2019-11-12 2025-12-09 Brexogen Inc. Composition for preventing or treating renal diseases, comprising exosomes derived from precursor cells of induced pluripotent stem cell-derived mesenchymal stem cells
JP2021116228A (ja) * 2020-01-22 2021-08-10 医薬資源研究所株式会社 抗酸化ストレス剤、化粧品、および医薬品
US12077780B2 (en) 2020-02-14 2024-09-03 Allergan Sales, Llc Conditioned medium from cells cultured under hypoxic conditions and uses thereof
KR20210127510A (ko) * 2020-04-14 2021-10-22 사회복지법인 삼성생명공익재단 트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 당뇨병성 피부질환 예방 또는 치료용 조성물
CN111888379A (zh) * 2020-08-17 2020-11-06 济宁医学院附属医院 干细胞来源的微囊泡在制备修复瘢痕的制剂中的应用
WO2022114730A2 (ko) * 2020-11-26 2022-06-02 사회복지법인 삼성생명공익재단 트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 감염성 질환 치료용 조성물
EP4364728A4 (en) * 2021-06-30 2025-07-02 Primoris Therapeutics Co Ltd PHARMACEUTICAL COMPOSITION CONTAINING NATURAL OR ARTIFICIAL CELL-DERIVED NANOVESICLES LOADED WITH AN ANTISENSE OLIGONUCLEOTIDE-BASED DRUG
CN114904043B (zh) * 2022-04-28 2023-07-21 深圳市儿童医院 复合水凝胶及其制备方法和应用
KR102633660B1 (ko) * 2022-05-04 2024-02-05 (주)에스엔이바이오 효능이 증진된 줄기세포 유래 세포외소포를 포함하는 상처 치료용 조성물
JP2025539861A (ja) * 2022-11-25 2025-12-09 エルピス・セル・セラピューティクス ｖＭＳＣのセクレトームおよびその用途

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JP5911874B2 (ja) * 2010-10-18 2016-04-27 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 発毛を促進又は増強するためのエキソソームの使用
EP2850178A4 (en) 2012-05-18 2015-10-28 Agency Science Tech & Res MESENCHYMAL NAIL STAMMING CELL EXOSOME
KR20140066456A (ko) 2012-11-23 2014-06-02 호서대학교 산학협력단 피부각질세포 유래 엑소좀, 엑소좀을 포함하는 분획물의 피부재생용 화장품 조성물 및 이의 용도
GB201317889D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product and use
US10167448B2 (en) * 2013-12-12 2019-01-01 Samsung Life Public Welfare Foundation Pharmaceutical composition for treating cerebrovascular diseases, containing stem cell-derived exosome as active ingredient
WO2015142061A1 (ko) * 2014-03-18 2015-09-24 사회복지법인 삼성생명공익재단 줄기세포 유래 엑소좀을 유효성분으로 포함하는 뇌 염증성 질환의 치료용 조성물
CN105477016A (zh) * 2015-11-13 2016-04-13 中国人民解放军第二军医大学 人间充质干细胞来源的外泌体在抗组织纤维化及瘢痕形成中的应用

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CN109641013A (zh) 2019-04-16
CN109641013B (zh) 2022-07-26
EP3479831A1 (en) 2019-05-08
KR20180003999A (ko) 2018-01-10
US12239695B2 (en) 2025-03-04
EP3479831B1 (en) 2022-06-15
JP2019520365A (ja) 2019-07-18
EP3479831A4 (en) 2020-03-25
KR101860266B1 (ko) 2018-05-24
US20190314469A1 (en) 2019-10-17

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