JP6678655B2 - Ｒａｆキナーゼ阻害剤としての化合物および組成物 - Google Patents

Ｒａｆキナーゼ阻害剤としての化合物および組成物 Download PDF

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JP6678655B2
JP6678655B2 JP2017513759A JP2017513759A JP6678655B2 JP 6678655 B2 JP6678655 B2 JP 6678655B2 JP 2017513759 A JP2017513759 A JP 2017513759A JP 2017513759 A JP2017513759 A JP 2017513759A JP 6678655 B2 JP6678655 B2 JP 6678655B2
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pharmaceutically acceptable
raf
cancer
acceptable salt
compound
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JP2017528475A (ja
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ティー． バーガー，マシュー
ティー． バーガー，マシュー
ラマーシー，サビスリ
アール． タフト，ベンジャミン
アール． タフト，ベンジャミン
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ノバルティス アーゲー
ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017513759A 2014-09-12 2015-09-11 Ｒａｆキナーゼ阻害剤としての化合物および組成物 Active JP6678655B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462049469P 2014-09-12 2014-09-12
US62/049,469 2014-09-12
PCT/IB2015/056986 WO2016038581A1 (en) 2014-09-12 2015-09-11 Compounds and compositions as raf kinase inhibitors

Publications (3)

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JP2017528475A JP2017528475A (ja) 2017-09-28
JP2017528475A5 JP2017528475A5 (index.php) 2018-10-18
JP6678655B2 true JP6678655B2 (ja) 2020-04-08

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US (2) US9573969B2 (index.php)
EP (1) EP3191472B1 (index.php)
JP (1) JP6678655B2 (index.php)
KR (1) KR20170053686A (index.php)
CN (1) CN107108671B (index.php)
AP (1) AP2017009830A0 (index.php)
AR (1) AR101815A1 (index.php)
AU (1) AU2015313782B2 (index.php)
BR (1) BR112017004741A2 (index.php)
CA (1) CA2960971A1 (index.php)
CL (1) CL2017000541A1 (index.php)
CO (1) CO2017002292A2 (index.php)
CR (1) CR20170092A (index.php)
CU (1) CU20170026A7 (index.php)
DO (1) DOP2017000066A (index.php)
EA (1) EA031061B1 (index.php)
EC (1) ECSP17021897A (index.php)
ES (1) ES2729243T3 (index.php)
IL (1) IL250950A0 (index.php)
MX (1) MX2017003233A (index.php)
NI (1) NI201700029A (index.php)
PE (1) PE20171338A1 (index.php)
PH (1) PH12017500416A1 (index.php)
SG (1) SG11201701734QA (index.php)
SV (1) SV2017005405A (index.php)
TN (1) TN2017000075A1 (index.php)
TW (1) TWI603977B (index.php)
UY (1) UY36294A (index.php)
WO (1) WO2016038581A1 (index.php)
ZA (1) ZA201701633B (index.php)

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CN105026395B (zh) 2013-03-14 2018-07-20 勃林格殷格翰国际有限公司 取代的氮杂双环酰胺类组织蛋白酶c抑制剂及其药物组合物和制药用途
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
AP2016009368A0 (en) * 2014-01-14 2016-08-31 Millennium Pharm Inc Heteroaryls and uses thereof
UY36294A (es) * 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
AP2017009733A0 (en) 2014-09-12 2017-02-28 Boehringer Ingelheim Int Spirocyclic inhibitors of cathepsin c
CN109715163B (zh) 2016-09-19 2022-11-22 诺华股份有限公司 包含raf抑制剂和erk抑制剂的治疗组合
TWI798218B (zh) 2017-05-02 2023-04-11 瑞士商諾華公司 組合療法
BR112020001916A2 (pt) * 2017-08-03 2020-07-28 Novartis Ag combinação terapêutica de um inibidor de tirosina quinase de egfr de terceira geração e um inibidor de raf
AU2020244761A1 (en) * 2019-03-22 2021-11-11 Kinnate Biopharma Inc. Inhibitors of RAF kinases
AR118826A1 (es) 2019-05-03 2021-11-03 Kinnate Biopharma Inc Inhibidores de cinasas raf
EP4563150A3 (en) * 2019-05-13 2025-07-23 Novartis AG New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl) isonicotinamide as raf inhibitors for the treatment of cancer
CA3158530A1 (en) * 2019-10-24 2021-04-29 Stephen W. Kaldor Inhibitors of raf kinases
JP7214925B2 (ja) * 2019-12-06 2023-01-30 メッドシャイン ディスカバリー インコーポレイテッド Ｐａｎ－ＲＡＦキナーゼ阻害剤としてのビアリール化合物
WO2022060996A1 (en) 2020-09-18 2022-03-24 Kinnate Biopharma Inc. Inhibitors of raf kinases
WO2022066580A1 (en) * 2020-09-23 2022-03-31 Kinnate Biopharma Inc. Raf degrading compounds
US11377431B2 (en) 2020-10-12 2022-07-05 Kinnate Biopharma Inc. Inhibitors of RAF kinases
EP4326256A4 (en) 2021-04-23 2025-03-19 Pierre Fabre Medicament Treating cancer with a RAF inhibition
CA3216258A1 (en) * 2021-04-23 2022-10-27 Stephen W. Kaldor Solid state forms of (s)-n-(3-(2-(((r)-1-hydroxypropan-2-yl)amino)-6-morpholinopyridin-4-yl)-4-methylphenyl)-3-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and salts thereof
AU2022274298A1 (en) * 2021-05-12 2023-09-28 Boehringer Ingelheim International Gmbh Pyridine derivatives with n-linked cyclic substituents as cgas inhibitors

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