JP6515182B2 - Ｗｔ１抗原ペプチドおよび免疫調節剤の併用 - Google Patents

Ｗｔ１抗原ペプチドおよび免疫調節剤の併用 Download PDF

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Publication number
JP6515182B2
JP6515182B2 JP2017519401A JP2017519401A JP6515182B2 JP 6515182 B2 JP6515182 B2 JP 6515182B2 JP 2017519401 A JP2017519401 A JP 2017519401A JP 2017519401 A JP2017519401 A JP 2017519401A JP 6515182 B2 JP6515182 B2 JP 6515182B2
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peptide
seq
cancer
antibody
cells
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Japanese (ja)
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JPWO2016186177A1 (ja
Inventor
秀夫 高須
秀夫 高須
恵弥 中村
恵弥 中村
後藤　正志
正志 後藤
奈津子 杉辺
奈津子 杉辺
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International Institute of Cancer Immunology Inc
Sumitomo Pharma Co Ltd
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Sumitomo Dainippon Pharma Co Ltd
International Institute of Cancer Immunology Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001152—Transcription factors, e.g. SOX or c-MYC
    • A61K39/001153—Wilms tumor 1 [WT1]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2017519401A 2015-05-20 2016-05-19 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用 Active JP6515182B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015103145 2015-05-20
JP2015103145 2015-05-20
PCT/JP2016/064923 WO2016186177A1 (ja) 2015-05-20 2016-05-19 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用

Related Child Applications (1)

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JP2019076826A Division JP6713160B2 (ja) 2015-05-20 2019-04-15 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用

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JPWO2016186177A1 JPWO2016186177A1 (ja) 2018-04-12
JP6515182B2 true JP6515182B2 (ja) 2019-05-15

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JP2017519401A Active JP6515182B2 (ja) 2015-05-20 2016-05-19 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用
JP2019076826A Active JP6713160B2 (ja) 2015-05-20 2019-04-15 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用
JP2020012396A Active JP6956967B2 (ja) 2015-05-20 2020-01-29 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用
JP2021154508A Active JP7253210B2 (ja) 2015-05-20 2021-09-22 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用

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JP2019076826A Active JP6713160B2 (ja) 2015-05-20 2019-04-15 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用
JP2020012396A Active JP6956967B2 (ja) 2015-05-20 2020-01-29 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用
JP2021154508A Active JP7253210B2 (ja) 2015-05-20 2021-09-22 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用

Country Status (7)

Country Link
US (2) US20180140691A1 (https=)
EP (1) EP3299028B1 (https=)
JP (4) JP6515182B2 (https=)
CN (1) CN107921106B (https=)
CA (1) CA2986367A1 (https=)
ES (1) ES2993462T3 (https=)
WO (1) WO2016186177A1 (https=)

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WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
US12383608B2 (en) 2016-11-30 2025-08-12 Sumitomo Pharma Co., Ltd. WT1 helper peptides and combinations of WT1 helper peptide and conjugate of cancer antigen peptides
ES2973548T3 (es) 2016-12-22 2024-06-20 Cue Biopharma Inc Polipéptidos multiméricos moduladores de linfocitos T y métodos para su uso
MY192920A (en) * 2017-03-15 2022-09-15 Cancer Res Malaysia Immunogenic peptide composition
US11696954B2 (en) 2017-04-28 2023-07-11 Exicure Operating Company Synthesis of spherical nucleic acids using lipophilic moieties
CN111051346A (zh) * 2017-05-31 2020-04-21 斯特库伯株式会社 使用免疫特异性结合btn1a1的抗体和分子治疗癌症的方法
BR112020003362A2 (pt) * 2017-08-28 2020-08-18 Bristol-Myers Squibb Company antagonistas de tim-3 para o tratamento e diagnóstico de cânceres
BR112020006677A2 (pt) * 2017-10-05 2020-10-06 Fulcrum Therapeutics, Inc. uso de inibidores p38 para reduzir a expressão de dux4
KR102184377B1 (ko) * 2018-02-19 2020-11-30 고려대학교 산학협력단 열충격단백질의 에피토프를 포함하는 백신 및 이의 용도
JP7162675B2 (ja) 2018-09-28 2022-10-28 住友ファーマ株式会社 注射用組成物
CA3115240A1 (en) 2018-10-05 2020-04-09 International Institute Of Cancer Immunology, Inc. Composition for preventing or treating benign tumor
MX2021012422A (es) * 2019-04-10 2022-01-19 Slsg Ltd Llc Composición de inmunoterapia multivalente y métodos para usarse en el tratamiento de cánceres positivos a la proteína del tumor de wilms 1 (wt1).
WO2021021924A1 (en) * 2019-07-29 2021-02-04 Huang Cai Gu Formulation of antibody based drugs for treating lung cancer by inhalation
CN114945383A (zh) 2019-12-10 2022-08-26 住友制药株式会社 肽乳液制剂的调制方法
AU2020414355A1 (en) * 2019-12-24 2022-08-11 Neoleukin Therapeutics, Inc. Combination therapy using an IL-2 receptor agonist and an immune checkpoint inhibitor
WO2021231405A1 (en) * 2020-05-12 2021-11-18 Board Of Regents, The University Of Texas System Methods for treating glioblastoma
WO2021231376A2 (en) 2020-05-12 2021-11-18 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof
WO2021230638A1 (en) * 2020-05-12 2021-11-18 Lg Chem, Ltd. Multimeric t-cell modulatory polypeptides and methods of use thereof
JP7153287B2 (ja) * 2020-05-12 2022-10-14 住友ファーマ株式会社 癌を処置するための医薬組成物
CN111647066B (zh) * 2020-07-01 2020-12-18 维肽瀛(上海)生物技术有限公司 Wt1多肽肿瘤抑制剂
US20240024444A1 (en) * 2020-08-07 2024-01-25 Medrx Co., Ltd. Combined Preparation
BR112023019492A2 (pt) * 2021-03-31 2023-10-31 Celleron Therapeutics Ltd Composto ou um sal ou solvato farmaceuticamente aceitável do mesmo, métodos para tratar ou prevenir uma doença, distúrbio ou condição, para potencializar uma resposta imunológica, para potencializar o efeito de uma vacina, para sensibilizar o sistema imunológico de um indivíduo, para potencializar a resposta imunológica a uma vacina em um indivíduo e para prevenir ou tratar uma doença, distúrbio ou condição, usos do composto ou um sal farmaceuticamente aceitável do mesmo e de uma combinação, combinação, produto farmacêutico, e, composição farmacêutica
CN117838860B (zh) * 2023-11-27 2025-03-14 四川大学 一种抑制周围神经侵袭的药物、药物组合物、联合用药物
CN120463819B (zh) * 2024-11-18 2026-01-27 北京宝易生物技术有限公司 疫苗稀释液制备方法和应用
CN121015864B (zh) * 2025-10-31 2026-02-03 可蓝赛生物医药(上海)有限公司 一种含有多糖佐剂的肿瘤疫苗及其应用

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Also Published As

Publication number Publication date
JP6956967B2 (ja) 2021-11-02
HK1250213A1 (en) 2018-12-07
US20180140691A1 (en) 2018-05-24
JPWO2016186177A1 (ja) 2018-04-12
ES2993462T3 (en) 2024-12-30
EP3299028A1 (en) 2018-03-28
JP6713160B2 (ja) 2020-06-24
JP2020075934A (ja) 2020-05-21
CA2986367A1 (en) 2016-11-24
JP2022000454A (ja) 2022-01-04
CN107921106A (zh) 2018-04-17
JP7253210B2 (ja) 2023-04-06
EP3299028A4 (en) 2019-02-27
WO2016186177A1 (ja) 2016-11-24
CN107921106B (zh) 2023-09-08
JP2019135251A (ja) 2019-08-15
US20240293521A1 (en) 2024-09-05
HK1248546A1 (zh) 2018-10-19
EP3299028B1 (en) 2024-10-30

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