JP6657413B2 - Ｐｐａｒアゴニスト、化合物、医薬組成物、及びその使用方法 - Google Patents

Ｐｐａｒアゴニスト、化合物、医薬組成物、及びその使用方法 Download PDF

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JP6657413B2
JP6657413B2 JP2018538052A JP2018538052A JP6657413B2 JP 6657413 B2 JP6657413 B2 JP 6657413B2 JP 2018538052 A JP2018538052 A JP 2018538052A JP 2018538052 A JP2018538052 A JP 2018538052A JP 6657413 B2 JP6657413 B2 JP 6657413B2
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methyl
mmol
compound
imidazol
pharmaceutically acceptable
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JP2018534355A (ja
JP2018534355A5 (OSRAM
Inventor
ダウンズ，マイケル
エヴァンス，ロナルド・エム
クルーゲ，アーサー
ラグ，バーラト
理憲 三浦
理憲 三浦
パーニーグラヒ，スニール・クマール
パタネ，マイケル
サマジダル，スサンタ
セナヤール，ラメーシュ
泰輔 高橋
泰輔 高橋
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Salk Institute for Biological Studies
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Salk Institute for Biological Studies
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2018538052A 2015-10-07 2016-10-05 Ｐｐａｒアゴニスト、化合物、医薬組成物、及びその使用方法 Active JP6657413B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562238629P 2015-10-07 2015-10-07
US62/238,629 2015-10-07
US201562243263P 2015-10-19 2015-10-19
US62/243,263 2015-10-19
US201662352348P 2016-06-20 2016-06-20
US62/352,348 2016-06-20
PCT/US2016/055521 WO2017062468A1 (en) 2015-10-07 2016-10-05 Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof

Related Child Applications (1)

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JP2018534355A JP2018534355A (ja) 2018-11-22
JP2018534355A5 JP2018534355A5 (OSRAM) 2019-11-14
JP6657413B2 true JP6657413B2 (ja) 2020-03-04

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JP2020016147A Active JP6866514B2 (ja) 2015-10-07 2020-02-03 Ｐｐａｒアゴニスト、化合物、医薬組成物、及びその使用方法

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US (6) US10399958B2 (OSRAM)
EP (3) EP3359528B1 (OSRAM)
JP (2) JP6657413B2 (OSRAM)
KR (2) KR102667385B1 (OSRAM)
CN (3) CN113024467B (OSRAM)
AU (3) AU2016333963C1 (OSRAM)
BR (1) BR112018006866B1 (OSRAM)
CA (1) CA3000431A1 (OSRAM)
CO (1) CO2018004473A2 (OSRAM)
DK (1) DK3359528T3 (OSRAM)
EA (1) EA037371B1 (OSRAM)
ES (3) ES2949852T3 (OSRAM)
HU (1) HUE058154T2 (OSRAM)
IL (3) IL258225B (OSRAM)
JO (3) JO3738B1 (OSRAM)
MA (2) MA52098A (OSRAM)
MX (3) MX392524B (OSRAM)
MY (1) MY203081A (OSRAM)
PH (1) PH12018500762A1 (OSRAM)
PL (1) PL3359528T3 (OSRAM)
PT (1) PT3359528T (OSRAM)
SG (1) SG10201906400SA (OSRAM)
TW (3) TWI730408B (OSRAM)
UA (1) UA122237C2 (OSRAM)
WO (1) WO2017062468A1 (OSRAM)
ZA (4) ZA201802029B (OSRAM)

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MY192385A (en) * 2016-10-05 2022-08-18 Mitobridge Inc Methods of treating acute kidney injury
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WO2022189856A1 (en) 2021-03-08 2022-09-15 Abionyx Pharma Sa Compounds useful for treating liver diseases
EP4346807A1 (en) 2021-06-02 2024-04-10 Astellas Pharma Inc. Methods of use of ppar agonist compounds and pharmaceutical compositions thereof
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JOP20200231A1 (ar) 2022-10-30
CN113004205A (zh) 2021-06-22
MX392524B (es) 2025-03-24
US20190084958A1 (en) 2019-03-21
ZA201802029B (en) 2022-01-26
EP3795566B1 (en) 2023-04-19
HUE058154T2 (hu) 2022-07-28
IL275392A (en) 2020-07-30
CN108349904A (zh) 2018-07-31
MX2018004295A (es) 2018-08-09
US20240417383A1 (en) 2024-12-19
IL275392B (en) 2022-05-01
ZA202003664B (en) 2022-08-31
JOP20200230A1 (ar) 2022-10-30
US20210253549A1 (en) 2021-08-19
AU2020281069A1 (en) 2021-01-07
US20230373948A1 (en) 2023-11-23
UA122237C2 (uk) 2020-10-12
MY203081A (en) 2024-06-07
TW201722919A (zh) 2017-07-01
TW202012375A (zh) 2020-04-01
WO2017062468A1 (en) 2017-04-13
AU2019283837A1 (en) 2020-01-16
KR102667385B1 (ko) 2024-05-21
MA52098A (fr) 2021-01-27
KR20180095797A (ko) 2018-08-28
ES2949852T3 (es) 2023-10-03
CN108349904B (zh) 2021-08-31
PL3359528T3 (pl) 2022-05-30
CN113004205B (zh) 2024-07-02
WO2017062468A8 (en) 2017-05-11
BR112018006866A2 (pt) 2018-10-16
EP3770146B1 (en) 2024-07-24
US10479775B1 (en) 2019-11-19
JP6866514B2 (ja) 2021-04-28
AU2019283837B2 (en) 2020-12-24
PT3359528T (pt) 2022-04-07
ES2988059T3 (es) 2024-11-19
JO3738B1 (ar) 2021-01-31
HK1257907A1 (zh) 2019-11-01
JP2020075939A (ja) 2020-05-21
AU2016333963B2 (en) 2021-01-07
ZA202003663B (en) 2022-08-31
IL275387A (en) 2020-07-30
AU2020281069B2 (en) 2022-10-27
MX2020011100A (es) 2022-05-23
IL258225A (en) 2018-05-31
JP2018534355A (ja) 2018-11-22
NZ740846A (en) 2024-12-20
US11578052B2 (en) 2023-02-14
TWI730006B (zh) 2021-06-11
EP3770146C0 (en) 2024-07-24
BR112018006866B1 (pt) 2023-11-21
EA037371B1 (ru) 2021-03-19
TWI742479B (zh) 2021-10-11
ES2906379T3 (es) 2022-04-18
AU2016333963C1 (en) 2021-05-27
CN113024467B (zh) 2024-08-06
EP3359528B1 (en) 2022-01-12
EA201890776A1 (ru) 2018-09-28
MX392523B (es) 2025-03-24
KR20210126150A (ko) 2021-10-19
CO2018004473A2 (es) 2018-09-20
SG10201906400SA (en) 2019-08-27
CN113024467A (zh) 2021-06-25
MA52648A (fr) 2021-10-13
EP3770146A1 (en) 2021-01-27
ZA202003662B (en) 2022-08-31
DK3359528T3 (en) 2022-03-07
EP3795566A1 (en) 2021-03-24
US10399958B2 (en) 2019-09-03
KR102667386B1 (ko) 2024-05-21
MX2020011099A (es) 2022-05-23
MX380281B (es) 2025-03-12
US20190337920A1 (en) 2019-11-07
US10906885B2 (en) 2021-02-02
AU2016333963A1 (en) 2018-04-12
TW201943705A (zh) 2019-11-16
CA3000431A1 (en) 2017-04-13
US20200157074A1 (en) 2020-05-21
TWI730408B (zh) 2021-06-11
EP3359528A1 (en) 2018-08-15
PH12018500762A1 (en) 2018-10-29
IL275387B (en) 2021-08-31
IL258225B (en) 2021-08-31

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