JP6487110B2 - 椎間板治療用組成物 - Google Patents

椎間板治療用組成物 Download PDF

Info

Publication number
JP6487110B2
JP6487110B2 JP2018507084A JP2018507084A JP6487110B2 JP 6487110 B2 JP6487110 B2 JP 6487110B2 JP 2018507084 A JP2018507084 A JP 2018507084A JP 2018507084 A JP2018507084 A JP 2018507084A JP 6487110 B2 JP6487110 B2 JP 6487110B2
Authority
JP
Japan
Prior art keywords
composition
nucleus pulposus
intervertebral disc
present
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018507084A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2017163603A1 (ja
Inventor
英毅 須藤
英毅 須藤
武尊 辻本
武尊 辻本
倫政 岩崎
倫政 岩崎
賢 清水
賢 清水
三津子 伊佐次
三津子 伊佐次
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hokkaido University NUC
Mochida Pharmaceutical Co Ltd
Original Assignee
Hokkaido University NUC
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hokkaido University NUC, Mochida Pharmaceutical Co Ltd filed Critical Hokkaido University NUC
Publication of JPWO2017163603A1 publication Critical patent/JPWO2017163603A1/ja
Priority to JP2019027933A priority Critical patent/JP6907254B2/ja
Application granted granted Critical
Publication of JP6487110B2 publication Critical patent/JP6487110B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A61F2002/444—Intervertebral or spinal discs, e.g. resilient for replacing the nucleus pulposus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/734—Alginic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Prostheses (AREA)
JP2018507084A 2016-03-23 2017-01-27 椎間板治療用組成物 Active JP6487110B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019027933A JP6907254B2 (ja) 2016-03-23 2019-02-20 椎間板治療用組成物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016058396 2016-03-23
JP2016058396 2016-03-23
PCT/JP2017/002925 WO2017163603A1 (ja) 2016-03-23 2017-01-27 椎間板治療用組成物

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019027933A Division JP6907254B2 (ja) 2016-03-23 2019-02-20 椎間板治療用組成物

Publications (2)

Publication Number Publication Date
JPWO2017163603A1 JPWO2017163603A1 (ja) 2019-01-31
JP6487110B2 true JP6487110B2 (ja) 2019-03-20

Family

ID=59901106

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2018507084A Active JP6487110B2 (ja) 2016-03-23 2017-01-27 椎間板治療用組成物
JP2019027933A Active JP6907254B2 (ja) 2016-03-23 2019-02-20 椎間板治療用組成物
JP2021107910A Active JP7314207B2 (ja) 2016-03-23 2021-06-29 椎間板治療用組成物
JP2023113813A Pending JP2023134610A (ja) 2016-03-23 2023-07-11 椎間板治療用組成物
JP2025126019A Pending JP2025160358A (ja) 2016-03-23 2025-07-29 椎間板治療用組成物

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2019027933A Active JP6907254B2 (ja) 2016-03-23 2019-02-20 椎間板治療用組成物
JP2021107910A Active JP7314207B2 (ja) 2016-03-23 2021-06-29 椎間板治療用組成物
JP2023113813A Pending JP2023134610A (ja) 2016-03-23 2023-07-11 椎間板治療用組成物
JP2025126019A Pending JP2025160358A (ja) 2016-03-23 2025-07-29 椎間板治療用組成物

Country Status (8)

Country Link
US (1) US12478636B2 (enExample)
EP (2) EP3434291B1 (enExample)
JP (5) JP6487110B2 (enExample)
CN (1) CN109069692A (enExample)
BR (2) BR122021024709B1 (enExample)
CA (1) CA3018152A1 (enExample)
ES (1) ES2972523T3 (enExample)
WO (1) WO2017163603A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021145325A1 (ja) 2020-01-14 2021-07-22 持田製薬株式会社 アルギン酸塩を使用した対象の処置のための組合せ及び方法
US12478637B2 (en) 2020-11-13 2025-11-25 National University Corporation Hokkaido University Method for suppressing intervertebral disc pain

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3593807B1 (en) 2017-03-07 2023-09-06 Mochida Pharmaceutical Co., Ltd. Alginate liquid formulation
WO2019151444A1 (ja) * 2018-01-31 2019-08-08 国立大学法人神戸大学 椎間板変性の治療剤および椎間板細胞培養材
JP7404228B2 (ja) 2018-03-22 2023-12-25 持田製薬株式会社 非ステロイド性抗炎症性化合物結合アルギン酸誘導体
CN113195083B (zh) * 2018-12-26 2022-12-27 东丽株式会社 多孔膜、复合膜和多孔膜的制造方法
EP4072608A1 (en) 2019-12-12 2022-10-19 Instituto de Engenharia Biomédica (INEB) Fetal decellularized nucleus pulposus material and methods for obtaining pharmaceutic compositions to be used in the treatment of intervertebral disc degeneration and back pain
US20230080690A1 (en) * 2020-01-17 2023-03-16 National University Corporation Hokkaido University Cartilage damage treatment material utilizing bone marrow fluid
JP7761941B2 (ja) * 2020-11-01 2025-10-29 日本全薬工業株式会社 脊髄損傷の治療剤
US20240100099A1 (en) * 2021-01-29 2024-03-28 National University Corporation Hokkaido University Composition for regeneration of intervertebral disc
CN116115824B (zh) * 2022-10-04 2025-08-26 奥美医疗用品股份有限公司 一种注射型髓核修复产品及其制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5589591A (en) 1986-07-03 1996-12-31 Advanced Magnetics, Inc. Endotoxin-free polysaccharides
WO1993013136A1 (en) 1991-12-20 1993-07-08 Howmedica Inc. Ultra-pure polysaccharide materials for medical use
AU2621295A (en) * 1994-05-24 1995-12-18 Smith & Nephew Plc Intervertebral disc implant
JPH08269102A (ja) 1995-03-30 1996-10-15 Shiseido Co Ltd エンドトキシンフリーのβ１，３−グルカン及びその製造法並びに医療用ゲル素材
JPH09324001A (ja) 1996-04-02 1997-12-16 Kyowa Hakko Kogyo Co Ltd ヒアルロン酸ナトリウムの精製法
JPH11253547A (ja) * 1998-03-11 1999-09-21 Kunio Ishikawa 細胞遮断膜
EP1135418A1 (en) 1998-11-13 2001-09-26 CP Kelco U.S., Inc. Biopolymer salts with low endotoxin levels, biopolymer compositions thereof and methods of making the same
US20030069639A1 (en) 2001-04-14 2003-04-10 Tom Sander Methods and compositions for repair or replacement of joints and soft tissues
EP1448089A4 (en) 2001-11-01 2008-06-04 Spine Wave Inc DEVICES AND METHODS FOR SPINACH RECOVERY
JP2005036036A (ja) 2003-07-16 2005-02-10 Tanabe Seiyaku Co Ltd エンドトキシン除去方法
US7938818B2 (en) 2005-05-03 2011-05-10 Yeung Jeffrey E Alleviate back pain by increasing pH of the disc
JP2008543449A (ja) * 2005-06-17 2008-12-04 アボット・ラボラトリーズ 変性脊椎疾患の改良型治療方法
ITPI20050071A1 (it) * 2005-06-20 2006-12-21 Giuseppe Calvosa Composizione biocompatibile per la sostituzione/rigenerazione di tessuti
US8506633B2 (en) 2005-12-27 2013-08-13 Warsaw Orthopedic, Inc. Rehydration and restoration of intervertebral discs with polyelectrolytes
MX2009008760A (es) 2007-02-21 2009-08-27 Mochida Pharm Co Ltd Composicion para el tratamiento de enfermedades del cartilago.
EP2082755A1 (de) 2008-01-16 2009-07-29 CellMed AG Monolithische in-situ vernetzte Alginatimplantate
US20140213524A1 (en) 2011-08-23 2014-07-31 National University Corporation Hokkaido University Composition for regeneration of cartilage
CN108135928B (zh) * 2015-09-07 2021-06-08 持田制药株式会社 藻酸冻结干燥制剂
JP6196283B2 (ja) 2015-12-10 2017-09-13 トヨタ自動車株式会社 燃料電池用電極、燃料電池用電極の製造方法、固体高分子形燃料電池、および触媒インクの製造方法
WO2018159768A1 (ja) 2017-03-02 2018-09-07 持田製薬株式会社 線維軟骨組織損傷治療用組成物

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021145325A1 (ja) 2020-01-14 2021-07-22 持田製薬株式会社 アルギン酸塩を使用した対象の処置のための組合せ及び方法
KR20220127821A (ko) 2020-01-14 2022-09-20 모찌다 세이야쿠 가부시끼가이샤 알긴산염을 사용한 대상의 처치를 위한 조합 및 방법
US12491208B2 (en) 2020-01-14 2025-12-09 Mochida Pharmaceutical Co., Ltd. Combination and method for treating subject using alginate
US12478637B2 (en) 2020-11-13 2025-11-25 National University Corporation Hokkaido University Method for suppressing intervertebral disc pain

Also Published As

Publication number Publication date
CA3018152A1 (en) 2017-09-28
JP2021154163A (ja) 2021-10-07
JP6907254B2 (ja) 2021-07-21
JP2019088900A (ja) 2019-06-13
EP4374886A1 (en) 2024-05-29
JPWO2017163603A1 (ja) 2019-01-31
EP3434291A4 (en) 2019-10-23
EP3434291A1 (en) 2019-01-30
US12478636B2 (en) 2025-11-25
BR122021024709B1 (pt) 2023-01-03
EP3434291B1 (en) 2023-11-29
WO2017163603A1 (ja) 2017-09-28
JP7314207B2 (ja) 2023-07-25
JP2023134610A (ja) 2023-09-27
CN109069692A (zh) 2018-12-21
JP2025160358A (ja) 2025-10-22
US20200289547A1 (en) 2020-09-17
BR112018069060A2 (pt) 2019-01-29
ES2972523T3 (es) 2024-06-13

Similar Documents

Publication Publication Date Title
JP7314207B2 (ja) 椎間板治療用組成物
JP5425134B2 (ja) 軟骨疾患治療用組成物
RU2698210C2 (ru) Состав fgf-18 в альгинатных/коллагеновых гидрогелях
JP5491866B2 (ja) 関節疾患治療用組成物
JP6116009B2 (ja) 軟骨再生用組成物
JP7191007B2 (ja) 線維軟骨組織損傷治療用組成物
JP7620891B2 (ja) 椎間板再生用組成物
JP7607595B2 (ja) 骨髄液を用いた軟骨損傷治療材
US12478637B2 (en) Method for suppressing intervertebral disc pain

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181225

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20181225

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20181225

A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20190108

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190129

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20190220

R150 Certificate of patent or registration of utility model

Ref document number: 6487110

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250