JP6646571B2 - 膵臓がんを検出するための方法および組成物 - Google Patents

膵臓がんを検出するための方法および組成物 Download PDF

Info

Publication number
JP6646571B2
JP6646571B2 JP2016502266A JP2016502266A JP6646571B2 JP 6646571 B2 JP6646571 B2 JP 6646571B2 JP 2016502266 A JP2016502266 A JP 2016502266A JP 2016502266 A JP2016502266 A JP 2016502266A JP 6646571 B2 JP6646571 B2 JP 6646571B2
Authority
JP
Japan
Prior art keywords
pancreatic cancer
subject
level
cancer biomarker
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2016502266A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016519285A5 (enExample
JP2016519285A (ja
Inventor
パンネル，ルイス・ケイ
ロッカー，ジャナ
Original Assignee
クリエイティクス エルエルシー
クリエイティクス エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by クリエイティクス エルエルシー, クリエイティクス エルエルシー filed Critical クリエイティクス エルエルシー
Publication of JP2016519285A publication Critical patent/JP2016519285A/ja
Publication of JP2016519285A5 publication Critical patent/JP2016519285A5/ja
Application granted granted Critical
Publication of JP6646571B2 publication Critical patent/JP6646571B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57525—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the liver or pancreas
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016502266A 2013-03-13 2014-03-13 膵臓がんを検出するための方法および組成物 Expired - Fee Related JP6646571B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361780574P 2013-03-13 2013-03-13
US61/780,574 2013-03-13
PCT/US2014/026857 WO2014160499A2 (en) 2013-03-13 2014-03-13 Methods and compositions for detecting pancreatic cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020001856A Division JP7109008B2 (ja) 2013-03-13 2020-01-09 膵臓がんを検出するための方法および組成物

Publications (3)

Publication Number Publication Date
JP2016519285A JP2016519285A (ja) 2016-06-30
JP2016519285A5 JP2016519285A5 (enExample) 2017-03-30
JP6646571B2 true JP6646571B2 (ja) 2020-02-14

Family

ID=50933479

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016502266A Expired - Fee Related JP6646571B2 (ja) 2013-03-13 2014-03-13 膵臓がんを検出するための方法および組成物
JP2020001856A Expired - Fee Related JP7109008B2 (ja) 2013-03-13 2020-01-09 膵臓がんを検出するための方法および組成物
JP2022109693A Withdrawn JP2022141755A (ja) 2013-03-13 2022-07-07 膵臓がんを検出するための方法および組成物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2020001856A Expired - Fee Related JP7109008B2 (ja) 2013-03-13 2020-01-09 膵臓がんを検出するための方法および組成物
JP2022109693A Withdrawn JP2022141755A (ja) 2013-03-13 2022-07-07 膵臓がんを検出するための方法および組成物

Country Status (7)

Country Link
US (3) US20160033511A1 (enExample)
EP (1) EP2972375A2 (enExample)
JP (3) JP6646571B2 (enExample)
AU (3) AU2014243704A1 (enExample)
CA (1) CA2902841A1 (enExample)
HK (1) HK1214652A1 (enExample)
WO (1) WO2014160499A2 (enExample)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2347775T3 (da) 2005-12-13 2020-07-13 Harvard College Skabeloner til celletransplantation
DK2140269T3 (da) 2007-03-27 2013-12-16 Immunovia Ab Proteinsignatur/markører til at detektere adenocarcinom
EP3620185A1 (en) 2010-10-06 2020-03-11 President and Fellows of Harvard College Injectable, pore-forming hydrogels for materials-based cell therapies
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
CA2848162C (en) 2011-09-12 2023-03-14 Creatics Llc Non-invasive methods of detecting target molecules
WO2013152860A2 (en) * 2012-04-11 2013-10-17 Dutalys Gmbh Improved antibody light chains
PT2838515T (pt) 2012-04-16 2020-02-25 Harvard College Composições de sílica mesoporosa para modular respostas imunológicas
CA2877721A1 (en) 2012-06-27 2014-01-03 Berg Llc Use of markers in the diagnosis and treatment of prostate cancer
ME03326B (me) 2013-03-15 2019-10-20 Shire Viropharma Inc C1-inh kompozicije i postupci za prevenciju i liječenje poremećaja koji su povezani sa deficijencijom inhibitora c1 esteraze
DK3387898T3 (da) 2013-03-15 2020-08-03 Mayo Found Medical Education & Res Identificering og monitorering af monoklonale immunglobuliner ved hjælp af molekylvægt
EP3159695A3 (en) * 2013-06-20 2017-07-05 The Trustees of The University of Pennsylvania Methods for diagnosing pancreatic cancer
CA2944767C (en) 2014-04-04 2022-07-12 Mayo Foundation For Medical Education And Research Isotyping immunoglobulins using accurate molecular mass
EP3137105A4 (en) 2014-04-30 2017-12-27 President and Fellows of Harvard College Combination vaccine devices and methods of killing cancer cells
CN106461678A (zh) * 2014-05-26 2017-02-22 奥林巴斯株式会社 胰腺癌判定方法
KR20160045547A (ko) * 2014-10-17 2016-04-27 에스케이텔레콤 주식회사 췌장암 진단용 조성물 및 이를 이용한 췌장암 진단방법
EP3230314B1 (en) 2014-12-08 2023-05-03 Berg LLC Use of markers including filamin a in the diagnosis and treatment of prostate cancer
CN107406483B (zh) 2014-12-19 2022-02-22 豪夫迈·罗氏有限公司 微生物转谷氨酰胺酶，其底物和其使用方法
CA2971246C (en) 2014-12-19 2020-07-14 F. Hoffmann-La Roche Ag Identification of transglutaminase substrates and uses therefor
US11054425B2 (en) 2014-12-19 2021-07-06 Roche Sequencing Solutions, Inc. System and method for identification and characterization of transglutaminase species
HK1247861A1 (zh) 2015-01-30 2018-10-05 President And Fellows Of Harvard College 用於癌症治疗的肿瘤周围和肿瘤内部材料
US20160271120A1 (en) * 2015-03-17 2016-09-22 Oakdene Holdings Llc Pharmaceutical composition for cleansing of the gastrointestinal tract
GB201505654D0 (en) * 2015-04-01 2015-05-13 Nordic Bioscience As Immunoassay for collagen type VI sequence
US20180306788A1 (en) * 2015-04-07 2018-10-25 President And Fellows Of Harvard College Compositions and methods for modulating hydroxylation of acc2 by phd3
CN114099793A (zh) 2015-04-10 2022-03-01 哈佛学院院长等 免疫细胞捕获装置及其制备和使用方法
JP2018513141A (ja) * 2015-04-20 2018-05-24 コンセジョ スペリオール デ インベスティガショネス シエンティフィカス ヒトカドヘリン−１７、ヒトカドヘリン−５、ヒトカドヘリン−６およびヒトカドヘリン−２０のｒｇｄモチーフに特異的に結合する薬剤
GB201511191D0 (en) * 2015-06-25 2015-08-12 Immatics Biotechnologies Gmbh T-cell epitopes for the immunotherapy of myeloma
HK1254866A1 (zh) 2015-06-25 2019-07-26 Immatics Biotechnologies Gmbh 用於骨髓瘤和其他癌症免疫治疗的新型细胞表位和细胞表位组合物
US10823735B2 (en) * 2015-09-03 2020-11-03 The University Of Hong Kong Monoclonal antibody for predicting tamoxifen response in breast cancer patients
EP3353200A4 (en) 2015-09-24 2019-06-26 Mayo Foundation for Medical Education and Research IDENTIFICATION OF FREE LIGHT CHAINS FROM IMMOBILIZED LOBULIN BY MASS SPECTROMETRY
CN105296613A (zh) * 2015-09-24 2016-02-03 郑州市职业病防治院 一种人TERF1基因rs3863242位点多态性检测技术
US11371099B2 (en) 2015-11-30 2022-06-28 Mayo Foundation For Medical Education And Research HEATR1 as a marker for chemoresistance
CN105785013A (zh) * 2016-04-21 2016-07-20 卢连伟 一种辅助检测胰腺癌的胶体金免疫层析试纸及其制备方法
GB201608192D0 (en) * 2016-05-10 2016-06-22 Immunovia Ab Method, array and use thereof
JP7075125B2 (ja) * 2016-05-25 2022-05-25 イマティクス バイオテクノロジーズ ゲーエムベーハー 標的としてのおよび胆嚢がんおよび胆管がんおよびその他のがんに対する免疫療法で使用するための新規ペプチド、ペプチド組み合わせ
EP3484448B1 (en) 2016-07-13 2025-04-09 President and Fellows of Harvard College Antigen-presenting cell-mimetic scaffolds and methods for making and using the same
RU2770060C2 (ru) 2016-08-02 2022-04-14 Президент Энд Феллоуз Оф Гарвард Колледж Биологические материалы для модуляции иммунных ответов
EP3523647B1 (en) 2016-09-07 2024-06-26 Mayo Foundation for Medical Education and Research Identification and monitoring of cleaved immunoglobulins by molecular mass
CN107655985B (zh) * 2017-08-25 2020-05-26 南京农业大学 一种基于lc-ms-ms技术的体内蛋白质营养的评价方法
EP3681528B1 (en) 2017-09-13 2025-07-23 Mayo Foundation for Medical Education and Research Identification and monitoring of apoptosis inhibitor of macrophage
EP3681907A4 (en) 2017-09-13 2021-07-07 Mayo Foundation for Medical Education and Research IDENTIFICATION AND MONITORING OF IMMUNOGLOBULIN J-CHAINS
JP2021520493A (ja) * 2018-04-03 2021-08-19 クリエイティクス エルエルシー 胃腸洗浄液試料における免疫グロブリンのグリカン結合パターンを評価するがん検出方法
WO2020061129A1 (en) 2018-09-19 2020-03-26 President And Fellows Of Harvard College Compositions and methods for labeling and modulation of cells in vitro and in vivo
WO2020101878A2 (en) * 2018-10-29 2020-05-22 The Johns Hopkins University Rasopathy treatment
WO2020223646A1 (en) * 2019-05-02 2020-11-05 Creatics Llc Methods for cancer detection by evaluation of alpha-1-antitrypsin (aat) and chymotrypsin-like elastase in gastrointestinal lavage fluid samples
BR112021026192A2 (pt) * 2019-06-24 2022-06-07 Urteste S A Marcador de diagnóstico para câncer pancreático
EP4034148A4 (en) 2019-09-23 2025-09-10 Harvard College BIOMATERIAL-BASED ANTIGEN-FREE VACCINE AND ITS USE
WO2021076036A1 (en) * 2019-10-18 2021-04-22 Reccan Diagnostics Ab Apparatuses and methods for detection of pancreatic cancer
JP7693718B2 (ja) * 2020-05-26 2025-06-17 エフ． ホフマン－ラ ロシュ アーゲー 定量器－確認器比チェックのために顧客質量分析機器を較正するためのコンピュータ実装方法
GB202010970D0 (en) 2020-07-16 2020-09-02 Immunovia Ab Methods, arrays and uses thereof
US20230272359A1 (en) * 2020-07-20 2023-08-31 Dana-Farber Cancer Institute, Inc. Methods and compositions for treatment and prevention of coronavirus infection
KR102448586B1 (ko) * 2020-10-08 2022-09-27 가톨릭대학교 산학협력단 췌장암 환자의 항암제 치료 반응성 예측용 마커
JP7825633B2 (ja) * 2020-12-08 2026-03-06 メモリアル スローン ケタリング キャンサー センター ガレクチン－３に対する抗体及びその使用方法
CN112461915B (zh) * 2020-12-08 2024-07-12 杭州汇健科技有限公司 一种与药物敏感相关的特征分子筛选、药敏程度检测、细胞亚型检测的方法
AU2021409465A1 (en) 2020-12-21 2023-08-03 Freenome Holdings, Inc. Markers for the early detection of colon cell proliferative disorders
US20240229154A9 (en) * 2021-02-12 2024-07-11 Institut National de la Santé et de la Recherche Médicale Method for prognosis and treating a patient suffering from cancer
WO2022221168A1 (en) * 2021-04-11 2022-10-20 Khurana Vikas System for pulse cycle harmonized ventilation and the method thereof
CN117813120A (zh) * 2021-06-07 2024-04-02 旗舰先锋创新Vii有限责任公司 用于靶向递送治疗剂的组合物和方法
EP4405681A4 (en) * 2021-09-20 2025-08-06 Droplet Biosciences Inc DIAGNOSTIC DRAINAGE FLUID
US12152280B2 (en) 2021-09-20 2024-11-26 Droplet Biosciences, Inc. Drain fluid for diagnostics
US12416626B2 (en) * 2022-07-22 2025-09-16 Droplet Biosciences, Inc. Methods for evaluating candidate therapy efficacy based on changes in lymphatic fluid biomarkers
WO2024086298A2 (en) * 2022-10-20 2024-04-25 The Johns Hopkins University Hla class i and class ii-restricted t-cell epitopes in pancreatic cancer tissues and uses thereof
WO2024206856A2 (en) * 2023-03-30 2024-10-03 Thomas Jefferson University Dna-dependent synthesis of rna by dna polymerase theta variants

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE28937T1 (de) * 1982-08-09 1987-08-15 Centocor Inc Immunotest fuer kohlehydrat-antigen-determinant.
JPH0673470B2 (ja) * 1986-07-15 1994-09-21 協和醗酵工業株式会社 抗ヒト胃癌単クロ−ン性抗体ａｍｃ−４６２
US5359681A (en) 1993-01-11 1994-10-25 University Of Washington Fiber optic sensor and methods and apparatus relating thereto
US6924153B1 (en) 1997-03-06 2005-08-02 Quidel Corporation Quantitative lateral flow assays and devices
JPH11225800A (ja) * 1998-02-10 1999-08-24 Kureha Chem Ind Co Ltd 体液を用いた癌検出方法及びキット
US6447763B1 (en) * 1998-06-12 2002-09-10 Ian L. Gordon Method and system for production and collection of lavage induced stool (LIS) for chemical and biologic tests of cells
EP1298205A4 (en) * 2000-07-03 2004-06-16 Mochida Pharm Co Ltd NEW LIPASE
WO2003014298A2 (en) * 2001-08-03 2003-02-20 Origene Technologies, Inc. Full-length prostate selective polynucleotides and polypeptides
US7291324B2 (en) * 2002-10-22 2007-11-06 Braintree Laboratories Inc. Method of bowel cleansing
US20040219572A1 (en) * 2002-12-17 2004-11-04 Jie Chen Specific markers for pancreatic cancer
WO2005053512A2 (en) * 2003-11-26 2005-06-16 Dana-Farber Cancer Institute, Inc. Animal models of pancreatic adenocarcinoma and uses therefor
ATE427499T1 (de) 2004-05-21 2009-04-15 Inst Systems Biology Zusammensetzungen und verfahren zur quantifizierung von serumglykoproteinen
CA2645125A1 (en) * 2006-03-02 2007-09-13 Oncotherapy Science, Inc. Methods for diagnosing pancreatic cancer using reg4 protein
EP2816122A1 (en) * 2008-02-15 2014-12-24 Mayo Foundation For Medical Education And Research Detecting neoplasm from a stool sample
US20090258090A1 (en) 2008-04-11 2009-10-15 Braintree Laboratories, Inc. Colon cleansing solution
JP5312684B2 (ja) * 2009-05-04 2013-10-09 エフ．ホフマン−ラ ロシュ アーゲー 癌のマーカーとしてのｄｐｐｉｖ／セプラーゼの使用
WO2011027311A2 (en) * 2009-09-03 2011-03-10 Koninklijke Philips Electronics N.V. Novel tumor markers
CN102762984A (zh) * 2009-11-05 2012-10-31 弗吉尼亚大学专利基金会 用于检测作为癌症生物标志的网蛋白-1的组合物和方法
AU2011260390B2 (en) * 2010-06-01 2016-11-24 Ernst-Moritz-Arndt Universitat Greifswald Means and methods for diagnosing pancreatic cancer in a subject
EP2603622A4 (en) * 2010-08-13 2015-04-22 Somalogic Inc BIOMARKERS FOR PANCREATIC CANCER AND USES THEREOF
AU2011351990A1 (en) * 2010-12-29 2013-07-18 Expression Pathology, Inc. Protein biomarkers of recurrent breast cancer
JP5984795B2 (ja) * 2011-04-05 2016-09-06 オリンパス株式会社 膵疾患を検出するためのデータを収集する方法
CA2848162C (en) * 2011-09-12 2023-03-14 Creatics Llc Non-invasive methods of detecting target molecules

Also Published As

Publication number Publication date
JP2022141755A (ja) 2022-09-29
JP7109008B2 (ja) 2022-08-10
AU2020202066B2 (en) 2022-06-02
EP2972375A2 (en) 2016-01-20
WO2014160499A2 (en) 2014-10-02
AU2020202066A1 (en) 2020-04-09
US20160033511A1 (en) 2016-02-04
AU2022224782A1 (en) 2022-09-22
JP2016519285A (ja) 2016-06-30
US20220128563A1 (en) 2022-04-28
JP2020091295A (ja) 2020-06-11
AU2014243704A1 (en) 2015-09-10
WO2014160499A3 (en) 2015-01-29
CA2902841A1 (en) 2014-10-02
US20190234951A1 (en) 2019-08-01
HK1214652A1 (zh) 2016-07-29

Similar Documents

Publication Publication Date Title
JP7109008B2 (ja) 膵臓がんを検出するための方法および組成物
JP2014526682A (ja) 標的分子を検出する非侵襲的方法
US10509034B2 (en) Bladder carcinoma biomarkers
US20190170769A1 (en) Methods and compositions for detecting endometrial or ovarian cancer
JP2018504609A (ja) 膵癌のバイオマーカー
WO2021045180A1 (ja) 胃がんマーカー、及びこれを用いた検査方法
JP2008014937A (ja) 腫瘍マーカー及び癌疾病の罹患の識別方法
US20090280512A1 (en) Tumor marker for renal cancer and method for determination of occurrence of renal cancer
JP2017526896A (ja) 補体因子ｂタンパク質に特異的に結合する抗体及び糖鎖抗原１９−９タンパク質に特異的に結合する抗体を含む膵臓癌診断用キット
WO2019242741A1 (en) Biomarkers for urothelial carcinoma and applications thereof
JP2021520493A (ja) 胃腸洗浄液試料における免疫グロブリンのグリカン結合パターンを評価するがん検出方法
WO2020223646A1 (en) Methods for cancer detection by evaluation of alpha-1-antitrypsin (aat) and chymotrypsin-like elastase in gastrointestinal lavage fluid samples
EP2312320B1 (en) Method for determining the stage of interstitial pneumonitis by determining PGE-MUM levels and reagent kit therefore
JP4795353B2 (ja) 腫瘍疾患および慢性炎症性腸疾患の診断のための液性バイオマーカーとしてのカルバモイルリン酸合成酵素１（ｃｐｓ１）の使用
JP7173815B2 (ja) 標的分子を検出する非侵襲的方法
KR20180117918A (ko) Mfap5 측정 제제를 포함하는 대장암 진단용 조성물, 키트, 및 이를 이용한 대장암 진단 방법
WO2022091793A1 (ja) 糞便由来タンパク質を用いた膵臓がんバイオマーカーの開発
JP2017151125A (ja) 標的分子を検出する非侵襲的方法
Wang et al. W1896 Prospective Randomized Multicenter Study of FISH in Patients with Barrett's Esophagus (BE)
Fu et al. W1898 Effect of Secreted Protein, Acidic and Rich in Cysteine in the AOM/DSS Mouse Model of Colitis-Induced Tumourogenesis
Goodbrand et al. W1897 Colorectal Cancer Biomarker Discovery Using Quantitative Proteomics
Venerito et al. W1895 Helicobacter pylori Infection, Gastric Atrophy and the Risk for Oesophageal Squamous Cell Carcinoma in Germany
Dutta et al. W1894 Elevated Plasma HSP70 in Patients with Pancreatic Cancer: A New Biomarker

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170227

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170227

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20171124

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180109

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180330

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180601

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180706

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190108

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190405

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190606

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20191112

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20191209

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20200110

R150 Certificate of patent or registration of utility model

Ref document number: 6646571

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees