JP6818007B2 - 損傷形成及び評価のためのシステム - Google Patents
損傷形成及び評価のためのシステム Download PDFInfo
- Publication number
- JP6818007B2 JP6818007B2 JP2018502383A JP2018502383A JP6818007B2 JP 6818007 B2 JP6818007 B2 JP 6818007B2 JP 2018502383 A JP2018502383 A JP 2018502383A JP 2018502383 A JP2018502383 A JP 2018502383A JP 6818007 B2 JP6818007 B2 JP 6818007B2
- Authority
- JP
- Japan
- Prior art keywords
- energy
- catheter
- light
- distal end
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000006378 damage Effects 0.000 title description 32
- 230000015572 biosynthetic process Effects 0.000 title description 6
- 238000011156 evaluation Methods 0.000 title 1
- 238000002679 ablation Methods 0.000 claims description 59
- 239000013307 optical fiber Substances 0.000 claims description 51
- 230000003287 optical effect Effects 0.000 claims description 50
- 239000000835 fiber Substances 0.000 claims description 35
- 230000002262 irrigation Effects 0.000 claims description 28
- 238000003973 irrigation Methods 0.000 claims description 28
- 238000012800 visualization Methods 0.000 claims description 16
- 239000000126 substance Substances 0.000 claims description 13
- 238000005057 refrigeration Methods 0.000 claims description 10
- 238000011298 ablation treatment Methods 0.000 claims description 8
- 238000011282 treatment Methods 0.000 claims description 6
- 238000013153 catheter ablation Methods 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 210000001519 tissue Anatomy 0.000 description 150
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 42
- 238000000034 method Methods 0.000 description 39
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 39
- 210000005003 heart tissue Anatomy 0.000 description 26
- 206010003658 Atrial Fibrillation Diseases 0.000 description 17
- 208000027418 Wounds and injury Diseases 0.000 description 16
- 208000014674 injury Diseases 0.000 description 16
- 238000003384 imaging method Methods 0.000 description 15
- 239000000463 material Substances 0.000 description 10
- 229950006238 nadide Drugs 0.000 description 10
- 210000004027 cell Anatomy 0.000 description 9
- 239000012530 fluid Substances 0.000 description 9
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 210000004165 myocardium Anatomy 0.000 description 8
- 102000008186 Collagen Human genes 0.000 description 7
- 108010035532 Collagen Proteins 0.000 description 7
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 description 7
- 229920001436 collagen Polymers 0.000 description 7
- 230000002503 metabolic effect Effects 0.000 description 7
- 230000002107 myocardial effect Effects 0.000 description 7
- 102000016942 Elastin Human genes 0.000 description 6
- 108010014258 Elastin Proteins 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 229920002549 elastin Polymers 0.000 description 6
- 230000005284 excitation Effects 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 6
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 6
- 230000006698 induction Effects 0.000 description 5
- 210000003470 mitochondria Anatomy 0.000 description 5
- 210000003492 pulmonary vein Anatomy 0.000 description 5
- 230000001678 irradiating effect Effects 0.000 description 4
- 238000002955 isolation Methods 0.000 description 4
- 206010021143 Hypoxia Diseases 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 210000003484 anatomy Anatomy 0.000 description 3
- 239000000560 biocompatible material Substances 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 230000000302 ischemic effect Effects 0.000 description 3
- -1 nicotinamide adenine dinucleotide hydrogen Chemical class 0.000 description 3
- 229910052697 platinum Inorganic materials 0.000 description 3
- 238000007674 radiofrequency ablation Methods 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 238000002604 ultrasonography Methods 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- 229910001260 Pt alloy Inorganic materials 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000030833 cell death Effects 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 238000000799 fluorescence microscopy Methods 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 230000007954 hypoxia Effects 0.000 description 2
- 208000028867 ischemia Diseases 0.000 description 2
- 238000000608 laser ablation Methods 0.000 description 2
- 210000005246 left atrium Anatomy 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000004611 spectroscopical analysis Methods 0.000 description 2
- 230000004102 tricarboxylic acid cycle Effects 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 230000033616 DNA repair Effects 0.000 description 1
- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 description 1
- 241001085205 Prenanthella exigua Species 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 230000001746 atrial effect Effects 0.000 description 1
- 206010003668 atrial tachycardia Diseases 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 238000003763 carbonization Methods 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 210000004413 cardiac myocyte Anatomy 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000012809 cooling fluid Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000002497 edematous effect Effects 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000005350 fused silica glass Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000002064 heart cell Anatomy 0.000 description 1
- 230000001146 hypoxic effect Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- HWLDNSXPUQTBOD-UHFFFAOYSA-N platinum-iridium alloy Chemical compound [Ir].[Pt] HWLDNSXPUQTBOD-UHFFFAOYSA-N 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000025600 response to UV Effects 0.000 description 1
- 229910052594 sapphire Inorganic materials 0.000 description 1
- 239000010980 sapphire Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000005476 soldering Methods 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002537 thrombolytic effect Effects 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 210000002620 vena cava superior Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/30—Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/06—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating caused by chemical reaction, e.g. moxaburners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
- A61B18/24—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
- A61B5/6869—Heart
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/361—Image-producing devices, e.g. surgical cameras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00057—Light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00057—Light
- A61B2017/00061—Light spectrum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00351—Heart
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00351—Heart
- A61B2018/00357—Endocardium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00351—Heart
- A61B2018/00363—Epicardium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00351—Heart
- A61B2018/00375—Ostium, e.g. ostium of pulmonary vein or artery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/0066—Sensing and controlling the application of energy without feedback, i.e. open loop control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00904—Automatic detection of target tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/0091—Handpieces of the surgical instrument or device
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00982—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00994—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combining two or more different kinds of non-mechanical energy or combining one or more non-mechanical energies with ultrasound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0212—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
- A61B2018/1861—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves with an instrument inserted into a body lumen or cavity, e.g. a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
- A61B2034/2046—Tracking techniques
- A61B2034/2051—Electromagnetic tracking systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/30—Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
- A61B2090/306—Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure using optical fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/361—Image-producing devices, e.g. surgical cameras
- A61B2090/3614—Image-producing devices, e.g. surgical cameras using optical fibre
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
- A61B2090/376—Surgical systems with images on a monitor during operation using X-rays, e.g. fluoroscopy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2218/00—Details of surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2218/001—Details of surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body having means for irrigation and/or aspiration of substances to and/or from the surgical site
- A61B2218/002—Irrigation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
Description
本出願は、2015年10月21日に出願された米国特許出願第14/919,004号及び2015年7月19日に出願された米国仮出願第62/194,276号の利益及び優先権を主張するものであり、両出願の全体が参照により本明細書に組み込まれる。
本開示は、概してカテーテルに関し、より具体的にはアブレーション及び視覚化カテーテルに関する。
尚、出願当初の請求項は以下の通りであった。
[請求項1]
アブレーションされた組織を視覚化するカテーテルであって、
カテーテル本体と、
前記カテーテル本体の遠位端部に配置されて照射キャビティを画定する遠位端部材と、
前記照射キャビティ内に配設される光誘導部材と、
を備え、
前記遠位端部材は、前記照射キャビティと組織との間で光エネルギーを交換するための1つ以上の開口部を有し、
前記光誘導部材は、前記遠位端部材の1つ以上の開口部を介して、組織に光エネルギーを誘導するように、かつ、組織から光エネルギーを誘導するように構成されている、
カテーテル。
[請求項2]
前記照射キャビティ内に至るまで延びて前記照射キャビティに対して光の送受を行う1つ以上の光ファイバを更に備える、請求項1に記載のカテーテル。
[請求項3]
前記遠位端部材はファイバ位置合わせ部材を更に備え、前記ファイバ位置合わせ部材は、前記1つ以上の光ファイバを前記光誘導部材の中心軸と位置合わせするように構成されている、請求項2に記載のカテーテル。
[請求項4]
前記光誘導部材及び前記1つ以上の開口部は、前記カテーテルの長手方向軸に対する径方向及び軸方向に組織を照らすことができるように構成されている、請求項1に記載のカテーテル。
[請求項5]
前記1つ以上の開口部は前記遠位端部材の側壁に沿って配設され、前記光誘導部材は、前記1つ以上の開口部を介して、前記カテーテルの長手方向軸に対するある角度で光エネルギーを誘導するように形成されている、請求項1に記載のカテーテル。
[請求項6]
前記光誘導部材は1つ以上の貫通孔を備え、前記遠位端部材は、前記遠位端部材の前壁に配設された1つ以上の開口部を備え、光が前記光誘導部材及び前記前壁の1つ以上の開口部を長手方向に通過することができる、請求項5に記載のカテーテル。
[請求項7]
前記1つ以上の開口部を介してのみ光を反射するように前記光誘導部材が前記1つ以上の開口部と位置合わせされている、請求項5に記載のカテーテル。
[請求項8]
前記1つ以上の開口部は、前記遠位端部材に沿って周方向に配設されて互いに等距離だけ離間され、前記光誘導部材は、前記1つ以上の開口部と位置合わせされた複数の等間隔のファセットを備える、請求項1に記載のカテーテル。
[請求項9]
前記遠位端部材は、アブレーションエネルギーを組織に供給するように構成され、前記アブレーションエネルギーは、高周波(RF)エネルギー、マイクロ波エネルギー、電気エネルギー、電磁エネルギー、冷凍エネルギー、レーザーエネルギー、超音波エネルギー、音響エネルギー、化学エネルギー、熱エネルギー及びそれらの組み合わせからなる群から選択される、請求項1〜請求項8のいずれか1つに記載のカテーテル。
[請求項10]
超音波トランスデューサを更に備える、請求項1〜請求項8のいずれか1つに記載のカテーテル。
[請求項11]
位置センサ又はナビゲーションセンサを更に備える、請求項1〜請求項8のいずれか1つに記載のカテーテル。
[請求項12]
アブレーションされた組織を視覚化するシステムであって、
カテーテルと、
光源と、
光測定器と、
前記光源及び前記光測定器とつながっている1つ以上の光ファイバと、
を備え、
前記カテーテルは、
カテーテル本体と、
前記カテーテル本体の遠位端部に配置されて照射キャビティを画定する遠位端部材と、
前記照射キャビティ内に配設される光誘導部材と、
を備え、
前記遠位端部材は、前記照射キャビティと組織との間で光エネルギーを交換するための1つ以上の開口部を有し、
前記光誘導部材は、前記遠位端部材の1つ以上の開口部を介して、組織に光エネルギーを誘導するように、かつ、組織から光エネルギーを誘導するように構成され、
前記1つ以上の光ファイバは、前記カテーテル本体を通って前記遠位端部材の前記照射キャビティ内に至るまで延び、
前記1つ以上の光ファイバは、前記遠位端部材の外側の組織を照らすために光エネルギーを前記光源から前記光誘導部材に送るように構成され、
前記1つ以上の光ファイバは、組織から反射された光エネルギーを前記光測定器に中継するように構成されている、
システム。
[請求項13]
前記1つ以上の光ファイバは、ファイババンドル又は単一のファイバを含む、請求項12に記載のシステム。
[請求項14]
前記遠位端部材はファイバ位置合わせ部材を更に備え、前記ファイバ位置合わせ部材は、前記1つ以上の光ファイバを前記光誘導部材の中心軸と位置合わせするように構成されている、請求項13に記載のシステム。
[請求項15]
前記光誘導部材及び前記1つ以上の開口部は、前記カテーテルの長手方向軸に対する径方向及び軸方向に組織を照らすことができるように構成されている、請求項12に記載のシステム。
[請求項16]
前記1つ以上の開口部は前記遠位端部材の側壁に沿って配設され、前記光誘導部材は、前記1つ以上の開口部を介して、前記カテーテルの長手方向軸に対するある角度で光エネルギーを誘導するように形成されている、請求項12に記載のシステム。
[請求項17]
前記光誘導部材は1つ以上の貫通孔を備え、前記遠位端部材は、前記遠位端部材の前壁に配設された1つ以上の開口部を備え、光が前記光誘導部材及び前記前壁の1つ以上の開口部を長手方向に通過することができる、請求項16に記載のシステム。
[請求項18]
前記1つ以上の開口部を介してのみ光を反射するように前記光誘導部材が前記1つ以上の開口部と位置合わせされている、請求項16に記載のシステム。
[請求項19]
前記1つ以上の開口部は、前記遠位端部材に沿って周方向に配設されて互いに等距離だけ離間され、前記光誘導部材は、前記1つ以上の開口部と位置合わせされた複数の等間隔のファセットを備える、請求項12に記載のシステム。
[請求項20]
前記遠位端部材は、アブレーションエネルギーを組織に供給するように構成され、前記アブレーションエネルギーは、高周波(RF)エネルギー、マイクロ波エネルギー、電気エネルギー、電磁エネルギー、冷凍エネルギー、レーザーエネルギー、超音波エネルギー、音響エネルギー、化学エネルギー、熱エネルギー及びそれらの組み合わせからなる群から選択される、請求項12〜請求項19のいずれか1つに記載のシステム。
[請求項21]
前記カテーテルは超音波トランスデューサを更に備える、請求項12〜請求項19のいずれか1つに記載のシステム。
[請求項22]
前記カテーテルは、位置センサ又はナビゲーションセンサを更に備える、請求項12〜請求項19のいずれか1つに記載のシステム。
[請求項23]
アブレーションされた組織を視覚化する方法であって、
カテーテル本体と、
前記カテーテル本体の遠位端部に配置されて照射キャビティを画定する遠位端部材であって、前記照射キャビティと組織との間で光を交換するための1つ以上の開口部を有する前記遠位端部材と、
前記照射キャビティ内に配設される光誘導部材であって、前記遠位端部材の1つ以上の開口部を介して、組織に光を誘導するように、かつ、組織から光を誘導するように構成されている前記光誘導部材と、
を備えるカテーテルを、アブレーションを必要とする心臓組織へ前進させること、
アブレーションされた心臓組織及びアブレーションされていない心臓組織を含む心臓組織の領域内のニコチンアミドアデニンジヌクレオチド水素(NADH)を励起するために、前記カテーテルの前記遠位端部材の1つ以上の開口部を介して前記光誘導部材に光を誘導させること、
心臓組織から反射された光を前記1つ以上の開口部を介して収集し、この収集された光を光測定器に誘導すること、
心臓組織の前記領域のNADH蛍光を検出するために心臓組織の前記領域を撮像すること、及び、
前記撮像されて照らされた心臓組織の表示を生成すること、
を含み、
前記表示は、前記アブレーションされた心臓組織を、前記アブレーションされていない心臓組織よりも少ない蛍光を呈するものとして示す、
方法。
[請求項24]
組織を撮像するに先立って、前記遠位端部材により組織をアブレーションすることを更に含む、請求項23に記載の方法。
[請求項25]
前記アブレーションされた心臓組織と前記アブレーションされていない心臓組織とを前記蛍光の量に基づいて区別することによって識別された別のアブレーションされていない心臓組織をアブレーションすることを更に含む、請求項24に記載の方法。
[請求項26]
前記光誘導部材及び前記1つ以上の開口部は、前記カテーテルの長手方向軸に対する径方向及び軸方向に心臓組織を照らすことができるように構成されている、請求項23に記載の方法。
[請求項27]
前記照射キャビティ内に至るまで延びて前記照射キャビティに対して光の送受を行う1つ以上の光ファイバを更に備える、請求項23に記載の方法。
[請求項28]
前記遠位端部材はファイバ位置合わせ部材を更に備え、前記ファイバ位置合わせ部材は、前記1つ以上の光ファイバを前記光誘導部材の中心軸と位置合わせするように構成されている、請求項27に記載の方法。
[請求項29]
前記光誘導部材及び前記1つ以上の開口部は、前記カテーテルの長手方向軸に対する径方向及び軸方向に組織を照らすことができるように構成されている、請求項23に記載の方法。
[請求項30]
前記1つ以上の開口部は前記遠位端部材の側壁に沿って配設され、前記光誘導部材は、前記1つ以上の開口部を介して、前記カテーテルの長手方向軸に対するある角度で光エネルギーを誘導するように形成されている、請求項23に記載の方法。
[請求項31]
前記光誘導部材は1つ以上の貫通孔を備え、前記遠位端部材は、前記遠位端部材の前壁に配設された1つ以上の開口部を備え、光が前記光誘導部材及び前記前壁の1つ以上の開口部を長手方向に通過することができる、請求項30に記載の方法。
[請求項32]
前記1つ以上の開口部を介してのみ光を反射するように前記光誘導部材が前記1つ以上の開口部と位置合わせされている、請求項30に記載の方法。
[請求項33]
前記1つ以上の開口部は、前記遠位端部材に沿って周方向に配設されて互いに等距離だけ離間され、前記光誘導部材は、前記1つ以上の開口部と位置合わせされた複数の等間隔のファセットを備える、請求項23に記載の方法。
[請求項34]
前記遠位端部材は、アブレーションエネルギーを組織に供給するように構成され、前記アブレーションエネルギーは、高周波(RF)エネルギー、マイクロ波エネルギー、電気エネルギー、電磁エネルギー、冷凍エネルギー、レーザーエネルギー、超音波エネルギー、音響エネルギー、化学エネルギー、熱エネルギー及びそれらの組み合わせからなる群から選択される、請求項23〜請求項33のいずれか1つに記載の方法。
[請求項35]
超音波トランスデューサを更に備える、請求項23〜請求項33のいずれか1つに記載の方法。
[請求項36]
位置センサ又はナビゲーションセンサを更に備える、請求項23〜請求項33のいずれか1つに記載の方法。
[請求項37]
アブレーションされた組織を視覚化するためのシステムであって、
カテーテルと、
アブレーション治療システムと、
視覚化システムと、
イリゲーションシステムと、
組織を超音波により評価するための超音波システムと、
前記カテーテルの位置特定及び誘導を行うためのナビゲーションシステムと、
を備え、
前記カテーテルは、
カテーテル本体と、
前記カテーテル本体の遠位端部に配置されて照射キャビティを画定する遠位端部材と、
前記照射キャビティ内に配設される光誘導部材と、
を備え、
前記遠位端部材は、アブレーションエネルギーを組織に供給するように構成され、
前記遠位端部材は、前記照射キャビティと組織との間で光エネルギーを交換するための1つ以上の開口部を有し、
前記光誘導部材は、前記遠位端部材の1つ以上の開口部を介して、組織に光エネルギーを誘導するように、かつ、組織から光エネルギーを誘導するように構成され、
前記カテーテルは、1つ以上の超音波トランスデューサ及び1つ以上の電磁位置センサを更に備え、
前記アブレーション治療システムは、前記アブレーションエネルギーを組織に供給するために前記遠位端部材とつながっており、
前記視覚化システムは、
光源と、
光測定器と、
前記光源及び前記光測定器とつながっている1つ以上の光ファイバと、
を備え、
前記1つ以上の光ファイバは、前記カテーテル本体を通って前記遠位端部材の前記照射キャビティ内に至るまで延び、
前記1つ以上の光ファイバは、前記照射キャビティと光エネルギーをやり取りするように構成され、
前記イリゲーションシステムは、前記1つ以上の開口部の洗浄を行うためのものであり、
前記超音波システムは、前記1つ以上の超音波トランスデューサとつながっており、
前記ナビゲーションシステムは、前記1つ以上の電磁位置センサとつながっている、
システム。
[請求項38]
前記アブレーションエネルギーは、高周波(RF)エネルギー、マイクロ波エネルギー、電気エネルギー、電磁エネルギー、冷凍エネルギー、レーザーエネルギー、超音波エネルギー、音響エネルギー、化学エネルギー、熱エネルギー及びそれらの組み合わせからなる群から選択される、請求項37に記載のシステム。
Claims (24)
- アブレーションされた組織を視覚化するカテーテルであって、
カテーテル本体と、
前記カテーテル本体の遠位端部に配置されて照射キャビティを画定する遠位端部材と、
前記照射キャビティ内に配設される光誘導部材と、
を備え、
前記遠位端部材は、前記照射キャビティと組織との間で光エネルギーを交換するための1つ以上の開口部を有し、
前記光誘導部材は、前面を形成するために、互いに隣接し、かつ、互いに対して角度付けされた複数のファセットを有し、
前記光誘導部材の前記複数のファセットは、前記遠位端部材の1つ以上の開口部を介して、組織に光エネルギーを反射するように、かつ、組織からの光エネルギーを反射するように、前記1つ以上の開口部から離間されている、
カテーテル。 - 前記照射キャビティ内に至るまで延びて前記照射キャビティに対して光エネルギーの送受を行う1つ以上の光ファイバを更に備える、請求項1に記載のカテーテル。
- 前記遠位端部材はファイバ位置合わせ部材を更に備え、前記ファイバ位置合わせ部材は、前記1つ以上の光ファイバを前記光誘導部材の中心軸と位置合わせするように構成されている、請求項2に記載のカテーテル。
- 前記光誘導部材及び前記1つ以上の開口部は、前記カテーテルの長手方向軸に対する径方向及び軸方向に組織を光エネルギーによって照らすことができるように構成されている、請求項1に記載のカテーテル。
- 前記1つ以上の開口部は前記遠位端部材の側壁に沿って配設され、前記光誘導部材は、前記1つ以上の開口部を介して、前記カテーテルの長手方向軸に対するある角度で光エネルギーを誘導するように形成されている、請求項1に記載のカテーテル。
- 前記光誘導部材は1つ以上の貫通孔を備え、前記遠位端部材は、前記遠位端部材の前壁に配設された1つ以上の開口部を備え、光エネルギーが前記光誘導部材及び前記前壁の1つ以上の開口部を長手方向に通過することができる、請求項5に記載のカテーテル。
- 前記1つ以上の開口部を介してのみ光エネルギーを反射するように前記光誘導部材が前記1つ以上の開口部と位置合わせされている、請求項5に記載のカテーテル。
- 前記1つ以上の開口部は、前記遠位端部材に沿って周方向に配設されて互いに等距離だけ離間され、前記光誘導部材の前記複数のファセットは、前記1つ以上の開口部と位置合わせされている、請求項1に記載のカテーテル。
- 前記遠位端部材は、アブレーションエネルギーを組織に供給するように構成され、前記アブレーションエネルギーは、高周波(RF)エネルギー、マイクロ波エネルギー、電気エネルギー、電磁エネルギー、冷凍エネルギー、レーザーエネルギー、超音波エネルギー、音響エネルギー、化学エネルギー、熱エネルギー及びそれらの組み合わせからなる群から選択される、請求項1〜請求項8のいずれか1つに記載のカテーテル。
- 超音波トランスデューサを更に備える、請求項1〜請求項8のいずれか1つに記載のカテーテル。
- 位置センサ又はナビゲーションセンサを更に備える、請求項1〜請求項8のいずれか1つに記載のカテーテル。
- アブレーションされた組織を視覚化するシステムであって、
カテーテルと、
光源と、
光測定器と、
前記光源及び前記光測定器とつながっている1つ以上の光ファイバと、
を備え、
前記カテーテルは、
カテーテル本体と、
前記カテーテル本体の遠位端部に配置されて照射キャビティを画定する遠位端部材と、
前記照射キャビティ内に配設される光誘導部材と、
を備え、
前記遠位端部材は、前記照射キャビティと組織との間で光エネルギーを交換するための1つ以上の開口部を有し、
前記光誘導部材は、前面を形成するために、互いに隣接し、かつ、互いに対して角度付けされた複数のファセットを有し、
前記光誘導部材の前記複数のファセットは、前記遠位端部材の1つ以上の開口部を介して、組織に光エネルギーを反射するように、かつ、組織からの光エネルギーを反射するように、前記1つ以上の開口部から離間され、
前記1つ以上の光ファイバは、前記カテーテル本体を通って前記遠位端部材の前記照射キャビティ内に至るまで延び、
前記1つ以上の光ファイバは、前記遠位端部材の外側の組織を照らすために光エネルギーを前記光源から前記光誘導部材に送るように構成され、
前記1つ以上の光ファイバは、組織から反射された光エネルギーを前記光測定器に中継するように構成されている、
システム。 - 前記1つ以上の光ファイバは、ファイババンドル又は単一のファイバを含む、請求項12に記載のシステム。
- 前記遠位端部材はファイバ位置合わせ部材を更に備え、前記ファイバ位置合わせ部材は、前記1つ以上の光ファイバを前記光誘導部材の中心軸と位置合わせするように構成されている、請求項12に記載のシステム。
- 前記光誘導部材及び前記1つ以上の開口部は、前記カテーテルの長手方向軸に対する径方向及び軸方向に組織を光エネルギーによって照らすことができるように構成されている、請求項12に記載のシステム。
- 前記1つ以上の開口部は前記遠位端部材の側壁に沿って配設され、前記光誘導部材は、前記1つ以上の開口部を介して、前記カテーテルの長手方向軸に対するある角度で光エネルギーを誘導するように形成されている、請求項12に記載のシステム。
- 前記光誘導部材は1つ以上の貫通孔を備え、前記遠位端部材は、前記遠位端部材の前壁に配設された1つ以上の開口部を備え、光エネルギーが前記光誘導部材及び前記前壁の1つ以上の開口部を長手方向に通過することができる、請求項16に記載のシステム。
- 前記1つ以上の開口部を介してのみ光エネルギーを反射するように前記光誘導部材が前記1つ以上の開口部と位置合わせされている、請求項16に記載のシステム。
- 前記1つ以上の開口部は、前記遠位端部材に沿って周方向に配設されて互いに等距離だけ離間され、前記光誘導部材の前記複数のファセットは、前記1つ以上の開口部と位置合わせされている、請求項12に記載のシステム。
- 前記遠位端部材は、アブレーションエネルギーを組織に供給するように構成され、前記アブレーションエネルギーは、高周波(RF)エネルギー、マイクロ波エネルギー、電気エネルギー、電磁エネルギー、冷凍エネルギー、レーザーエネルギー、超音波エネルギー、音響エネルギー、化学エネルギー、熱エネルギー及びそれらの組み合わせからなる群から選択される、請求項12〜請求項19のいずれか1つに記載のシステム。
- 前記カテーテルは超音波トランスデューサを更に備える、請求項12〜請求項19のいずれか1つに記載のシステム。
- 前記カテーテルは、位置センサ又はナビゲーションセンサを更に備える、請求項12〜請求項19のいずれか1つに記載のシステム。
- アブレーションされた組織を視覚化するためのシステムであって、
カテーテルと、
アブレーション治療システムと、
視覚化システムと、
イリゲーションシステムと、
組織を超音波により評価するための超音波システムと、
前記カテーテルの位置特定及び誘導を行うためのナビゲーションシステムと、
を備え、
前記カテーテルは、
カテーテル本体と、
前記カテーテル本体の遠位端部に配置されて照射キャビティを画定する遠位端部材と、
前記照射キャビティ内に配設される光誘導部材と、
を備え、
前記遠位端部材は、アブレーションエネルギーを組織に供給するように構成され、
前記遠位端部材は、前記照射キャビティと組織との間で光エネルギーを交換するための1つ以上の開口部を有し、
前記光誘導部材は、前面を形成するために、互いに隣接し、かつ、互いに対して角度付けされた複数のファセットを有し、
前記光誘導部材の前記複数のファセットは、前記遠位端部材の1つ以上の開口部を介して、組織に光エネルギーを反射するように、かつ、組織からの光エネルギーを反射するように、前記1つ以上の開口部から離間され、
前記カテーテルは、1つ以上の超音波トランスデューサ及び1つ以上の電磁位置センサを更に備え、
前記アブレーション治療システムは、前記アブレーションエネルギーを組織に供給するために前記遠位端部材とつながっており、
前記視覚化システムは、
光源と、
光測定器と、
前記光源及び前記光測定器とつながっている1つ以上の光ファイバと、
を備え、
前記1つ以上の光ファイバは、前記カテーテル本体を通って前記遠位端部材の前記照射キャビティ内に至るまで延び、
前記1つ以上の光ファイバは、前記照射キャビティと光エネルギーをやり取りするように構成され、
前記イリゲーションシステムは、前記1つ以上の開口部の洗浄を行うためのものであり、
前記超音波システムは、前記1つ以上の超音波トランスデューサとつながっており、
前記ナビゲーションシステムは、前記1つ以上の電磁位置センサとつながっている、
システム。 - 前記アブレーションエネルギーは、高周波(RF)エネルギー、マイクロ波エネルギー、電気エネルギー、電磁エネルギー、冷凍エネルギー、レーザーエネルギー、超音波エネルギー、音響エネルギー、化学エネルギー、熱エネルギー及びそれらの組み合わせからなる群から選択される、請求項23に記載のシステム。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562194276P | 2015-07-19 | 2015-07-19 | |
US62/194,276 | 2015-07-19 | ||
US14/919,004 | 2015-10-21 | ||
US14/919,004 US10779904B2 (en) | 2015-07-19 | 2015-10-21 | Systems and methods for lesion formation and assessment |
PCT/US2016/042891 WO2017015257A1 (en) | 2015-07-19 | 2016-07-19 | Systems and methods for lesion formation and assessment |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020215456A Division JP7116151B2 (ja) | 2015-07-19 | 2020-12-24 | 損傷形成及び評価のためのシステム |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2018520795A JP2018520795A (ja) | 2018-08-02 |
JP6818007B2 true JP6818007B2 (ja) | 2021-01-20 |
Family
ID=57774829
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018502383A Active JP6818007B2 (ja) | 2015-07-19 | 2016-07-19 | 損傷形成及び評価のためのシステム |
JP2020215456A Active JP7116151B2 (ja) | 2015-07-19 | 2020-12-24 | 損傷形成及び評価のためのシステム |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020215456A Active JP7116151B2 (ja) | 2015-07-19 | 2020-12-24 | 損傷形成及び評価のためのシステム |
Country Status (8)
Country | Link |
---|---|
US (2) | US10779904B2 (ja) |
EP (1) | EP3324832B1 (ja) |
JP (2) | JP6818007B2 (ja) |
KR (1) | KR20180041130A (ja) |
CN (2) | CN108135475B (ja) |
AU (1) | AU2016297534B2 (ja) |
CA (1) | CA2993167A1 (ja) |
WO (1) | WO2017015257A1 (ja) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2757933B1 (en) | 2011-09-22 | 2019-02-06 | The George Washington University | Systems for visualizing ablated tissue |
CN104066368B (zh) | 2011-09-22 | 2017-02-22 | 乔治华盛顿大学 | 用于使经消融组织可视化的系统和方法 |
US11096584B2 (en) | 2013-11-14 | 2021-08-24 | The George Washington University | Systems and methods for determining lesion depth using fluorescence imaging |
JP2017500550A (ja) | 2013-11-20 | 2017-01-05 | ザ・ジョージ・ワシントン・ユニバーシティThe George Washingtonuniversity | 心臓組織のハイパースペクトル分析のためのシステム及び方法 |
JP2017537681A (ja) | 2014-11-03 | 2017-12-21 | ザ・ジョージ・ワシントン・ユニバーシティThe George Washingtonuniversity | 損傷評価システム及びその方法 |
EP3215001A4 (en) | 2014-11-03 | 2018-04-04 | Luxcath, LLC | Systems and methods for assessment of contact quality |
EP3226793A4 (en) | 2014-12-01 | 2018-11-07 | Vesica E.K. Therapeutics Ltd | Device and method for ablative treatment of targeted areas within a body lumen |
US10779904B2 (en) | 2015-07-19 | 2020-09-22 | 460Medical, Inc. | Systems and methods for lesion formation and assessment |
US10321878B2 (en) | 2016-12-22 | 2019-06-18 | Biosense Webster (Israel) Ltd. | Pulmonary vein display in two dimensions |
JP7177072B2 (ja) * | 2017-02-04 | 2022-11-22 | ヴェッシー メディカル リミテッド | 凍結療法デバイスの流れ制御 |
CA3054481C (en) * | 2017-02-24 | 2023-08-22 | Synaptive Medical (Barbados) Inc. | Suction tool with integrated optical probe and use thereof |
CN112236097A (zh) * | 2018-06-08 | 2021-01-15 | 圣犹达医疗用品国际控股有限公司 | 一种光纤力和形状感测 |
DE102019102841A1 (de) | 2019-02-05 | 2020-08-06 | Olympus Winter & Ibe Gmbh | Lösbarer Isoliereinsatz zur Verwendung in einem Resektoskop |
DE102019102839A1 (de) | 2019-02-05 | 2020-08-06 | Olympus Winter & Ibe Gmbh | Spülflüssigkeit für die Resektion |
US11484361B2 (en) * | 2019-08-27 | 2022-11-01 | Nikolai Tankovich | Tip for multiple beam tissue therapy |
US20210145510A1 (en) * | 2019-11-18 | 2021-05-20 | Nido Surgical Inc. | Instrument port for epicardial ablation with inflatable balloon |
CN115103647A (zh) * | 2020-01-08 | 2022-09-23 | 460医学股份有限公司 | 用于消融损伤的光学询问的系统和方法 |
US11331142B2 (en) * | 2020-01-13 | 2022-05-17 | Medlumics S.L. | Methods, devices, and support structures for assembling optical fibers in catheter tips |
CA3162823A1 (en) | 2020-01-13 | 2021-07-22 | Medlumics S.L. | Systems for optical analysis and prediction of lesion using ablation catheters |
DE21701063T1 (de) | 2020-01-13 | 2023-03-23 | Medlumics S.L. | Optisch geführtes ablationssystem zur verwendung mit gepulster feldenergiequelle |
WO2021243061A1 (en) * | 2020-05-27 | 2021-12-02 | The George Washington University | Lesion visualization using dual wavelength approach |
CN116056651A (zh) * | 2020-07-28 | 2023-05-02 | 460医学股份有限公司 | 用于损伤形成和评估的系统和方法 |
CN116322468A (zh) * | 2020-09-29 | 2023-06-23 | 奥林巴斯株式会社 | 辅助装置、内窥镜系统、辅助方法以及程序 |
GB2601336A (en) * | 2020-11-26 | 2022-06-01 | Creo Medical Ltd | Endoscopic, electrosurgical instrument, electrosurgical apparatus comprising such electrosurgical instrument, and endoscopic electrosurgical kit |
CA3150572A1 (en) * | 2021-03-04 | 2022-09-04 | Medlumics S.L. | Methods, devices, and support structures for assembling optical fibers in catheter tips |
Family Cites Families (350)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4619247A (en) | 1983-03-31 | 1986-10-28 | Sumitomo Electric Industries, Ltd. | Catheter |
JPS60182928A (ja) | 1984-03-01 | 1985-09-18 | オリンパス光学工業株式会社 | 固体撮像素子内蔵の内視鏡 |
JPS63262613A (ja) | 1987-04-20 | 1988-10-28 | Olympus Optical Co Ltd | 立体視内視鏡装置 |
EP0449883B1 (en) | 1988-12-21 | 1996-01-31 | Massachusetts Institute Of Technology | A method for laser induced fluorescence of tissue |
US5421337A (en) | 1989-04-14 | 1995-06-06 | Massachusetts Institute Of Technology | Spectral diagnosis of diseased tissue |
US5074306A (en) | 1990-02-22 | 1991-12-24 | The General Hospital Corporation | Measurement of burn depth in skin |
JP3164609B2 (ja) | 1990-10-31 | 2001-05-08 | オリンパス光学工業株式会社 | 内視鏡装置 |
US6485413B1 (en) | 1991-04-29 | 2002-11-26 | The General Hospital Corporation | Methods and apparatus for forward-directed optical scanning instruments |
CA2042075C (en) | 1991-05-08 | 2001-01-23 | Branko Palcic | Endoscopic imaging system |
US5540681A (en) | 1992-04-10 | 1996-07-30 | Medtronic Cardiorhythm | Method and system for radiofrequency ablation of tissue |
US5350375A (en) | 1993-03-15 | 1994-09-27 | Yale University | Methods for laser induced fluorescence intensity feedback control during laser angioplasty |
AU7404994A (en) | 1993-07-30 | 1995-02-28 | Regents Of The University Of California, The | Endocardial infusion catheter |
US5749830A (en) | 1993-12-03 | 1998-05-12 | Olympus Optical Co., Ltd. | Fluorescent endoscope apparatus |
US5590660A (en) | 1994-03-28 | 1997-01-07 | Xillix Technologies Corp. | Apparatus and method for imaging diseased tissue using integrated autofluorescence |
WO1995029737A1 (en) | 1994-05-03 | 1995-11-09 | Board Of Regents, The University Of Texas System | Apparatus and method for noninvasive doppler ultrasound-guided real-time control of tissue damage in thermal therapy |
US20080154257A1 (en) | 2006-12-22 | 2008-06-26 | Shiva Sharareh | Real-time optoacoustic monitoring with electophysiologic catheters |
US5810802A (en) | 1994-08-08 | 1998-09-22 | E.P. Technologies, Inc. | Systems and methods for controlling tissue ablation using multiple temperature sensing elements |
US8025661B2 (en) | 1994-09-09 | 2011-09-27 | Cardiofocus, Inc. | Coaxial catheter instruments for ablation with radiant energy |
US6572609B1 (en) | 1999-07-14 | 2003-06-03 | Cardiofocus, Inc. | Phototherapeutic waveguide apparatus |
US6423055B1 (en) | 1999-07-14 | 2002-07-23 | Cardiofocus, Inc. | Phototherapeutic wave guide apparatus |
US5954665A (en) | 1995-06-07 | 1999-09-21 | Biosense, Inc. | Cardiac ablation catheter using correlation measure |
US5713364A (en) | 1995-08-01 | 1998-02-03 | Medispectra, Inc. | Spectral volume microprobe analysis of materials |
US6309352B1 (en) | 1996-01-31 | 2001-10-30 | Board Of Regents, The University Of Texas System | Real time optoacoustic monitoring of changes in tissue properties |
US5885258A (en) | 1996-02-23 | 1999-03-23 | Memory Medical Systems, Inc. | Medical instrument with slotted memory metal tube |
WO1997037622A1 (en) | 1996-04-08 | 1997-10-16 | The University Of Southern California | Method and apparatus for using laser-induced fluorescence during photoretractive keratectomy |
US5904651A (en) | 1996-10-28 | 1999-05-18 | Ep Technologies, Inc. | Systems and methods for visualizing tissue during diagnostic or therapeutic procedures |
JP3003597B2 (ja) | 1996-11-18 | 2000-01-31 | 日本電気株式会社 | 固体撮像素子 |
US5833688A (en) | 1997-02-24 | 1998-11-10 | Boston Scientific Corporation | Sensing temperature with plurality of catheter sensors |
US6208886B1 (en) | 1997-04-04 | 2001-03-27 | The Research Foundation Of City College Of New York | Non-linear optical tomography of turbid media |
US6124597A (en) | 1997-07-07 | 2000-09-26 | Cedars-Sinai Medical Center | Method and devices for laser induced fluorescence attenuation spectroscopy |
EP1016430B1 (en) | 1997-09-12 | 2004-12-15 | Nippon Zeon Co., Ltd. | Balloon catheter |
US6238389B1 (en) | 1997-09-30 | 2001-05-29 | Boston Scientific Corporation | Deflectable interstitial ablation device |
US6289236B1 (en) | 1997-10-10 | 2001-09-11 | The General Hospital Corporation | Methods and apparatus for distinguishing inflamed and tumorous bladder tissue |
US6937885B1 (en) | 1997-10-30 | 2005-08-30 | Hypermed, Inc. | Multispectral/hyperspectral medical instrument |
DE69938493T2 (de) | 1998-01-26 | 2009-05-20 | Massachusetts Institute Of Technology, Cambridge | Endoskop zur erfassung von fluoreszenzbilder |
US6174291B1 (en) | 1998-03-09 | 2001-01-16 | Spectrascience, Inc. | Optical biopsy system and methods for tissue diagnosis |
US6251107B1 (en) | 1998-06-25 | 2001-06-26 | Cardima, Inc. | Ep catheter |
US6112123A (en) | 1998-07-28 | 2000-08-29 | Endonetics, Inc. | Device and method for ablation of tissue |
US8024027B2 (en) | 1998-09-03 | 2011-09-20 | Hyperspectral Imaging, Inc. | Infrared endoscopic balloon probes |
EP1112022A4 (en) | 1998-09-11 | 2004-08-04 | Spectrx Inc | MULTI-MODAL OPTICAL TISSUE DIAGNOSIS DEVICE |
US6178346B1 (en) | 1998-10-23 | 2001-01-23 | David C. Amundson | Infrared endoscopic imaging in a liquid with suspended particles: method and apparatus |
US6701176B1 (en) | 1998-11-04 | 2004-03-02 | Johns Hopkins University School Of Medicine | Magnetic-resonance-guided imaging, electrophysiology, and ablation |
US6210406B1 (en) | 1998-12-03 | 2001-04-03 | Cordis Webster, Inc. | Split tip electrode catheter and signal processing RF ablation system |
US6423057B1 (en) | 1999-01-25 | 2002-07-23 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Method and apparatus for monitoring and controlling tissue temperature and lesion formation in radio-frequency ablation procedures |
WO2001001854A2 (en) | 1999-07-02 | 2001-01-11 | Hypermed Imaging, Inc. | Integrated imaging apparatus |
JP2001017379A (ja) | 1999-07-09 | 2001-01-23 | Fuji Photo Film Co Ltd | 蛍光診断装置 |
US6219566B1 (en) | 1999-07-13 | 2001-04-17 | Photonics Research Ontario | Method of measuring concentration of luminescent materials in turbid media |
US8900219B2 (en) | 1999-07-14 | 2014-12-02 | Cardiofocus, Inc. | System and method for visualizing tissue during ablation procedures |
US9033961B2 (en) | 1999-07-14 | 2015-05-19 | Cardiofocus, Inc. | Cardiac ablation catheters for forming overlapping lesions |
US8540704B2 (en) | 1999-07-14 | 2013-09-24 | Cardiofocus, Inc. | Guided cardiac ablation catheters |
WO2001005306A1 (en) | 1999-07-19 | 2001-01-25 | Epicor, Inc. | Apparatus and method for ablating tissue |
US6343228B1 (en) | 1999-10-19 | 2002-01-29 | The Hong Kong University Of Science And Technology | Method and apparatus for fluorescence imaging of tissue |
US6542767B1 (en) | 1999-11-09 | 2003-04-01 | Biotex, Inc. | Method and system for controlling heat delivery to a target |
US8221402B2 (en) | 2000-01-19 | 2012-07-17 | Medtronic, Inc. | Method for guiding a medical device |
US6663622B1 (en) | 2000-02-11 | 2003-12-16 | Iotek, Inc. | Surgical devices and methods for use in tissue ablation procedures |
GR1004180B (el) | 2000-03-28 | 2003-03-11 | ����������� ����� ��������� (����) | Μεθοδος και συστημα χαρακτηρισμου και χαρτογραφησης αλλοιωσεων των ιστων |
WO2001082811A1 (en) | 2000-04-27 | 2001-11-08 | Medtronic, Inc. | System and method for assessing transmurality of ablation lesions |
US20020107514A1 (en) | 2000-04-27 | 2002-08-08 | Hooven Michael D. | Transmural ablation device with parallel jaws |
US7252664B2 (en) | 2000-05-12 | 2007-08-07 | Cardima, Inc. | System and method for multi-channel RF energy delivery with coagulum reduction |
ATE413848T1 (de) | 2000-05-12 | 2008-11-15 | Cardima Inc | Mehrkanaliges hochfrequenzabgabesystem mit koagulierungsreduktion |
US6975898B2 (en) | 2000-06-19 | 2005-12-13 | University Of Washington | Medical imaging, diagnosis, and therapy using a scanning single optical fiber system |
IL138683A0 (en) | 2000-09-25 | 2001-10-31 | Vital Medical Ltd | Apparatus and method for monitoring tissue vitality parameters |
US6450971B1 (en) | 2000-10-05 | 2002-09-17 | Scimed Life Systems, Inc. | Temperature measuring balloon |
US6663561B2 (en) | 2000-10-05 | 2003-12-16 | Pentax Corporation | Video endoscope system |
US7047068B2 (en) | 2000-12-11 | 2006-05-16 | C.R. Bard, Inc. | Microelectrode catheter for mapping and ablation |
JP2002253500A (ja) | 2001-03-05 | 2002-09-10 | Olympus Optical Co Ltd | 内視鏡用光源装置 |
US6743225B2 (en) | 2001-03-27 | 2004-06-01 | Uab Research Foundation | Electrophysiologic measure of endpoints for ablation lesions created in fibrillating substrates |
US6663627B2 (en) | 2001-04-26 | 2003-12-16 | Medtronic, Inc. | Ablation system and method of use |
US6989010B2 (en) | 2001-04-26 | 2006-01-24 | Medtronic, Inc. | Ablation system and method of use |
US6648883B2 (en) | 2001-04-26 | 2003-11-18 | Medtronic, Inc. | Ablation system and method of use |
US7959626B2 (en) | 2001-04-26 | 2011-06-14 | Medtronic, Inc. | Transmural ablation systems and methods |
US7250048B2 (en) | 2001-04-26 | 2007-07-31 | Medtronic, Inc. | Ablation system and method of use |
ATE418287T1 (de) | 2001-04-27 | 2009-01-15 | Bard Inc C R | Katheter zur drei-dimensionallen abbildung der elektrischen aktivität in blutgefässen |
US7727229B2 (en) | 2001-05-01 | 2010-06-01 | C.R. Bard, Inc. | Method and apparatus for altering conduction properties in the heart and in adjacent vessels |
WO2002087679A2 (en) | 2001-05-01 | 2002-11-07 | C.R. Bard, Inc. | Method and apparatus for altering conduction properties along pathways in the heart and in vessels in conductive communication with the heart |
US20030208252A1 (en) | 2001-05-14 | 2003-11-06 | O' Boyle Gary S. | Mri ablation catheter |
US8078268B2 (en) | 2001-06-28 | 2011-12-13 | Chemimage Corporation | System and method of chemical imaging using pulsed laser excitation and time-gated detection to determine tissue margins during surgery |
US7596404B2 (en) | 2001-06-28 | 2009-09-29 | Chemimage Corporation | Method of chemical imaging to determine tissue margins during surgery |
US6761716B2 (en) | 2001-09-18 | 2004-07-13 | Cardiac Pacemakers, Inc. | System and method for assessing electrode-tissue contact and lesion quality during RF ablation by measurement of conduction time |
CA2460501A1 (en) | 2001-09-28 | 2003-04-10 | Institut De Cardiologie De Montreal | Method for identification and visualization of atrial tissue |
AU2002365095A1 (en) | 2001-11-09 | 2003-07-09 | Cardio-Optics, Inc. | Coronary sinus access catheter with forward-imaging |
US20030120144A1 (en) | 2001-11-16 | 2003-06-26 | Grabek James R. | Intrapericardial temperature measurement device and method |
US20090281541A1 (en) | 2008-05-09 | 2009-11-12 | Estech, Inc. | Conduction block systems and methods |
US7749157B2 (en) | 2001-12-04 | 2010-07-06 | Estech, Inc. (Endoscopic Technologies, Inc.) | Methods and devices for minimally invasive cardiac surgery for atrial fibrillation |
US20040092806A1 (en) | 2001-12-11 | 2004-05-13 | Sagon Stephen W | Microelectrode catheter for mapping and ablation |
US6825928B2 (en) | 2001-12-19 | 2004-11-30 | Wisconsin Alumni Research Foundation | Depth-resolved fluorescence instrument |
US6873868B2 (en) | 2001-12-31 | 2005-03-29 | Infraredx, Inc. | Multi-fiber catheter probe arrangement for tissue analysis or treatment |
US20040215310A1 (en) | 2002-01-17 | 2004-10-28 | Omar Amirana | Stent and delivery method for applying RF energy to a pulmonary vein and the atrial wall around its ostium to eliminate atrial fibrillation while preventing stenosis of the pulmonary vein thereafter |
US7967816B2 (en) | 2002-01-25 | 2011-06-28 | Medtronic, Inc. | Fluid-assisted electrosurgical instrument with shapeable electrode |
US7192427B2 (en) | 2002-02-19 | 2007-03-20 | Afx, Inc. | Apparatus and method for assessing transmurality of a tissue ablation |
US20050075629A1 (en) | 2002-02-19 | 2005-04-07 | Afx, Inc. | Apparatus and method for assessing tissue ablation transmurality |
US7846157B2 (en) | 2002-03-15 | 2010-12-07 | C.R. Bard, Inc. | Method and apparatus for control of ablation energy and electrogram acquisition through multiple common electrodes in an electrophysiology catheter |
US6746401B2 (en) | 2002-05-06 | 2004-06-08 | Scimed Life Systems, Inc. | Tissue ablation visualization |
EP1501435B1 (en) | 2002-05-06 | 2007-08-29 | Covidien AG | Blood detector for controlling an esu |
US8956280B2 (en) | 2002-05-30 | 2015-02-17 | Intuitive Surgical Operations, Inc. | Apparatus and methods for placing leads using direct visualization |
US6979290B2 (en) | 2002-05-30 | 2005-12-27 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for coronary sinus access |
US20050119548A1 (en) | 2002-07-05 | 2005-06-02 | Vanderbilt University | Method and apparatus for optical spectroscopic detection of cell and tissue death |
AU2003279097A1 (en) | 2002-09-30 | 2004-04-19 | Vanderbilt University | Optical apparatus for guided liver tumor treatment and methods |
US7001383B2 (en) | 2002-10-21 | 2006-02-21 | Biosense, Inc. | Real-time monitoring and mapping of ablation lesion formation in the heart |
US7306593B2 (en) | 2002-10-21 | 2007-12-11 | Biosense, Inc. | Prediction and assessment of ablation of cardiac tissue |
CN1764419A (zh) | 2003-02-20 | 2006-04-26 | 普罗里森姆股份有限公司 | 心脏消融装置 |
EP1644867B1 (en) | 2003-04-18 | 2010-08-11 | Medispectra, Inc. | A system and diagnostic method for optical detection of suspect portions of a tissue sample |
WO2004096049A2 (en) * | 2003-04-28 | 2004-11-11 | Board Of Regents, The University Of Texas System | Catheter imaging probe and method |
US7539530B2 (en) | 2003-08-22 | 2009-05-26 | Infraredx, Inc. | Method and system for spectral examination of vascular walls through blood during cardiac motion |
US7534204B2 (en) | 2003-09-03 | 2009-05-19 | Guided Delivery Systems, Inc. | Cardiac visualization devices and methods |
US20060009755A1 (en) | 2003-09-04 | 2006-01-12 | Sra Jasbir S | Method and system for ablation of atrial fibrillation and other cardiac arrhythmias |
US7289205B2 (en) | 2003-09-19 | 2007-10-30 | The General Hospital Corporation | Fluorescence polarization imaging devices and methods |
US8172747B2 (en) | 2003-09-25 | 2012-05-08 | Hansen Medical, Inc. | Balloon visualization for traversing a tissue wall |
WO2005041753A2 (en) | 2003-10-20 | 2005-05-12 | Johns Hopkins University | Catheter and method for ablation of atrial tissue |
WO2005044124A1 (en) | 2003-10-30 | 2005-05-19 | Medical Cv, Inc. | Apparatus and method for laser treatment |
US7232437B2 (en) | 2003-10-30 | 2007-06-19 | Medical Cv, Inc. | Assessment of lesion transmurality |
US20050137459A1 (en) | 2003-12-17 | 2005-06-23 | Scimed Life Systems, Inc. | Medical device with OLED illumination light source |
US7587236B2 (en) | 2004-01-08 | 2009-09-08 | Lawrence Livermore National Security, Llc | Optical spectroscopy for the detection of ischemic tissue injury |
US20050215899A1 (en) | 2004-01-15 | 2005-09-29 | Trahey Gregg E | Methods, systems, and computer program products for acoustic radiation force impulse (ARFI) imaging of ablated tissue |
US20050228452A1 (en) | 2004-02-11 | 2005-10-13 | Mourlas Nicholas J | Steerable catheters and methods for using them |
US20050197623A1 (en) | 2004-02-17 | 2005-09-08 | Leeflang Stephen A. | Variable steerable catheters and methods for using them |
US20050251116A1 (en) | 2004-05-05 | 2005-11-10 | Minnow Medical, Llc | Imaging and eccentric atherosclerotic material laser remodeling and/or ablation catheter |
ATE399579T1 (de) | 2004-05-14 | 2008-07-15 | Medtronic Inc | System zur verwendung von hochintensivem fokussiertem ultraschall zur bildung eines ablatierten gewebebereiches |
US7640046B2 (en) | 2004-06-18 | 2009-12-29 | Cardiac Pacemakers, Inc. | Methods and apparatuses for localizing myocardial infarction during catheterization |
US7527625B2 (en) | 2004-08-04 | 2009-05-05 | Olympus Corporation | Transparent electrode for the radiofrequency ablation of tissue |
US20060089637A1 (en) | 2004-10-14 | 2006-04-27 | Werneth Randell L | Ablation catheter |
US20060089636A1 (en) | 2004-10-27 | 2006-04-27 | Christopherson Mark A | Ultrasound visualization for transurethral needle ablation |
US7417740B2 (en) | 2004-11-12 | 2008-08-26 | Medeikon Corporation | Single trace multi-channel low coherence interferometric sensor |
US20060122587A1 (en) | 2004-11-17 | 2006-06-08 | Shiva Sharareh | Apparatus for real time evaluation of tissue ablation |
US10413188B2 (en) | 2004-11-17 | 2019-09-17 | Lawrence Livermore National Security, Llc | Assessment of tissue or lesion depth using temporally resolved light scattering spectroscopy |
US20060229515A1 (en) | 2004-11-17 | 2006-10-12 | The Regents Of The University Of California | Fiber optic evaluation of tissue modification |
US8548570B2 (en) | 2004-11-29 | 2013-10-01 | Hypermed Imaging, Inc. | Hyperspectral imaging of angiogenesis |
JP4656924B2 (ja) | 2004-12-03 | 2011-03-23 | 株式会社トプコン | 分光眼底画像データ測定装置 |
US7367944B2 (en) | 2004-12-13 | 2008-05-06 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Method and system for monitoring ablation of tissues |
US8858495B2 (en) | 2004-12-28 | 2014-10-14 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Five degree of freedom ultrasound catheter and catheter control handle |
US7727231B2 (en) | 2005-01-08 | 2010-06-01 | Boston Scientific Scimed, Inc. | Apparatus and methods for forming lesions in tissue and applying stimulation energy to tissue in which lesions are formed |
US7776033B2 (en) | 2005-01-08 | 2010-08-17 | Boston Scientific Scimed, Inc. | Wettable structures including conductive fibers and apparatus including the same |
US7862561B2 (en) | 2005-01-08 | 2011-01-04 | Boston Scientific Scimed, Inc. | Clamp based lesion formation apparatus with variable spacing structures |
US7729750B2 (en) | 2005-01-20 | 2010-06-01 | The Regents Of The University Of California | Method and apparatus for high resolution spatially modulated fluorescence imaging and tomography |
US8050746B2 (en) | 2005-02-02 | 2011-11-01 | Voyage Medical, Inc. | Tissue visualization device and method variations |
US8078266B2 (en) | 2005-10-25 | 2011-12-13 | Voyage Medical, Inc. | Flow reduction hood systems |
US7860555B2 (en) | 2005-02-02 | 2010-12-28 | Voyage Medical, Inc. | Tissue visualization and manipulation system |
US7930016B1 (en) | 2005-02-02 | 2011-04-19 | Voyage Medical, Inc. | Tissue closure system |
US8137333B2 (en) | 2005-10-25 | 2012-03-20 | Voyage Medical, Inc. | Delivery of biological compounds to ischemic and/or infarcted tissue |
US20080009747A1 (en) | 2005-02-02 | 2008-01-10 | Voyage Medical, Inc. | Transmural subsurface interrogation and ablation |
US20080015569A1 (en) | 2005-02-02 | 2008-01-17 | Voyage Medical, Inc. | Methods and apparatus for treatment of atrial fibrillation |
US10064540B2 (en) | 2005-02-02 | 2018-09-04 | Intuitive Surgical Operations, Inc. | Visualization apparatus for transseptal access |
US7860556B2 (en) | 2005-02-02 | 2010-12-28 | Voyage Medical, Inc. | Tissue imaging and extraction systems |
US7918787B2 (en) | 2005-02-02 | 2011-04-05 | Voyage Medical, Inc. | Tissue visualization and manipulation systems |
CA2947613C (en) | 2005-04-04 | 2019-11-05 | Hypermed Imaging, Inc. | Hyperspectral imaging in diabetes and peripheral vascular disease |
WO2006122061A1 (en) | 2005-05-06 | 2006-11-16 | Acumen Medical, Inc. | Complexly shaped steerable catheters and methods for making and using them |
DE102005021205B4 (de) | 2005-05-07 | 2007-08-16 | Mfd Diagnostics Gmbh | Verfahren und Anordnung zur lokalen Erfassung der Vitalität von lebenden Zellen in Zellkulturen oder im Gewebe |
US20070038126A1 (en) | 2005-06-23 | 2007-02-15 | Pyle Jason L | System and method for monitoring of end organ oxygenation by measurement of in vivo cellular energy status |
US8556851B2 (en) | 2005-07-05 | 2013-10-15 | Angioslide Ltd. | Balloon catheter |
DE102005032755B4 (de) | 2005-07-13 | 2014-09-04 | Siemens Aktiengesellschaft | System zur Durchführung und Überwachung minimal-invasiver Eingriffe |
US8894589B2 (en) | 2005-08-01 | 2014-11-25 | Endosense Sa | Medical apparatus system having optical fiber load sensing capability |
US7681579B2 (en) | 2005-08-02 | 2010-03-23 | Biosense Webster, Inc. | Guided procedures for treating atrial fibrillation |
US7877128B2 (en) | 2005-08-02 | 2011-01-25 | Biosense Webster, Inc. | Simulation of invasive procedures |
US8583220B2 (en) | 2005-08-02 | 2013-11-12 | Biosense Webster, Inc. | Standardization of catheter-based treatment for atrial fibrillation |
US7740584B2 (en) | 2005-08-16 | 2010-06-22 | The General Electric Company | Method and system for mapping physiology information onto ultrasound-based anatomic structure |
JP4681981B2 (ja) | 2005-08-18 | 2011-05-11 | Hoya株式会社 | 電子内視鏡装置 |
US7824397B2 (en) | 2005-08-19 | 2010-11-02 | Boston Scientific Scimed, Inc. | Occlusion apparatus |
EP1922005B1 (en) | 2005-08-25 | 2011-12-21 | Koninklijke Philips Electronics N.V. | System for electrophysiology regaining support to continue line and ring ablations |
WO2007041542A2 (en) * | 2005-09-30 | 2007-04-12 | Cornova, Inc. | Systems and methods for analysis and treatment of a body lumen |
US20070270717A1 (en) | 2005-09-30 | 2007-11-22 | Cornova, Inc. | Multi-faceted optical reflector |
US8929973B1 (en) | 2005-10-24 | 2015-01-06 | Lockheed Martin Corporation | Apparatus and method for characterizing optical sources used with human and animal tissues |
US8221310B2 (en) | 2005-10-25 | 2012-07-17 | Voyage Medical, Inc. | Tissue visualization device and method variations |
US9492226B2 (en) | 2005-12-06 | 2016-11-15 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Graphical user interface for real-time RF lesion depth display |
US8317783B2 (en) | 2005-12-06 | 2012-11-27 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Assessment of electrode coupling for tissue ablation |
US9254163B2 (en) | 2005-12-06 | 2016-02-09 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Assessment of electrode coupling for tissue ablation |
US8406866B2 (en) | 2005-12-06 | 2013-03-26 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for assessing coupling between an electrode and tissue |
US8603084B2 (en) | 2005-12-06 | 2013-12-10 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for assessing the formation of a lesion in tissue |
BRPI0619725A2 (pt) | 2005-12-06 | 2011-10-11 | St Jude Medical Atrial Fibrill | avaliação de junção de eletrodo para ablação do tecido |
US8403925B2 (en) | 2006-12-06 | 2013-03-26 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for assessing lesions in tissue |
US8998890B2 (en) | 2005-12-06 | 2015-04-07 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Assessment of electrode coupling for tissue ablation |
EP2289398A3 (en) | 2006-01-19 | 2011-04-06 | The General Hospital Corporation | Methods and systems for optical imaging of epithelial luminal organs by beam scanning thereof |
EP2659851A3 (en) | 2006-02-01 | 2014-01-15 | The General Hospital Corporation | Apparatus for applying a plurality of electro-magnetic radiations to a sample |
US20070185479A1 (en) | 2006-02-06 | 2007-08-09 | Liming Lau | Methods and devices for performing ablation and assessing efficacy thereof |
US7918850B2 (en) | 2006-02-17 | 2011-04-05 | Biosense Wabster, Inc. | Lesion assessment by pacing |
WO2007109554A2 (en) | 2006-03-17 | 2007-09-27 | Voyage Medical, Inc. | Tissue visualization and manipulation systems |
US20070225697A1 (en) | 2006-03-23 | 2007-09-27 | Ketan Shroff | Apparatus and methods for cardiac ablation |
US20080058785A1 (en) | 2006-04-12 | 2008-03-06 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Autofluorescent imaging and target ablation |
US20080058786A1 (en) | 2006-04-12 | 2008-03-06 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Autofluorescent imaging and target ablation |
US8129105B2 (en) | 2006-04-13 | 2012-03-06 | Ralph Zuckerman | Method and apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy |
US8628520B2 (en) | 2006-05-02 | 2014-01-14 | Biosense Webster, Inc. | Catheter with omni-directional optical lesion evaluation |
US20070270792A1 (en) | 2006-05-08 | 2007-11-22 | Willard Hennemann | Interferometric characterization of ablated tissue |
WO2007134258A2 (en) | 2006-05-12 | 2007-11-22 | Vytronus, Inc. | Device for ablating body tissue |
US20100198065A1 (en) | 2009-01-30 | 2010-08-05 | VyntronUS, Inc. | System and method for ultrasonically sensing and ablating tissue |
JP2007313169A (ja) | 2006-05-29 | 2007-12-06 | Olympus Corp | 病変抽出装置および病変抽出方法 |
JP2009538672A (ja) | 2006-05-30 | 2009-11-12 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 組織属性の奥行き解像された測定のための装置 |
EP2034890A4 (en) | 2006-06-01 | 2011-02-16 | Gen Hospital Corp | IN VIVO OPTICAL IMAGING METHOD COMPRISING THE ANALYSIS OF DYNAMIC IMAGES |
US9220402B2 (en) | 2006-06-07 | 2015-12-29 | Intuitive Surgical Operations, Inc. | Visualization and treatment via percutaneous methods and devices |
US8048063B2 (en) | 2006-06-09 | 2011-11-01 | Endosense Sa | Catheter having tri-axial force sensor |
US8567265B2 (en) | 2006-06-09 | 2013-10-29 | Endosense, SA | Triaxial fiber optic force sensing catheter |
US7662152B2 (en) | 2006-06-13 | 2010-02-16 | Biosense Webster, Inc. | Catheter with multi port tip for optical lesion evaluation |
WO2008002654A2 (en) | 2006-06-28 | 2008-01-03 | C.R. Bard, Inc. | Methods and apparatus for assessing and improving electrode contact with cardiac tissue |
US20080033241A1 (en) | 2006-08-01 | 2008-02-07 | Ruey-Feng Peh | Left atrial appendage closure |
JP2010502313A (ja) | 2006-09-01 | 2010-01-28 | ボエッジ メディカル, インコーポレイテッド | 心房細動の治療のための方法および装置 |
US20080097476A1 (en) | 2006-09-01 | 2008-04-24 | Voyage Medical, Inc. | Precision control systems for tissue visualization and manipulation assemblies |
US10004388B2 (en) | 2006-09-01 | 2018-06-26 | Intuitive Surgical Operations, Inc. | Coronary sinus cannulation |
WO2008028298A1 (en) | 2006-09-06 | 2008-03-13 | University Health Network | Fluorescence quantification and image acquisition in highly turbid media |
US8147484B2 (en) | 2006-10-23 | 2012-04-03 | Biosense Webster, Inc. | Apparatus and method for monitoring early formation of steam pop during ablation |
US10335131B2 (en) | 2006-10-23 | 2019-07-02 | Intuitive Surgical Operations, Inc. | Methods for preventing tissue migration |
DE102006050885B4 (de) | 2006-10-27 | 2016-11-03 | Siemens Healthcare Gmbh | Vorrichtung zur Erzeugung von Gewebeschnittbildern |
US8986298B2 (en) | 2006-11-17 | 2015-03-24 | Biosense Webster, Inc. | Catheter with omni-directional optical tip having isolated optical paths |
US20080183036A1 (en) | 2006-12-18 | 2008-07-31 | Voyage Medical, Inc. | Systems and methods for unobstructed visualization and ablation |
US8131350B2 (en) | 2006-12-21 | 2012-03-06 | Voyage Medical, Inc. | Stabilization of visualization catheters |
US8758229B2 (en) | 2006-12-21 | 2014-06-24 | Intuitive Surgical Operations, Inc. | Axial visualization systems |
US7591816B2 (en) | 2006-12-28 | 2009-09-22 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Irrigated ablation catheter having a pressure sensor to detect tissue contact |
US7766907B2 (en) | 2006-12-28 | 2010-08-03 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Ablation catheter with sensor array and discrimination circuit to minimize variation in power density |
US8460285B2 (en) | 2006-12-29 | 2013-06-11 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Ablation catheter electrode having multiple thermal sensors and method of use |
WO2008109414A2 (en) | 2007-03-02 | 2008-09-12 | Wisconsin Alumni Research Foundation | Use of endogenous fluorescence to identify invading metastatic breast tumor cells |
US20080221448A1 (en) | 2007-03-07 | 2008-09-11 | Khuri-Yakub Butrus T | Image-guided delivery of therapeutic tools duing minimally invasive surgeries and interventions |
US20080228079A1 (en) | 2007-03-16 | 2008-09-18 | Donaldson Brenda L | Clinical utilization of contrast agents to define specific areas within the myocardial wall to provide guidance and localization for ablation, cyroablation, or other techniques in patients with post myocardial infarction |
JP2008229024A (ja) | 2007-03-20 | 2008-10-02 | Olympus Corp | 蛍光観察装置 |
EP2136702B1 (en) | 2007-03-26 | 2015-07-01 | Boston Scientific Limited | High resolution electrophysiology catheter |
WO2008134457A1 (en) | 2007-04-27 | 2008-11-06 | Voyage Medical, Inc. | Complex shape steerable tissue visualization and manipulation catheter |
US8657805B2 (en) | 2007-05-08 | 2014-02-25 | Intuitive Surgical Operations, Inc. | Complex shape steerable tissue visualization and manipulation catheter |
EP3025636B1 (en) | 2007-05-11 | 2017-11-01 | Intuitive Surgical Operations, Inc. | Visual electrode ablation systems |
US10220187B2 (en) | 2010-06-16 | 2019-03-05 | St. Jude Medical, Llc | Ablation catheter having flexible tip with multiple flexible electrode segments |
WO2008154578A1 (en) | 2007-06-11 | 2008-12-18 | Board Of Regents, The University Of Texas System | Characterization of a near-infrared laparoscopic hyperspectral imaging system |
US7976537B2 (en) | 2007-06-28 | 2011-07-12 | Biosense Webster, Inc. | Optical pyrometric catheter for tissue temperature monitoring during cardiac ablation |
US8123745B2 (en) | 2007-06-29 | 2012-02-28 | Biosense Webster, Inc. | Ablation catheter with optically transparent, electrically conductive tip |
US20090030276A1 (en) | 2007-07-27 | 2009-01-29 | Voyage Medical, Inc. | Tissue visualization catheter with imaging systems integration |
US8131379B2 (en) | 2007-08-27 | 2012-03-06 | St. Jude Medical Atrial Fibrillation Division, Inc. | Cardiac tissue elasticity sensing |
US8235985B2 (en) | 2007-08-31 | 2012-08-07 | Voyage Medical, Inc. | Visualization and ablation system variations |
US20090062790A1 (en) | 2007-08-31 | 2009-03-05 | Voyage Medical, Inc. | Direct visualization bipolar ablation systems |
DE102007043731A1 (de) | 2007-09-13 | 2009-04-02 | Siemens Ag | Medizinische Bildaufnahmeeinrichtung, insbesondere zur Erstellung von Bildaufnahmen im Rahmen einer Behandlung von Herzrhythmusstörungen, sowie zugehöriges Verfahren |
DE102007043732A1 (de) | 2007-09-13 | 2009-04-02 | Siemens Ag | Herzmuskelgewebe-Ablationsvorrichtung zur Behandlung von Herzrhythmusstörungen durch Ablation von Herzmuskelgewebe bei einem Patienten sowie zugehöriger Katheter und zugehöriges Verfahren |
US20090082660A1 (en) | 2007-09-20 | 2009-03-26 | Norbert Rahn | Clinical workflow for treatment of atrial fibrulation by ablation using 3d visualization of pulmonary vein antrum in 2d fluoroscopic images |
NL2002010C2 (en) | 2007-09-28 | 2009-10-06 | Gen Electric | Imaging and navigation system. |
US8535308B2 (en) | 2007-10-08 | 2013-09-17 | Biosense Webster (Israel), Ltd. | High-sensitivity pressure-sensing probe |
JP5372356B2 (ja) | 2007-10-18 | 2013-12-18 | オリンパスメディカルシステムズ株式会社 | 内視鏡装置及び内視鏡装置の作動方法 |
US8195271B2 (en) | 2007-11-06 | 2012-06-05 | Siemens Aktiengesellschaft | Method and system for performing ablation to treat ventricular tachycardia |
US20090125022A1 (en) | 2007-11-12 | 2009-05-14 | Voyage Medical, Inc. | Tissue visualization and ablation systems |
US8906011B2 (en) | 2007-11-16 | 2014-12-09 | Kardium Inc. | Medical device for use in bodily lumens, for example an atrium |
US8500730B2 (en) * | 2007-11-16 | 2013-08-06 | Biosense Webster, Inc. | Catheter with omni-directional optical tip having isolated optical paths |
WO2009065140A1 (en) | 2007-11-16 | 2009-05-22 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Device and method for real-time lesion estimation during ablation |
US20090143640A1 (en) | 2007-11-26 | 2009-06-04 | Voyage Medical, Inc. | Combination imaging and treatment assemblies |
US8849380B2 (en) | 2007-11-26 | 2014-09-30 | Canfield Scientific Inc. | Multi-spectral tissue imaging |
US8998892B2 (en) | 2007-12-21 | 2015-04-07 | Atricure, Inc. | Ablation device with cooled electrodes and methods of use |
US8353907B2 (en) | 2007-12-21 | 2013-01-15 | Atricure, Inc. | Ablation device with internally cooled electrodes |
US9204927B2 (en) | 2009-05-13 | 2015-12-08 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for presenting information representative of lesion formation in tissue during an ablation procedure |
US7996078B2 (en) | 2007-12-31 | 2011-08-09 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Systems and methods of photodynamic-based cardiac ablation via the esophagus |
US8858609B2 (en) | 2008-02-07 | 2014-10-14 | Intuitive Surgical Operations, Inc. | Stent delivery under direct visualization |
US20090306643A1 (en) | 2008-02-25 | 2009-12-10 | Carlo Pappone | Method and apparatus for delivery and detection of transmural cardiac ablation lesions |
US8298227B2 (en) | 2008-05-14 | 2012-10-30 | Endosense Sa | Temperature compensated strain sensing catheter |
CN104939806B (zh) | 2008-05-20 | 2021-12-10 | 大学健康网络 | 用于基于荧光的成像和监测的装置和方法 |
US10568535B2 (en) | 2008-05-22 | 2020-02-25 | The Trustees Of Dartmouth College | Surgical navigation with stereovision and associated methods |
US8357149B2 (en) | 2008-06-05 | 2013-01-22 | Biosense Webster, Inc. | Filter for simultaneous pacing and ablation |
WO2010011820A2 (en) | 2008-07-23 | 2010-01-28 | St. Jude Medical, Inc. | Ablation and monitoring system including a fiber optic imaging catheter and an optical coherence tomography system |
JP2010029382A (ja) | 2008-07-28 | 2010-02-12 | Olympus Medical Systems Corp | 内視鏡挿入補助具及び内視鏡装置 |
US8203709B2 (en) | 2008-09-17 | 2012-06-19 | Fujifilm Corporation | Image obtaining method and image obtaining apparatus |
US20100081873A1 (en) | 2008-09-30 | 2010-04-01 | AiHeart Medical Technologies, Inc. | Systems and methods for optical viewing and therapeutic intervention in blood vessels |
US8333012B2 (en) | 2008-10-10 | 2012-12-18 | Voyage Medical, Inc. | Method of forming electrode placement and connection systems |
US8808281B2 (en) | 2008-10-21 | 2014-08-19 | Microcube, Llc | Microwave treatment devices and methods |
US9033885B2 (en) | 2008-10-30 | 2015-05-19 | Vytronus, Inc. | System and method for energy delivery to tissue while monitoring position, lesion depth, and wall motion |
US8414508B2 (en) | 2008-10-30 | 2013-04-09 | Vytronus, Inc. | System and method for delivery of energy to tissue while compensating for collateral tissue |
US9220924B2 (en) | 2008-10-30 | 2015-12-29 | Vytronus, Inc. | System and method for energy delivery to tissue while monitoring position, lesion depth, and wall motion |
US9192789B2 (en) | 2008-10-30 | 2015-11-24 | Vytronus, Inc. | System and method for anatomical mapping of tissue and planning ablation paths therein |
US9468364B2 (en) | 2008-11-14 | 2016-10-18 | Intuitive Surgical Operations, Inc. | Intravascular catheter with hood and image processing systems |
JP5941281B2 (ja) | 2008-11-17 | 2016-06-29 | バイトロナス, インコーポレイテッド | 体組織を切除するシステムおよび方法 |
US20100152728A1 (en) | 2008-12-11 | 2010-06-17 | Park Christopher J | Method and apparatus for determining the efficacy of a lesion |
US20100160768A1 (en) | 2008-12-24 | 2010-06-24 | Marrouche Nassir F | Therapeutic outcome assessment for atrial fibrillation |
US8864757B2 (en) | 2008-12-31 | 2014-10-21 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for measuring force and torque applied to a catheter electrode tip |
WO2010090673A1 (en) | 2009-01-20 | 2010-08-12 | The Trustees Of Dartmouth College | Method and apparatus for depth-resolved fluorescence, chromophore, and oximetry imaging for lesion identification during surgery |
US20100204561A1 (en) | 2009-02-11 | 2010-08-12 | Voyage Medical, Inc. | Imaging catheters having irrigation |
JP5786108B2 (ja) | 2009-05-08 | 2015-09-30 | セント・ジュード・メディカル・ルクセンブルク・ホールディング・エスエーアールエル | カテーテルアブレーション治療において病変部サイズを制御するための方法および装置 |
RU2539010C2 (ru) | 2009-05-15 | 2015-01-10 | Конинклейке Филипс Электроникс Н.В. | Устройство, способ и компьютерная программа для определения характеристик сердца |
US9259290B2 (en) | 2009-06-08 | 2016-02-16 | MRI Interventions, Inc. | MRI-guided surgical systems with proximity alerts |
US20100331838A1 (en) | 2009-06-25 | 2010-12-30 | Estech, Inc. (Endoscopic Technologies, Inc.) | Transmurality clamp systems and methods |
DE102009034249A1 (de) | 2009-07-22 | 2011-03-24 | Siemens Aktiengesellschaft | Verfahren und Vorrichtung zur Regelung der Ablationsenergie zur Durchführung einer elektrophysiologischen Katheteranwendung |
US8874230B2 (en) | 2009-08-27 | 2014-10-28 | New Jersey Institute Of Technology | Integrated fiber optic raman spectroscopy and radio frequency ablation |
DE112010003647T5 (de) | 2009-09-15 | 2012-10-31 | C.R. Bard, Inc. | System und Verfahren zum Vorhersagen einer Läsionsgröße kurznach Beginn einer RF Energiezuführung |
WO2011041635A2 (en) | 2009-10-02 | 2011-04-07 | Cardiofocus, Inc. | Cardiac ablation system with inflatable member having multiple inflation settings |
WO2011041638A2 (en) | 2009-10-02 | 2011-04-07 | Cardiofocus, Inc. | Cardiac ablation system with automatic safety shut-off feature |
US8702688B2 (en) | 2009-10-06 | 2014-04-22 | Cardiofocus, Inc. | Cardiac ablation image analysis system and process |
US20110257563A1 (en) | 2009-10-26 | 2011-10-20 | Vytronus, Inc. | Methods and systems for ablating tissue |
US8568401B2 (en) | 2009-10-27 | 2013-10-29 | Covidien Lp | System for monitoring ablation size |
US8382750B2 (en) | 2009-10-28 | 2013-02-26 | Vivant Medical, Inc. | System and method for monitoring ablation size |
EP2512577B1 (en) | 2009-12-16 | 2018-03-07 | Boston Scientific Scimed, Inc. | Arrangements for effecting an endoluminal anatomical structure |
CA2784856C (en) | 2009-12-18 | 2019-05-07 | University Health Network | System and method for sub-surface fluorescence imaging |
US8926604B2 (en) | 2009-12-23 | 2015-01-06 | Biosense Webster (Israel) Ltd. | Estimation and mapping of ablation volume |
US10561318B2 (en) | 2010-01-25 | 2020-02-18 | University Health Network | Device, system and method for quantifying fluorescence and optical properties |
JP5719159B2 (ja) | 2010-03-15 | 2015-05-13 | ソニー株式会社 | 評価装置 |
WO2011113162A1 (en) | 2010-03-17 | 2011-09-22 | Haishan Zeng | Rapid multi-spectral imaging methods and apparatus and applications for cancer detection and localization |
JP5432793B2 (ja) | 2010-03-29 | 2014-03-05 | オリンパス株式会社 | 蛍光内視鏡装置 |
EP2558014A4 (en) | 2010-04-13 | 2017-11-29 | Sentreheart, Inc. | Methods and devices for treating atrial fibrillation |
US9918787B2 (en) | 2010-05-05 | 2018-03-20 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Monitoring, managing and/or protecting system and method for non-targeted tissue |
US20140171806A1 (en) | 2012-12-17 | 2014-06-19 | Biosense Webster (Israel), Ltd. | Optical lesion assessment |
DE102010032755B4 (de) | 2010-07-29 | 2019-05-23 | Siemens Healthcare Gmbh | Verfahren zur Visualisierung eines Vorhofs des Herzens eines Patienten |
WO2012025856A1 (en) | 2010-08-23 | 2012-03-01 | Koninklijke Philips Electronics N.V. | Mapping system and method for medical procedures |
JP5663240B2 (ja) | 2010-08-31 | 2015-02-04 | 株式会社トプコン | 光断層画像化装置及びその作動方法 |
CN103153174B (zh) | 2010-10-14 | 2015-08-19 | 皇家飞利浦电子股份有限公司 | 用于确定对象的性质的性质确定装置 |
US9254090B2 (en) | 2010-10-22 | 2016-02-09 | Intuitive Surgical Operations, Inc. | Tissue contrast imaging systems |
US20120123276A1 (en) | 2010-11-16 | 2012-05-17 | Assaf Govari | Catheter with optical contact sensing |
RU2573443C2 (ru) | 2010-11-18 | 2016-01-20 | Конинклейке Филипс Электроникс Н.В. | Медицинское устройство с ультразвуковыми преобразователями, встроенными в гибкую пленку |
US11246653B2 (en) | 2010-12-07 | 2022-02-15 | Boaz Avitall | Catheter systems for cardiac arrhythmia ablation |
US8998893B2 (en) | 2010-12-07 | 2015-04-07 | Boaz Avitall | Catheter systems for cardiac arrhythmia ablation |
JP5485190B2 (ja) | 2011-01-19 | 2014-05-07 | 富士フイルム株式会社 | 内視鏡装置 |
JP5485191B2 (ja) | 2011-01-19 | 2014-05-07 | 富士フイルム株式会社 | 内視鏡装置 |
US9265557B2 (en) | 2011-01-31 | 2016-02-23 | Medtronic Ablation Frontiers Llc | Multi frequency and multi polarity complex impedance measurements to assess ablation lesions |
EP3275390B1 (en) | 2011-02-10 | 2019-06-19 | Corvia Medical, Inc. | Apparatus to create and maintain an intra-atrial pressure relief opening |
US9233241B2 (en) | 2011-02-28 | 2016-01-12 | Ethicon Endo-Surgery, Inc. | Electrical ablation devices and methods |
US9743881B2 (en) | 2011-03-29 | 2017-08-29 | Koninklijke Philips N.V. | Photoacoustic catheter for functional-imaging-based ablation monitoring |
US8986292B2 (en) | 2011-04-13 | 2015-03-24 | St. Jude Medical, Inc. | Optical feedback RF ablator and ablator tip |
US9387031B2 (en) | 2011-07-29 | 2016-07-12 | Medtronic Ablation Frontiers Llc | Mesh-overlayed ablation and mapping device |
WO2013022853A1 (en) | 2011-08-05 | 2013-02-14 | Mc10, Inc. | Catheter balloon methods and apparatus employing sensing elements |
US8900228B2 (en) | 2011-09-01 | 2014-12-02 | Biosense Webster (Israel) Ltd. | Catheter adapted for direct tissue contact and pressure sensing |
CN104066368B (zh) * | 2011-09-22 | 2017-02-22 | 乔治华盛顿大学 | 用于使经消融组织可视化的系统和方法 |
EP2757933B1 (en) | 2011-09-22 | 2019-02-06 | The George Washington University | Systems for visualizing ablated tissue |
DE102011083522B4 (de) | 2011-09-27 | 2015-06-18 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Verfahren und Vorrichtung zur Visualisierung der Qualität eines Ablationsvorgangs |
US10791950B2 (en) | 2011-09-30 | 2020-10-06 | Biosense Webster (Israel) Ltd. | In-vivo calibration of contact force-sensing catheters using auto zero zones |
JP5830348B2 (ja) | 2011-10-26 | 2015-12-09 | オリンパス株式会社 | 撮像装置 |
CN103917155B (zh) | 2011-11-07 | 2017-02-15 | 皇家飞利浦有限公司 | 用于确定组织状态的检测装置 |
US10456196B2 (en) | 2011-12-15 | 2019-10-29 | Biosense Webster (Israel) Ltd. | Monitoring and tracking bipolar ablation |
US9241761B2 (en) | 2011-12-28 | 2016-01-26 | Koninklijke Philips N.V. | Ablation probe with ultrasonic imaging capability |
US9687289B2 (en) | 2012-01-04 | 2017-06-27 | Biosense Webster (Israel) Ltd. | Contact assessment based on phase measurement |
WO2013106557A1 (en) | 2012-01-10 | 2013-07-18 | Boston Scientific Scimed, Inc. | Electrophysiology system |
US20150044098A1 (en) | 2012-01-30 | 2015-02-12 | Scanadu Incorporated | Hyperspectral imaging systems, units, and methods |
EP2814397B1 (en) | 2012-02-14 | 2020-01-15 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System for assessing effects of ablation therapy on cardiac tissue using photoacoustics |
EP2817061B1 (en) | 2012-02-24 | 2018-02-07 | Isolase, Ltd. | Improvements in ablation techniques for the treatment of atrial fibrillation |
US20130281920A1 (en) | 2012-04-20 | 2013-10-24 | Elwha LLC, a limited liability company of the State of Delaware | Endometrial Ablation |
US20130282005A1 (en) | 2012-04-24 | 2013-10-24 | Siemens Corporation | Catheter navigation system |
US20130296840A1 (en) | 2012-05-01 | 2013-11-07 | Medtronic Ablation Frontiers Llc | Systems and methods for detecting tissue contact during ablation |
US8900225B2 (en) | 2012-05-07 | 2014-12-02 | Biosense Webster (Israel) Ltd. | Automatic ablation tracking |
CN107157575B (zh) | 2012-05-11 | 2020-03-06 | 美敦力Af卢森堡有限责任公司 | 导管设备 |
EP2852324A4 (en) | 2012-05-21 | 2016-02-24 | Univ Colorado Regents | THREE-DIMENSIONAL IMAGING AND THERAPY OF PROSTATE CANCER |
US20150209551A1 (en) | 2012-08-15 | 2015-07-30 | Everette C. Burdette | Mri compatible ablation catheter system incorporating directional high-intensity ultrasound for treatment |
US20140073907A1 (en) | 2012-09-12 | 2014-03-13 | Convergent Life Sciences, Inc. | System and method for image guided medical procedures |
US20140058244A1 (en) | 2012-08-21 | 2014-02-27 | Regents Of The University Of Minnesota | Photoacoustic monitoring |
US8923959B2 (en) | 2012-08-27 | 2014-12-30 | Birinder Robert Boveja | Methods and system for real-time cardiac mapping |
US20140058246A1 (en) | 2012-08-27 | 2014-02-27 | Birinder Robert Boveja | System and methods for real-time cardiac mapping |
US10098692B2 (en) | 2012-11-30 | 2018-10-16 | Intuitive Surgical Operations, Inc. | Apparatus and method for delivery and monitoring of ablation therapy |
US20140163360A1 (en) | 2012-12-07 | 2014-06-12 | Boston Scientific Scimed, Inc. | Irrigated catheter |
US20140171936A1 (en) | 2012-12-17 | 2014-06-19 | Biosense Webster (Israel) Ltd. | Irrigated catheter tip with temperature sensor and optic fiber arrays |
US9615878B2 (en) | 2012-12-21 | 2017-04-11 | Volcano Corporation | Device, system, and method for imaging and tissue characterization of ablated tissue |
BR112015016375A2 (pt) | 2013-01-08 | 2017-07-11 | Harvard College | métodos de imagiologia metabólica para avaliação de oócitos e embriões |
US20140276771A1 (en) | 2013-03-15 | 2014-09-18 | Volcano Corporation | Systems and methods for controlled tissue ablation |
US10194830B2 (en) | 2013-03-15 | 2019-02-05 | University Of Utah Research Foundation | High temporal resolution monitoring of contact between catheter tip and target tissue during a real-time-MRI-guided ablation |
US20140276687A1 (en) | 2013-03-15 | 2014-09-18 | Volcano Corporation | Assessment of varicose vein ablation via imaging or functional measurement analysis |
US10098694B2 (en) | 2013-04-08 | 2018-10-16 | Apama Medical, Inc. | Tissue ablation and monitoring thereof |
KR20150140760A (ko) | 2013-04-08 | 2015-12-16 | 아파마 메디칼, 인크. | 심장 절제 카테터 및 그의 사용 방법 |
US20140378845A1 (en) | 2013-06-19 | 2014-12-25 | The General Hospital Corporation | Apparatus, devices and methods for obtaining omnidirectional viewing by a catheter |
EP3010389B1 (en) | 2013-06-19 | 2020-08-26 | The General Hospital Corporation | Omni-directional viewing apparatus and method |
US9907471B2 (en) | 2013-10-08 | 2018-03-06 | The Board Of Trustees Of The Leland Stanford Junior University | Visualization of heart wall tissue |
CN112674861A (zh) | 2013-11-14 | 2021-04-20 | 乔治华盛顿大学 | 用于使用荧光成像来确定损伤灶深度的系统和方法 |
US11096584B2 (en) | 2013-11-14 | 2021-08-24 | The George Washington University | Systems and methods for determining lesion depth using fluorescence imaging |
JP2017500550A (ja) | 2013-11-20 | 2017-01-05 | ザ・ジョージ・ワシントン・ユニバーシティThe George Washingtonuniversity | 心臓組織のハイパースペクトル分析のためのシステム及び方法 |
US10278775B2 (en) * | 2013-12-31 | 2019-05-07 | Biosense Webster (Israel) Ltd. | Catheter utilizing optical spectroscopy for measuring tissue contact area |
EP3215001A4 (en) | 2014-11-03 | 2018-04-04 | Luxcath, LLC | Systems and methods for assessment of contact quality |
JP2017537681A (ja) | 2014-11-03 | 2017-12-21 | ザ・ジョージ・ワシントン・ユニバーシティThe George Washingtonuniversity | 損傷評価システム及びその方法 |
EP3223735A4 (en) | 2014-11-25 | 2018-07-11 | Luxcath, LLC | Visualization catheters |
US10779904B2 (en) | 2015-07-19 | 2020-09-22 | 460Medical, Inc. | Systems and methods for lesion formation and assessment |
EP3374017A1 (en) | 2015-11-13 | 2018-09-19 | Boston Scientific Scimed, Inc. | Direct visualization devices, systems, and methods for transseptal crossing |
-
2015
- 2015-10-21 US US14/919,004 patent/US10779904B2/en active Active
-
2016
- 2016-07-19 CN CN201680050369.0A patent/CN108135475B/zh active Active
- 2016-07-19 WO PCT/US2016/042891 patent/WO2017015257A1/en active Application Filing
- 2016-07-19 CA CA2993167A patent/CA2993167A1/en active Pending
- 2016-07-19 KR KR1020187004502A patent/KR20180041130A/ko not_active Application Discontinuation
- 2016-07-19 CN CN202110618987.3A patent/CN113384340A/zh active Pending
- 2016-07-19 JP JP2018502383A patent/JP6818007B2/ja active Active
- 2016-07-19 AU AU2016297534A patent/AU2016297534B2/en active Active
- 2016-07-19 EP EP16828397.6A patent/EP3324832B1/en active Active
-
2020
- 2020-07-30 US US16/943,542 patent/US20210045834A1/en active Pending
- 2020-12-24 JP JP2020215456A patent/JP7116151B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
AU2016297534B2 (en) | 2021-04-29 |
AU2016297534A1 (en) | 2018-03-15 |
EP3324832A4 (en) | 2019-03-20 |
US10779904B2 (en) | 2020-09-22 |
JP7116151B2 (ja) | 2022-08-09 |
US20210045834A1 (en) | 2021-02-18 |
EP3324832A1 (en) | 2018-05-30 |
JP2021072880A (ja) | 2021-05-13 |
CN108135475B (zh) | 2021-06-25 |
CN113384340A (zh) | 2021-09-14 |
EP3324832B1 (en) | 2023-01-04 |
KR20180041130A (ko) | 2018-04-23 |
US20170014202A1 (en) | 2017-01-19 |
JP2018520795A (ja) | 2018-08-02 |
CA2993167A1 (en) | 2017-01-26 |
CN108135475A (zh) | 2018-06-08 |
WO2017015257A1 (en) | 2017-01-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6818007B2 (ja) | 損傷形成及び評価のためのシステム | |
US11559352B2 (en) | Systems and methods for lesion assessment | |
AU2020213406B2 (en) | Systems And Methods For Visualizing Ablated Tissue | |
US11596472B2 (en) | Systems and methods for assessment of contact quality | |
US20220031377A1 (en) | Systems and Methods for Lesion Formation and Assessment | |
US20230404373A1 (en) | Magnetic catheter |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190717 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20200414 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200424 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200721 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20200820 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20201201 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20201225 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6818007 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |