JP6797122B2 - 安定性が増加されたグルカゴン誘導体 - Google Patents

安定性が増加されたグルカゴン誘導体 Download PDF

Info

Publication number
JP6797122B2
JP6797122B2 JP2017535417A JP2017535417A JP6797122B2 JP 6797122 B2 JP6797122 B2 JP 6797122B2 JP 2017535417 A JP2017535417 A JP 2017535417A JP 2017535417 A JP2017535417 A JP 2017535417A JP 6797122 B2 JP6797122 B2 JP 6797122B2
Authority
JP
Japan
Prior art keywords
glucagon
present
obesity
glucagon derivative
cysteine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017535417A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018504901A5 (show.php
JP2018504901A (ja
Inventor
ジョンクク キム
ジョンクク キム
ジョンミン イ
ジョンミン イ
サンユン キム
サンユン キム
ソンミン ペ
ソンミン ペ
サンヨプ ジョン
サンヨプ ジョン
セチャン クォン
セチャン クォン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hanmi Pharmaceutical Co Ltd
Original Assignee
Hanmi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharmaceutical Co Ltd filed Critical Hanmi Pharmaceutical Co Ltd
Publication of JP2018504901A publication Critical patent/JP2018504901A/ja
Publication of JP2018504901A5 publication Critical patent/JP2018504901A5/ja
Application granted granted Critical
Publication of JP6797122B2 publication Critical patent/JP6797122B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2017535417A 2014-12-30 2015-12-30 安定性が増加されたグルカゴン誘導体 Active JP6797122B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2014-0193800 2014-12-30
KR20140193800 2014-12-30
PCT/KR2015/014422 WO2016108586A1 (ko) 2014-12-30 2015-12-30 안정성이 증가된 글루카곤 유도체

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020144259A Division JP7079301B2 (ja) 2014-12-30 2020-08-28 安定性が増加されたグルカゴン誘導体

Publications (3)

Publication Number Publication Date
JP2018504901A JP2018504901A (ja) 2018-02-22
JP2018504901A5 JP2018504901A5 (show.php) 2019-02-07
JP6797122B2 true JP6797122B2 (ja) 2020-12-09

Family

ID=56284642

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2017535417A Active JP6797122B2 (ja) 2014-12-30 2015-12-30 安定性が増加されたグルカゴン誘導体
JP2020144259A Active JP7079301B2 (ja) 2014-12-30 2020-08-28 安定性が増加されたグルカゴン誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020144259A Active JP7079301B2 (ja) 2014-12-30 2020-08-28 安定性が増加されたグルカゴン誘導体

Country Status (28)

Country Link
US (1) US11135271B2 (show.php)
EP (2) EP3241841A4 (show.php)
JP (2) JP6797122B2 (show.php)
KR (1) KR102291020B1 (show.php)
CN (1) CN107636009B (show.php)
AR (1) AR103322A1 (show.php)
AU (1) AU2015372818A1 (show.php)
CL (1) CL2017001718A1 (show.php)
CO (1) CO2017006308A2 (show.php)
CR (1) CR20170293A (show.php)
DO (1) DOP2017000156A (show.php)
EA (1) EA035527B1 (show.php)
EC (1) ECSP17040923A (show.php)
ES (1) ES2976562T3 (show.php)
GT (1) GT201700150A (show.php)
HK (1) HK1248713A1 (show.php)
IL (2) IL253206B (show.php)
MA (1) MA40709B1 (show.php)
MX (1) MX2017008569A (show.php)
MY (1) MY185334A (show.php)
PE (2) PE20230304A1 (show.php)
PH (1) PH12017501222B1 (show.php)
SG (1) SG11201705376SA (show.php)
TN (1) TN2017000271A1 (show.php)
TW (1) TW201639878A (show.php)
UA (1) UA126960C2 (show.php)
WO (1) WO2016108586A1 (show.php)
ZA (1) ZA201705015B (show.php)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020188819A (ja) * 2014-12-30 2020-11-26 ハンミ ファーマシューティカル カンパニー リミテッド 安定性が増加されたグルカゴン誘導体
US11261227B2 (en) 2015-06-30 2022-03-01 Hanmi Pharm. Co., Ltd. Glucagon derivative and a composition comprising a long acting conjugate of the same
US11332508B2 (en) 2015-12-31 2022-05-17 Hanmi Pharm. Co., Ltd. Triple glucagon/GLP-1/GIP receptor agonist

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI622596B (zh) 2015-10-26 2018-05-01 美國禮來大藥廠 升糖素受體促效劑
SG11201811697SA (en) * 2016-06-29 2019-01-30 Hanmi Pharmaceutical Co Ltd Glucagon derivative, conjugate thereof, composition comprising same and therapeutic use thereof
CN110545849A (zh) 2017-02-03 2019-12-06 韩美药品株式会社 具有增加的持续性的生理活性物质的缀合物及其应用
EP3708661A4 (en) * 2017-12-22 2021-12-01 Hanmi Pharm. Co., Ltd. THERAPEUTIC ENZYMFUSION PROTEIN WITH A NEW STRUCTURE AND ITS USE
KR20200134213A (ko) * 2018-01-23 2020-12-01 엑스에리스 파머수티클스, 인크. 소 용량의 안정한 글루카곤을 사용한 베리아트릭 후 저혈당증의 치료
US20220064248A1 (en) 2018-12-21 2022-03-03 HANMl PHARM. CO., LTD Pharmaceutical composition including insulin and glucagon
CN109836486B (zh) * 2019-01-30 2020-09-08 北京双因生物科技有限公司 成纤维生长因子21变体、其融合蛋白及其用途
WO2021235907A1 (ko) 2020-05-22 2021-11-25 한미약품 주식회사 글루카곤 유도체의 지속형 결합체의 액상 제제
MX2023000698A (es) 2020-07-15 2023-04-18 Hanmi Pharmaceutical Co Ltd Uso terapeutico del derivado de glucagon o conjugado del mismo para enfermedades hepaticas.
AU2022254588A1 (en) 2021-04-09 2023-09-21 Hanmi Pharm. Co., Ltd. Pharmaceutical composition for preventing or treating chronic renal disease including glucagon derivative
KR20230095666A (ko) 2021-12-22 2023-06-29 한미약품 주식회사 간 표적 물질 및 이의 용도
CN115536739B (zh) * 2022-07-04 2023-04-14 北京惠之衡生物科技有限公司 一种glp-1受体和gcg受体共激动多肽衍生物的制备方法

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5408037A (en) 1991-01-17 1995-04-18 Zymogenetics, Inc. Methods for detecting glucagon antagonists
GB9423277D0 (en) 1994-11-18 1995-01-11 Univ Nottingham Pulsed laser deposition of coatings
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
CA2249195A1 (en) 1996-03-18 1997-09-25 Board Of Regents, The University Of Texas System Immunoglobin-like domains with increased half lives
US6677136B2 (en) 2000-05-03 2004-01-13 Amgen Inc. Glucagon antagonists
EP1411968B1 (en) 2001-07-31 2008-09-17 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Glp-1 exendin-4 peptide analogs and uses thereof
HRP20050683A2 (en) 2003-03-19 2006-07-31 Eli Lilly And Company Polyethylene glycol linked glp-1 compounds
CN1723220A (zh) 2003-11-13 2006-01-18 韩美药品工业株式会社 含有免疫球蛋白fc区作为载体的药物组合物
US8263084B2 (en) 2003-11-13 2012-09-11 Hanmi Science Co., Ltd Pharmaceutical composition for treating obesity-related disease comprising insulinotropic peptide conjugate
EP2574624A1 (en) 2006-04-20 2013-04-03 Amgen Inc. GLP-1 compounds
US20090098130A1 (en) 2007-01-05 2009-04-16 Bradshaw Curt W Glucagon-like protein-1 receptor (glp-1r) agonist compounds
WO2008086086A2 (en) 2007-01-05 2008-07-17 Indiana University Research And Technology Corporation Glucagon analogs exhibiting enhanced solubility in physiological ph buffers
JP2008169195A (ja) 2007-01-05 2008-07-24 Hanmi Pharmaceutical Co Ltd キャリア物質を用いたインスリン分泌ペプチド薬物結合体
EP2111414B1 (en) * 2007-02-15 2014-07-02 Indiana University Research and Technology Corporation Glucagon/glp-1 receptor co-agonists
JP5385266B2 (ja) 2007-06-15 2014-01-08 ジーランド ファーマ アクティーゼルスカブ グルカゴン類似体
KR20100049032A (ko) 2007-06-19 2010-05-11 오츠카 가가쿠 가부시키가이샤 당사슬 부가 ｇｌｐ―１ 펩티드
JP5476304B2 (ja) * 2007-09-05 2014-04-23 ノボ・ノルデイスク・エー／エス グルカゴン様ペプチド−１誘導体及びそれらの医薬用途
EP2249853A4 (en) 2008-01-30 2012-12-26 Univ Indiana Res & Tech Corp ESTER BASED PEPTIDE PRODRUGS
CN104447980A (zh) * 2008-06-17 2015-03-25 印第安纳大学研究及科技有限公司 在生理pH缓冲液中具有增强的溶解性和稳定性的胰高血糖素类似物
AU2009274425B2 (en) 2008-06-17 2014-05-15 Indiana University Research And Technology Corporation GIP-based mixed agonists for treatment of metabolic disorders and obesity
WO2010096052A1 (en) 2009-02-19 2010-08-26 Merck Sharp & Dohme Corp. Oxyntomodulin analogs
CN102459325B (zh) 2009-06-16 2015-03-25 印第安纳大学科技研究有限公司 胃抑胜肽受体活化的胰高血糖素化合物
WO2011006497A1 (en) 2009-07-13 2011-01-20 Zealand Pharma A/S Acylated glucagon analogues
GB0917072D0 (en) 2009-09-29 2009-11-11 Univ Ulster Peptide analogues of glucagon for diabetes therapy
WO2011075393A2 (en) 2009-12-18 2011-06-23 Indiana University Research And Technology Corporation Glucagon/glp-1 receptor co-agonists
US20130157953A1 (en) 2010-01-20 2013-06-20 Zealand Pharma A/S Treatment of cardiac conditions
US20130035285A1 (en) * 2010-03-26 2013-02-07 Novo Nordisk A/S Novel glucagon analogues
JP6050746B2 (ja) 2010-05-13 2016-12-21 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation Ｇタンパク質共役受容体活性を示すグルカゴンスーパーファミリーのペプチド
KR101382593B1 (ko) 2010-07-21 2014-04-10 한미사이언스 주식회사 신규한 지속형 글루카곤 결합체 및 이를 포함하는 비만 예방 및 치료용 약학적 조성물
CA2821766A1 (en) 2010-12-22 2012-06-28 Indiana University Research And Technology Corporation Glucagon analogs exhibiting gip receptor activity
WO2012150503A2 (en) 2011-05-03 2012-11-08 Zealand Pharma A/S Glu-glp-1 dual agonist signaling-selective compounds
CN103732617A (zh) 2011-05-18 2014-04-16 梅德瑞斯糖尿病有限责任公司 用于胰岛素抵抗的改进的肽医药
CA3064214C (en) 2011-06-10 2023-03-07 Hanmi Science Co., Ltd. Novel oxyntomodulin derivatives and pharmaceutical composition for treating obesity comprising the same
MX353402B (es) * 2011-06-17 2018-01-11 Hanmi Science Co Ltd Un conjugado que comprende oxintomodulina y un fragmento de inmunoglobulina, y uso del mismo.
US9944687B2 (en) 2011-07-04 2018-04-17 Imperial Innovations Limited Compounds and their effects on feeding behaviour
EP2780031B1 (en) * 2011-11-17 2018-03-07 Indiana University Research and Technology Corporation Glucagon superfamily peptides exhibiting glucocorticoid receptor activity
KR20150023013A (ko) 2012-06-21 2015-03-04 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 수용체 활성을 나타내는 글루카곤 유사체
AU2013277372B2 (en) 2012-06-21 2018-03-29 Indiana University Research And Technology Corporation Analogs of glucagon exhibiting GIP receptor activity
AR094821A1 (es) 2012-07-25 2015-09-02 Hanmi Pharm Ind Co Ltd Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada
KR101968344B1 (ko) 2012-07-25 2019-04-12 한미약품 주식회사 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물
AR092873A1 (es) 2012-09-26 2015-05-06 Cadila Healthcare Ltd Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon
KR101993393B1 (ko) 2012-11-06 2019-10-01 한미약품 주식회사 옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물
SG10201602801YA (en) 2012-11-06 2016-05-30 Hanmi Pharm Ind Co Ltd Liquid formulation of protein conjugate comprising the oxyntomodulin and an immunoglobulin fragment
US10005817B2 (en) 2012-11-20 2018-06-26 Eumederis Pharmaceuticals, Inc. Peptide pharmaceuticals
KR102213907B1 (ko) 2012-11-20 2021-02-09 메더리스 다이어비티즈, 엘엘씨 인슐린 저항성에 대한 개선된 펩티드 약제
CA2895875A1 (en) 2012-12-21 2014-06-26 Sanofi Exendin-4 derivatives
WO2014170496A1 (en) 2013-04-18 2014-10-23 Novo Nordisk A/S Stable, protracted glp-1/glucagon receptor co-agonists for medical use
EP3033355A1 (en) 2013-08-16 2016-06-22 Medimmune Limited Gip and glp-1 receptor dual-agonists for the treatment of diabetes
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
TWI684458B (zh) 2014-05-30 2020-02-11 南韓商韓美藥品股份有限公司 包含胰島素及ｇｌｐ-１/昇糖素雙重促效劑之治療糖尿病之組成物
TWI802396B (zh) 2014-09-16 2023-05-11 南韓商韓美藥品股份有限公司 長效glp-1/高血糖素受體雙促效劑治療非酒精性脂肝疾病之用途
ES2822994T3 (es) 2014-09-24 2021-05-05 Univ Indiana Res & Tech Corp Conjugados de incretina-insulina
KR102418477B1 (ko) * 2014-12-30 2022-07-08 한미약품 주식회사 글루카곤 유도체
PE20230304A1 (es) 2014-12-30 2023-02-13 Hanmi Pharm Ind Co Ltd Derivados de glucagon como agentes hipoglucemicos y antiobesidad
FI3322437T3 (fi) 2015-06-30 2024-02-20 Hanmi Pharmaceutical Co Ltd Glukagonijohdannainen ja sen pitkävaikutteisen konjugaatin käsittävä koostumus
TW201718629A (zh) * 2015-09-25 2017-06-01 韓美藥品股份有限公司 包含多個生理多肽及免疫球蛋白Ｆｃ區之蛋白質接合物
TWI877582B (zh) 2015-12-31 2025-03-21 南韓商韓美藥品股份有限公司 三重升糖素／ｇｌｐ－１／ｇｉｐ受體促效劑

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020188819A (ja) * 2014-12-30 2020-11-26 ハンミ ファーマシューティカル カンパニー リミテッド 安定性が増加されたグルカゴン誘導体
JP7079301B2 (ja) 2014-12-30 2022-06-01 ハンミ ファーマシューティカル カンパニー リミテッド 安定性が増加されたグルカゴン誘導体
US11261227B2 (en) 2015-06-30 2022-03-01 Hanmi Pharm. Co., Ltd. Glucagon derivative and a composition comprising a long acting conjugate of the same
US11667688B2 (en) 2015-06-30 2023-06-06 Hanmi Pharm. Co., Ltd. Glucagon derivative and a composition comprising a long acting conjugate of the same
US11332508B2 (en) 2015-12-31 2022-05-17 Hanmi Pharm. Co., Ltd. Triple glucagon/GLP-1/GIP receptor agonist

Also Published As

Publication number Publication date
PH12017501222B1 (en) 2024-07-03
ZA201705015B (en) 2018-04-25
SG11201705376SA (en) 2017-08-30
HK1248713A1 (en) 2018-10-19
EA035527B1 (ru) 2020-06-30
CA2972748A1 (en) 2016-07-07
UA126960C2 (uk) 2023-03-01
IL281375B (en) 2021-10-31
ECSP17040923A (es) 2017-12-01
EA201791333A1 (ru) 2017-12-29
PH12017501222A1 (en) 2018-01-15
US20170360892A1 (en) 2017-12-21
EP3575314B1 (en) 2024-02-14
KR20160082482A (ko) 2016-07-08
JP2018504901A (ja) 2018-02-22
EP3575314A3 (en) 2020-01-22
EP3241841A1 (en) 2017-11-08
EP3575314C0 (en) 2024-02-14
CN107636009B (zh) 2021-04-16
TN2017000271A1 (en) 2018-10-19
AU2015372818A1 (en) 2017-07-27
JP2020188819A (ja) 2020-11-26
WO2016108586A1 (ko) 2016-07-07
IL253206A0 (en) 2017-08-31
EP3575314A2 (en) 2019-12-04
CO2017006308A2 (es) 2017-09-29
MA40709A1 (fr) 2017-12-29
MX2017008569A (es) 2017-10-20
CN107636009A (zh) 2018-01-26
JP7079301B2 (ja) 2022-06-01
IL281375A (en) 2021-04-29
TW201639878A (zh) 2016-11-16
GT201700150A (es) 2018-12-12
MA40709B1 (fr) 2019-07-31
CL2017001718A1 (es) 2018-01-12
NZ770767A (en) 2024-04-26
KR102291020B1 (ko) 2021-08-20
BR112017014205A2 (pt) 2018-03-06
AR103322A1 (es) 2017-05-03
MY185334A (en) 2021-05-06
CR20170293A (es) 2017-11-03
PE20171154A1 (es) 2017-08-16
US11135271B2 (en) 2021-10-05
ES2976562T3 (es) 2024-08-05
NZ733464A (en) 2024-01-26
DOP2017000156A (es) 2017-10-15
IL253206B (en) 2021-10-31
EP3241841A4 (en) 2018-10-17
PE20230304A1 (es) 2023-02-13

Similar Documents

Publication Publication Date Title
JP7079301B2 (ja) 安定性が増加されたグルカゴン誘導体
CA3064214C (en) Novel oxyntomodulin derivatives and pharmaceutical composition for treating obesity comprising the same
US12018060B2 (en) Glucagon derivatives
CA2972748C (en) Glucagon derivatives with improved stability
HK40010066A (en) Glucagon derivative
HK40010066B (en) Glucagon derivative
BR112017014205B1 (pt) Derivados de glucagon e seu uso, e uso de uma composição farmacêutica
HK1246323B (en) Glucagon derivatives
NZ740049B2 (en) Novel oxyntomodulin derivatives and pharmaceutical composition for treating obesity comprising the same
NZ734808B2 (en) Novel oxyntomodulin derivatives and pharmaceutical composition for treating obesity comprising the same
NZ755534B2 (en) Novel oxyntomodulin derivatives and pharmaceutical composition for treating obesity comprising the same

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181218

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20181218

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20191216

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200316

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20200428

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200828

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20200828

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20200904

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20200907

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20201026

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20201117

R150 Certificate of patent or registration of utility model

Ref document number: 6797122

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250