JP6559191B2 - 光学的な探査及び検知に基づくバイオセンサ - Google Patents
光学的な探査及び検知に基づくバイオセンサ Download PDFInfo
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/255—Details, e.g. use of specially adapted sources, lighting or optical systems
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
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- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/26—Optical coupling means
- G02B6/28—Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals
- G02B6/293—Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means
- G02B6/29331—Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means operating by evanescent wave coupling
- G02B6/29335—Evanescent coupling to a resonator cavity, i.e. between a waveguide mode and a resonant mode of the cavity
- G02B6/29338—Loop resonators
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- G—PHYSICS
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- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/26—Optical coupling means
- G02B6/34—Optical coupling means utilising prism or grating
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
- G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
- G02B2006/12083—Constructional arrangements
- G02B2006/12097—Ridge, rib or the like
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
- G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
- G02B2006/12133—Functions
- G02B2006/12138—Sensor
Description
本特許文献は、「BIOSENSORS BASED ON OPTICAL PROBING AND SENSING(光学的な探査
及び検知に基づくバイオセンサ)」と題された2008年10月27日出願の米国仮出願第61/108,862号の利益及び優先権を主張する。該仮出願は、参照によって本文献の一部として組み込まれるものとする。
本文献は、生物物質及び化学物質を含む物質の光学的検知に関する。
本文献は、センサチップ上の光学センサを使用して物質を光学的に検知するための装置、センサチップ、及び技術を説明する。
る光学センサを識別するための一意のコードを有するように及びプローブ光と光学的に相互作用してそのコードを運ぶ、戻り識別光を生成するように構成される。
ローブ光を受信し、該走査プローブ光をセンサチップ上へ方向付ける対物レンズとを含む。装置は、波長可変レーザの様々な波長にわたって戻りプローブ光の一部分を受信するために及びセンサチップ上の各光学センサの応答を検出するために光学システムと連絡している光学検出器を含む。
スポット位置に作用するように設計された第2のミラーによって走査を完了すること、及びバイオセンサ結合の光学効率が最適化されるまでこの行為を繰り返し実施することによってなされる方法が提供される。
査すること、及びセンサを通って伝播された後の光を捕えることによって得られる。なお、リング共振器センサの場合、光は、共振外のときはセンサに対して主に弱く結合され、共振状態のときはセンサ内を強く通り抜けることに留意せよ。
ら現れ出る光を前進経路の入射角と一致する角度にするように構成することができる。この構成下では、チップから現れ出る光は、逆進経路をたどって自由空間ビーム分割器に到達する。
アによってプログラム可能である。上記のように、エタロンのFSRは、既知で且つ制御状態にあり、一定であると想定される。ソフトウェアは、位置、Q値(Q)、消光比(ER)、左右の壁の傾斜、ピーク透過、並びに線形、分裂、非線形などのピークの特性を含む、共振線形状の重要な特質を決定する。検出処理ユニットは、また、エタロンスペクトル中に存在する全てのピークの位置を決定するために使用することもできる。センサ共振ピーク位置の正確な測定を行うために、2つのスペクトル(センサ及びエタロン)が重ね合わされる。検出処理ユニットに加えて、コントローラユニットもまた、各種の素子の動作を制御するために及び各種の素子の動作を連係させるために提供することができる。例えば、センサチップ上へのプローブ光の走査と、波長可変レーザの走査及びその他の制御動作との同期化を、コントローラユニットにおいて実施することができる。一部の実装形態では、コントローラユニットは、検出処理ユニットとは別のユニットであってよく、検出処理ユニットからの出力を受信し、このような出力を制御動作の実施に使用する。その他の実装形態では、コントローラユニットは、検出処理ユニットと統合して1つのユニットにすることができる。コントローラユニットの一部として、コンピュータ又はマイクロプロセッサを使用することができる。
とは限らないことに留意せよ。特定のリングは、センサ出力から温度などの影響を排除してシステムを較正する制御のために、稼働バイオセンサとしてではなく参照リング共振器として使用され得るように、手つかずのままで被覆を有することができる。
。リング503内にシリコン導波路502が形成され、薄い二酸化シリコン層510でコーティングされる。この薄い二酸化シリコン層510は、エバネッセント場が、上に配された任意の化学物質と強く反応しつつも、ガラスと共有結合するシランとして知られるクラスの分子を通じた表面結合を開始させるよくあるやり式としても機能することを可能にする。2つの異なるタイプの一般的な導波路が図示されており、図7aには、下方被覆508を露出させた完全にエッチングされた導波路502が、図7bには、下方被覆508が露呈していない部分的にエッチングされた導波路502が、それぞれ示されている。
ンサに一意の識別子を割り振ることによって分離及び識別する必要がある。各センサに一意の識別子を割り振るには、センサから実際の測定値を得るためのセンシングラスタ走査が実施される前に、光学調査器によって、チップに対して登録のための光学ラスタ走査を実施してチップを「登録」すればよい。
、このような動作が、所望の結果を得るために、図示されている特定の順序で又は起こった順番で実施される必要があるとも、又は例示されている全ての動作が実施される必要があるとも理解されるべきでない。
Claims (11)
- 所定範囲の波長を含む入力光を生成し、前記入力光の第1部分を前記所定範囲の波長内の共振を含む第1出力波形を生成する共振光学バイオセンサに提供する光源と、
前記共振は前記共振光学バイオセンサにおける分析物の存在に基づいて変化する波長に対応し、
前記共振光学バイオセンサからの前記第1出力波形を検出する第1検出器と、
前記光源からの前記入力光の第2部分を受信し、前記所定範囲の波長内の複数の共振を含む第2出力波形を生成する波長参照装置と、
前記波長参照装置からの前記第2出力波形を検出する第2検出器と、
前記第1出力波形及び前記第2出力波形を分析し、前記波長参照装置の複数の共振の少なくとも一部に基づいて前記共振光学バイオセンサの前記共振に対応する前記波長を決定するプロセッサと、
を含むバイオセンシングシステム。 - 前記プロセッサは、さらに、
前記第1出力波形における前記共振の波長よりも短い波長で前記第2出力波形における第1共振を識別し、
前記第1出力波形における前記共振の波長よりも長い波長で前記第2出力波形における第2共振を識別し、
前記第2出力波形の前記第1共振及び前記第2共振に関連する前記第1出力波形の前記共振の位置を決定することによって、少なくとも部分的に、前記共振光学バイオセンサの前記共振に対応する前記波長を決定する、
請求項1に記載のバイオセンシングシステム。 - 前記光源は、波長可変光源である、
請求項1に記載のバイオセンシングシステム。 - 前記光源は、時間経過とともに前記所定範囲の波長を通って前記入力光の前記波長を掃引する、
請求項3に記載のバイオセンシングシステム。 - 前記プロセッサは、さらに、少なくとも部分的に波長掃引の速度の変動を補正する、
請求項4に記載のバイオセンシングシステム。 - 前記第1出力波形は、前記共振光学バイオセンサの複数の共振を含み、前記共振光学バイオセンサの前記複数の共振は、それらの間の第1自由スペクトル範囲の波長間隔を有し、
前記第2出力波形における前記複数の共振は、それらの間の第2自由スペクトル範囲の波長間隔を有し、
前記第1自由スペクトル範囲は前記第2自由スペクトル範囲より大きい、
請求項1に記載のバイオセンシングシステム。 - 前記プロセッサは、さらに、
前記第1出力波形における前記複数の共振のそれぞれについて、前記第1出力波形におけるそれぞれの前記共振の波長よりも短い波長における前記第2出力波形におけるそれぞれの第1共振を識別し、
前記第1出力波形における前記複数の共振のそれぞれについて、前記第1出力波形におけるそれぞれの前記共振の波長よりも長い波長における前記第2出力波形におけるそれぞれの第2共振を識別し、
前記第2出力波形のそれぞれの前記第1共振及び前記第2共振に関連する前記第1出力波形のそれぞれの前記共振の位置を決定することによって、前記第1出力波形における前記複数の共振のそれぞれについて、少なくとも部分的に、前記共振光学バイオセンサの前記共振に対応する前記波長を決定する、
請求項6に記載のバイオセンシングシステム。 - 前記共振光学バイオセンサは、リング共振器と隣接導波路とを含む、
請求項7に記載のバイオセンシングシステム。 - 前記波長参照装置は、エタロンを含む、
請求項1に記載のバイオセンシングシステム。 - 同時に、前記入力光の前記第1部分を前記共振光学バイオセンサに提供し、前記波長参照装置に前記入力光の前記第2部分を提供する、
請求項1に記載のバイオセンシングシステム。 - 前記第1出力波形及び前記第2出力波形を、同時に、サンプル抽出する、
請求項10に記載のバイオセンシングシステム。
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JP2017215343A (ja) | 2017-12-07 |
JP2019053089A (ja) | 2019-04-04 |
US20220042920A1 (en) | 2022-02-10 |
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US9846126B2 (en) | 2017-12-19 |
JP2022065011A (ja) | 2022-04-26 |
WO2010062627A3 (en) | 2010-08-26 |
EP3572796A2 (en) | 2019-11-27 |
US20180202937A1 (en) | 2018-07-19 |
EP3572796B1 (en) | 2022-12-07 |
EP2347247A4 (en) | 2018-03-07 |
EP3572796B8 (en) | 2023-01-18 |
JP2021015127A (ja) | 2021-02-12 |
JP2015062027A (ja) | 2015-04-02 |
EP3572796A3 (en) | 2020-02-26 |
EP2347247A2 (en) | 2011-07-27 |
WO2010062627A2 (en) | 2010-06-03 |
JP2012507035A (ja) | 2012-03-22 |
JP5656853B2 (ja) | 2015-01-21 |
US20120092650A1 (en) | 2012-04-19 |
US11041811B2 (en) | 2021-06-22 |
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