JP6669822B2 - サーマス・サーモフィラスと酵母菌との組合せの発酵方法 - Google Patents
サーマス・サーモフィラスと酵母菌との組合せの発酵方法 Download PDFInfo
- Publication number
- JP6669822B2 JP6669822B2 JP2018150901A JP2018150901A JP6669822B2 JP 6669822 B2 JP6669822 B2 JP 6669822B2 JP 2018150901 A JP2018150901 A JP 2018150901A JP 2018150901 A JP2018150901 A JP 2018150901A JP 6669822 B2 JP6669822 B2 JP 6669822B2
- Authority
- JP
- Japan
- Prior art keywords
- yeast
- fermentation
- culture
- thermophilus
- rpm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000855 fermentation Methods 0.000 title claims description 151
- 230000004151 fermentation Effects 0.000 title claims description 150
- 240000004808 Saccharomyces cerevisiae Species 0.000 title claims description 93
- 238000000034 method Methods 0.000 title claims description 41
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims description 92
- 241000589499 Thermus thermophilus Species 0.000 claims description 24
- 230000003698 anagen phase Effects 0.000 claims description 24
- 241000894006 Bacteria Species 0.000 claims description 23
- 238000012258 culturing Methods 0.000 claims description 23
- 230000012010 growth Effects 0.000 claims description 20
- 238000001914 filtration Methods 0.000 claims description 18
- 238000003860 storage Methods 0.000 claims description 8
- 239000012535 impurity Substances 0.000 claims description 7
- 244000005700 microbiome Species 0.000 claims description 6
- 241000051160 Thermus thermophilus HB27 Species 0.000 claims description 4
- 230000002378 acidificating effect Effects 0.000 claims description 4
- 238000011081 inoculation Methods 0.000 claims description 4
- 238000004321 preservation Methods 0.000 claims description 4
- 210000005253 yeast cell Anatomy 0.000 claims description 3
- 230000001877 deodorizing effect Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 description 80
- 239000000047 product Substances 0.000 description 75
- 230000000694 effects Effects 0.000 description 41
- 210000004027 cell Anatomy 0.000 description 40
- 238000005273 aeration Methods 0.000 description 31
- 230000001580 bacterial effect Effects 0.000 description 29
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 26
- 238000012360 testing method Methods 0.000 description 26
- 210000003491 skin Anatomy 0.000 description 25
- 239000000203 mixture Substances 0.000 description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 22
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 20
- 239000000306 component Substances 0.000 description 18
- 230000003110 anti-inflammatory effect Effects 0.000 description 17
- 239000003153 chemical reaction reagent Substances 0.000 description 15
- 230000001965 increasing effect Effects 0.000 description 15
- 241000894007 species Species 0.000 description 15
- 108090000790 Enzymes Proteins 0.000 description 14
- 102000004190 Enzymes Human genes 0.000 description 14
- 206010000496 acne Diseases 0.000 description 14
- 239000000126 substance Substances 0.000 description 14
- 235000019156 vitamin B Nutrition 0.000 description 14
- 239000011720 vitamin B Substances 0.000 description 14
- 208000002874 Acne Vulgaris Diseases 0.000 description 13
- 239000002253 acid Substances 0.000 description 12
- 230000008859 change Effects 0.000 description 12
- 239000002537 cosmetic Substances 0.000 description 12
- 238000002156 mixing Methods 0.000 description 12
- 230000007423 decrease Effects 0.000 description 11
- 239000006228 supernatant Substances 0.000 description 11
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 10
- 239000001888 Peptone Substances 0.000 description 10
- 108010080698 Peptones Proteins 0.000 description 10
- 239000013543 active substance Substances 0.000 description 10
- 239000003513 alkali Substances 0.000 description 10
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 10
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 10
- 235000011130 ammonium sulphate Nutrition 0.000 description 10
- 239000012528 membrane Substances 0.000 description 10
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 10
- 235000019796 monopotassium phosphate Nutrition 0.000 description 10
- 235000019319 peptone Nutrition 0.000 description 10
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 10
- 238000000746 purification Methods 0.000 description 10
- 239000011780 sodium chloride Substances 0.000 description 10
- 230000002757 inflammatory effect Effects 0.000 description 9
- FBAFATDZDUQKNH-UHFFFAOYSA-M iron chloride Chemical compound [Cl-].[Fe] FBAFATDZDUQKNH-UHFFFAOYSA-M 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 239000002994 raw material Substances 0.000 description 8
- 230000000975 bioactive effect Effects 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- 210000002510 keratinocyte Anatomy 0.000 description 7
- 210000002966 serum Anatomy 0.000 description 7
- 101100377299 Arabidopsis thaliana ZHD13 gene Proteins 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 229930003270 Vitamin B Natural products 0.000 description 6
- 239000012670 alkaline solution Substances 0.000 description 6
- 238000004113 cell culture Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000005909 Kieselgur Substances 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 238000005119 centrifugation Methods 0.000 description 5
- 230000008029 eradication Effects 0.000 description 5
- 230000001976 improved effect Effects 0.000 description 5
- 239000002054 inoculum Substances 0.000 description 5
- 230000003020 moisturizing effect Effects 0.000 description 5
- 235000019645 odor Nutrition 0.000 description 5
- 230000008439 repair process Effects 0.000 description 5
- 238000000926 separation method Methods 0.000 description 5
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 4
- 239000006285 cell suspension Substances 0.000 description 4
- 238000003501 co-culture Methods 0.000 description 4
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 4
- 229960003957 dexamethasone Drugs 0.000 description 4
- 230000002500 effect on skin Effects 0.000 description 4
- 210000002950 fibroblast Anatomy 0.000 description 4
- 230000014509 gene expression Effects 0.000 description 4
- 235000015097 nutrients Nutrition 0.000 description 4
- 210000000434 stratum corneum Anatomy 0.000 description 4
- 238000004383 yellowing Methods 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 108090001005 Interleukin-6 Proteins 0.000 description 3
- 108090001007 Interleukin-8 Proteins 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 102000019197 Superoxide Dismutase Human genes 0.000 description 3
- 108010012715 Superoxide dismutase Proteins 0.000 description 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 3
- 102100040247 Tumor necrosis factor Human genes 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 238000000540 analysis of variance Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000003833 cell viability Effects 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
- 229920000053 polysorbate 80 Polymers 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000008591 skin barrier function Effects 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- 229920001503 Glucan Polymers 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 229920000057 Mannan Polymers 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 238000012136 culture method Methods 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 230000019612 pigmentation Effects 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000000475 sunscreen effect Effects 0.000 description 2
- 239000000516 sunscreening agent Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 241000589596 Thermus Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000037354 amino acid metabolism Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000012364 cultivation method Methods 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 231100000263 cytotoxicity test Toxicity 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000004332 deodorization Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229940075529 glyceryl stearate Drugs 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 229940097275 indigo Drugs 0.000 description 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012067 mathematical method Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012533 medium component Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 210000001626 skin fibroblast Anatomy 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000008833 sun damage Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000012747 synergistic agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000036572 transepidermal water loss Effects 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P39/00—Processes involving microorganisms of different genera in the same process, simultaneously
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/18—Baker's yeast; Brewer's yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- Birds (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cosmetics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810358237.5 | 2018-04-20 | ||
| CN201810358237.5A CN108517345B (zh) | 2018-04-20 | 2018-04-20 | 一种嗜热栖热菌和酵母菌组合发酵的方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019187409A JP2019187409A (ja) | 2019-10-31 |
| JP6669822B2 true JP6669822B2 (ja) | 2020-03-18 |
Family
ID=63429837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018150901A Active JP6669822B2 (ja) | 2018-04-20 | 2018-08-09 | サーマス・サーモフィラスと酵母菌との組合せの発酵方法 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP6669822B2 (zh) |
| CN (1) | CN108517345B (zh) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017094027A (ja) * | 2015-11-14 | 2017-06-01 | 株式会社三洋物産 | 遊技機 |
| CN113952284B (zh) * | 2020-02-26 | 2023-08-01 | 广州留今科学研究有限公司 | 一种共生菌组合发酵物及其制备方法和应用 |
| CN111297792B (zh) * | 2020-02-26 | 2021-07-27 | 广州一一生物技术有限公司 | 一种包含共生菌组合发酵物的氨基酸表活组合物、洁面乳及其制备方法 |
| CN113616584B (zh) * | 2020-05-08 | 2023-05-05 | 上海中翊日化有限公司 | 含双菌发酵产物与活性葡萄籽提取物抵御城市污染的抗炎护肤品组合物 |
| CN111778189A (zh) * | 2020-07-15 | 2020-10-16 | 曲靖凯美冠有机肥生产有限公司 | 一种复合发酵菌种配方、发酵工艺及其复配装置 |
| CN112618464A (zh) * | 2021-01-28 | 2021-04-09 | 广州市玉鑫化妆品有限公司 | 一种酵母菌大米发酵产物滤液的制备方法 |
| CN114525319A (zh) * | 2022-03-11 | 2022-05-24 | 杭州优玛达生物科技有限公司 | 一种热休克蛋白-依克多因组合物及其制备方法和应用 |
| CN114525230B (zh) * | 2022-03-31 | 2024-04-09 | 杭州优玛达生物科技有限公司 | 发酵培养物及嗜热栖热菌采用发酵培养物的发酵方法 |
| CN114592023B (zh) * | 2022-03-31 | 2023-03-24 | 杭州优玛达生物科技有限公司 | 一种细胞裂解自组装多肽复合物、自组装方法、自组装多肽制剂及应用 |
| CN114574403A (zh) * | 2022-04-13 | 2022-06-03 | 广东药科大学 | 一种利用米糠酶水解液制备嗜热栖热菌发酵产物的方法 |
| CN115678805B (zh) * | 2022-11-02 | 2023-06-13 | 稀物集(广州)生物科技有限公司 | 一种具有修复抗衰功效的松茸酵母发酵液的制备方法及其应用 |
| CN116497077A (zh) * | 2023-05-12 | 2023-07-28 | 广东药科大学 | 一种利用银耳提取液制备嗜热栖热菌发酵产物的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101433502A (zh) * | 2007-11-14 | 2009-05-20 | 高宝化妆品（中国）有限公司 | 一种生物酶防晒乳组合物 |
| CN103173371B (zh) * | 2011-12-20 | 2014-07-02 | 辽宁威兰生物技术有限责任公司 | 酿酒酵母与嗜酸乳杆菌的饲料用复合微生物制剂的生产 |
| CN105434319B (zh) * | 2015-12-07 | 2018-09-14 | 华南理工大学 | 一种基于红发夫酵母原料的化妆品及其制备方法 |
| CN107184411B (zh) * | 2017-04-21 | 2019-02-22 | 韩后化妆品股份有限公司 | 一种复合水嫩因子、化妆品及化妆品的制备方法 |
| CN107362129B (zh) * | 2017-08-23 | 2019-10-18 | 广东丸美生物技术股份有限公司 | 护肤基质、制备方法及其应用和化妆品及其制备方法 |
-
2018
- 2018-04-20 CN CN201810358237.5A patent/CN108517345B/zh active Active
- 2018-08-09 JP JP2018150901A patent/JP6669822B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019187409A (ja) | 2019-10-31 |
| CN108517345A (zh) | 2018-09-11 |
| CN108517345B (zh) | 2021-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6669822B2 (ja) | サーマス・サーモフィラスと酵母菌との組合せの発酵方法 | |
| JP6793692B2 (ja) | サーマス・サーモフィラスと酵母菌との組合せによる発酵生成物の用途 | |
| US20230193196A1 (en) | Bifidobacterium animalis subsp. lactis gfc-b09 strain and cosmetic composition containing same | |
| CN110592151A (zh) | 乳酸菌生产高含γ-氨基丁酸发酵液及其在化妆品中的应用 | |
| CN109893487B (zh) | 一种大米玫瑰发酵原浆及其制备方法与应用 | |
| CN105560097A (zh) | 一种牡丹鲜花酵素及其制备方法和用途 | |
| CN111534455B (zh) | 一种乳酸杆菌溶孢产物的制备及其在化妆品的应用 | |
| CN111973498A (zh) | 一种灵芝发酵物及其制备方法和应用 | |
| CN106726949B (zh) | 一种葡萄籽发酵原浆化妆品及其制备方法与应用 | |
| CN112999127B (zh) | 一种龙胆复方酵素及其制备方法和应用 | |
| CN102851259A (zh) | 抗氧化剂的制造方法 | |
| CN111514084B (zh) | 一种大米发酵物保湿剂及其制备方法和应用 | |
| KR20110135477A (ko) | 항산화 및 미백 효능을 갖는 효모 발효액 및 이의 제조 방법 | |
| CN115569096B (zh) | 一种山茶花发酵滤液及发酵工艺 | |
| CN115634163A (zh) | 美白护肤精华乳及其制备方法 | |
| CN115337238A (zh) | 一种咖啡发酵物的制备方法和应用 | |
| CN111544352B (zh) | 银耳-灵芝复合发酵物、具有抗衰老功效的化妆品用组合物及其制备方法和应用 | |
| WO2021217693A1 (zh) | 一种水解假丝酵母和日本清酒酵母共生发酵产物的用途 | |
| CN108888573B (zh) | 舒敏保湿滋润霜及其制备方法 | |
| CN108969430B (zh) | 一种西洋参发酵液作为护肤品或护肤品添加剂的应用 | |
| CN111568799A (zh) | 一种海参酵解素在美白产品中的应用 | |
| KR20170031578A (ko) | 구절초를 이용한 삼투압 효소 발효물의 제조방법, 이로부터 제조된 발효물 및 이를 포함하는 화장료, 식품 또는 약학 조성물 | |
| CN113332192B (zh) | 一种日本紫珠果发酵物及其制备方法和应用 | |
| KR20210105234A (ko) | 고사리 생물전환물질을 이용한 미백 및 주름 개선 코스메슈티컬 제품 개발 | |
| KR102627236B1 (ko) | 바이오 전환 기술을 접목시킨 멍게 껍질 발효물, 이를 포함하는 조성물 및 이를 포함하는 항염, 항산화, 주름개선, 피부 재생, 피부 탄력, 피부 진정용 화장료 조성물 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20180809 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190730 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190925 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200107 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200108 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20200225 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20200227 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6669822 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |