JP6498601B2 - 多価ヘテロ多量体足場設計および構築物 - Google Patents
多価ヘテロ多量体足場設計および構築物 Download PDFInfo
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- C07K14/76—Albumins
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- C—CHEMISTRY; METALLURGY
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Landscapes
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/US2013/050408 WO2014012082A2 (en) | 2012-07-13 | 2013-07-12 | Multivalent heteromultimer scaffold design an constructs |
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| CN106164094B (zh) | 2014-03-21 | 2021-05-14 | X博迪公司 | 双特异性抗原结合多肽 |
| BR112016027888A2 (pt) | 2014-05-28 | 2017-10-24 | Zymeworks Inc | construto de polipeptídeo de ligação ao antígeno isolado, polinucleotídeo isolado ou um conjunto de polinucleotídeos isolados, vetor ou conjunto de vetores, célula isolada, composição farmacêutica, uso do construto, método para tratar um sujeito com uma doença ou distúrbio, método para obter um construto, método para preparar um construto, meio de armazenamento legível por computador, método para produzir um construto de polipeptídeo de ligação com antígeno bi-específico e método para preparar um construto de polipeptídeo de ligação com antígeno isolado |
| IL305193A (en) * | 2014-12-22 | 2023-10-01 | Systimmune Inc | Bispecific tetravalent antibodies and methods for their preparation and use |
| EP3322735A4 (en) | 2015-07-15 | 2019-03-13 | Zymeworks Inc. | ACTIVE CONJUGATED BIS-SPECIFIC ANTIGEN-BONDING CONSTRUCTS |
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| US11531030B2 (en) | 2017-04-21 | 2022-12-20 | Mayo Foundation For Medical Education And Research | Polypeptide-antibody complexes and uses thereof |
| US10676516B2 (en) | 2017-05-24 | 2020-06-09 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
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| AR112603A1 (es) | 2017-07-10 | 2019-11-20 | Lilly Co Eli | Anticuerpos biespecíficos inhibidores de punto de control |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| EP3749331A4 (en) * | 2018-02-06 | 2021-08-04 | Mayo Foundation for Medical Education and Research | ANTIBODY PEPTIDE COMPLEX AND THEIR USES |
| HRP20231280T1 (hr) | 2018-03-13 | 2024-02-02 | Zymeworks Bc Inc. | Anti-her2 biparatopski antitijelo-konjugati lijeka i načini uporabe |
| CA3102562A1 (en) * | 2018-06-07 | 2019-12-12 | Cullinan Management, Inc. | Multi-specific binding proteins and methods of use thereof |
| CN113710229A (zh) | 2019-02-25 | 2021-11-26 | 芝加哥大学 | 用与抗炎剂连接的ecm亲和肽治疗炎症性和自身免疫性病症的方法和组合物 |
| US11208477B2 (en) * | 2019-04-01 | 2021-12-28 | Novo Nordisk A/S | Antibodies and use thereof |
| KR102244760B1 (ko) * | 2019-04-29 | 2021-04-27 | 주식회사 다나그린 | 혈청유래 단백질을 포함하는 다공성 세포지지체 및 제조방법 |
| WO2020236875A1 (en) | 2019-05-20 | 2020-11-26 | Pandion Therapeutics, Inc. | Madcam targeted immunotolerance |
| AU2020282736B2 (en) * | 2019-05-29 | 2025-10-30 | Cue Biopharma, Inc. | Multimeric T-cell modulatory polypeptides and methods of use thereof |
| US12428480B2 (en) | 2019-12-11 | 2025-09-30 | Cullinan Therapeutics, Inc. | Anti-CD19 antibodies and multi-specific binding proteins |
| US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
| EP4282876A4 (en) | 2020-09-25 | 2025-06-11 | Proabtech Inc. | URICASE-ALBUMIN CONJUGATE, PREPARATION METHOD THEREOF AND USE THEREOF |
| WO2022065936A1 (ko) * | 2020-09-25 | 2022-03-31 | 주식회사 프로앱텍 | 기능성 폴리펩티드 변이체의 컨쥬게이트 및 그 용도 |
| CN114736291B (zh) * | 2021-01-07 | 2023-08-11 | 中国科学院微生物研究所 | 特异性结合发热伴血小板减少综合征病毒的囊膜蛋白Gn的人源单克隆抗体及其用途 |
| CN113563474B (zh) * | 2021-06-11 | 2023-05-02 | 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） | EpCAM-CD16-NKG2D三特异性抗体及其应用 |
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| CA2878640A1 (en) | 2014-01-16 |
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