JP6511430B2 - がんの治療のための化合物および組成物 - Google Patents

がんの治療のための化合物および組成物 Download PDF

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Publication number
JP6511430B2
JP6511430B2 JP2016501185A JP2016501185A JP6511430B2 JP 6511430 B2 JP6511430 B2 JP 6511430B2 JP 2016501185 A JP2016501185 A JP 2016501185A JP 2016501185 A JP2016501185 A JP 2016501185A JP 6511430 B2 JP6511430 B2 JP 6511430B2
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JP2016512520A (ja
JP2016512520A5 (enExample
Inventor
ルイス エイ ティモシー
ルイス エイ ティモシー
ムニョス ベニート
ムニョス ベニート
ドゥ ヴァール ルシアン
ドゥ ヴァール ルシアン
グロイリッヒ ハイジ
グロイリッヒ ハイジ
マイヤーソン マシュー
マイヤーソン マシュー
ニコール ゲチジャン ララ
ニコール ゲチジャン ララ
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Dana Farber Cancer Institute Inc
Broad Institute Inc
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Dana Farber Cancer Institute Inc
Broad Institute Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016501185A 2013-03-11 2014-03-11 がんの治療のための化合物および組成物 Active JP6511430B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361776520P 2013-03-11 2013-03-11
US61/776,520 2013-03-11
PCT/US2014/023263 WO2014164704A2 (en) 2013-03-11 2014-03-11 Compounds and compositions for the treatment of cancer

Publications (3)

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JP2016512520A JP2016512520A (ja) 2016-04-28
JP2016512520A5 JP2016512520A5 (enExample) 2017-04-13
JP6511430B2 true JP6511430B2 (ja) 2019-05-15

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US (2) US9890127B2 (enExample)
EP (1) EP2970145B1 (enExample)
JP (1) JP6511430B2 (enExample)
WO (1) WO2014164704A2 (enExample)

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UY37113A (es) * 2016-02-05 2017-08-31 Dana Farber Cancer Inst Inc Compuestos, composiciones y métodos para la estratificación de pacientes de cáncer y su tratamiento
US10562872B2 (en) * 2016-02-08 2020-02-18 H. Lundbeck A/S Synthesis of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine
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CN105968054B (zh) * 2016-05-12 2018-09-14 海门慧聚药业有限公司 匹莫苯丹关键中间体的制备
KR102526032B1 (ko) 2017-01-11 2023-04-25 로딘 테라퓨틱스, 인크. 히스톤 데아세틸라제의 바이시클릭 억제제
CN110831599B (zh) * 2017-02-03 2023-03-28 布罗德研究所股份有限公司 用于癌症治疗的化合物、组合物和方法
JOP20200024A1 (ar) * 2017-08-04 2020-02-02 Bayer Ag مركبات ثنائي هيدروكساديازينون
CA3071795A1 (en) 2017-08-04 2019-02-07 Bayer Aktiengesellschaft 6-phenyl-4,5-dihydropyridazin-3(2h)-one derivatives as pde3a and pde3b inhibitors for treating cancer
DK3664802T3 (en) 2017-08-07 2022-05-30 Alkermes Inc Bicyclic inhibitors of histone deacetylase
JP7104588B2 (ja) * 2017-09-01 2022-07-21 大塚製薬株式会社 ５－メチル－６－フェニル－４，５－ジヒドロ－２ｈ－ピリダジン－３－オン誘導体を含有する悪性腫瘍治療剤
CN110117257B (zh) * 2018-02-05 2022-12-06 安徽省新星药物开发有限责任公司 一种含胍基的p2y12受体拮抗剂、制备方法及其用途
CN108997349B (zh) * 2018-06-20 2021-03-16 合肥华方医药科技有限公司 一种依匹斯汀有关物质的制备方法
CN112512589A (zh) 2018-07-11 2021-03-16 H·李·莫菲特癌症中心研究有限公司 二聚体免疫调节化合物对抗基于cereblon的机制
WO2020157201A1 (en) * 2019-02-01 2020-08-06 Bayer Aktiengesellschaft Oxadiazinone compounds for the treatment of hyperproliferative diseases
WO2020157199A1 (en) * 2019-02-01 2020-08-06 Bayer Aktiengesellschaft Annulated dihydropyridazinone compounds as anti-cancer compounds
WO2020157188A1 (en) * 2019-02-01 2020-08-06 Bayer Aktiengesellschaft Dihydrooxadiazinones for the treatment of hyperproliferative diseases
AR117929A1 (es) * 2019-02-01 2021-09-01 Bayer Ag Compuestos de 1,2,4-triazin-3(2h)-ona
CN113582974B (zh) * 2020-04-30 2022-05-17 江西济民可信集团有限公司 一类作为蛋白降解剂的化合物及其制备方法和医药用途

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JP2016512520A (ja) 2016-04-28
US9890127B2 (en) 2018-02-13
EP2970145B1 (en) 2020-05-06
EP2970145A2 (en) 2016-01-20
US20180244629A1 (en) 2018-08-30
US20160016913A1 (en) 2016-01-21
WO2014164704A2 (en) 2014-10-09
WO2014164704A3 (en) 2014-12-31

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